TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T40332	Neutrophil elastase	B0K5OS	(S)-N1-(1-(Benzo[d]thiazol-2-yl)-1-oxopropan-2-yl)-2-((S)-2-(3,3-dimethylbutanamido)-3,3-dimethylbutanamido)-N4,N4-dimethylsuccinamide	Investigative	10507077	C28H41N5O5S	559.7	CC(C(=O)C1=NC2=CC=CC=C2S1)NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	B0OI3U	(S)-N1-((S)-1-Benzyloxy-2-oxo-azetidin-3-yl)-2-[(S)-2-(3,3-dimethyl-butanoylamino)-3,3-dimethyl-butanoylamino]-N4,N4-dimethyl-succinamide	Investigative	10745144	C28H43N5O6	545.7	CC(C)(C)CC(=O)N[C@H](C(=O)N[C@@H](CC(=O)N(C)C)C(=O)N[C@H]1CN(C1=O)OCC2=CC=CC=C2)C(C)(C)C	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	B15RQG	Benzyl N-[(2S)-1-[[(2S)-1-[(2R)-2-[[[(2S)-3-methyl-1-oxo-1-[[(2S)-1-oxo-1-[[(2S)-1-oxo-1-(propan-2-ylamino)propan-2-yl]amino]propan-2-yl]amino]butan-2-yl]amino]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]carbamate	Investigative	44363092	C33H52N8O8	688.8	C[C@@H](C(=O)NC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NNC(=O)[C@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCC2=CC=CC=C2	Ki = 595000 nM	Non binder
T40332	Neutrophil elastase	B1QK5H	3-Acetoxymethyl-7-dibromomethylene-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester	Investigative	10483607	C24H19Br2NO5S	593.3	CC(=O)OCC1=C(N2C(C(=C(Br)Br)C2=O)SC1)C(=O)OC(C3=CC=CC=C3)C4=CC=CC=C4	IC50 = 260000 nM	Non binder
T40332	Neutrophil elastase	B27NKA	Benzyl (3aS,6aR)-6-allyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1(2H)-carboxylate	Investigative	10661946	C17H20N2O3	300.35	C=CC[C@@H]1[C@@H]2[C@H](CCN2C(=O)OCC3=CC=CC=C3)NC1=O	IC50 > 500000 nM	Non binder
T40332	Neutrophil elastase	B29JGP	(S)-3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester	Investigative	44343069	C24H23NO8S	485.5	CC(=O)OCC1=C(N2C([C@H](C2=O)OC)S(=O)(=O)C1)C(=O)OC(C3=CC=CC=C3)C4=CC=CC=C4	IC50 = 280000 nM	Non binder
T40332	Neutrophil elastase	B2K5WC	[4-[[2-[(E)-Hydroxyiminomethyl]phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoate	Investigative	118010067	C18H20N2O5S	376.4	CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2/C=N/O	IC50 = 394440 nM	Non binder
T40332	Neutrophil elastase	B45QMV	[4-[[2-[(E)-C-Ethyl-N-hydroxycarbonimidoyl]phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoate	Investigative	118010065	C20H24N2O5S	404.5	CC/C(=N\\O)/C1=CC=CC=C1NS(=O)(=O)C2=CC=C(C=C2)OC(=O)C(C)(C)C	IC50 = 679370 nM	Non binder
T40332	Neutrophil elastase	B46EOG	(2S)-2-[[(2R)-2-[[(2S)-6-(Adamantane-1-carbonylamino)-2-[[(2S,3R)-2-(benzylamino)-3-methylpentanoyl]amino]hexanoyl]amino]-3-sulfanylpropanoyl]amino]-3-methylbutanoic acid	Investigative	56674980	C38H59N5O6S	714	CC[C@@H](C)[C@@H](C(=O)N[C@@H](CCCCNC(=O)C12CC3CC(C1)CC(C3)C2)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)O)NCC4=CC=CC=C4	Ki = 269700 nM	Non binder
