Resistance mutation info of target

Target General Information
Target ID T78173
Target Name Fungal squalene epoxidase (ERG1) Target Info
Gene Name ERG1
Species Candida albicans
Uniprot ID ERG1_CANAL
Sequence MSSVKYDAIIIGAGVIGPTIATAFARQGRKVLIVERDWSKPDRIVGELMQPAGIKALREL
GMIKAINNIRAVDCTGYYIKYYDETITIPYPLKKDACITNPVKPVPDAVDGVNDKLDSDS
TLNVDDWDFDERVRGAAFHHGDFLMNLRQICRDEPNVTAVEATVTKILRDPSDPNTVIGV
QTKQPSGTVDYHAKLTISCDGIYSKFRKELSPTNVPTIGSYFIGLYLKNAELPAKGKGHV
LLGGHAPALIYSVSPTETRVLCVYVSSKPPSAANDAVYKYLRDNILPAIPKETVPAFKEA
LEERKFRIMPNQYLSAMKQGSENHKGFILLGDSLNMRHPLTGGGMTVGLNDSVLLAKLLH
PKFVEDFDDHQLIAKRLKTFHRKRKNLDAVINTLSISLYSLFAADKKPLRILRNGCFKYF
QRGGECVNGPIGLLSGMLPFPMLLFNHFFSVAFYSVYLNFIERGLLGFPLALFEAFEVLF
TAIVIFTPYLWNEIVR [Candida albicans]
Drug Resistance Mutation and Corresponding Drugs
Ref 536662Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. Ther Clin Risk Manag. 2005 Dec;1(4):299-306.
Mutation Info Missense: P430A
Drugs
Drug Name Terbinafine Drug Info [1559284]
Targeted Disease Candidiasis
Level of Resistance Low-level resistance
Reference
Ref 1559284Terbinafine resistance in a pleiotropic yeast mutant is caused by a single point mutation in the ERG1 gene.

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