TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T32880	HIF-prolyl hydroxylase 2	D03GOO	Fumaric acid	Phase 3	444972	C4H4O4	116.07	C(=C/C(=O)O)\\C(=O)O	IC50 = 220000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B0GHL3	2-(3-Hydroxyureido)acetic acid	Investigative	13770962	C3H6N2O4	134.09	C(C(=O)O)NC(=O)NO	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B14FUX	5-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-pentanoic acid	Investigative	60150989	C22H20N4O5	420.4	C1=CC=C(C=C1)CN2C=CC3=C(C2=O)C(=NC(=C3O)C(=O)NCCCCC(=O)O)C#N	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B19GPL	7-Benzyl-1-cyano-4-hydroxy-N-methyl-8-oxo-2,7-naphthyridine-3-carboxamide	Investigative	68297472	C18H14N4O3	334.3	CNC(=O)C1=C(C2=C(C(=N1)C#N)C(=O)N(C=C2)CC3=CC=CC=C3)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B1UDQ7	1-Benzyl-8-hydroxy-N-[2-(methanesulfonamido)ethyl]-2-oxo-1,6-naphthyridine-7-carboxamide	Investigative	86714129	C19H20N4O5S	416.5	CS(=O)(=O)NCCNC(=O)C1=NC=C2C=CC(=O)N(C2=C1O)CC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B2Y1GA	1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(2,2,2-trifluoro-acetylamino)-ethyl]amide	Investigative	90073972	C26H21F3N4O4	510.5	C1=CC=C(C=C1)CN2C3=CN=C(C(=C3C=C(C2=O)C4=CC=CC=C4)O)C(=O)NCCNC(=O)C(F)(F)F	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B3JF9Y	7-(2,4-Dimethoxy-benzyl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid 4-fluoro-benzylamide	Investigative	68297178	C25H22FN3O5	463.5	COC1=CC(=C(C=C1)CN2C=CC3=C(C(=NC=C3C2=O)C(=O)NCC4=CC=C(C=C4)F)O)OC	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B3Q1LT	2-(2,3-Dioxo-3-phenylpropanamido)acetic acid	Investigative	45482772	C11H9NO5	235.19	C1=CC=C(C=C1)C(=O)C(=O)C(=O)NCC(=O)O	IC50 = 538000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B3TY9G	[[5-(2-Naphthyl)pyridine-2-yl]carbonylamino]acetic acid	Investigative	76335997	C18H14N2O3	306.3	C1=CC=C2C=C(C=CC2=C1)C3=CN=C(C=C3)C(=O)NCC(=O)O	IC50 > 500000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B4D9JP	2-(3-Oxo-3-phenylpropanamido)acetic acid	Investigative	45482768	C11H11NO4	221.21	C1=CC=C(C=C1)C(=O)CC(=O)NCC(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B5ER4J	N-Oxalyl-D-homophenylalanine, 1c	Investigative	25138008	C12H13NO5	251.23	C1=CC=C(C=C1)CC[C@H](C(=O)O)NC(=O)C(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B5L6CK	2-(2,3-Dioxopiperazin-1-yl)acetic acid	Investigative	22122176	C6H8N2O4	172.14	C1CN(C(=O)C(=O)N1)CC(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B6A5WE	2,5-Pyridinedicarboxylic acid	Investigative	7493	C7H5NO4	167.12	C1=CC(=NC=C1C(=O)O)C(=O)O	Ki > 300000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B6JDQ2	2-(2-(Benzylamino)-2-oxoacetamido)acetic acid	Investigative	23260762	C11H12N2O4	236.22	C1=CC=C(C=C1)CNC(=O)C(=O)NCC(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B6PSZ9	(2R)-3-(Naphthalen-1-ylmethylsulfanyl)-2-(oxaloamino)propanoic acid	Investigative	56964909	C16H15NO5S	333.4	C1=CC=C2C(=C1)C=CC=C2CSC[C@@H](C(=O)O)NC(=O)C(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B7A8BS	3-(2-Fluoroanilino)pyridine-2,4-dicarboxylic acid	Investigative	50916282	C13H9FN2O4	276.22	C1=CC=C(C(=C1)NC2=C(C=CN=C2C(=O)O)C(=O)O)F	IC50 > 400000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B7EMP0	7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid (3-propylcarbamoyl-propyl)-amide	Investigative	86714116	C24H25N5O4	447.5	CCCNC(=O)CCCNC(=O)C1=C(C2=C(C(=N1)C#N)C(=O)N(C=C2)CC3=CC=CC=C3)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B7SZA2	7-Benzyl-4-hydroxy-8-oxo-N-[2-(propan-2-ylcarbamoylamino)ethyl]-2,7-naphthyridine-3-carboxamide	Investigative	86714120	C22H25N5O4	423.5	CC(C)NC(=O)NCCNC(=O)C1=NC=C2C(=C1O)C=CN(C2=O)CC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B8MP4U	