T40332	Neutrophil elastase	B52EAB	(S)-2-[(S)-2-(3,3-Dimethyl-butanoylamino)-3,3-dimethyl-butanoylamino]-N4,N4-dimethyl-N1-[1-methyl-2-(4-methyl-benzoxazol-2-yl)-2-oxo-ethyl]-succinamide	Investigative	10507021	C29H43N5O6	557.7	CC1=C2C(=CC=C1)OC(=N2)C(=O)C(C)NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	B5K9OX	[2,4-Dioxo-9-(3-phenylpropyl)-1H-[1,3]oxazino[4,5-b]indol-6-yl] acetate	Investigative	44384856	C21H18N2O5	378.4	CC(=O)OC1=CC2=C(C=C1)N(C3=C2C(=O)OC(=O)N3)CCCC4=CC=CC=C4	IC50 = 305000 nM	Non binder
T40332	Neutrophil elastase	B5TEG2	(S)-2-[(S)-2-(3,3-Dimethyl-butanoylamino)-3,3-dimethyl-butanoylamino]-N4,N4-dimethyl-N1-[1-methyl-2-(5-methyl-benzoxazol-2-yl)-2-oxo-ethyl]-succinamide	Investigative	10816650	C29H43N5O6	557.7	CC1=CC2=C(C=C1)OC(=N2)C(=O)C(C)NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	B61YFS	[2,4-Dioxo-9-(pyridin-2-ylmethyl)-1H-[1,3]oxazino[4,5-b]indol-6-yl] acetate	Investigative	44385735	C18H13N3O5	351.3	CC(=O)OC1=CC2=C(C=C1)N(C3=C2C(=O)OC(=O)N3)CC4=CC=CC=N4	IC50 = 292000 nM	Non binder
T40332	Neutrophil elastase	B64JTF	[3,5-Dibutyl-2-(3-methyloxiran-2-yl)-6-oxopyran-4-yl] acetate	Investigative	23276169	C18H26O5	322.4	CCCCC1=C(OC(=O)C(=C1OC(=O)C)CCCC)C2C(O2)C	Ki = 338844.16 nM	Non binder
T40332	Neutrophil elastase	B6EIG3	(S)-2-[(S)-2-(3,3-Dimethyl-butanoylamino)-3,3-dimethyl-butanoylamino]-N4,N4-dimethyl-N1-(3,3,4,4,4-pentafluoro-1-methyl-2-oxo-butyl)-succinamide	Investigative	10460031	C23H37F5N4O5	544.6	CC(C(=O)C(C(F)(F)F)(F)F)NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	B6JAR4	3,5-Dibutyl-4-hydroxy-6-[(E)-1-phenylprop-1-enyl]pyran-2-one	Investigative	54733674	C22H28O3	340.5	CCCCC1=C(C(=C(OC1=O)/C(=C/C)/C2=CC=CC=C2)CCCC)O	Ki = 363078.05 nM	Non binder
T40332	Neutrophil elastase	B6NT2Y	(S)-2-[(S)-2-(3,3-Dimethyl-butanoylamino)-3,3-dimethyl-butanoylamino]-N4,N4-dimethyl-N1-[1-methyl-2-(6-methyl-benzoxazol-2-yl)-2-oxo-ethyl]-succinamide	Investigative	10674356	C29H43N5O6	557.7	CC1=CC2=C(C=C1)N=C(O2)C(=O)C(C)NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	B7JG5X	Benzhydryl (7Z)-3-(acetyloxymethyl)-7-(cyanomethylidene)-5,5,8-trioxo-5lambda6-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate	Investigative	44342991	C25H20N2O7S	492.5	CC(=O)OCC1=C(N2C(/C(=C\\C#N)/C2=O)S(=O)(=O)C1)C(=O)OC(C3=CC=CC=C3)C4=CC=CC=C4	IC50 = 490000 nM	Non binder
T40332	Neutrophil elastase	B7OVR6	5-Methyl-N-(4-methoxyphenyl)oxazolidine-2,4-dione	Investigative	70696249	C11H11NO4	221.21	CC1C(=O)N(C(=O)O1)C2=CC=C(C=C2)OC	IC50 > 500000 nM	Non binder
T40332	Neutrophil elastase	B7R3JX	3,5-Dibutyl-4-hydroxy-6-(2-oxopropyl)pyran-2-one	Investigative	54694053	C16H24O4	280.36	CCCCC1=C(OC(=O)C(=C1O)CCCC)CC(=O)C	Ki = 489778.82 nM	Non binder
T40332	Neutrophil elastase	B8A5NH	[3,5-Dibutyl-2-oxo-6-(2-oxopropyl)pyran-4-yl] acetate	Investigative	23276168	C18H26O5	322.4	CCCCC1=C(OC(=O)C(=C1OC(=O)C)CCCC)CC(=O)C	Ki = 288403.15 nM	Non binder
