TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T05031	PI3-kinase beta	D0DF2M	PMID28870136-Compound-48	Patented	2153	C7H8N4O2	180.16	CN1C2=C(C(=O)N(C1=O)C)NC=N2	IC50 = 800000 nM	Non binder
T05031	PI3-kinase beta	D0H9IX	PMID28870136-Compound-52	Patented	2519	C8H10N4O2	194.19	CN1C=NC2=C1C(=O)N(C(=O)N2C)C	IC50 = 400000 nM	Non binder
T05031	PI3-kinase beta	B4E7QZ	7-[5-(2,2-Dimethylazetidin-1-yl)sulfonylpyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Investigative	71454160	C16H18N6O2S	358.4	CC1(CCN1S(=O)(=O)C2=CN=CC(=C2)C3=CC4=NC(=NN4C=C3)N)C	IC50 = 50118723.36 nM	Non binder
T05031	PI3-kinase beta	B4VL3W	Chembl4228200	Investigative	145970017	C27H25N5O2	451.5	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=C(N=N4)C5=C(C=C(C=C5)OC)C	IC50 = 355000 nM	Non binder
T05031	PI3-kinase beta	B8F2OT	5-(2-Amino-5-fluoro-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	Investigative	44621458	C15H17FN6O2S	364.4	CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C(=C2)F)N	IC50 = 31622776.6 nM	Non binder
T05031	PI3-kinase beta	BF70MB	CID 44621448	Investigative	44621448	C13H11F3N6O2S	372.33	C1=CN2C(=NC(=N2)N)C=C1C3=CC(=CN=C3)S(=O)(=O)NCC(F)(F)F	IC50 = 12589254.12 nM	Non binder
T05031	PI3-kinase beta	BFB28C	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N,N-diethylpyridine-3-sulfonamide	Investigative	44621442	C15H18N6O2S	346.4	CCN(CC)S(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 25118864.32 nM	Non binder
T05031	PI3-kinase beta	BG1L6I	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-3-sulfonamide	Investigative	44621456	C11H10N6O2S	290.3	C1=CN2C(=NC(=N2)N)C=C1C3=CC(=CN=C3)S(=O)(=O)N	IC50 = 39810717.06 nM	Non binder
T05031	PI3-kinase beta	BG3HJ9	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-propylpyridine-3-sulfonamide	Investigative	44621440	C14H16N6O2S	332.38	CCCNS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 31622776.6 nM	Non binder
T05031	PI3-kinase beta	BG5J6E	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	Investigative	44557921	C15H18N6O2S	346.4	CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 50118723.36 nM	Non binder
T05031	PI3-kinase beta	BH0XL5	Chembl4229035	Investigative	145986347	C25H21N5O	407.5	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=C(N=N4)C5=CC=CC=C5	IC50 = 430000 nM	Non binder
T05031	PI3-kinase beta	BK4BY1	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-methylpyridine-3-sulfonamide	Investigative	44621447	C12H12N6O2S	304.33	CNS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 39810717.06 nM	Non binder
T05031	PI3-kinase beta	BK6Y9P	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-propan-2-ylpyridine-3-sulfonamide	Investigative	44621441	C14H16N6O2S	332.38	CC(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 63095734.45 nM	Non binder
T05031	PI3-kinase beta	BKNH58	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-benzylpyridine-3-sulfonamide	Investigative	44621452	C18H16N6O2S	380.4	C1=CC=C(C=C1)CNS(=O)(=O)C2=CN=CC(=C2)C3=CC4=NC(=NN4C=C3)N	IC50 = 25118864.32 nM	Non binder
T05031	PI3-kinase beta	BKW5D3	7-(5-Methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Investigative	44621454	C12H11N5O2S	289.32	CS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 39810717.06 nM	Non binder
T05031	PI3-kinase beta	BQ2BT1	13-Morpholin-4-yl-11-(morpholin-4-ylmethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione	Investigative	122180839	C24H30N6O2S	466.6	C1CC2C3=C(N=C(N=C3N(C(=S)N2C1)C4=CC=CC=C4)CN5CCOCC5)N6CCOCC6	IC50 = 323450 nM	Non binder
T05031	PI3-kinase beta	BURI07	CID 44621449	Investigative	44621449	C15H15F3N6O2S	400.4	CC(C)(C(F)(F)F)NS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 31622776.6 nM	Non binder
T05031	PI3-kinase beta	BX5E8Y	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-phenylpyridine-3-sulfonamide	Investigative	44621451	C17H14N6O2S	366.4	C1=CC=C(C=C1)NS(=O)(=O)C2=CN=CC(=C2)C3=CC4=NC(=NN4C=C3)N	IC50 = 31622776.6 nM	Non binder
T05031	PI3-kinase beta	BZ42BQ	13-Morpholin-4-yl-11-(1-morpholin-4-ylethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione	Investigative	122180840	C25H32N6O2S	480.6	CC(C1=NC(=C2C3CCCN3C(=S)N(C2=N1)C4=CC=CC=C4)N5CCOCC5)N6CCOCC6	IC50 = 418160 nM	Non binder