TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T36741	p53-binding protein Mdm4	B2O1SQ	Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate	Investigative	52949945	C38H48N8O5	696.8	CC(C)(C)OC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NCC4=CC=CC=C4	IC50 = 307000 nM	Non binder
T36741	p53-binding protein Mdm4	B3PV6F	5-[[5-Tert-butyl-1-(4-chlorophenyl)-2-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione	Investigative	90666840	C25H22ClN3O2S	464	CC(C)(C)C1=CC(=C(N1C2=CC=C(C=C2)Cl)C3=CC=CC=C3)C=C4C(=O)NC(=S)NC4=O	IC50 = 1684000 nM	Non binder
T36741	p53-binding protein Mdm4	B5S8QE	5-[[1-(4-Bromophenyl)-5-tert-butyl-2-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione	Investigative	90666839	C25H22BrN3O2S	508.4	CC(C)(C)C1=CC(=C(N1C2=CC=C(C=C2)Br)C3=CC=CC=C3)C=C4C(=O)NC(=S)NC4=O	IC50 = 963000 nM	Non binder
T36741	p53-binding protein Mdm4	B9J4ZM	(1'R,2'R,3S,4'R)-6-Chloro-2'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-4'-(2,2-dimethylpropyl)-5-fluoro-2-oxospiro[1H-indole-3,3'-cyclopentane]-1'-carboxamide	Investigative	118718079	C28H33Cl2FN2O4	551.5	CC(C)(C)C[C@H]1C[C@H]([C@@H]([C@]12C3=CC(=C(C=C3NC2=O)Cl)F)C4=CC(=CC=C4)Cl)C(=O)NCC[C@@H](CO)O	Ki > 50000000 nM	Non binder
T36741	p53-binding protein Mdm4	BC3AO8	5-[[1-(4-Bromophenyl)-2-cyclopropyl-5-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione	Investigative	90666842	C24H18BrN3O2S	492.4	C1CC1C2=C(C=C(N2C3=CC=C(C=C3)Br)C4=CC=CC=C4)C=C5C(=O)NC(=S)NC5=O	IC50 = 3428000 nM	Non binder
T36741	p53-binding protein Mdm4	BFIW47	2-Methylpropyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate	Investigative	52945083	C35H50N8O5	662.8	CC(C)COC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NC(C)(C)C	IC50 = 300000 nM	Non binder
T36741	p53-binding protein Mdm4	BFY28L	Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate	Investigative	52943867	C35H50N8O5	662.8	CC(C)(C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OC(C)(C)C	IC50 = 339000 nM	Non binder
T36741	p53-binding protein Mdm4	BHD07A	5-[[1-(4-Bromophenyl)-5-cyclopropyl-2-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione	Investigative	90667001	C24H18BrN3O2S	492.4	C1CC1C2=CC(=C(N2C3=CC=C(C=C3)Br)C4=CC=CC=C4)C=C5C(=O)NC(=S)NC5=O	IC50 = 5322000 nM	Non binder
T36741	p53-binding protein Mdm4	BIL09W	5-[[1-(4-Chlorophenyl)-2-cyclopropyl-5-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione	Investigative	90666841	C24H18ClN3O2S	447.9	C1CC1C2=C(C=C(N2C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C=C5C(=O)NC(=S)NC5=O	IC50 = 3486000 nM	Non binder
T36741	p53-binding protein Mdm4	BK35OR	((S)-5-((S)-3-(1H-Indol-3-yl)-1-oxo-1-((S)-1-oxo-3-phenyl-1-(piperidin-1-yl)propan-2-ylamino)propan-2-ylamino)-4-(tert-butoxycarbonylamino)-5-oxopentylamino)(amino)methaniminium	Investigative	52945082	C36H50N8O5	674.8	CC(C)(C)OC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N4CCCCC4	IC50 = 463000 nM	Non binder
T36741	p53-binding protein Mdm4	BL6XU8	5-[[1-(4-Chlorophenyl)-5-cyclopropyl-2-phenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione	Investigative	90667000	C24H18ClN3O2S	447.9	C1CC1C2=CC(=C(N2C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C=C5C(=O)NC(=S)NC5=O	IC50 = 4916000 nM	Non binder
T36741	p53-binding protein Mdm4	BMQC90	Benzyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate	Investigative	52945081	C38H48N8O5	696.8	CC(C)(C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC4=CC=CC=C4	IC50 = 348000 nM	Non binder