T40332	Neutrophil elastase	B8I3AL	Benzhydryl (7E)-3-(acetyloxymethyl)-7-(bromomethylidene)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate	Investigative	44343164	C24H20BrNO5S	514.4	CC(=O)OCC1=C(N2C(/C(=C/Br)/C2=O)SC1)C(=O)OC(C3=CC=CC=C3)C4=CC=CC=C4	IC50 = 390000 nM	Non binder
T40332	Neutrophil elastase	B8IBT4	N-[3-[(2-Fluorophenyl)methoxy]phenyl]-1-pyridin-4-ylpiperidine-4-carboxamide	Investigative	72712051	C24H24FN3O2	405.5	C1CN(CCC1C(=O)NC2=CC(=CC=C2)OCC3=CC=CC=C3F)C4=CC=NC=C4	Ki > 250000 nM	Non binder
T40332	Neutrophil elastase	B8SML1	(R)-3-Methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzyl ester	Investigative	44312771	C14H13NO3S	275.32	CC1=C(N2[C@H](S1)CC2=O)C(=O)OCC3=CC=CC=C3	Ki = 310000 nM	Non binder
T40332	Neutrophil elastase	B8T4ZO	e-64	Investigative	123985	C15H27N5O5	357.41	CC(C)C[C@@H](C(=O)NCCCCN=C(N)N)NC(=O)[C@@H]1[C@H](O1)C(=O)O	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	B9P8QA	5,5-Dimethyl-N-(4-nitrophenyl)oxazolidine-2,4-dione	Investigative	70687894	C11H10N2O5	250.21	CC1(C(=O)N(C(=O)O1)C2=CC=C(C=C2)[N+](=O)[O-])C	IC50 > 500000 nM	Non binder
T40332	Neutrophil elastase	BA5O6Y	Met-Phe-Leu-Glu-Ala-Ile-Pro-Met	Investigative	44273732	C44H70N8O11S2	951.2	CC[C@@H](C)[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCSC)N	Ki = 270000 nM	Non binder
T40332	Neutrophil elastase	BA7HD9	4-Hydroxy-3-methyl-6-phenacylpyran-2-one	Investigative	54733673	C14H12O4	244.24	CC1=C(C=C(OC1=O)CC(=O)C2=CC=CC=C2)O	Ki = 977237.22 nM	Non binder
T40332	Neutrophil elastase	BAU7J3	5-Methyl-N-(4-nitrophenyl)oxazolidine-2,4-dione	Investigative	70681508	C10H8N2O5	236.18	CC1C(=O)N(C(=O)O1)C2=CC=C(C=C2)[N+](=O)[O-]	IC50 > 500000 nM	Non binder
T40332	Neutrophil elastase	BB93SR	(2S,3S)-2-Acetamido-N-[(1R)-1-[[3-(butylamino)-3-oxopropyl]-dihydroxysilyl]-3-methylbutyl]-3-methylpentanamide	Investigative	71457476	C20H41N3O5Si	431.6	CCCCNC(=O)CC[Si]([C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)C)(O)O	IC50 > 200000 nM	Non binder
T40332	Neutrophil elastase	BC12LY	[4-[[2-[(E)-N-Hydroxy-C-propylcarbonimidoyl]phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoate	Investigative	118010066	C21H26N2O5S	418.5	CCC/C(=N\\O)/C1=CC=CC=C1NS(=O)(=O)C2=CC=C(C=C2)OC(=O)C(C)(C)C	IC50 = 367500 nM	Non binder
T40332	Neutrophil elastase	BENX24	N-[3-[(3,5-Difluorophenyl)methoxy]phenyl]-1-pyridin-4-ylpiperidine-4-carboxamide	Investigative	72712053	C24H23F2N3O2	423.5	C1CN(CCC1C(=O)NC2=CC(=CC=C2)OCC3=CC(=CC(=C3)F)F)C4=CC=NC=C4	Ki > 250000 nM	Non binder
T40332	Neutrophil elastase	BF65JT	L-N-(Imidazol-1-ylcarbonyl)norvaline methyl ester	Investigative	44306172	C10H15N3O3	225.24	CCC[C@@H](C(=O)OC)NC(=O)N1C=CN=C1	Ki = 320000 nM	Non binder
T40332	Neutrophil elastase	BGE58N	2,3-Dimethyl-1-(3-phenyl-propyl)-1,7-dihydro-5-oxa-1,7-diaza-indene-4,6-dione	Investigative	44385646	C17H18N2O3	298.34	CC1=C(N(C2=C1C(=O)OC(=O)N2)CCCC3=CC=CC=C3)C	IC50 = 895000 nM	Non binder
