Resistance mutation info of target

Target General Information
Target ID T83793
Target Name HIV Negative factor (nef) Target Info
Gene Name nef
Species Human immunodeficiency virus type 1 (HIV-1)
Uniprot ID NEF_HV1A2
Sequence MGGKWSKRSMGGWSAIRERMRRAEPRAEPAADGVGAVSRDLEKHGAITSSNTAATNADCA
WLEAQEEEEVGFPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYH
TQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVEPEKVEEANEGENNSLLHPMSLHGMEDA
EKEVLVWRFDSKLAFHHMARELHPEYYKDC [Human immunodeficiency virus
type 1 (HIV-1)]
Drug Resistance Mutation and Corresponding Drugs
Ref 524080ClinicalTrials.gov (NCT01697293) Triciribine Phosphate in Breast Cancer. U.S. National Institutes of Health.
Ref 541208(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5920).
Mutation Info Missense: D174N
Drugs
Drug Name Triciribine Drug Info [1559256]
Targeted Disease HIV infection
Reference
Ref 1559256Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef.Antimicrob Agents Chemother.2010 Apr;54(4):1512-9.

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