TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T02703	Nitric-oxide synthase inducible	D0D3AI	L-NAME	Phase 2	39836	C7H15N5O4	233.23	COC(=O)[C@H](CCCN=C(N)N[N+](=O)[O-])N	IC50 = 300000000 nM	Non binder
T02703	Nitric-oxide synthase inducible	D0O3IT	L-NMMA	Discontinued in Phase 2	132862	C7H16N4O2	188.23	CN=C(N)NCCC[C@@H](C(=O)O)N	IC50 = 170000000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B02GWM	1-[3-(2-Amino-5-chlorophenyl)-3-hydroxypropyl]-3-methylthiourea	Investigative	127047637	C11H16ClN3OS	273.78	CNC(=S)NCCC(C1=C(C=CC(=C1)Cl)N)O	IC50 = 710000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B0BN1G	4-(1-Diazo-2,2,2-trifluoro-ethyl)-benzoic acid 2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl ester	Investigative	136109082	C16H10F3N7O3	405.29	C1=CC(=CC=C1C(=[N+]=[N-])C(F)(F)F)C(=O)OCC2=CN=C3C(=N2)C(=O)NC(=N3)N	IC50 = 374200 nM	Non binder
T02703	Nitric-oxide synthase inducible	B29SFA	1-[3-(2-Aminophenyl)-3-hydroxypropyl]-3-propylthiourea	Investigative	127048125	C13H21N3OS	267.39	CCCNC(=S)NCCC(C1=CC=CC=C1N)O	IC50 = 880000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B4NW3M	2,7-Diamino-7-iminoheptanoic acid	Investigative	4479245; 44392184	C7H15N3O2	173.21	C(CCC(=N)N)CC(C(=O)O)N	Ki > 3000000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B5Y7ZM	3-Quinolinecarbonitrile, 4-[(2-amino-6-benzothiazolyl)amino]-6-methyl-7-[2-(1-piperidinyl)ethoxy]-	Investigative	25169119	C25H26N6OS	458.6	CC1=CC2=C(C(=CN=C2C=C1OCCN3CCCCC3)C#N)NC4=CC5=C(C=C4)N=C(S5)N	IC50 = 313000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B64BXA	N'-[5-Fluoro-1-[4-(methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide	Investigative	56950331	C20H25FN4S	372.5	CNC1CCC(CC1)N2CCC3=CC(=C(C=C32)N=C(C4=CC=CS4)N)F	IC50 = 522000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B6C7VT	(2S)-2-Amino-5-[carbamoyl(methyl)amino]pentanoic acid	Investigative	24787679	C7H15N3O3	189.21	CN(CCC[C@@H](C(=O)O)N)C(=O)N	IC50 = 5000000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B6COE8	1-[3-(2-Aminophenyl)-3-hydroxypropyl]-3-methylthiourea	Investigative	127047755	C11H17N3OS	239.34	CNC(=S)NCCC(C1=CC=CC=C1N)O	IC50 = 350000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B6DF5Y	2-Amino-6-(ethoxymethyl)pteridin-4(1H)-one	Investigative	135674618	C9H11N5O2	221.22	CCOCC1=CN=C2C(=N1)C(=O)NC(=N2)N	IC50 > 500000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B6EQ8V	3-Cyclopropyl-3,4-dihydroisoquinolin-1-amine	Investigative	10977064	C12H14N2	186.25	C1CC1C2CC3=CC=CC=C3C(=N2)N	IC50 = 300000000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B6VC7Q	N',N'-Dibenzyl-6-(4-methoxyphenyl)pteridine-2,4-diamine	Investigative	10575453	C27H24N6O	448.5	COC1=CC=C(C=C1)C2=CN=C3C(=N2)C(=NC(=N3)N)N(CC4=CC=CC=C4)CC5=CC=CC=C5	IC50 = 400000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B7RUZ8	6-Methyl-arginine	Investigative	13154333	C7H16N4O2	188.23	CN(CCCC(C(=O)O)N)C(=N)N	Ki = 1400000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B7ZQB3	6-(4-Methoxyphenyl)-4-N,4-N-dipropyl-5,6,7,8-tetrahydropteridine-2,4-diamine	Investigative	10948273	C19H28N6O	356.5	CCCN(CCC)C1=NC(=NC2=C1NC(CN2)C3=CC=C(C=C3)OC)N	IC50 = 280500 nM	Non binder
