TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T06046	Nitric-oxide synthase endothelial	D05QJT	GW274150	Phase 2	9797017	C8H17N3O2S	219.31	CC(=NCCSCC[C@@H](C(=O)O)N)N	IC50 = 466000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B08VRT	8-Chloro-6,7-difluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	Investigative	44320115	C12H11ClF2N2	256.68	C1C[C@H]2[C@@H](C1)C(=NC3=C(C(=C(C=C23)Cl)F)F)N	IC50 > 200000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B0BN1G	4-(1-Diazo-2,2,2-trifluoro-ethyl)-benzoic acid 2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl ester	Investigative	136109082	C16H10F3N7O3	405.29	C1=CC(=CC=C1C(=[N+]=[N-])C(F)(F)F)C(=O)OCC2=CN=C3C(=N2)C(=O)NC(=N3)N	IC50 = 208600 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B0UB5I	7-(2-Methoxyethoxy)-2-[2-(4-methoxypyridin-2-yl)ethyl]-1H-imidazo[4,5-b]pyridine	Investigative	10215218	C17H20N4O3	328.4	COCCOC1=C2C(=NC=C1)N=C(N2)CCC3=NC=CC(=C3)OC	IC50 = 204173.79 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B19PWK	(S)-6-Acetimidoylamino-2-(R)-amino-5-fluoro-hexanoic acid	Investigative	11390106	C8H16FN3O2	205.23	CC(=NC[C@H](CC[C@H](C(=O)O)N)F)N	IC50 = 374000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B1YMB6	2-Imino-6-cyclohexylmethylpiperidine	Investigative	10799502	C12H22N2	194.32	C1CCC(CC1)CC2CCCC(=N2)N	IC50 = 375000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B4D0GU	7-Methoxy-2-[2-(4-methoxypyridin-2-yl)ethyl]-1H-imidazo[4,5-b]pyridine	Investigative	56673237	C15H16N4O2	284.31	COC1=CC(=NC=C1)CCC2=NC3=NC=CC(=C3N2)OC	IC50 = 204173.79 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B64BXA	N'-[5-Fluoro-1-[4-(methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide	Investigative	56950331	C20H25FN4S	372.5	CNC1CCC(CC1)N2CCC3=CC(=C(C=C32)N=C(C4=CC=CS4)N)F	IC50 = 220000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B64QOR	3-(2-Butenyl)-5-iminohexahydro-1,4-oxazepine	Investigative	44322605	C9H16N2O	168.24	C/C=C/CC1COCCC(=N1)N	IC50 = 709000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B6C7VT	(2S)-2-Amino-5-[carbamoyl(methyl)amino]pentanoic acid	Investigative	24787679	C7H15N3O3	189.21	CN(CCC[C@@H](C(=O)O)N)C(=O)N	IC50 = 4000000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B6DF5Y	2-Amino-6-(ethoxymethyl)pteridin-4(1H)-one	Investigative	135674618	C9H11N5O2	221.22	CCOCC1=CN=C2C(=N1)C(=O)NC(=N2)N	IC50 > 500000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B6FRH1	N'-[(3S,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]ethane-1,2-diamine	Investigative	11188611	C13H23N5	249.36	CC1=CC(=NC(=C1)N)C[C@H]2CNC[C@H]2NCCN	Ki = 282900 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B6ZX5C	2-Benzyl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-amine;hydrochloride	Investigative	45265035	C12H14ClF3N2	278.7	C1C(C(N=C1N)CC2=CC=CC=C2)C(F)(F)F.Cl	IC50 = 1010000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B76KPG	(2R,3R)-3-Methyl-2-pentyl-3,4-dihydro-2H-pyrrol-5-amine;hydrochloride	Investigative	10398017	C10H21ClN2	204.74	CCCCC[C@@H]1[C@@H](CC(=N1)N)C.Cl	IC50 = 226000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B7KY1Z	7-(2-Ethylbutyl)hexahydro-1H-azepin-2-imine, monohydrochloride	