Resistance mutation info of target

Target General Information
Target ID T49995
Target Name Bacterial Arylamine N-acetyltransferase (nhoA) Target Info
Gene Name nhoA
Species Mycobacterium tuberculosis
Uniprot ID NAT_MYCTU
Sequence MALDLTAYFDRINYRGATDPTLDVLQDLVTVHSRTIPFENLDPLLGVPVDDLSPQALADK
LVLRRRGGYCFEHNGLMGYVLAELGYRVRRFAARVVWKLAPDAPLPPQTHTLLGVTFPGS
GGCYLVDVGFGGQTPTSPLRLETGAVQPTTHEPYRLEDRVDGFVLQAMVRDTWQTLYEFT
TQTRPQIDLKVASWYASTHPASKFVTGLTAAVITDDARWNLSGRDLAVHRAGGTEKIRLA
DAAAVVDTLSERFGINVADIGERGALETRIDELLARQPGADAP [Mycobacterium t
uberculosis]
Drug Resistance Mutation and Corresponding Drugs
Ref 536472Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.
Mutation Info Missense: G207E
Drugs
Drug Name Isoniazid Drug Info [555514]
Targeted Disease Tuberculosis
Mutation Prevalence 6 out of 38 isolates in all nhoA mutations
Mutation Info Missense: G67R
Drugs
Drug Name Isoniazid Drug Info [555514]
Targeted Disease Tuberculosis
Mutation Prevalence 6 out of 38 isolates in all nhoA mutations
Reference
Ref 555514Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2003 Apr;47(4):1241-50.

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