TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T12808	Protein kinase C alpha	D06VML	Seroxat	Approved	43815	C19H20FNO3	329.4	C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4	IC50 = 220000 nM	Non binder
T12808	Protein kinase C alpha	D0U3EP	Resveratrol	Phase 3	445154	C14H12O3	228.24	C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O	EC50 = 5780000 nM	Non binder
T12808	Protein kinase C alpha	D09DHT	phorbol 12-myristate 13-acetate	Phase 2	27924	C36H56O8	616.8	CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C	EC50 = 1700000 nM	Non binder
T12808	Protein kinase C alpha	D0A3MV	AR-A014418	Patented	448014	C12H12N4O4S	308.32	COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]	IC50 > 100000000 nM	Non binder
T12808	Protein kinase C alpha	B0QN7J	13-(1,3-Dihydroxypropan-2-ylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione	Investigative	44273560	C29H28N4O11	608.6	C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(CO)CO)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O	IC50 > 200000 nM	Non binder
T12808	Protein kinase C alpha	B0XKW1	1-[(4-Methoxyphenyl)methyl]-3-[6-(2H-tetrazol-5-yl)-1,3-benzothiazol-2-yl]urea	Investigative	53388145	C17H15N7O2S	381.4	COC1=CC=C(C=C1)CNC(=O)NC2=NC3=C(S2)C=C(C=C3)C4=NNN=N4	IC50 = 24200000 nM	Non binder
T12808	Protein kinase C alpha	B3VZT5	Acetic acid (2S,3R)-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester	Investigative	44276164	C7H10O5	174.15	CC(=O)O[C@@H]1CC(=O)O[C@H]1CO	Ki > 1700000 nM	Non binder
T12808	Protein kinase C alpha	B3ZC6X	13-(Ethylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione	Investigative	44273491	C28H26N4O9	562.5	CCNN1C(=O)C2=C3C4=C(C(=CC=C4)O)NC3=C5C(=C2C1=O)C6=C(N5C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O	IC50 > 200000 nM	Non binder
T12808	Protein kinase C alpha	B4GVJ9	3-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]propanenitrile	Investigative	44273598	C29H25N5O9	587.5	C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NCCC#N)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O	IC50 > 200000 nM	Non binder
T12808	Protein kinase C alpha	B5N3EA	1-Methyl-4-amino-2-methylquinolinium	Investigative	129831	C11H13IN2	300.14	CC1=[N+](C2=CC=CC=C2C(=C1)N)C.[I-]	IC50 = 3590000 nM	Non binder
T12808	Protein kinase C alpha	B7M0KI	N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]formamide	Investigative	17874201	C27H22N4O10	562.5	C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC=O)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O	IC50 > 200000 nM	Non binder
T12808	Protein kinase C alpha	B8VQU0	[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]urea	Investigative	44273561	C27H23N5O10	577.5	C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(=O)N)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O	IC50 > 200000 nM	Non binder
T12808	Protein kinase C alpha	B9CVE0	5-[(E)-2-(4-Hexadecoxyphenyl)ethenyl]benzene-1,3-diol	Investigative	56665223	C30H44O3	452.7	CCCCCCCCCCCCCCCCOC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)O)O	EC50 = 5040000 nM	Non binder
T12808	Protein kinase C alpha	BB4D1Z	N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine	Investigative	10686149	C16H13N5O2	307.31	CC1=C(C=C(C=C1)[N+](=O)[O-])NC2=NC=CC(=N2)C3=CN=CC=C3	IC50 > 500000 nM	Non binder
T12808	Protein kinase C alpha	BBW31R	N-(4-Pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine	Investigative	9943194	C15H13N5	263.3	C1=CC(=CC(=C1)NC2=NC=CC(=N2)C3=CN=CC=C3)N	IC50 = 210000 nM	Non binder
