TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T05090	Histone deacetylase 3	D0B7CH	Phenylbutyrate	Phase 2	4775	C10H12O2	164.2	C1=CC=C(C=C1)CCCC(=O)O	IC50 = 260000 nM	Non binder
T05090	Histone deacetylase 3	B2YIB7	N-((R)-5-((1R,3As,7aR,E)-4-(2-((3R,5R)-3,5-Dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)butane-1-sulfonamide	Investigative	46907280	C28H49NO4S	495.8	CCCCS(=O)(=O)NCCCC[C@@H](C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C3C[C@H](C[C@@H](C3)O)O)C	IC50 = 725000 nM	Non binder
T05090	Histone deacetylase 3	B31LNR	N-(2-Aminophenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)nicotinamide	Investigative	24746435	C20H25N5O	351.4	C1CNCC12CCN(CC2)C3=NC=C(C=C3)C(=O)NC4=CC=CC=C4N	IC50 = 340000 nM	Non binder
T05090	Histone deacetylase 3	B37LNB	N-(2-Amino-5-(thiophen-3-yl)phenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)nicotinamide	Investigative	24746436	C24H27N5OS	433.6	C1CNCC12CCN(CC2)C3=NC=C(C=C3)C(=O)NC4=C(C=CC(=C4)C5=CSC=C5)N	IC50 = 1270000 nM	Non binder
T05090	Histone deacetylase 3	B3M2YW	(2S)-2-Hexyl-N-hydroxy-N'-phenyloctanediamide	Investigative	134136160	C20H32N2O3	348.5	CCCCCC[C@@H](CCCCCC(=O)NC1=CC=CC=C1)C(=O)NO	IC50 = 530000 nM	Non binder
T05090	Histone deacetylase 3	B3TCW8	N-Hydroxy-2-propylpentanamide	Investigative	88129	C8H17NO2	159.23	CCCC(CCC)C(=O)NO	IC50 = 340000 nM	Non binder
T05090	Histone deacetylase 3	B3X9UO	(R)-N-(2-Aminophenyl)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexanamide	Investigative	46907124	C30H44N2O3	480.7	C[C@H](CCCC(=O)NC1=CC=CC=C1N)[C@H]2CC[C@@H]\\3[C@@]2(CCC/C3=C\\C=C4C[C@H](C[C@@H](C4)O)O)C	IC50 = 460000 nM	Non binder
T05090	Histone deacetylase 3	B5F4EH	N-((R)-5-((1R,3As,7aR,E)-4-(2-((3R,5R)-3,5-Dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)trifluoromethanesulfonamide	Investigative	46907198	C25H40F3NO4S	507.7	C[C@H](CCCCNS(=O)(=O)C(F)(F)F)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C3C[C@H](C[C@@H](C3)O)O)C	IC50 = 695000 nM	Non binder
T05090	Histone deacetylase 3	B61FPY	N-(2-Amino-5-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)nicotinamide	Investigative	44589911	C24H29N7O	431.5	CN1C=C(C=N1)C2=CC(=C(C=C2)N)NC(=O)C3=CN=C(C=C3)N4CCC5(CCNC5)CC4	IC50 = 5340000 nM	Non binder
T05090	Histone deacetylase 3	B91PWS	(1R,3As,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]-7a-methyl-1-[(2R)-6-(sulfamoylamino)hexan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-indene	Investigative	46906597	C24H42N2O4S	454.7	C[C@H](CCCCNS(=O)(=O)N)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C3C[C@H](C[C@@H](C3)O)O)C	IC50 = 470000 nM	Non binder
T05090	Histone deacetylase 3	BA0F4L	N-(2-Amino-5-(thiophen-2-yl)phenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)nicotinamide	Investigative	24746434	C24H27N5OS	433.6	C1CNCC12CCN(CC2)C3=NC=C(C=C3)C(=O)NC4=C(C=CC(=C4)C5=CC=CS5)N	IC50 = 1260000 nM	Non binder
T05090	Histone deacetylase 3	BA8BT9	(E)-3-[4-[3-(1-Adamantyl)-4-(cyanomethyl)phenyl]-3-chlorophenyl]-N-hydroxyprop-2-enamide	Investigative	90654946	C27H27ClN2O2	447	C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=C(C=C(C=C5)/C=C/C(=O)NO)Cl)CC#N	IC50 = 340000 nM	Non binder
T05090	Histone deacetylase 3	BG6M7J	N-((R)-5-((1R,3As,7aR,E)-4-(2-((3R,5R)-3,5-Dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)benzenesulfonamide	Investigative	46907281	C30H45NO4S	515.7	C[C@H](CCCCNS(=O)(=O)C1=CC=CC=C1)[C@H]2CC[C@@H]\\3[C@@]2(CCC/C3=C\\C=C4C[C@H](C[C@@H](C4)O)O)C	IC50 = 508000 nM	Non binder
T05090	Histone deacetylase 3	BJ1K2H	(1R,3As,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]-7a-methyl-1-[(2R)-7-(sulfamoylamino)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-indene	Investigative	46906641	C25H44N2O4S	468.7	C[C@H](CCCCCNS(=O)(=O)N)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C3C[C@H](C[C@@H](C3)O)O)C	IC50 = 605000 nM	Non binder
T05090	Histone deacetylase 3	BK84SE	N-(2-Amino-5-(1-methyl-1H-imidazol-4-yl)phenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)nicotinamide	Investigative	44589913	C24H29N7O	431.5	CN1C=C(N=C1)C2=CC(=C(C=C2)N)NC(=O)C3=CN=C(C=C3)N4CCC5(CCNC5)CC4	IC50 > 30000000 nM	Non binder
T05090	Histone deacetylase 3	BP2N0X	N-((R)-4-((1R,3As,7aR,E)-4-(2-((3R,5R)-3,5-Dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentyl)methanesulfonamide	Investigative	46907196	C24H41NO4S	439.7	C[C@H](CCCNS(=O)(=O)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C3C[C@H](C[C@@H](C3)O)O)C	IC50 = 730000 nM	Non binder
T05090	Histone deacetylase 3	BQ6U9X	N-(2-Amino-5-(1H-pyrazol-3-yl)phenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)nicotinamide	Investigative	44589912	C23H27N7O	417.5	C1CNCC12CCN(CC2)C3=NC=C(C=C3)C(=O)NC4=C(C=CC(=C4)C5=CC=NN5)N	IC50 = 5500000 nM	Non binder
T05090	Histone deacetylase 3	BY9H6R	N-((R)-5-((1R,3As,7aR,E)-4-(2-((3R,5R)-3,5-Dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexyl)methanesulfonamide	Investigative	46907197	C25H43NO4S	453.7	C[C@H](CCCCNS(=O)(=O)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C3C[C@H](C[C@@H](C3)O)O)C	IC50 = 718000 nM	Non binder