Resistance mutation info of target

Target General Information
Target ID T40696
Target Name Bacterial DNA topoisomerase 4 subunit A (parC) Target Info
Gene Name parC
Species Escherichia coli
Uniprot ID PARC_ECOLI
Sequence MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKF
KKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRY
TESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDI
PPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVR
MRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIV
PRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRR
RLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILEL
KLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPL
QEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSN
QPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDA
GYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDL
PQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGE
RGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE [Escherichia coli]
Drug Resistance Mutation and Corresponding Drugs
Ref 525081ClinicalTrials.gov (NCT02357407) Development of an Adjustment Assistance Tool Dosage of Fluoroquinolones in a Population Pharmacokinetic Model. U.S. National Institutes of Health.
Ref 536854Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Mutation Info Missense: A85T
Drugs
Drug Name Fluoroquinolones Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: D111H
Drugs
Drug Name Fluoroquinolones Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: E84G
Drugs
Drug Name Fluoroquinolone Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: E87Q
Drugs
Drug Name Fluoroquinolone Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: E91G
Drugs
Drug Name Fluoroquinolone Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: S129P
Drugs
Drug Name Fluoroquinolones Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: S80I
Drugs
Drug Name Fluoroquinolone Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: S83L
Drugs
Drug Name Fluoroquinolone Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: S83W
Drugs
Drug Name Fluoroquinolone Drug Info [556229]
Targeted Disease Bacterial infection
Drug Name Quinolone Drug Info [1559231]
Targeted Disease Bacterial infection
Mutation Info Missense: S84F
Drugs
Drug Name Fluoroquinolones Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: S84P
Drugs
Drug Name Fluoroquinolone Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: S87R
Drugs
Drug Name Fluoroquinolone Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: W106G
Drugs
Drug Name Fluoroquinolones Drug Info [556229]
Targeted Disease Bacterial infection
Reference
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.
Ref 1559231Antibacterial Resistance in Ureaplasma species and Mycoplasma hominis Isolates from Urine Cultures in College-aged Females.Antimicrob Agents Chemother.2017 Aug 21.

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