T02703	Nitric-oxide synthase inducible	B83WDF	1-Amino-3-phenyl-8-fluoro-3,4-dihydroisoquinoline	Investigative	9873870	C15H13FN2	240.27	C1C(N=C(C2=C1C=CC=C2F)N)C3=CC=CC=C3	IC50 = 130000000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B8FD6O	2-Amino-5-benzoyl-5,6,7,8-tetrahydro-3H-pteridin-4-one	Investigative	136035302	C13H13N5O2	271.27	C1CN(C2=C(N1)N=C(NC2=O)N)C(=O)C3=CC=CC=C3	IC50 > 500000 nM	Non binder
T02703	Nitric-oxide synthase inducible	B8LD1T	2-Amino-4-hydroxy-6-(4-fluorophenyl)pteridine	Investigative	135973134	C12H8FN5O	257.22	C1=CC(=CC=C1C2=CN=C3C(=N2)C(=O)NC(=N3)N)F	IC50 > 500000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BA02KT	6-(4-Chloro-phenyl)-N*4*,N*4*-diethyl-5,6,7,8-tetrahydro-pteridine-2,4-diamine	Investigative	9819003	C16H21ClN6	332.8	CCN(CC)C1=NC(=NC2=C1NC(CN2)C3=CC=C(C=C3)Cl)N	IC50 = 307400 nM	Non binder
T02703	Nitric-oxide synthase inducible	BANP59	2-Amino-propionic acid 2-amino-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl ester	Investigative	136109078	C10H16N6O3	268.27	CC(C(=O)OCC1CNC2=C(N1)C(=O)NC(=N2)N)N	IC50 > 500000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BBD5H8	N'-[4-[2-(Methylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-6-yl]thiophene-2-carboximidamide	Investigative	44600413	C16H20N4S2	332.5	CNCCN1CCSC2=C1C=C(C=C2)N=C(C3=CC=CS3)N	IC50 = 348000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BBE4P1	1-[3-(2-Amino-5-chlorophenyl)-3-hydroxypropyl]-3-propylthiourea	Investigative	127047968	C13H20ClN3OS	301.84	CCCNC(=S)NCCC(C1=C(C=CC(=C1)Cl)N)O	IC50 > 1000000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BC8W2E	1-Amino-3-(4-fluorophenyl)-8-chloro-3,4-dihydroisoquinoline	Investigative	18785885	C15H12ClFN2	274.72	C1C(N=C(C2=C1C=CC=C2Cl)N)C3=CC=C(C=C3)F	IC50 = 350000000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BE03ZY	N'-[4-[2-(Methylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-7-yl]furan-2-carboximidamide	Investigative	44600248	C16H20N4OS	316.4	CNCCN1CCSC2=C1C=CC(=C2)N=C(C3=CC=CO3)N	IC50 = 268000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BHQ8F7	2-Amino-6-naphthalen-1-yl-3H-pteridin-4-one	Investigative	136109080	C16H11N5O	289.29	C1=CC=C2C(=C1)C=CC=C2C3=CN=C4C(=N3)C(=O)NC(=N4)N	IC50 > 500000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BK3E1F	2-[2-[7-[[Amino(thiophen-2-yl)methylidene]amino]-2,3-dihydro-1,4-benzothiazin-4-yl]ethyl-methylamino]acetic acid	Investigative	44600245	C18H22N4O2S2	390.5	CN(CCN1CCSC2=C1C=CC(=C2)N=C(C3=CC=CS3)N)CC(=O)O	IC50 = 241000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BL13FE	(2S)-1-[2-[7-[[Amino(thiophen-2-yl)methylidene]amino]-2,3-dihydro-1,4-benzothiazin-4-yl]ethyl]pyrrolidine-2-carboxylic acid	Investigative	44600246	C20H24N4O2S2	416.6	C1C[C@H](N(C1)CCN2CCSC3=C2C=CC(=C3)N=C(C4=CC=CS4)N)C(=O)O	IC50 = 341000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BN08DF	(2S)-2-Amino-6-(1-aminoethylideneamino)-N-(2H-tetrazol-5-yl)hexanamide;dihydrochloride	