Investigative	45259669	C12H25ClN2	232.79	CCC(CC)CC1CCCCC(=N1)N.Cl	IC50 = 660000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B89DKI	2-[(4-Ethoxyphenyl)methyl]-1-[2-(1-methylpyrrolidin-2-yl)ethyl]-5-nitrobenzimidazole;dihydrochloride	Investigative	90664349	C23H30Cl2N4O3	481.4	CCOC1=CC=C(C=C1)CC2=NC3=C(N2CCC4CCCN4C)C=CC(=C3)[N+](=O)[O-].Cl.Cl	IC50 = 317000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B8B2GN	Hexahydro-3-(2-propenyl)-1H-azepin-2-imine, monohydrochloride	Investigative	45259623	C9H17ClN2	188.7	C=CCC1CCCCN=C1N.Cl	IC50 = 380000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B8FD6O	2-Amino-5-benzoyl-5,6,7,8-tetrahydro-3H-pteridin-4-one	Investigative	136035302	C13H13N5O2	271.27	C1CN(C2=C(N1)N=C(NC2=O)N)C(=O)C3=CC=CC=C3	IC50 > 500000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B8LD1T	2-Amino-4-hydroxy-6-(4-fluorophenyl)pteridine	Investigative	135973134	C12H8FN5O	257.22	C1=CC(=CC=C1C2=CN=C3C(=N2)C(=O)NC(=N3)N)F	IC50 = 253000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B8T7DX	(3S)-2-Imino-4alpha-methyl-5alpha-pentylpyrrolidine-3beta-ol	Investigative	44341315	C10H20N2O	184.28	CCCCC[C@H]1[C@H]([C@@H](C(=N1)N)O)C	IC50 = 930000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B8UBS6	L-Ornithine, N5-[hydrazino(methylthio)methylene]-	Investigative	10585015	C7H16N4O2S	220.3	CSC(=NCCC[C@@H](C(=O)O)N)NN	IC50 = 752000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B90MSW	N'-[3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl]benzenecarboximidamide;dihydrochloride	Investigative	90664467	C21H26Cl2N4	405.4	CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CC=C4)N.Cl.Cl	IC50 = 249000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	B96YTR	2-Imino-4-methyl-5-pentyl-pyrrolidin-3-ol	Investigative	44341316	C10H20N2O	184.28	CCCCC[C@@H]1[C@@H]([C@H](C(=N1)N)O)C	IC50 = 695000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BANP59	2-Amino-propionic acid 2-amino-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl ester	Investigative	136109078	C10H16N6O3	268.27	CC(C(=O)OCC1CNC2=C(N1)C(=O)NC(=N2)N)N	IC50 > 500000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BB98TH	2-Benzyl-3-methyl-3,4-dihydro-2H-pyrrol-5-amine;hydrochloride	Investigative	17793168	C12H17ClN2	224.73	CC1CC(=NC1CC2=CC=CC=C2)N.Cl	IC50 = 458000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BBY76S	(2R)-2-Amino-3-[(2R)-1-(diaminomethylideneamino)propan-2-yl]sulfanyl-2-methylpropanoic acid;dihydrochloride	Investigative	134147034	C8H20Cl2N4O2S	307.24	C[C@H](CN=C(N)N)SC[C@@](C)(C(=O)O)N.Cl.Cl	IC50 = 266000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BCP8Z9	5-(2-Methyl-1-isothioureido)-L-Nva-L-Phe-OH	Investigative	9823715	C16H24N4O3S	352.5	CSC(=NCCC[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)N)N	IC50 > 1000000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BCR15J	3-Methyl-2-pentyl-3,4-dihydro-2H-pyrrol-5-amine;hydrochloride	Investigative	45261746	C10H21ClN2	204.74	CCCCCC1C(CC(=N1)N)C.Cl	IC50 = 226000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BG4BO6	(3R)-2-Imino-4alpha-methyl-5alpha-pentylpyrrolidine-3alpha-ol	Investigative	44341087	C10H20N2O	184.28	