TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T31424	Adrenergic receptor Alpha-2	B36TAY	3,7-Bis(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline	Investigative	11680583	C11H9F6N	269.19	C1C(NCC2=C1C=CC(=C2)C(F)(F)F)C(F)(F)F	Ki > 1000000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	B36UCW	7-Isoquinolinecarbonitrile, 1,2,3,4-tetrahydro-3-(trifluoromethyl)-	Investigative	44340624	C11H9F3N2	226.2	C1C(NCC2=C1C=CC(=C2)C#N)C(F)(F)F	Ki = 2900000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	B3RCY5	7-Nitro-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline	Investigative	10332138	C10H9F3N2O2	246.19	C1C(NCC2=C1C=CC(=C2)[N+](=O)[O-])C(F)(F)F	Ki = 1400000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	B3U1LQ	3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Investigative	10263774	C10H14N2O3S	242.3	C1C(NCC2=C1C=CC(=C2)S(=O)(=O)N)CO	Ki = 1400000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	B5KO6M	4,4'-Di(2-imidazolidinylimino)diphenyl sulfide	Investigative	17755548	C18H20N6S	352.5	C1CN=C(N1)NC2=CC=C(C=C2)SC3=CC=C(C=C3)NC4=NCCN4	EC50 = 332000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	B5YZP9	1-N-(4,5-Dihydro-1H-imidazol-2-yl)-4-N,4-N-dimethylbenzene-1,4-diamine	Investigative	17755236	C11H16N4	204.27	CN(C)C1=CC=C(C=C1)NC2=NCCN2	EC50 = 355000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	B9VZN1	3-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Investigative	44405494	C10H11F3N2O2S	280.27	C1C(NCC2=C1C=CC(=C2)S(=O)(=O)N)C(F)(F)F	Ki > 1000000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	B9X2WM	7-Bromo-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline	Investigative	10401405	C10H9BrF3N	280.08	C1C(NCC2=C1C=CC(=C2)Br)C(F)(F)F	Ki > 1000000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	BD9I5H	7-Methanesulfonyl-3-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline	Investigative	44340588	C11H12F3NO2S	279.28	CS(=O)(=O)C1=CC2=C(CC(NC2)C(F)(F)F)C=C1	Ki = 3900000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	BHZ10J	3-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline	Investigative	21539587	C10H10F3N	201.19	C1C(NCC2=CC=CC=C21)C(F)(F)F	Ki = 400000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	BNKR03	7-Chloro-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline	Investigative	44405404	C10H9ClF3N	235.63	C1C(NCC2=C1C=CC(=C2)Cl)C(F)(F)F	Ki > 1000000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	BUZ38O	Isoquinoline, 1,2,3,4-tetrahydro-7-iodo-3-(trifluoromethyl)-	Investigative	44405493	C10H9F3IN	327.08	C1C(NCC2=C1C=CC(=C2)I)C(F)(F)F	Ki > 1000000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	BXC49Y	N-Ethyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Investigative	44405471	C12H15F3N2O2S	308.32	CCNS(=O)(=O)C1=CC2=C(CC(NC2)C(F)(F)F)C=C1	Ki > 1000000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	D00GEE	corynanthine	Investigative	92766	C21H26N2O3	354.4	COC(=O)[C@@H]1[C@H](CC[C@@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C5=CC=CC=C5N4)O	IC50 = 211000 nM	Non binder
T31424	Adrenergic receptor Alpha-2	D0F3AR	4-((Z)-1-Naphthalen-1-yl-propenyl)-1H-imidazole	Investigative	9991628	C16H14N2	234.29	C/C=C(/C1=CC=CC2=CC=CC=C21)\\C3=CN=CN3	IC50 = 215400 nM	Non binder