TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T26500	Histamine H4 receptor	B1MT6L	2-(1H-Imidazol-4-ylmethyl)piperidine	Investigative	44211094	C9H15N3	165.24	C1CCNC(C1)CC2=CN=CN2	Ki = 112000000000000 nM	Non binder
T26500	Histamine H4 receptor	B1S4QY	4-(1H-Imidazol-5-yl)-1,2,3,6-tetrahydropyridine	Investigative	24729202	C8H11N3	149.19	C1CNCC=C1C2=CN=CN2	Ki = 3800000000000 nM	Non binder
T26500	Histamine H4 receptor	B3EO5F	(4-Bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone	Investigative	11120826	C14H16BrN3O	322.2	CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC=C3Br	Ki = 31988951.1 nM	Non binder
T26500	Histamine H4 receptor	B3YXC5	2,4-Imidazolidinedione, 5,5-diphenyl-3-(3-(1-piperidinyl)propyl)-	Investigative	3041343	C23H27N3O2	377.5	C1CCN(CC1)CCCN2C(=O)C(NC2=O)(C3=CC=CC=C3)C4=CC=CC=C4	Ki = 489778.82 nM	Non binder
T26500	Histamine H4 receptor	B4TBD7	Piperidine, 4-(1H-imidazol-4-ylmethylene)-	Investigative	11788475	C9H13N3	163.22	C1CNCCC1=CC2=CN=CN2	Ki = 575000000000000 nM	Non binder
T26500	Histamine H4 receptor	B4Z3GK	(7-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone	Investigative	9878733	C14H16ClN3O	277.75	CN1CCN(CC1)C(=O)C2=CC3=C(N2)C(=CC=C3)Cl	Ki = 19010782.8 nM	Non binder
T26500	Histamine H4 receptor	B5F8KP	(5-Fluoro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone	Investigative	4906599	C14H16FN3O	261.29	CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)F	Ki = 14996848.36 nM	Non binder
T26500	Histamine H4 receptor	B64UXD	1H-Imidazole-4-propanamine	Investigative	170389	C6H11N3	125.17	C1=C(NC=N1)CCCN	Ki = 28800000000000000 nM	Non binder
T26500	Histamine H4 receptor	B6JEF4	4-[2-(1H-Imidazol-4-yl)ethyl]piperidine	Investigative	10176370	C10H17N3	179.26	C1CNCCC1CCC2=CN=CN2	Ki = 2690000000000000 nM	Non binder
T26500	Histamine H4 receptor	B6Z3MX	3-(1H-Imidazol-5-ylmethyl)piperidine	Investigative	16078981	C9H15N3	165.24	C1CC(CNC1)CC2=CN=CN2	Ki = 1620000000000000 nM	Non binder
T26500	Histamine H4 receptor	B74UHT	4-((2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)methyl)benzoic acid	Investigative	46228087	C17H22N6O2	342.4	CN1CCN(CC1)C2=NC(=NC(=C2)NCC3=CC=C(C=C3)C(=O)O)N	Ki = 376600 nM	Non binder
T26500	Histamine H4 receptor	B7J9NB	2-[3-(1H-Imidazol-5-yl)propyl]piperidine	Investigative	11148240	C11H19N3	193.29	C1CCNC(C1)CCCC2=CN=CN2	Ki = 1740000000000000 nM	Non binder
T26500	Histamine H4 receptor	B7R4NI	2-[2-(1H-Imidazol-5-yl)ethyl]piperidine	Investigative	11412714	C10H17N3	179.26	C1CCNC(C1)CCC2=CN=CN2	Ki = 224000000000000 nM	Non binder
T26500	Histamine H4 receptor	B7RT6D	3-[2-(1H-Imidazol-4-yl)ethyl]piperidine	Investigative	11171320	C10H17N3	179.26	C1CC(CNC1)CCC2=CN=CN2	Ki = 3090000000000000 nM	Non binder
T26500	Histamine H4 receptor	B8PT4W	(2S)-2-[[4-(3-Piperidin-1-ylpropoxy)phenyl]methylamino]propanamide	Investigative	90654502	C18H29N3O2	319.4	C[C@@H](C(=O)N)NCC1=CC=C(C=C1)OCCCN2CCCCC2	Ki = 331131.12 nM	Non binder
T26500	Histamine H4 receptor	B8Y9OH	(5-Amino-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone	Investigative	10988959	C14H18N4O	258.32	CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)N	Ki = 14996848.36 nM	Non binder
T26500	Histamine H4 receptor	BB49AV	(R)-4-(Pyrrolidin-3-ylmethyl)-1H-imidazole	Investigative	44367567	C8H13N3	151.21	C1CNC[C@H]1CC2=CN=CN2	Ki = 26900000000000000 nM	Non binder
T26500	Histamine H4 receptor	BCPY34	(5,7-Dichloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone	Investigative	9944571	C14H15Cl2N3O	312.2	CN1CCN(CC1)C(=O)C2=CC3=CC(=CC(=C3N2)Cl)Cl	Ki = 5000345.35 nM	Non binder
T26500	Histamine H4 receptor	BDQT98	(5-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone	Investigative	9923162	C14H16BrN3O	322.2	CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)Br	Ki = 7998342.55 nM	Non binder
T26500	Histamine H4 receptor	BE56KF	3-[5-Methyl-4-[4-(3-piperidin-1-ylpropoxy)phenyl]-1,2,4-triazol-3-yl]pyridine	Investigative	71712245	C22H27N5O	377.5	CC1=NN=C(N1C2=CC=C(C=C2)OCCCN3CCCCC3)C4=CN=CC=C4	Ki = 1412537.54 nM	Non binder
