Resistance mutation info of target

Target General Information
Target ID T52227
Target Name Bacterial Thymidylate synthase (thyA) Target Info
Gene Name thyA
Species Mycobacterium tuberculosis
Uniprot ID TYSY_MYCTU
Sequence MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELL
WFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLR
TDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIAS
YALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFE
YTYEDIVVKNYDPHPAIKAPVAV [Mycobacterium tuberculosis]
Drug Resistance Mutation and Corresponding Drugs
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Mutation Info Missense: R222G
Drugs
Drug Name Aminosalicylic Acid Drug Info [555541]
Targeted Disease Tuberculosis
Mutation Info Missense: T202A
Drugs
Drug Name Aminosalicylic Acid Drug Info [555541]
Targeted Disease Tuberculosis
Reference
Ref 555541The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol Microbiol. 2004 Jul;53(1):275-82.

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