TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T20371	Prolylcarboxypeptidase	B0NOU8	(S)-Benzyl 2-((S)-2-(benzylcarbamoyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate	Investigative	121596892	C25H29N3O4	435.5	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3)C(=O)NCC4=CC=CC=C4	Ki = 338400 nM	Non binder
T20371	Prolylcarboxypeptidase	B0PXJ4	3-(Biphenyl-4-yl)-1-{2-[5-(4-methylthiophen-2-yl)-1H-imidazol-2-yl]pyrrolidin-1-yl}propan-1-one	Investigative	52949699	C28H27N3O2S	469.6	CC1=C(SC=C1)C2=CN=C(N2)C(=O)[C@@H]3CCCN3C(=O)CCC4=CC=C(C=C4)C5=CC=CC=C5	IC50 = 274000 nM	Non binder
T20371	Prolylcarboxypeptidase	B3RO6Z	Benzyl (2S)-2-[(2S)-2-[(4-chlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596900	C25H28ClN3O4	470	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3)C(=O)NCC4=CC=C(C=C4)Cl	Ki = 257100 nM	Non binder
T20371	Prolylcarboxypeptidase	B4WR8N	3-(Biphenyl-4-yl)-1-{(2S)-2-[5-(propan-2-yl)-1H-imidazol-2-yl]-pyrrolidin-1-yl}propan-1-one	Investigative	52947260	C26H29N3O2	415.5	CC(C)C1=CN=C(N1)C(=O)[C@@H]2CCCN2C(=O)CCC3=CC=C(C=C3)C4=CC=CC=C4	IC50 = 710000 nM	Non binder
T20371	Prolylcarboxypeptidase	B6N2HG	3-(Biphenyl-4-yl)-1-{2-[5-(3-chloro-4-fluorophenyl)-1H-imidazol-2-yl]pyrrolidin-1-yl}propan-1-one	Investigative	52946024	C29H25ClFN3O2	502	C1C[C@H](N(C1)C(=O)CCC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)C4=NC=C(N4)C5=CC(=C(C=C5)F)Cl	IC50 = 320000 nM	Non binder
T20371	Prolylcarboxypeptidase	B6UI7O	3-(Biphenyl-4-yl)-1-[2-(6-chloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]propan-1-one	Investigative	52947234	C27H24ClN3O2	457.9	C1C[C@H](N(C1)C(=O)CCC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)C4=NC5=C(N4)C=C(C=C5)Cl	IC50 = 221000 nM	Non binder
T20371	Prolylcarboxypeptidase	B79STA	3-(2-{1-[3-(Biphenyl-4-yl)propanoyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)benzoic acid	Investigative	52949696	C30H27N3O4	493.6	C1C[C@H](N(C1)C(=O)CCC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)C4=NC=C(N4)C5=CC(=CC=C5)C(=O)O	IC50 = 827000 nM	Non binder
T20371	Prolylcarboxypeptidase	B81GRY	Benzyl (2S)-2-[(2S)-2-(pentylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596906	C23H33N3O4	415.5	CCCCCNC(=O)[C@@H]1CCCN1C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3	Ki = 289200 nM	Non binder
T20371	Prolylcarboxypeptidase	BC3WA9	Benzyl (2S)-2-[(2S)-2-[(2,6-difluorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596901	C25H27F2N3O4	471.5	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3)C(=O)NCC4=C(C=CC=C4F)F	Ki = 541500 nM	Non binder
T20371	Prolylcarboxypeptidase	BDSZ18	3-(Biphenyl-4-yl)-1-[2-(4-methyl-5-phenyl-1H-imidazol-2-yl)-pyrrolidin-1-yl]propan-1-one	Investigative	52946016	C30H29N3O2	463.6	CC1=C(N=C(N1)C(=O)[C@@H]2CCCN2C(=O)CCC3=CC=C(C=C3)C4=CC=CC=C4)C5=CC=CC=C5	IC50 = 338000 nM	Non binder
T20371	Prolylcarboxypeptidase	BE46IN	Benzyl (2S)-2-[(2S)-2-[(2-chlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596897	C25H28ClN3O4	470	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3)C(=O)NCC4=CC=CC=C4Cl	Ki = 203100 nM	Non binder
T20371	Prolylcarboxypeptidase	BF02QH	3-(Biphenyl-4-yl)-1-[2-(6-fluoro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]propan-1-one	Investigative	52944766	C27H24FN3O2	441.5	C1C[C@H](N(C1)C(=O)CCC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)C4=NC5=C(N4)C=C(C=C5)F	IC50 = 280000 nM	Non binder
T20371	Prolylcarboxypeptidase	BJ9RT4	Benzyl (2S)-2-[(2S)-2-[2-(2-methoxyphenyl)ethylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596895	C27H33N3O5	479.6	COC1=CC=CC=C1CCNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)OCC4=CC=CC=C4	Ki = 424600 nM	Non binder
T20371	Prolylcarboxypeptidase	BLP1J5	Benzyl (2S)-2-[(2S)-2-[(2-methoxyphenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596903	C26H31N3O5	465.5	COC1=CC=CC=C1CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)OCC4=CC=CC=C4	Ki = 289200 nM	Non binder
T20371	Prolylcarboxypeptidase	BP76UT	Benzyl (2S)-2-[[4-[(2-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Investigative	121596909	C24H28ClN3O4	457.9	C1C[C@H](N(C1)C(=O)OCC2=CC=CC=C2)C(=O)NCCCC(=O)NCC3=CC=CC=C3Cl	Ki = 332300 nM	Non binder
T20371	Prolylcarboxypeptidase	BR8M0B	Benzyl (2S)-2-[[4-[(3-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Investigative	121596910	C24H28ClN3O4	457.9	C1C[C@H](N(C1)C(=O)OCC2=CC=CC=C2)C(=O)NCCCC(=O)NCC3=CC(=CC=C3)Cl	Ki = 227700 nM	Non binder
T20371	Prolylcarboxypeptidase	BS6P8E	Benzyl (2S)-2-[(2S)-2-[(3-chlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596902	C25H28ClN3O4	470	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3)C(=O)NCC4=CC(=CC=C4)Cl	Ki = 467700 nM	Non binder
T20371	Prolylcarboxypeptidase	BV4D8Y	Benzyl (2S)-2-[[4-[(4-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Investigative	121596911	C24H28ClN3O4	457.9	C1C[C@H](N(C1)C(=O)OCC2=CC=CC=C2)C(=O)NCCCC(=O)NCC3=CC=C(C=C3)Cl	Ki = 258500 nM	Non binder
T20371	Prolylcarboxypeptidase	BXO7N1	Benzyl (2S)-2-[(2S)-2-[(3-methoxyphenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596904	C26H31N3O5	465.5	COC1=CC=CC(=C1)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)OCC4=CC=CC=C4	Ki = 393800 nM	Non binder
T20371	Prolylcarboxypeptidase	BZ3DT6	3-(Biphenyl-4-yl)-1-{(2S)-2-[5-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl]pyrrolidin-1-yl}propan-1-one	Investigative	52948472	C25H24F3N3O2	455.5	C1C[C@H](N(C1)C(=O)CCC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)C4=NC=C(N4)CC(F)(F)F	IC50 = 476000 nM	Non binder