TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T22274	Histone deacetylase 6	D0L7LC	Romidepsin	Approved	5352062	C24H36N4O6S2	540.7	C/C=C\\1/C(=O)N[C@H](C(=O)O[C@H]\\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C	IC50 > 500000 nM	Non binder
T22274	Histone deacetylase 6	D0Y3KG	Valproate	Approved	3121	C8H16O2	144.21	CCCC(CCC)C(=O)O	IC50 > 2000000 nM	Non binder
T22274	Histone deacetylase 6	D0B7CH	Phenylbutyrate	Phase 2	4775	C10H12O2	164.2	C1=CC=C(C=C1)CCCC(=O)O	IC50 = 240000 nM	Non binder
T22274	Histone deacetylase 6	B1UI2V	(3S,6S,9S,12R)-3,6-Dimethyl-9-[6-(oxiran-2-yl)-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone	Investigative	44363187	C21H32N4O6	436.5	C[C@H]1C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(=O)N1)CCCCCC(=O)C3CO3)C	EC50 = 360000 nM	Non binder
T22274	Histone deacetylase 6	B2YZN6	3-{3-[(Pyridin-2-Yl)methoxy]quinoxalin-2-Yl}propanoic Acid	Investigative	129626301	C17H15N3O3	309.32	C1=CC=C2C(=C1)N=C(C(=N2)OCC3=CC=CC=N3)CCC(=O)O	IC50 = 270000 nM	Non binder
T22274	Histone deacetylase 6	B3JBR0	3-(4-Oxo-1,2,3-benzotriazin-3(4H)-yl)propanoic acid	Investigative	4245760	C10H9N3O3	219.2	C1=CC=C2C(=C1)C(=O)N(N=N2)CCC(=O)O	IC50 = 240000 nM	Non binder
T22274	Histone deacetylase 6	B3X9UO	(R)-N-(2-Aminophenyl)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexanamide	Investigative	46907124	C30H44N2O3	480.7	C[C@H](CCCC(=O)NC1=CC=CC=C1N)[C@H]2CC[C@@H]\\3[C@@]2(CCC/C3=C\\C=C4C[C@H](C[C@@H](C4)O)O)C	IC50 = 330000 nM	Non binder
T22274	Histone deacetylase 6	B43QGU	3-Methylquinoline-8-thiol	Investigative	25146686	C10H9NS	175.25	CC1=CC2=C(C(=CC=C2)S)N=C1	IC50 > 200000 nM	Non binder
T22274	Histone deacetylase 6	B6T5RQ	5-Methylquinoline-8-thiol	Investigative	12507616	C10H9NS	175.25	CC1=C2C=CC=NC2=C(C=C1)S	IC50 > 200000 nM	Non binder
T22274	Histone deacetylase 6	B9V2OY	(S)-N-(1-(5-(2-Methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-oxooctyl)-1-methylazetidine-3-carboxamide	Investigative	11556677	C27H35N5O3	477.6	CCC(=O)CCCCC[C@@H](C1=NC=C(N1)C2=CC3=CC=CC=C3N=C2OC)NC(=O)C4CN(C4)C	IC50 = 680000 nM	Non binder
T22274	Histone deacetylase 6	BAK37S	Chembl4214608	Investigative	56755438	C15H13N3O3S	315.3	C1=CC=C2C(=C1)N=C(N2C3=CSC(=C3)C(=O)N)CCC(=O)O	IC50 = 640000 nM	Non binder
T22274	Histone deacetylase 6	BB08IA	4-Methylquinoline-8-thiol	Investigative	12344252	C10H9NS	175.25	CC1=C2C=CC=C(C2=NC=C1)S	IC50 > 200000 nM	Non binder
T22274	Histone deacetylase 6	BCN15U	2-Quinolinepropanoic acid	Investigative	264313	C12H11NO2	201.22	C1=CC=C2C(=C1)C=CC(=N2)CCC(=O)O	IC50 > 720000 nM	Non binder
T22274	Histone deacetylase 6	BF3S9N	2-(Benzo[d]thiazol-2-yl)acetic acid	Investigative	4961664	C9H7NO2S	193.22	C1=CC=C2C(=C1)N=C(S2)CC(=O)O	IC50 = 390000 nM	Non binder
T22274	Histone deacetylase 6	BFR24W	(3S,6S,9S,12R)-3,6-Dibenzyl-9-[6-(oxiran-2-yl)-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone	Investigative	44268300	C34H42N4O6	602.7	C1CCN2[C@H](C1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C2=O)CC3=CC=CC=C3)CC4=CC=CC=C4)CCCCCC(=O)C5CO5	EC50 = 524000 nM	Non binder
T22274	Histone deacetylase 6	BG6M7J	N-((R)-5-((1R,3As,7aR,E)-4-(2-((3R,5R)-3,5-Dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)benzenesulfonamide	Investigative	46907281	C30H45NO4S	515.7	C[C@H](CCCCNS(=O)(=O)C1=CC=CC=C1)[C@H]2CC[C@@H]\\3[C@@]2(CCC/C3=C\\C=C4C[C@H](C[C@@H](C4)O)O)C	IC50 = 293000 nM	Non binder
T22274	Histone deacetylase 6	BJLO75	3-(6-Oxidanylidene-3-Pyridin-3-Yl-Pyridazin-1-Yl)propanoic Acid	Investigative	52903573	C12H11N3O3	245.23	C1=CC(=CN=C1)C2=NN(C(=O)C=C2)CCC(=O)O	IC50 = 350000 nM	Non binder
T22274	Histone deacetylase 6	BPD5F2	3-(4-Oxo-3,4-dihydroquinazolin-2-yl)propanoic acid	Investigative	135449434	C11H10N2O3	218.21	C1=CC=C2C(=C1)C(=O)NC(=N2)CCC(=O)O	IC50 = 230000 nM	Non binder
T22274	Histone deacetylase 6	BQP57S	8-Mercaptoquinoline	Investigative	96028	C9H7NS	161.23	C1=CC2=C(C(=C1)S)N=CC=C2	IC50 > 200000 nM	Non binder
T22274	Histone deacetylase 6	BR8NQ4	Chembl4249195	Investigative	145983616	C22H25N3O6	427.4	CC(C)C1=CC(=C(C=C1O)O)C(=O)N2CCC3=C2C=CC(=C3)NC(=O)CCC(=O)NO	IC50 > 10000000 nM	Non binder
T22274	Histone deacetylase 6	BSX94T	8-[2-[[(5S,5As,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-5-yl]amino]phenoxy]-N-hydroxyoctanamide	Investigative	71495674	C35H40N2O10	648.7	COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)NC6=CC=CC=C6OCCCCCCCC(=O)NO	IC50 = 217000 nM	Non binder
T22274	Histone deacetylase 6	BWC15E	(4-Oxo-4H-quinazolin-3-yl)-acetic acid	Investigative	729359	C10H8N2O3	204.18	C1=CC=C2C(=C1)C(=O)N(C=N2)CC(=O)O	IC50 = 320000 nM	Non binder
T22274	Histone deacetylase 6	D0T4JQ	Butanoic Acid	Investigative	264	C4H8O2	88.11	CCCC(=O)O	IC50 > 2000000 nM	Non binder