T26500	Histamine H4 receptor	BF0N7I	(S)-4-(Pyrrolidin-3-ylmethyl)-1H-imidazole	Investigative	44367568	C8H13N3	151.21	C1CNC[C@@H]1CC2=CN=CN2	Ki = 7080000000000000 nM	Non binder
T26500	Histamine H4 receptor	BF3C4S	(5-Methyl-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone	Investigative	4242975	C15H19N3O	257.329	CC1=CC2=C(C=C1)NC(=C2)C(=O)N3CCN(CC3)C	Ki = 46025657.36 nM	Non binder
T26500	Histamine H4 receptor	BJ9QV5	(4,5-Dichloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone	Investigative	11066922	C14H15Cl2N3O	312.2	CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3Cl)Cl	Ki = 5000345.35 nM	Non binder
T26500	Histamine H4 receptor	BK8UY3	[2-(1H-Imidazol-5-yl)cyclopropyl]methanamine	Investigative	9793791	C7H11N3	137.18	C1C(C1C2=CN=CN2)CN	Ki = 8910000000000000 nM	Non binder
T26500	Histamine H4 receptor	BK9YH2	4-(1H-Imdazol-4-yl)piperidine	Investigative	10678418	C8H13N3	151.21	C1CNCCC1C2=CN=CN2	Ki = 457000000000000 nM	Non binder
T26500	Histamine H4 receptor	BL31DX	(7-Amino-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone	Investigative	10967174	C14H18N4O	258.32	CN1CCN(CC1)C(=O)C2=CC3=C(N2)C(=CC=C3)N	Ki = 7998342.55 nM	Non binder
T26500	Histamine H4 receptor	BMX79O	(5-Hydroxy-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone	Investigative	10923241	C14H17N3O2	259.3	CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)O	Ki = 23014418.17 nM	Non binder
T26500	Histamine H4 receptor	BO1BS6	6-(1H-Imidazol-5-yl)hexan-1-amine	Investigative	10261471	C9H17N3	167.25	C1=C(NC=N1)CCCCCCN	Ki = 1320000000000000 nM	Non binder
T26500	Histamine H4 receptor	BOE4S2	4-[1-(1H-Imidazol-4-yl)vinyl]piperidine	Investigative	11275349	C10H15N3	177.25	C=C(C1CCNCC1)C2=CN=CN2	Ki = 355000000000000 nM	Non binder
T26500	Histamine H4 receptor	BQE6H1	3-[3-(1H-Imidazol-5-yl)propyl]piperidine	Investigative	11159854	C11H19N3	193.29	C1CC(CNC1)CCCC2=CN=CN2	Ki = 2570000000000000 nM	Non binder
T26500	Histamine H4 receptor	BSUO54	(5,7-Difluoro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone	Investigative	9900313	C14H15F2N3O	279.28	CN1CCN(CC1)C(=O)C2=CC3=CC(=CC(=C3N2)F)F	Ki = 13995873.23 nM	Non binder
T26500	Histamine H4 receptor	BTK9M3	(7-Methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone	Investigative	11065080	C15H19N3O	257.329	CC1=C2C(=CC=C1)C=C(N2)C(=O)N3CCN(CC3)C	Ki = 6998419.96 nM	Non binder
T26500	Histamine H4 receptor	BTM8W6	(5,7-Dimethyl-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone	Investigative	10934567	C16H21N3O	271.36	CC1=CC(=C2C(=C1)C=C(N2)C(=O)N3CCN(CC3)C)C	Ki = 30974192.99 nM	Non binder
T26500	Histamine H4 receptor	BV3D6S	5-(Pyrrolidin-3-ylmethyl)-1H-imidazole	Investigative	11819221	C8H13N3	151.21	C1CNCC1CC2=CN=CN2	Ki = 19500000000000000 nM	Non binder
T26500	Histamine H4 receptor	BVA4X1	1H-Imidazol-5-yl(piperidin-4-yl)methanone	Investigative	11252330	C9H13N3O	179.22	C1CNCCC1C(=O)C2=CN=CN2	Ki = 2090000000000 nM	Non binder
T26500	Histamine H4 receptor	BXIF42	(7-Bromo-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone	Investigative	9966927	C14H16BrN3O	322.2	CN1CCN(CC1)C(=O)C2=CC3=C(N2)C(=CC=C3)Br	Ki = 61094202.49 nM	Non binder
T26500	Histamine H4 receptor	D01CJZ	VUF 5681	Investigative	10330240	C11H19N3	193.29	C1CNCCC1CCCC2=CN=CN2	Ki = 1620000000000000 nM	Non binder
T26500	Histamine H4 receptor	D0E5EB	impentamine	Investigative	9793868	C8H15N3	153.22	C1=C(NC=N1)CCCCCN	Ki = 2690000000000000 nM	Non binder
T26500	Histamine H4 receptor	D0E5XM	imbutamine	Investigative	13499360	C7H13N3	139.2	C1=C(NC=N1)CCCCN	Ki = 69200000000000000 nM	Non binder
T26500	Histamine H4 receptor	D0H3DY	VUF-5297	Investigative	10374457	C6H9N3	123.16	C1[C@@H]([C@H]1N)C2=CN=CN2	Ki = 912000000000000 nM	Non binder
T26500	Histamine H4 receptor	D0K6AK	VUF-5296	Investigative	10103168	C6H9N3	123.16	C1[C@H]([C@@H]1N)C2=CN=CN2	Ki = 263000000000000 nM	Non binder
T26500	Histamine H4 receptor	D0OM9G	Immepip	Investigative	3035842	C9H15N3	165.24	C1CNCCC1CC2=CN=CN2	Ki = 45700000000000000 nM	Non binder