Resistance mutation info of target

Target General Information
Target ID T72657
Target Name Bacterial 30S ribosomal protein S12 (rpsL) Target Info
Gene Name rpsL
Species Mycobacterium tuberculosis
Uniprot ID RS12_MYCTU
Sequence MPTIQQLVRKGRRDKISKVKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVKLTSQ
VEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAK
KEKG [Mycobacterium tuberculosis]
Drug Resistance Mutation and Corresponding Drugs
Ref 536838Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22.
Mutation Info Missense: G84V
Drugs
Drug Name Streptomycin Drug Info [555546]
Targeted Disease Tuberculosis
Mutation Info Missense: K43R
Drugs
Drug Name Streptomycin Drug Info [556174], [556243]
Targeted Disease Tuberculosis
Mutation Info Missense: K43T
Drugs
Drug Name Streptomycin Drug Info [556172]
Targeted Disease Tuberculosis
Mutation Prevalence 5 out of 15 isolates
Mutation Info Missense: K51N
Drugs
Drug Name Streptomycin Drug Info [555546]
Targeted Disease Tuberculosis
Mutation Info Missense: K88M
Drugs
Drug Name Streptomycin Drug Info [556211]
Targeted Disease Tuberculosis
Mutation Prevalence 10 out of 17 isolates
Mutation Info Missense: K88Q
Drugs
Drug Name Streptomycin Drug Info [556189], [556243]
Targeted Disease Tuberculosis
Mutation Prevalence 9 out of 139 isolates
Mutation Info Missense: K88R
Drugs
Drug Name Streptomycin Drug Info [556172], [556243]
Targeted Disease Tuberculosis
Mutation Prevalence 2 out of 15 isolates
Mutation Info Missense: K88T
Drugs
Drug Name Streptomycin Drug Info [556211]
Targeted Disease Tuberculosis
Mutation Prevalence 10 out of 17 isolates
Mutation Info Missense: R86P
Drugs
Drug Name Streptomycin Drug Info [555624]
Targeted Disease Tuberculosis
Mutation Info Missense: R86W
Drugs
Drug Name Streptomycin Drug Info [555546]
Targeted Disease Tuberculosis
Mutation Info Missense: R9H
Drugs
Drug Name Streptomycin Drug Info [556189]
Targeted Disease Tuberculosis
Mutation Prevalence 1 out of 139 isolates
Mutation Info Missense: T40I
Drugs
Drug Name Streptomycin Drug Info [555546], [556243]
Targeted Disease Tuberculosis
Mutation Info Missense: T41S
Drugs
Drug Name Streptomycin Drug Info [555546]
Targeted Disease Tuberculosis
Mutation Info Missense: V52G
Drugs
Drug Name Streptomycin Drug Info [555546]
Targeted Disease Tuberculosis
Mutation Info Missense: V87L
Drugs
Drug Name Streptomycin Drug Info [555546]
Targeted Disease Tuberculosis
Mutation Info Missense: V93M
Drugs
Drug Name Streptomycin Drug Info [556189]
Targeted Disease Tuberculosis
Mutation Prevalence 1 out of 139 isolates
Reference
Ref 555546Molecular characterisation of streptomycin-resistant Mycobacterium tuberculosis strains isolated in Poland. Int J Tuberc Lung Dis. 2004 Aug;8(8):1032-5.
Ref 555624Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria. Mol Microbiol. 2007 Feb;63(4):1096-106.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.
Ref 556172Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot. Mol Microbiol. 1993 Sep;9(6):1239-46.
Ref 556174The rpsL gene and streptomycin resistance in single and multiple drug-resistant strains of Mycobacterium tuberculosis. Mol Microbiol. 1993 Nov;10(3):521-7.
Ref 556189Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities. Antimicrob Agents Chemother. 1996 Apr;40(4):1024-6.
Ref 556211Characterization of the rpsL and rrs genes of streptomycin-resistant clinical isolates of Mycobacterium tuberculosis in Japan. J Appl Microbiol. 1997 Nov;83(5):634-40.

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