CCCCC[C@H]1[C@H]([C@H](C(=N1)N)O)C	IC50 = 2930000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BH83MQ	N-((5S,6R)-5-Amino-6,7-dihydroxy-heptyl)-acetamidine	Investigative	10330523	C9H21N3O2	203.28	CC(=NCCCC[C@@H]([C@H](CO)O)N)N	IC50 = 8420000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BHQ8F7	2-Amino-6-naphthalen-1-yl-3H-pteridin-4-one	Investigative	136109080	C16H11N5O	289.29	C1=CC=C2C(=C1)C=CC=C2C3=CN=C4C(=N3)C(=O)NC(=N4)N	IC50 = 350700 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BICT94	N'-[3-[4-(Ethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	Investigative	57385794	C21H27ClN4S	403	CCNC1CCC(CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N.Cl	IC50 = 216000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BK7GW9	N-(1-(Piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide dihydrochloride	Investigative	67492912	C18H24Cl2N4S	399.4	C1CNCCC1N2CCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N.Cl.Cl	IC50 = 415000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BKC3I5	N'-[3-[4-(Dimethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	Investigative	57385792	C21H27ClN4S	403	CN(C)C1CCC(CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N.Cl	IC50 = 284000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BL6E3W	L-Ornithine, N5-(hydrazinothioxomethyl)-	Investigative	10798324	C6H14N4O2S	206.27	C(C[C@@H](C(=O)O)N)CNC(=S)NN	IC50 = 3065000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BL9RJ6	(2R)-2-Amino-3-[2-(diaminomethylideneamino)ethylsulfonyl]-2-methylpropanoic acid;dihydrochloride	Investigative	134138805	C7H18Cl2N4O4S	325.21	C[C@](CS(=O)(=O)CCN=C(N)N)(C(=O)O)N.Cl.Cl	IC50 = 1080000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BN08DF	(2S)-2-Amino-6-(1-aminoethylideneamino)-N-(2H-tetrazol-5-yl)hexanamide;dihydrochloride	Investigative	49796134	C9H20Cl2N8O	327.21	CC(=NCCCC[C@@H](C(=O)NC1=NNN=N1)N)N.Cl.Cl	IC50 = 2420000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BONI41	N',N'-Dibenzyl-6-phenylpteridine-2,4-diamine	Investigative	9931834	C26H22N6	418.5	C1=CC=C(C=C1)CN(CC2=CC=CC=C2)C3=NC(=NC4=NC=C(N=C43)C5=CC=CC=C5)N	IC50 = 343400 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BQN80C	(2R,3S,4S)-5-Amino-3-methyl-2-pentyl-3,4-dihydro-2H-pyrrol-4-ol;hydrochloride	Investigative	49796514	C10H21ClN2O	220.74	CCCCC[C@@H]1[C@@H]([C@@H](C(=N1)N)O)C.Cl	IC50 = 1980000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BR06SW	Hexahydro-7-phenyl-1H-azepin-2-imine, monohydrochloride	Investigative	45259666	C12H17ClN2	224.73	C1CCC(=NC(C1)C2=CC=CC=C2)N.Cl	IC50 = 215000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BS6F2W	N'-(5-Fluoro-1-piperidin-4-yl-2,3-dihydroindol-6-yl)thiophene-2-carboximidamide	Investigative	56950187	C18H21FN4S	344.5	C1CNCCC1N2CCC3=CC(=C(C=C32)N=C(C4=CC=CS4)N)F	IC50 = 243000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BSPK10	(2R)-2-Amino-2-[2-(diaminomethylideneamino)ethylsulfanylmethyl]-3-methoxypropanoic acid;dihydrochloride	Investigative	134143646	C8H20Cl2N4O3S	323.24	COC[C@](CSCCN=C(N)N)(C(=O)O)N.Cl.Cl	IC50 = 302000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BUN2Y3	N'-[[3-[[(4-Methylphenyl)sulfonylamino]methyl]phenyl]methyl]ethanimidamide;hydrochloride	