Resistance mutation info of target

Target General Information
Target ID T82916
Target Name HCV Non-structural protein 5A (NS5A) Target Info
Gene Name NS5A
Species Hepatitis C virus genotype 1a
Uniprot ID POLG_HCV1(1973-2420)
Sequence SGSWLRDIWDWICEVLSDFKTWLKAKLMPQLPGIPFVSCQRGYKGVWRVDGIMHTRCHCG
AEITGHVKNGTMRIVGPRTCRNMWSGTFPINAYTTGPCTPLPAPNYTFALWRVSAEEYVE
IRQVGDFHYVTGMTTDNLKCPCQVPSPEFFTELDGVRLHRFAPPCKPLLREEVSFRVGLH
EYPVGSQLPCEPEPDVAVLTSMLTDPSHITAEAAGRRLARGSPPSVASSSASQLSAPSLK
ATCTANHDSPDAELIEANLLWRQEMGGNITRVESENKVVILDSFDPLVAEEDEREISVPA
EILRKSRRFAQALPVWARPDYNPPLVETWKKPDYEPPVVHGCPLPPPKSPPVPPPRKKRT
VVLTESTLSTALAELATRSFGSSSTSGITGDNTTTSSEPAPSGCPPDSDAESYSSMPPLE
GEPGDPDLSDGSWSTVSSEANAEDVVCC [Hepatitis C virus genotype 1a]
Drug Resistance Mutation and Corresponding Drugs
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Mutation Info Missense: L31M
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 3350 fold resistance
Mutation Info Missense: L31V
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 233 fold resistance
Mutation Info Missense: L31V + Y93H
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 8336 fold resistance
Mutation Info Missense: M28T
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 683 fold resistance
Mutation Info Missense: M28T + Q30H
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 8336 fold resistance
Mutation Info Missense: P32L
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 1850 fold resistance
Mutation Info Missense: Q30E
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 24933 fold resistance
Mutation Info Missense: Q30H
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 1450 fold resistance
Mutation Info Missense: Q30R
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 1217 fold resistance
Mutation Info Missense: Y93C
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 5367 fold resistance
Mutation Info Missense: Y93H
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 47477 fold resistance
Mutation Info Missense: Y93N
Drugs
Drug Name Daclatasvir Drug Info [555755], [555761]
Targeted Disease HCV infection
Level of Resistance Confer 103767 fold resistance
Reference
Ref 555755Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010 May 6;465(7294):96-100. doi: 10.1038/nature08960. Epub 2010 Apr 21.
Ref 555761Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system. Antimicrob Agents Chemother. 2010 Sep;54(9):3641-50. doi: 10.1128/AAC.00556-10. Epub 2010 Jun 28.

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