T12808	Protein kinase C alpha	BE42RB	N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]methanesulfonamide	Investigative	44273700	C27H24N4O11S	612.6	CS(=O)(=O)NN1C(=O)C2=C3C4=C(C(=CC=C4)O)NC3=C5C(=C2C1=O)C6=C(N5C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O	IC50 > 200000 nM	Non binder
T12808	Protein kinase C alpha	BEJ62B	4-Phenyl-[1]benzofuro[2,3-b]pyridine-3,6-diol	Investigative	51000510	C17H11NO3	277.27	C1=CC=C(C=C1)C2=C3C4=C(C=CC(=C4)O)OC3=NC=C2O	Ki > 1000000 nM	Non binder
T12808	Protein kinase C alpha	BEP1H3	1-[(4-Methoxyphenyl)methyl]-3-[4-(2H-tetrazol-5-yl)pyridin-2-yl]urea	Investigative	53388146	C15H15N7O2	325.33	COC1=CC=C(C=C1)CNC(=O)NC2=NC=CC(=C2)C3=NNN=N3	IC50 > 100000000 nM	Non binder
T12808	Protein kinase C alpha	BJC20B	5,21-Dihydroxy-13-(2-hydroxyethylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione	Investigative	44273597	C28H26N4O10	578.5	C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NCCO)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O	IC50 > 200000 nM	Non binder
T12808	Protein kinase C alpha	BM2R3B	N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-2-(dimethylamino)acetamide	Investigative	44273623	C30H29N5O10	619.6	CN(C)CC(=O)NN1C(=O)C2=C3C4=C(C(=CC=C4)O)NC3=C5C(=C2C1=O)C6=C(N5C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O	IC50 > 200000 nM	Non binder
T12808	Protein kinase C alpha	BOW25V	Tetradecanoic acid (2R,3R)-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester	Investigative	15119072	C19H34O5	342.5	CCCCCCCCCCCCCC(=O)O[C@@H]1CC(=O)O[C@@H]1CO	Ki = 300000 nM	Non binder
T12808	Protein kinase C alpha	BPYO17	13-(2,3-Dihydroxypropylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione	Investigative	44273647	C29H28N4O11	608.6	C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NCC(CO)O)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O	IC50 > 200000 nM	Non binder
T12808	Protein kinase C alpha	BQK7G2	13-Amino-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione	Investigative	19037238	C26H22N4O9	534.5	C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)N)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O	IC50 > 200000 nM	Non binder
T12808	Protein kinase C alpha	BQL98K	1-(4-Cyanopyridin-2-yl)-3-[(4-methoxyphenyl)methyl]urea	Investigative	56675716	C15H14N4O2	282.3	COC1=CC=C(C=C1)CNC(=O)NC2=NC=CC(=C2)C#N	IC50 > 100000000 nM	Non binder
T12808	Protein kinase C alpha	BSZ98H	1-[(4-Methoxyphenyl)methyl]-3-(6-nitro-1,3-benzothiazol-2-yl)urea	Investigative	56668847	C16H14N4O4S	358.4	COC1=CC=C(C=C1)CNC(=O)NC2=NC3=C(S2)C=C(C=C3)[N+](=O)[O-]	IC50 > 100000000 nM	Non binder
T12808	Protein kinase C alpha	BXR0Q7	N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-2-hydroxyacetamide	Investigative	44273624	C28H24N4O11	592.5	C1=CC2=C(C(=C1)O)NC3=C4C(=C5C(=C23)C(=O)N(C5=O)NC(=O)CO)C6=C(N4C7C(C(C(C(O7)CO)O)O)O)C(=CC=C6)O	IC50 > 200000 nM	Non binder
T12808	Protein kinase C alpha	BY1CM2	5,5'-(1E)-1,2-Ethenediylbis-1,2,3-benzenetriol	Investigative	10221222	C14H12O6	276.24	C1=C(C=C(C(=C1O)O)O)/C=C/C2=CC(=C(C(=C2)O)O)O	EC50 = 2980000 nM	Non binder
T12808	Protein kinase C alpha	D05BPX	3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol	Investigative	16757577	C16H16ClN3O2S	349.8	C1COCCN1C2=NC(=NC3=C2SC=C3)C4=CC(=CC=C4)O.Cl	IC50 = 466000 nM	Non binder
T12808	Protein kinase C alpha	D0O9NE	TRISMETHOXYRESVERATROL	Investigative	5388063	C17H18O3	270.32	COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC	EC50 = 1560000 nM	Non binder