TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T15855	Dipeptidyl peptidase 8	D0M6CN	US8470836, 5	Patented	44126186	C21H26F5N5O3	491.5	C1CC(C1)C2=NC3=C(CCN(C3)C(=O)C[C@@H](CN4C(C(CCC4=O)(F)F)O)N)C(=N2)C(F)(F)F	IC50 > 400000 nM	Non binder
T15855	Dipeptidyl peptidase 8	D0MF7O	US8470836, 8	Patented	59550092	C21H22F5N5O4	503.4	C1CC([C@@H](N(C1=O)C[C@H](CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C4=CC=CO4)N)O)(F)F	IC50 > 400000 nM	Non binder
T15855	Dipeptidyl peptidase 8	D0S8CH	US8470836, 2	Patented	42635875	C18H19F8N5O3	505.4	C1CC([C@@H](N(C1=O)C[C@H](CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C(F)(F)F)N)O)(F)F	IC50 > 400000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B03NFK	(1R)-2-((3R,4R)-1-(2-Methyl-4-(1H-1,2,4-triazol-1-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)cyclopentanecarbonitrile	Investigative	44443366	C21H26N6O	378.5	CC1=C(C=CC(=C1)N2C=NC=N2)CN3C[C@H]([C@H](C3)N)C(=O)C4CCC[C@H]4C#N	IC50 = 203000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B0ZB5V	(S)-2,6-Diamino-1-(3,4-dihydroquinolin-1(2H)-yl)hexan-1-one	Investigative	44560929	C15H23N3O	261.36	C1CC2=CC=CC=C2N(C1)C(=O)[C@H](CCCCN)N	IC50 = 312000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B16KXF	(S)-2-Amino-1-(pyrrolidine-1-yl)-3-(1H-indole-3-yl)propane-1-one	Investigative	10780092	C15H19N3O	257.329	C1CCN(C1)C(=O)[C@H](CC2=CNC3=CC=CC=C32)N	IC50 = 242000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B25IZH	(S)-1-((3R,4R)-1-(4-(1H-Pyrazol-5-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	44443353	C20H24N6O	364.4	C1C[C@H](N(C1)C(=O)[C@@H]2CN(C[C@@H]2N)CC3=CC=C(C=C3)C4=CC=NN4)C#N	IC50 = 326000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B26FCE	(S)-Benzyl 5-amino-6-(3,4-dihydroquinolin-1(2H)-yl)-6-oxohexylcarbamate	Investigative	15101668	C23H29N3O3	395.5	C1CC2=CC=CC=C2N(C1)C(=O)[C@H](CCCCNC(=O)OCC3=CC=CC=C3)N	IC50 > 500000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B2DY5F	(6S)-1-[(2S)-2-Amino-4-[2-(2-methoxyethyl)-4-(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoro-6-hydroxypiperidin-2-one	Investigative	44126292	C20H26F5N5O4	495.4	COCCC1=NC2=C(CCN(C2)C(=O)C[C@@H](CN3[C@H](C(CCC3=O)(F)F)O)N)C(=N1)C(F)(F)F	IC50 > 400000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B2I5KY	(2S,4R)-4-(4-Chlorobenzylamino)-2-amino-5-phenyl-1-(piperidin-1-yl)pentan-1-one	Investigative	44415944	C23H30ClN3O	400	C1CCN(CC1)C(=O)[C@H](C[C@@H](CC2=CC=CC=C2)NCC3=CC=C(C=C3)Cl)N	IC50 > 500000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B3C0RX	(1R)-2-((3R,4R)-1-(1-(4-(1H-1,2,4-Triazol-1-yl)phenyl)ethyl)-3-aminopyrrolidine-4-carbonyl)cyclopentanecarbonitrile	Investigative	44443357	C21H26N6O	378.5	CC(C1=CC=C(C=C1)N2C=NC=N2)N3C[C@H]([C@H](C3)N)C(=O)C4CCC[C@H]4C#N	IC50 = 586000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B47EMW	(S)-1-((3R,4R)-1-(4-(3-Methyl-1H-1,2,4-triazol-1-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	44443350	C20H25N7O	379.5	CC1=NN(C=N1)C2=CC=C(C=C2)CN3C[C@H]([C@H](C3)N)C(=O)N4CCC[C@H]4C#N	IC50 = 858000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B73QOW	(S)-1-((3R,4R)-1-(4-(1H-1,2,4-Triazol-1-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	44443347	C19H23N7O	365.4	C1C[C@H](N(C1)C(=O)[C@@H]2CN(C[C@@H]2N)CC3=CC=C(C=C3)N4C=NC=N4)C#N	IC50 = 461000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B8OCY0	4-(((3R,4R)-3-Amino-4-((2R)-2-cyanocyclopentanecarbonyl)pyrrolidin-1-yl)methyl)-2-methylbenzonitrile	Investigative	24755210	C20H24N4O	336.4	CC1=C(C=CC(=C1)CN2C[C@H]([C@H](C2)N)C(=O)C3CCC[C@H]3C#N)C#N	IC50 = 460000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B8WLG0	4-(((3R,4R)-3-Amino-4-((2R)-2-cyanocyclopentanecarbonyl)pyrrolidin-1-yl)methyl)-2,6-diethylbenzonitrile	Investigative	44443364	C23H30N4O	378.5	CCC1=CC(=CC(=C1C#N)CC)CN2C[C@H]([C@H](C2)N)C(=O)C3CCC[C@H]3C#N	IC50 = 417000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B9FG3O	1-((3R,4R)-3-Amino-4-((2R)-2-cyanocyclopentanecarbonyl)pyrrolidin-1-yl)-2,3-dihydro-1H-indene-5-carbonitrile	