(S)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)-3-methylbutanoic acid	Investigative	44819566	C15H15ClN2O4	322.74	CC(C)[C@@H](C(=O)O)NC(=O)C1=C(C2=CC=CC=C2C(=N1)Cl)O	IC50 > 400000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B91OJT	(S)-2-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-3-phenyl-propionic acid	Investigative	68297392	C26H20N4O5	468.5	C1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)C2=C(C3=C(C(=N2)C#N)C(=O)N(C=C3)CC4=CC=CC=C4)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	B9P1EA	(2S)-2-Amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propanoic acid	Investigative	89812894	C19H17N3O5	367.4	C1=CC=C(C=C1)OC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NC[C@@H](C(=O)O)N	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BBZO35	N-(Carboxycarbonyl)-S-(Naphthalen-2-Ylmethyl)-L-Cysteine	Investigative	56684141	C16H15NO5S	333.4	C1=CC=C2C=C(C=CC2=C1)CSC[C@@H](C(=O)O)NC(=O)C(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BC0HO5	3-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-2,2-dimethyl-propionic acid	Investigative	60152771	C22H20N4O5	420.4	CC(C)(CNC(=O)C1=C(C2=C(C(=N1)C#N)C(=O)N(C=C2)CC3=CC=CC=C3)O)C(=O)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BC4KI8	7-Benzyl-1-cyano-4-hydroxy-N-(2-morpholin-4-ylethyl)-8-oxo-2,7-naphthyridine-3-carboxamide	Investigative	60150991	C23H23N5O4	433.5	C1COCCN1CCNC(=O)C2=C(C3=C(C(=N2)C#N)C(=O)N(C=C3)CC4=CC=CC=C4)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BCT0I8	(R)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)-3-methylbutanoic acid	Investigative	44819735	C15H15ClN2O4	322.74	CC(C)[C@H](C(=O)O)NC(=O)C1=C(C2=CC=CC=C2C(=N1)Cl)O	IC50 > 400000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BE9P6X	(2S)-2-Amino-5-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]pentanoic acid	Investigative	117850108	C22H20N4O5	420.4	C1=CC=C(C=C1)OC2=CC3=C(C=C2)C(=C(N=C3C#N)C(=O)NCCC[C@@H](C(=O)O)N)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BG9BE6	3-[(1-Benzyl-8-hydroxy-5-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carbonyl)-amino]-propionic acid	Investigative	60151403	C20H19N3O5	381.4	CC1=C2C=CC(=O)N(C2=C(C(=N1)C(=O)NCCC(=O)O)O)CC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BGR1Q7	3-[(1-Benzyl-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carbonyl)-amino]-2,2-dimethyl-propionic acid	Investigative	68297462	C21H21N3O5	395.4	CC(C)(CNC(=O)C1=NC=C2C=CC(=O)N(C2=C1O)CC3=CC=CC=C3)C(=O)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BHA69Z	(R)-2-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-3-phenyl-propionic acid	Investigative	68297677	C26H20N4O5	468.5	C1=CC=C(C=C1)C[C@H](C(=O)O)NC(=O)C2=C(C3=C(C(=N2)C#N)C(=O)N(C=C3)CC4=CC=CC=C4)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BJ7S8F	(3S)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2,4-trimethylpentanoic acid	Investigative	117850102	C25H25N3O5	447.5	CC(C)[C@@H](C(C)(C)C(=O)O)NC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=N1)C#N)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BKXD67	(R)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)propanoic acid	Investigative	44591755	C13H11ClN2O4	294.69	C[C@H](C(=O)O)NC(=O)C1=C(C2=CC=CC=C2C(=N1)Cl)O	IC50 = 230000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BL4KW0	5-(Ethylamino)-4,5-dioxopenthanoic acid	Investigative	45482742	C7H11NO4	173.17	CCNC(=O)C(=O)CCC(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BOQ0T4	1-Benzyl-5-cyano-8-hydroxy-N-methyl-2-oxo-1,6-naphthyridine-7-carboxamide	Investigative	68297560	C18H14N4O3	334.3	CNC(=O)C1=NC(=C2C=CC(=O)N(C2=C1O)CC3=CC=CC=C3)C#N	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BP08KE	