T40332	Neutrophil elastase	BH26JB	(S)-2-[(S)-2-(3,3-Dimethyl-butanoylamino)-3,3-dimethyl-butanoylamino]-N4,N4-dimethyl-N1-[1-methyl-2-(7-methyl-benzoxazol-2-yl)-2-oxo-ethyl]-succinamide	Investigative	10554839	C29H43N5O6	557.7	CC1=C2C(=CC=C1)N=C(O2)C(=O)C(C)NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	BH3NK0	(S)-N1-((S)-3-Benzylcarbamoyl-3,3-difluoro-1-methyl-2-oxo-propyl)-2-[(S)-2-(3,3-dimethyl-butanoylamino)-3,3-dimethyl-butanoylamino]-N4,N4-dimethyl-succinamide	Investigative	10817508	C30H45F2N5O6	609.7	C[C@@H](C(=O)C(C(=O)NCC1=CC=CC=C1)(F)F)NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	BHC89A	1-[[(2S)-4-(Dimethylamino)-2-[[(2S)-2-(3,3-dimethylbutanoylamino)-3,3-dimethylbutanoyl]amino]-4-oxobutanoyl]amino]ethyl-(diphenoxymethyl)-oxophosphanium	Investigative	44354163	C33H48N4O7P+	643.7	CC(NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C)[P+](=O)C(OC1=CC=CC=C1)OC2=CC=CC=C2	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	BHO28L	Benzhydryl (7E)-3-(acetyloxymethyl)-7-(1-bromo-2-methoxy-2-oxoethylidene)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate	Investigative	44342891	C26H22BrNO7S	572.4	CC(=O)OCC1=C(N2C(/C(=C(\\C(=O)OC)/Br)/C2=O)SC1)C(=O)OC(C3=CC=CC=C3)C4=CC=CC=C4	IC50 = 210000 nM	Non binder
T40332	Neutrophil elastase	BHR7P6	(9-Butyl-2,4-dioxo-1H-[1,3]oxazino[4,5-b]indol-6-yl) acetate	Investigative	44384637	C16H16N2O5	316.31	CCCCN1C2=C(C=C(C=C2)OC(=O)C)C3=C1NC(=O)OC3=O	IC50 = 810000 nM	Non binder
T40332	Neutrophil elastase	BI6SW3	3,5-Dibutyl-4-hydroxy-6-methylpyran-2-one	Investigative	54694049	C14H22O3	238.32	CCCCC1=C(OC(=O)C(=C1O)CCCC)C	Ki = 645654.23 nM	Non binder
T40332	Neutrophil elastase	BIG60O	(9-Cyclohexyl-2,4-dioxo-1H-[1,3]oxazino[4,5-b]indol-6-yl) acetate	Investigative	44385436	C18H18N2O5	342.3	CC(=O)OC1=CC2=C(C=C1)N(C3=C2C(=O)OC(=O)N3)C4CCCCC4	IC50 = 454000 nM	Non binder
T40332	Neutrophil elastase	BJB0L6	(2S,3S)-N-[(2S)-1-[[2-(Butylamino)-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]-3-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentanamide	Investigative	71455700	C20H35F3N4O4	452.5	CCCCNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)C(F)(F)F	IC50 > 200000 nM	Non binder
T40332	Neutrophil elastase	BJCW94	(S)-2-((S)-2-(3,3-Dimethylbutanamido)-3,3-dimethylbutanamido)-N4,N4-dimethyl-N1-(1-(oxazolo[4,5-b]pyridin-2-yl)-1-oxopropan-2-yl)succinamide	Investigative	11800689	C27H40N6O6	544.6	CC(C(=O)C1=NC2=C(O1)C=CC=N2)NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	BJWN19	6-Methoxy-9-(3-phenyl-propyl)-1,9-dihydro-[1,3]oxazino[4,5-b]indole-2,4-dione	Investigative	44384797	C20H18N2O4	350.4	COC1=CC2=C(C=C1)N(C3=C2C(=O)OC(=O)N3)CCCC4=CC=CC=C4	IC50 = 989000 nM	Non binder
