Resistance mutation info of target

Target General Information
Target ID T81503
Target Name Bacterial DNA gyrase subunit B (gyrB) Target Info
Gene Name gyrB
Species Mycobacterium tuberculosis
Uniprot ID GYRB_MYCTU
Sequence MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
YATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGL
HGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVF
ETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAES
TAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISV
KVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKK
INKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARR
SFITRNAKDVRFLDV [Mycobacterium tuberculosis]
Drug Resistance Mutation and Corresponding Drugs
Ref 525081ClinicalTrials.gov (NCT02357407) Development of an Adjustment Assistance Tool Dosage of Fluoroquinolones in a Population Pharmacokinetic Model. U.S. National Institutes of Health.
Ref 536854Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6.
Ref 536838Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22.
Ref 1572605The ChEMBL database in 2017.
Mutation Info Missense: A473V
Drugs
Drug Name Fluoroquinolones Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: A515T
Drugs
Drug Name Fluoroquinolones Drug Info [555668]
Targeted Disease Bacterial infection
Mutation Prevalence 1 out of 48 isolates
Mutation Info Missense: A515V
Drugs
Drug Name Fluoroquinolones Drug Info [555668]
Targeted Disease Bacterial infection
Mutation Prevalence 3 out of 48 isolates
Mutation Info Missense: D464N
Drugs
Drug Name Fluoroquinolone Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: D472A
Drugs
Drug Name Fluoroquinolones Drug Info [555727]
Targeted Disease Bacterial infection
Mutation Info Missense: D472H
Drugs
Drug Name Fluoroquinolones Drug Info [555580], [555727]
Targeted Disease Bacterial infection
Mutation Info Missense: D472N
Drugs
Drug Name Fluoroquinolones Drug Info [555584], [555727]
Targeted Disease Bacterial infection
Mutation Info Missense: D476N
Drugs
Drug Name Fluoroquinolones Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: D505A
Drugs
Drug Name Fluoroquinolones Drug Info [555499]
Targeted Disease Bacterial infection
Mutation Info Missense: E466D
Drugs
Drug Name Fluoroquinolone Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: E502Q
Drugs
Drug Name Fluoroquinolone Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: E504V
Drugs
Drug Name Fluoroquinolone Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: E512D
Drugs
Drug Name Fluoroquinolones Drug Info [555727]
Targeted Disease Bacterial infection
Mutation Info Missense: E512V
Drugs
Drug Name Fluoroquinolones Drug Info [555727]
Targeted Disease Bacterial infection
Mutation Info Missense: G124S
Drugs
Drug Name Aminocoumarin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: G481A
Drugs
Drug Name Fluoroquinolones Drug Info [555727]
Targeted Disease Bacterial infection
Mutation Info Missense: G78S
Drugs
Drug Name Aminocoumarin Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: G85S
Drugs
Drug Name Aminocoumarin Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: I102S
Drugs
Drug Name Aminocoumarin Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: I56S
Drugs
Drug Name Aminocoumarin Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: M437I
Drugs
Drug Name Fluoroquinolones Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: N502D
Drugs
Drug Name Fluoroquinolone Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: N510D
Drugs
Drug Name Fluoroquinolones Drug Info [555580]
Targeted Disease Bacterial infection
Mutation Info Missense: N510T
Drugs
Drug Name Fluoroquinolones Drug Info [555727]
Targeted Disease Bacterial infection
Mutation Info Missense: N52T
Drugs
Drug Name Streptomycin Drug Info [556243]
Targeted Disease Tuberculosis
Mutation Info Missense: P462S
Drugs
Drug Name Fluoroquinolone Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: Q510K
Drugs
Drug Name Fluoroquinolones Drug Info [555668]
Targeted Disease Bacterial infection
Mutation Prevalence 1 out of 48 isolates
Mutation Info Missense: Q549H
Drugs
Drug Name Fluoroquinolones Drug Info [555668]
Targeted Disease Bacterial infection
Mutation Prevalence 1 out of 48 isolates
Mutation Info Missense: R136C
Drugs
Drug Name Aminocoumarin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R136E
Drugs
Drug Name Aminocoumarin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R136G
Drugs
Drug Name Aminocoumarin Drug Info [556229], [556243]
Targeted Disease Bacterial infection
Drug Name Aminocoumarin Drug Info [556229], [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R136H
Drugs
Drug Name Aminocoumarin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R136I
Drugs
Drug Name Aminocoumarin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R136L
Drugs
Drug Name Aminocoumarin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R136S
Drugs
Drug Name Aminocoumarin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R144I
Drugs
Drug Name Aminocoumarin Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: R144S
Drugs
Drug Name Aminocoumarin Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: R184Q
Drugs
Drug Name Aminocoumarin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R457C
Drugs
Drug Name Fluoroquinolones Drug Info [555708]
Targeted Disease Bacterial infection
Mutation Info Missense: S128L
Drugs
Drug Name Aminocoumarin Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: S458F
Drugs
Drug Name Fluoroquinolones Drug Info [555727]
Targeted Disease Bacterial infection
Mutation Info Missense: S464Y
Drugs
Drug Name Fluoroquinolone Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: T173A
Drugs
Drug Name Aminocoumarin Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: T214A
Drugs
Drug Name Aminocoumarin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: T214I
Drugs
Drug Name Aminocoumarin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: T511P
Drugs
Drug Name Fluoroquinolones Drug Info [555727]
Targeted Disease Bacterial infection
Mutation Info Missense: V461G
Drugs
Drug Name Fluoroquinolones Drug Info [556229]
Targeted Disease Bacterial infection
Reference
Ref 555499Characterization of pyrazinamide and ofloxacin resistance among drug resistant Mycobacterium tuberculosis isolates from Singapore. Int J Infect Dis. 2002 Mar;6(1):48-51.
Ref 555580Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes. Antimicrob Agents Chemother. 2006 Jan;50(1):104-12.
Ref 555584Mutations in the gyrA and gyrB genes of fluoroquinolone-resistant Mycobacterium tuberculosis from TB patients in Thailand. Southeast Asian J Trop Med Public Health. 2005;36 Suppl 4:228-37.
Ref 555668Molecular characterization of ofloxacin-resistant Mycobacterium tuberculosis strains from Russia. Antimicrob Agents Chemother. 2008 Aug;52(8):2937-9. doi: 10.1128/AAC.00036-08. Epub 2008 Jun 16.
Ref 555708Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother. 2009 Aug;53(8):3248-55. doi: 10.1128/AAC.00079-09. Epub 2009 May 26.
Ref 555727Beijing genotype of Mycobacterium tuberculosis is significantly associated with high-level fluoroquinolone resistance in Vietnam. Antimicrob Agents Chemother. 2009 Nov;53(11):4835-9. doi: 10.1128/AAC.00541-09. Epub 2009 Aug 31.
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.

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