Resistance mutation info of target

Target General Information
Target ID T91001
Target Name Bacterial Elongation factor Tu (EF-Tu) Target Info
Gene Name EF-Tu
Species Peptoclostridium difficile
Uniprot ID EFTU_PEPD6
Sequence MAKAKYERTKPHVNIGTIGHVDHGKTTLTAAITKTLYDRYQLGEAVDFANIDKAPEERER
GITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSATDGPMPQTREH
ILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLTEYDFPGDDTPIVRGSALMAL
EDPKSEWGDKIVELFEQIDEYIPAPERDTDKPFLMPVEDVFSITGRGTVATGRVERGVLK
VQDEVELVGLTEAPRKVVVTGVEMFRKLLDQAQAGDNIGALLRGVQRNEIERGQVLAKTG
SVKAHTKFTAEVYVLKKEEGGRHTPFFDGYRPQFYFRTTDVTGACKLPEGIEMVMPGDNV
TMEVDLINSIVVEEGLRFSIREGGRTVASGVVATIIE [Peptoclostridium diff
icile]
Drug Resistance Mutation and Corresponding Drugs
Ref
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
Ref 1572605The ChEMBL database in 2017.
Ref 1572605The ChEMBL database in 2017.
Mutation Info Missense: A376S
Drugs
Drug Name Kirromycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: A376V
Drugs
Drug Name Kirromycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: E379K
Drugs
Drug Name Kirromycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: G261E
Drugs
Drug Name Elfamycin Drug Info [556229]
Targeted Disease Enterocolitis Due To Clostridium Difficile
Mutation Info Missense: G317D
Drugs
Drug Name Kirromycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: L121Q
Drugs
Drug Name Kirromycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: Q125E
Drugs
Drug Name Kirromycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: Q125K
Drugs
Drug Name Kirromycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: Q125R
Drugs
Drug Name Kirromycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R231C
Drugs
Drug Name Pulvomycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R231V
Drugs
Drug Name Pulvomycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R234F
Drugs
Drug Name Pulvomycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R234S
Drugs
Drug Name Pulvomycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: R334C
Drugs
Drug Name Pulvomycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: T335A
Drugs
Drug Name Pulvomycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: Y161C
Drugs
Drug Name Kirromycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: Y161D
Drugs
Drug Name Kirromycin Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: Y161N
Drugs
Drug Name Kirromycin Drug Info [556243]
Targeted Disease Bacterial infection
Reference
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.

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