Resistance mutation info of target

Target General Information
Target ID T11843
Target Name Vitamin K epoxide reductase complex subunit 1 (VKORC1) Target Info
Gene Name VKORC1
Species Homo sapiens
Uniprot ID VKOR1_HUMAN
Sequence MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWG
RGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYL
AWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH [Homo sapiens]
Drug Resistance Mutation and Corresponding Drugs
Ref 536186Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
Ref 541933(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6853).
Ref 550766Drug information of Acenocoumarol, 2008. eduDrugs.
Mutation Info Missense: V66M
Drugs
Drug Name Warfarin Drug Info [1559274]
Targeted Disease Blood clots
Drug Name Acenocoumarol Drug Info [1559223]
Targeted Disease Recurrent pulmonary embolism
Reference
Ref 1559274VKORC1 V66M mutation in African Brazilian patients resistant to oral anticoagulant therapy.Thromb Res.2010 Sep;126(3):e206-10.
Ref 1559223[Resistance to acenocoumarol revealing a missense mutation of the vitamin K epoxyde reductase VKORC1: a case report].Ann Cardiol Angeiol (Paris).2015 Feb;64(1):59-61.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.