TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T32972	Lanosterol 14-alpha demethylase	D00BCP	Chlorpropamide	Approved	2727	C10H13ClN2O3S	276.74	CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)Cl	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D02YIZ	Erythromycin	Approved	12560	C37H67NO13	733.9	CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D06OIV	Tolbutamide	Approved	5505	C12H18N2O3S	270.35	CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D06WTZ	Lovastatin	Approved	53232	C24H36O5	404.5	CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D07BSQ	Progesterone	Approved	5994	C21H30O2	314.5	CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D09LNI	Fluconazole	Approved	3365	C13H12F2N6O	306.27	C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D0A2ZX	Metronidazole	Approved	4173	C6H9N3O3	171.15	CC1=NC=C(N1CCO)[N+](=O)[O-]	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D0A4YE	Sulfaphenazole	Approved	5335	C15H14N4O2S	314.4	C1=CC=C(C=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)N	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D0J2KV	Propafenone	Approved	4932	C21H27NO3	341.4	CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D0S4BR	Methimazole	Approved	1349907	C4H6N2S	114.17	CN1C=CNC1=S	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D0B4RU	Pregnenolone	Phase 4	8955	C21H32O2	316.5	CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D03TFJ	Benzimidazole	Patented	5798	C7H6N2	118.14	C1=CC=C2C(=C1)NC=N2	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	B7J0IG	2-[(5-Chloro-1H-indole-2-carbonyl)-amino]-3-phenyl-propionic acid	Investigative	15521016	C18H15ClN2O3	342.8	C1=CC=C(C=C1)CC(C(=O)O)NC(=O)C2=CC3=C(N2)C=CC(=C3)Cl	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	BD6H3M	N-[1-(4-Hydroxypiperidin-1-yl)-1-oxo-3-phenylpropan-2-yl]-1H-pyrrole-2-carboxamide	Investigative	44450765	C19H23N3O3	341.4	C1CN(CCC1O)C(=O)C(CC2=CC=CC=C2)NC(=O)C3=CC=CN3	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	BPFR74	N-[(2S)-1-(4-Hydroxypiperidin-1-yl)-1-oxo-3-phenylpropan-2-yl]-4,5,6,7-tetrahydro-1H-indole-2-carboxamide	Investigative	44450766	C23H29N3O3	395.5	C1CCC2=C(C1)C=C(N2)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N4CCC(CC4)O	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D02DLW	Cholesterol	Investigative	5997	C27H46O	386.7	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D0A9PS	Anandamide	Investigative	5281969	C22H37NO2	347.5	CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)NCCO	IC50 > 200000 nM	Non binder
T32972	Lanosterol 14-alpha demethylase	D0HD9P	Arachidonic Acid	Investigative	444899	C20H32O2	304.5	CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)O	IC50 > 200000 nM	Non binder