Investigative	49796134	C9H20Cl2N8O	327.21	CC(=NCCCC[C@@H](C(=O)NC1=NNN=N1)N)N.Cl.Cl	IC50 > 1850000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BNC70P	1-Amino-3-(2-thiazolyl)-3,4-dihydroisoquinoline	Investigative	18785857	C12H11N3S	229.3	C1C(N=C(C2=CC=CC=C21)N)C3=NC=CS3	IC50 = 880000000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BNL3U1	1-Amino-3-(4-fluorophenyl)-8-fluoro-3,4-dihydroisoquinoline	Investigative	10445220	C15H12F2N2	258.269	C1C(N=C(C2=C1C=CC=C2F)N)C3=CC=C(C=C3)F	IC50 = 350000000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BONI41	N',N'-Dibenzyl-6-phenylpteridine-2,4-diamine	Investigative	9931834	C26H22N6	418.5	C1=CC=C(C=C1)CN(CC2=CC=CC=C2)C3=NC(=NC4=NC=C(N=C43)C5=CC=CC=C5)N	IC50 = 451800 nM	Non binder
T02703	Nitric-oxide synthase inducible	BR6UZ4	1-[3-(2-Amino-5-chlorophenyl)-3-hydroxypropyl]-3-ethylthiourea	Investigative	127047967	C12H18ClN3OS	287.81	CCNC(=S)NCCC(C1=C(C=CC(=C1)Cl)N)O	IC50 = 770000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BS2K8F	[(1R)-1-Acetamido-4-(diaminomethylideneamino)butyl]boronic acid;hydrochloride	Investigative	10332472	C7H18BClN4O3	252.51	B([C@H](CCCN=C(N)N)NC(=O)C)(O)O.Cl	IC50 > 500000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BS6F2W	N'-(5-Fluoro-1-piperidin-4-yl-2,3-dihydroindol-6-yl)thiophene-2-carboximidamide	Investigative	56950187	C18H21FN4S	344.5	C1CNCCC1N2CCC3=CC(=C(C=C32)N=C(C4=CC=CS4)N)F	IC50 = 481000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BS9B0I	6-(4-Chloro-phenyl)-N*4*-cyclohexylmethyl-5,6,7,8-tetrahydro-pteridine-2,4-diamine	Investigative	9907534	C19H25ClN6	372.9	C1CCC(CC1)CNC2=NC(=NC3=C2NC(CN3)C4=CC=C(C=C4)Cl)N	IC50 = 214200 nM	Non binder
T02703	Nitric-oxide synthase inducible	BT9L2H	6-Phenyl-N*4*,N*4*-dipropyl-5,6,7,8-tetrahydro-pteridine-2,4-diamine	Investigative	17958630	C18H26N6	326.4	CCCN(CCC)C1=NC(=NC2=C1NC(CN2)C3=CC=CC=C3)N	IC50 = 229800 nM	Non binder
T02703	Nitric-oxide synthase inducible	BU7AB3	[(1R)-1-Amino-4-(diaminomethylideneamino)butyl]boronic acid;dihydrochloride	Investigative	10354581	C5H17BCl2N4O2	246.93	B([C@H](CCCN=C(N)N)N)(O)O.Cl.Cl	IC50 = 300000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BVYU09	Tert-butyl (2S,3S)-2-amino-3-[2-[[amino(methylsulfanyl)methylidene]amino]ethyl]hexanoate	Investigative	44402628	C14H29N3O2S	303.47	CCC[C@@H](CCN=C(N)SC)[C@@H](C(=O)OC(C)(C)C)N	IC50 = 370000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BXD70V	6-[[(3S,4S)-1-Benzyl-4-(3-phenylpropylamino)pyrrolidin-3-yl]methyl]pyridin-2-amine	Investigative	24850852	C26H32N4	400.6	C1[C@@H]([C@@H](CN1CC2=CC=CC=C2)NCCCC3=CC=CC=C3)CC4=NC(=CC=C4)N	Ki = 609000 nM	Non binder
T02703	Nitric-oxide synthase inducible	BYMB25	(R)-5-Acetimidoylamino-2-(S)-amino-3-methyl-pentanoic acid	Investigative	44402453	C8H17N3O2	187.24	C[C@H](CCN=C(C)N)[C@@H](C(=O)O)N	IC50 > 1000000 nM	Non binder
T02703	Nitric-oxide synthase inducible	D0V9FZ	L-2-Amino-4-(Guanidinooxy)Butyric Acid	Investigative	439202	C5H12N4O3	176.17	C(CON=C(N)N)[C@@H](C(=O)O)N	Ki = 220000 nM	Non binder