Investigative	25231830	C17H22ClN3O2S	367.9	CC1=CC=C(C=C1)S(=O)(=O)NCC2=CC(=CC=C2)CN=C(C)N.Cl	IC50 = 300000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BV2G6K	1-Benzyl-3-(2-isobutyrylamino-4-oxo-6,7-diphenyl-4,6,7,8-tetrahydro-3H-pteridine-5-carbonyl)-pyridinium	Investigative	136035301	C35H33N6O3+	585.7	CC(C)C(=O)NC1=NC2=C(C(=O)N1)N(C(C(N2)C3=CC=CC=C3)C4=CC=CC=C4)C(=O)C5=C[N+](=CC=C5)CC6=CC=CC=C6	IC50 = 253200 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BVO4Q6	(2R)-2-Amino-3-[(2S)-1-(diaminomethylideneamino)propan-2-yl]sulfanyl-2-methylpropanoic acid;dihydrochloride	Investigative	134144338	C8H20Cl2N4O2S	307.24	C[C@@H](CN=C(N)N)SC[C@@](C)(C(=O)O)N.Cl.Cl	IC50 = 1100000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BVYU09	Tert-butyl (2S,3S)-2-amino-3-[2-[[amino(methylsulfanyl)methylidene]amino]ethyl]hexanoate	Investigative	44402628	C14H29N3O2S	303.47	CCC[C@@H](CCN=C(N)SC)[C@@H](C(=O)OC(C)(C)C)N	IC50 > 1000000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BX75FW	6,8-Dichloro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	Investigative	44320069	C12H12Cl2N2	255.14	C1C[C@H]2[C@@H](C1)C(=NC3=C2C=C(C=C3Cl)Cl)N	IC50 > 200000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BXF71K	2-Pentyl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-amine;hydrochloride	Investigative	45261788	C10H18ClF3N2	258.709	CCCCCC1C(CC(=N1)N)C(F)(F)F.Cl	IC50 = 212000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BXR2P7	(S)-3-(2-Acetimidoylamino-ethanesulfonyl)-2-amino-propionic acid	Investigative	44370729	C7H15N3O4S	237.28	CC(=NCCS(=O)(=O)C[C@H](C(=O)O)N)N	IC50 > 1000000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BXT09N	(R)-2-(S)-Amino-3-methyl-5-(2-methyl-isothioureido)-pentanoic acid tert-butyl ester	Investigative	44402389	C12H25N3O2S	275.41	C[C@H](CCN=C(N)SC)[C@@H](C(=O)OC(C)(C)C)N	IC50 > 1000000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	BYMB25	(R)-5-Acetimidoylamino-2-(S)-amino-3-methyl-pentanoic acid	Investigative	44402453	C8H17N3O2	187.24	C[C@H](CCN=C(C)N)[C@@H](C(=O)O)N	IC50 > 1000000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	D01YNT	((E)-7-But-2-enyl)-azepan-(2Z)-ylideneamine	Investigative	10012278	C10H18N2	166.26	C/C=C/CC1CCCCC(=N1)N	IC50 = 205900 nM	Non binder
T06046	Nitric-oxide synthase endothelial	D03QSQ	5-Ethyl-4-propyl-pyrrolidin-(2Z)-ylideneamine	Investigative	19049087	C9H18N2	154.25	CCCC1CC(=NC1CC)N	IC50 = 227000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	D05PZA	N-benzylacetimidamide hydrobromide	Investigative	25231659	C9H13BrN2	229.12	CC(=NCC1=CC=CC=C1)N.Br	IC50 = 350000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	D07MFH	3-(2-Amino-ethyl)-5-imino-[1,4]oxazepane	Investigative	44323014	C7H15N3O	157.21	C1COCC(N=C1N)CCN	IC50 = 247800 nM	Non binder
T06046	Nitric-oxide synthase endothelial	D0L9SL	3-Butyl-[1,4]oxazepan-(5Z)-ylideneamine	Investigative	44322997	C9H18N2O	170.25	CCCCC1COCCC(=N1)N	IC50 = 1363000 nM	Non binder
T06046	Nitric-oxide synthase endothelial	D0S7MJ	(S)-N-(1-phenylethyl)acetimidamide hydrobromide	Investigative	25231669	C10H15BrN2	243.14	C[C@@H](C1=CC=CC=C1)N=C(C)N.Br	IC50 = 300000 nM	Non binder