Resistance mutation info of target

Target General Information
Target ID T17234
Target Name HCMV Serine/threonine protein kinase (UL97) Target Info
Gene Name UL97
Species Human cytomegalovirus
Uniprot ID UL97_HCMVA
Sequence MSSALRSRARSASLGTTTQGWDPPPLRRPSRARRRQWMREAAQAAAQAAVQAAQAAAAQV
AQAHVDENEVVDLMADEAGGGVTTLTTLSSVSTTTVLGHATFSACVRSDVMRDGEKEDAA
SDKENLRRPVVPSTSSRGSAASGDGYHGLRCRETSAMWSFEYDRDGDVTSVRRALFTGGS
DPSDSVSGVRGGRKRPLRPPLVSLARTPLCRRRVGGVDAVLEENDVELRAESQDSAVASG
PGRIPQPLSGSSGEESATAVEADSTSHDDVHCTCSNDQIITTSIRGLTCDPRMFLRLTHP
ELCELSISYLLVYVPKEDDFCHKICYAVDMSDESYRLGQGSFGEVWPLDRYRVVKVARKH
SETVLTVWMSGLIRTRAAGEQQQPPSLVGTGVHRGLLTATGCCLLHNVTVHRRFHTDMFH
HDQWKLACIDSYRRAFCTLADAIKFLNHQCRVCHFDITPMNVLIDVNPHNPSEIVRAALC
DYSLSEPYPDYNERCVAVFQETGTARRIPNCSHRLRECYHPAFRPMPLQKLLICDPHARF
PVAGLRRYCMSELSALGNVLGFCLMRLLDRRGLDEVRMGTEALLFKHAGAACRALENGKL
THCSDACLLILAAQMSYGACLLGEHGAALVSHTLRFVEAKMSSCRVRAFRRFYHECSQTM
LHEYVRKNVERLLATSDGLYLYNAFRRTTSIICEEDLDGDCRQLFPE [Human cytom
egalovirus]
Drug Resistance Mutation and Corresponding Drugs
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Mutation Info Deletion: A594
Drugs
Drug Name Ganciclovir Drug Info [556138]
Targeted Disease Bacterial infection
Mutation Info Missense: A594V
Drugs
Drug Name Ganciclovir Drug Info [556138]
Targeted Disease Bacterial infection
Mutation Prevalence 26.43% of the specimens
Mutation Info Missense: C518Y
Drugs
Drug Name Ganciclovir Drug Info [1559224]
Targeted Disease Bacterial infection
Mutation Info Missense: C592G
Drugs
Drug Name Ganciclovir Drug Info [556138]
Targeted Disease Bacterial infection
Mutation Prevalence 10.34% of the specimens
Mutation Info Missense: C603W
Drugs
Drug Name Ganciclovir Drug Info [556138]
Targeted Disease Bacterial infection
Mutation Prevalence 6.89% of the specimens
Mutation Info Missense: C607F
Drugs
Drug Name Ganciclovir Drug Info [1559224]
Targeted Disease Bacterial infection
Mutation Info Missense: D605E
Drugs
Drug Name Ganciclovir Drug Info [1559224]
Targeted Disease Bacterial infection
Mutation Prevalence 30 out of 70
Mutation Info Missense: E596G
Drugs
Drug Name Ganciclovir Drug Info [556138]
Targeted Disease Bacterial infection
Mutation Prevalence 1.14% of the specimens
Mutation Info Missense: H520Q
Drugs
Drug Name Ganciclovir Drug Info [556138]
Targeted Disease Bacterial infection
Mutation Prevalence 18.39% of the specimens
Mutation Info Missense: L595S
Drugs
Drug Name Ganciclovir Drug Info [556138]
Targeted Disease Bacterial infection
Mutation Prevalence 2.29% of the specimens
Mutation Info Missense: L595W
Drugs
Drug Name Ganciclovir Drug Info [1559224]
Targeted Disease Bacterial infection
Mutation Info Missense: M460I
Drugs
Drug Name Ganciclovir Drug Info [556138]
Targeted Disease Bacterial infection
Mutation Prevalence 9.19% of the specimens
Mutation Info Missense: M460V
Drugs
Drug Name Ganciclovir Drug Info [556138], [1559221]
Targeted Disease Bacterial infection
Mutation Prevalence 3.3% of patients
Reference
Ref 556138Assessment of the Human Cytomegalovirus UL97 Gene for Identification of Resistance to Ganciclovir in Iranian Immunosuppressed Patients. Jundishapur J Microbiol. 2016 May 29;9(5):e31733. doi: 10.5812/jjm.31733. eCollection 2016 May.
Ref 1559224A new mutation in the human cytomegalovirus UL97 gene may confer ganciclovir resistance in Chinese kidney transplant recipients.Arch Virol.2013 Jan;158(1):247-50.
Ref 1559221[Investigation of ganciclovir resistance in CMV UL54 and UL97 gene regions in immunocompromised patients receiving gancyclovir treatment].Mikrobiyol Bul.2015 Jul;49(3):393-402.

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