Resistance mutation info of target

Target General Information
Target ID T98264
Target Name Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) Target Info
Gene Name PTPN6
Species Homo sapiens
Uniprot ID PTN6_HUMAN
Sequence MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF
YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA
ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD
YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK
CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH
GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT
YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK [Hom
o sapiens]
Drug Resistance Mutation and Corresponding Drugs
Ref 1572605The ChEMBL database in 2017.
Mutation Info Missense: A550V
Drugs
Drug Name WHIP-154 Drug Info [1559259]
Targeted Disease Diffuse large B-cell lymphoma
Mutation Prevalence 2 out of 38 patients
Mutation Info Missense: N225K
Drugs
Drug Name WHIP-154 Drug Info [1559259]
Targeted Disease Diffuse large B-cell lymphoma
Mutation Prevalence 2 out of 38 patients
Reference
Ref 1559259Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma.Oncotarget.2015 Dec 29;6(42):44703-13.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.