2-[4-[[4-[(1S,2R)-2-Aminocyclopropyl]phenyl]carbamoyl]pyridin-2-yl]pyridine-4-carboxylic acid;2,2,2-trifluoroacetic acid	Investigative	76317452	C23H19F3N4O5	488.4	C1[C@H]([C@@H]1N)C2=CC=C(C=C2)NC(=O)C3=CC(=NC=C3)C4=NC=CC(=C4)C(=O)O.C(=O)(C(F)(F)F)O	IC50 = 278000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BPE9U5	2-(3-Ethoxy-3-oxopropanamido)acetic acid	Investigative	45482769	C7H11NO5	189.17	CCOC(=O)CC(=O)NCC(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BQ14CT	Isocitric acid	Investigative	1198	C6H8O7	192.12	C(C(C(C(=O)O)O)C(=O)O)C(=O)O	IC50 > 10000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BQG75A	2-(2-Methoxy-2-oxoethylamino)-2-oxoacetic acid	Investigative	45482778	C5H7NO5	161.11	COC(=O)CNC(=O)C(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BRJN90	1-Benzyl-8-hydroxy-N-[2-[methyl(methylsulfonyl)amino]ethyl]-2-oxo-1,6-naphthyridine-7-carboxamide	Investigative	86714127	C20H22N4O5S	430.5	CN(CCNC(=O)C1=NC=C2C=CC(=O)N(C2=C1O)CC3=CC=CC=C3)S(=O)(=O)C	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BS18HL	5-[(1-Benzyl-8-cyano-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-pentanoic acid	Investigative	68297596	C28H24N4O5	496.5	C1=CC=C(C=C1)CN2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C#N)C(=O)NCCCCC(=O)O)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BS4WJ0	3-[[7-Benzyl-1-(5-fluoropyridin-3-yl)-4-hydroxy-8-oxo-2,7-naphthyridine-3-carbonyl]amino]-2,2-dimethylpropanoic acid	Investigative	68297315	C26H23FN4O5	490.5	CC(C)(CNC(=O)C1=C(C2=C(C(=N1)C3=CC(=CN=C3)F)C(=O)N(C=C2)CC4=CC=CC=C4)O)C(=O)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BTS8U1	3-(Carboxymethylamino)-3-oxopropanoic acid	Investigative	22345738	C5H7NO5	161.11	C(C(=O)NCC(=O)O)C(=O)O	IC50 = 398000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BUI8X2	1-Benzyl-8-cyano-5-hydroxy-N-methyl-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide	Investigative	60151543	C24H18N4O3	410.4	CNC(=O)C1=C(C2=C(C(=N1)C#N)N(C(=O)C(=C2)C3=CC=CC=C3)CC4=CC=CC=C4)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BV2W4P	N-(Carboxycarbonyl)-S-(3-Nitrobenzyl)-L-Cysteine	Investigative	56684140	C12H12N2O7S	328.3	C1=CC(=CC(=C1)[N+](=O)[O-])CSC[C@@H](C(=O)O)NC(=O)C(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BV5B2E	1-Benzyl-8-hydroxy-N-methyl-2-oxo-1,6-naphthyridine-7-carboxamide	Investigative	68297613	C17H15N3O3	309.32	CNC(=O)C1=NC=C2C=CC(=O)N(C2=C1O)CC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BV8WM7	1-Benzyl-5-cyano-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carboxylic acid (2-sulfamoyl-ethyl)-amide	Investigative	91758382	C19H17N5O5S	427.4	C1=CC=C(C=C1)CN2C(=O)C=CC3=C(N=C(C(=C32)O)C(=O)NCCS(=O)(=O)N)C#N	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BVH0X4	Glycine, N-(1,3-dioxobutyl)-	Investigative	76549	C6H9NO4	159.14	CC(=O)CC(=O)NCC(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BW5IC6	2-(2-(Ethylamino)-2-oxoacetamido)acetic acid	Investigative	45482725	C6H10N2O4	174.15	CCNC(=O)C(=O)NCC(=O)O	IC50 > 1000000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BX30RP	1-Benzyl-5-hydroxy-N-methyl-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide	Investigative	60151132	C23H19N3O3	385.4	CNC(=O)C1=NC=C2C(=C1O)C=C(C(=O)N2CC3=CC=CC=C3)C4=CC=CC=C4	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BY15PZ	7-Benzyl-1-cyano-N-cyclopropyl-4-hydroxy-8-oxo-2,7-naphthyridine-3-carboxamide	Investigative	68297197	C20H16N4O3	360.4	C1CC1NC(=O)C2=C(C3=C(C(=N2)C#N)C(=O)N(C=C3)CC4=CC=CC=C4)O	IC50 > 200000 nM	Non binder
T32880	HIF-prolyl hydroxylase 2	BZB98L	7-[(2,4-Dimethoxyphenyl)methyl]-4-hydroxy-8-oxo-N-(2-phenylethyl)-2,7-naphthyridine-3-carboxamide	Investigative	60151130	C26H25N3O5	459.5	COC1=CC(=C(C=C1)CN2C=CC3=C(C(=NC=C3C2=O)C(=O)NCCC4=CC=CC=C4)O)OC	IC50 > 200000 nM	Non binder