Investigative	44443358	C21H24N4O	348.4	C1C[C@H](C(C1)C(=O)[C@@H]2CN(C[C@@H]2N)C3CCC4=C3C=CC(=C4)C#N)C#N	IC50 = 258000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B9QW0J	(S)-2-Amino-3-hydroxy-1-(pyrrolidin-1-yl)propan-1-one	Investigative	11309656	C7H14N2O2	158.2	C1CCN(C1)C(=O)[C@H](CO)N	IC50 > 500000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B9SBH1	(S)-1-((3R,4R)-1-(4-(2H-1,2,3-Triazol-2-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	44443351	C19H23N7O	365.4	C1C[C@H](N(C1)C(=O)[C@@H]2CN(C[C@@H]2N)CC3=CC=C(C=C3)N4N=CC=N4)C#N	IC50 = 247000 nM	Non binder
T15855	Dipeptidyl peptidase 8	B9VCO1	(S)-1-((3R,4R)-1-(3-Cyano-4-fluorobenzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	44443349	C18H20FN5O	341.4	C1C[C@H](N(C1)C(=O)[C@@H]2CN(C[C@@H]2N)CC3=CC(=C(C=C3)F)C#N)C#N	IC50 = 922000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BBT45Y	(S)-2-Amino-1-(pyrrolidin-1-yl)propan-1-one	Investigative	11389441	C7H14N2O	142.2	C[C@@H](C(=O)N1CCCC1)N	IC50 = 411000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BC3B2W	(S)-1-((3R,4R)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	44443354	C20H24N6O2	380.4	CC1=NN=C(O1)C2=CC=C(C=C2)CN3C[C@H]([C@H](C3)N)C(=O)N4CCC[C@H]4C#N	IC50 = 704000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BC78BY	(2S)-2-Amino-1-(2-diphenoxyphosphorylpyrrolidin-1-yl)-3-hydroxy-propan-1-one	Investigative	11731880	C19H23N2O5P	390.4	C1CC(N(C1)C(=O)[C@H](CO)N)P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3	IC50 > 500000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BFA87K	(6S)-1-[(2S)-2-Amino-4-oxo-4-[2-thiophen-2-yl-4-(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]butyl]-5,5-difluoro-6-hydroxypiperidin-2-one	Investigative	59550101	C21H22F5N5O3S	519.5	C1CC([C@@H](N(C1=O)C[C@H](CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C4=CC=CS4)N)O)(F)F	IC50 > 400000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BI3VQ6	(2S)-1-[(2S)-2-Amino-3-(furan-3-yl)propanoyl]pyrrolidine-2-carbonitrile	Investigative	76325642	C12H15N3O2	233.27	C1C[C@H](N(C1)C(=O)[C@H](CC2=COC=C2)N)C#N	IC50 > 288200 nM	Non binder
T15855	Dipeptidyl peptidase 8	BKY97M	(S)-1-((3R,4R)-1-(4-Cyanobenzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	44443346	C18H21N5O	323.4	C1C[C@H](N(C1)C(=O)[C@@H]2CN(C[C@@H]2N)CC3=CC=C(C=C3)C#N)C#N	IC50 = 560000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BM5FI2	1-Isoleucylhexahydro-1H-azepine	Investigative	10798619	C12H24N2O	212.33	CC[C@H](C)[C@@H](C(=O)N1CCCCCC1)N	IC50 = 612000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BN1G3B	4-(((3R,4R)-3-Amino-4-((2R)-2-cyanocyclopentanecarbonyl)pyrrolidin-1-yl)methyl)-2,6-dimethylbenzonitrile	Investigative	44443363	C21H26N4O	350.5	CC1=CC(=CC(=C1C#N)C)CN2C[C@H]([C@H](C2)N)C(=O)C3CCC[C@H]3C#N	IC50 = 346000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BQ4PJ9	(S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butanamide	Investigative	11229192	C8H15N3O2	185.22	C1CCN(C1)C(=O)[C@H](CC(=O)N)N	IC50 > 500000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BS1J5R	(1R,3S)-2-((3R,4R)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)-3-fluorocyclopentanecarbonitrile	Investigative	44443361	C21H24FN5O2	397.4	CC1=NN=C(O1)C2=CC=C(C=C2)CN3C[C@H]([C@H](C3)N)C(=O)C4[C@@H](CC[C@@H]4F)C#N	IC50 = 332000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BWS74H	(S)-1-((3R,4R)-1-(4-(1-Methyl-1H-pyrazol-4-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	44443355	C21H26N6O	378.5	CN1C=C(C=N1)C2=CC=C(C=C2)CN3C[C@H]([C@H](C3)N)C(=O)N4CCC[C@H]4C#N	IC50 = 363000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BXLH78	Chembl4162340	Investigative	145958227	C19H19FN6O	366.4	C1C[C@H](CN(C1)C2=NC3=C(C(=O)N2CC4=C(C=CC(=C4)F)C#N)NC=C3)N	IC50 > 300000 nM	Non binder
T15855	Dipeptidyl peptidase 8	BY8B0T	(S)-2-Amino-3-(1H-imidazol-4-yl)-1-(pyrrolidin-1-yl)propan-1-one	Investigative	11321743	C10H16N4O	208.26	C1CCN(C1)C(=O)[C@H](CC2=CN=CN2)N	IC50 > 500000 nM	Non binder