Resistance mutation info of target

Target General Information
Target ID T98089
Target Name Deoxycytidine kinase (DCK) Target Info
Gene Name DCK
Species Homo sapiens
Uniprot ID DCK_HUMAN
Sequence MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL [Homo sapiens]
Drug Resistance Mutation and Corresponding Drugs
Ref 468022(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4793).
Ref 536739Emerging drugs in cutaneous T cell lymphoma. Expert Opin Emerg Drugs. 2008 Jun;13(2):345-61.
Mutation Info Missense: E197K
Drugs
Drug Name Gemcitabine Drug Info [1559228]
Targeted Disease Gastric cancer
Reference
Ref 1559228Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK.Biochem Biophys Res Commun.2015 Sep 4;464(4):1084-9.

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