T40332	Neutrophil elastase	BL9BE5	(2S,3S)-2-Acetamido-N-[(2S)-1-[[2-(butylamino)-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]-3-methylpentanamide	Investigative	71455699	C20H38N4O4	398.5	CCCCNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)C	IC50 > 200000 nM	Non binder
T40332	Neutrophil elastase	BMB9E7	[9-(2,2-Dimethoxyethyl)-2,4-dioxo-1H-[1,3]oxazino[4,5-b]indol-6-yl] acetate	Investigative	44384840	C16H16N2O7	348.31	CC(=O)OC1=CC2=C(C=C1)N(C3=C2C(=O)OC(=O)N3)CC(OC)OC	IC50 = 742000 nM	Non binder
T40332	Neutrophil elastase	BP67RW	4-Hydroxy-6-nonyl-pyran-2-one	Investigative	54735926	C14H22O3	238.32	CCCCCCCCCC1=CC(=CC(=O)O1)O	Ki = 400000 nM	Non binder
T40332	Neutrophil elastase	BQ2X5R	4-(Morpholine-4-carbonyl)-N-{(R)-2-oxo-1-[(3,3,4,4,4-pentafluoro-1-isopropyl-2-oxo-butylcarbamoyl)-methyl]-pyrrolidin-3-yl}-benzamide	Investigative	44461760	C25H29F5N4O6	576.5	CC(C)C(C(=O)C(C(F)(F)F)(F)F)NC(=O)CN1CC[C@H](C1=O)NC(=O)C2=CC=C(C=C2)C(=O)N3CCOCC3	Ki = 400000 nM	Non binder
T40332	Neutrophil elastase	BQ90MB	4-((2S,3S)-3-Ethyl-4-oxo-azetidin-2-yloxy)-benzoic acid	Investigative	15035342	C12H13NO4	235.24	CC[C@H]1[C@@H](NC1=O)OC2=CC=C(C=C2)C(=O)O	Ki = 290000 nM	Non binder
T40332	Neutrophil elastase	BQ9L6R	(S)-2-{[(2S,4R)-1-((S)-2-{(S)-2-[(R)-2-((S)-2-Acetylamino-3-carboxy-propionylamino)-4-carboxy-butyrylamino]-2-cyclohexyl-acetylamino}-3-methyl-butyryl)-4-(naphthalen-2-ylmethoxy)-pyrrolidine-2-carbonyl]-amino}-pentanoic acid	Investigative	481437	C45H62N6O13	895	CCC[C@@H](C(=O)O)NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@H](C(C)C)NC(=O)[C@H](C2CCCCC2)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)C)OCC3=CC4=CC=CC=C4C=C3	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	BQW7Z8	(S)-2-((S)-2-(3,3-Dimethylbutanamido)-3,3-dimethylbutanamido)-N4,N4-dimethyl-N1-(4,4,4-trifluoro-3-oxobutan-2-yl)succinamide	Investigative	15407997	C22H37F3N4O5	494.5	C[C@@H](C(=O)C(F)(F)F)NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	BS0K6N	5,5-Dimethyl-N-(4-methoxyphenyl)oxazolidine-2,4-dione	Investigative	70687893	C12H13NO4	235.24	CC1(C(=O)N(C(=O)O1)C2=CC=C(C=C2)OC)C	IC50 > 500000 nM	Non binder
T40332	Neutrophil elastase	BT9OX7	[3,5-Dibutyl-2-(2-hydroxypropyl)-6-oxopyran-4-yl] acetate	Investigative	23276182	C18H28O5	324.4	CCCCC1=C(OC(=O)C(=C1OC(=O)C)CCCC)CC(C)O	Ki = 346736.85 nM	Non binder
T40332	Neutrophil elastase	BV67KT	[4-[[2-[(E)-N-Methoxy-C-methylcarbonimidoyl]phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoate	Investigative	118010068	C20H24N2O5S	404.5	C/C(=N\\OC)/C1=CC=CC=C1NS(=O)(=O)C2=CC=C(C=C2)OC(=O)C(C)(C)C	IC50 = 323890 nM	Non binder
T40332	Neutrophil elastase	BVM3P9	C(C(C)(C)C)(=O)OC1=CC=C(C=C1)S(NC1=C(C=CC=C1)/C(/C)=N/OC)(=O)=O	Investigative	118010069	C20H24N2O5S	404.5	C/C(=N/OC)/C1=CC=CC=C1NS(=O)(=O)C2=CC=C(C=C2)OC(=O)C(C)(C)C	IC50 = 367180 nM	Non binder
T40332	Neutrophil elastase	BW51QJ	(S)-N1-(2-Benzylcarbamoyl-1-methyl-2-oxoethyl)-2-[(S)-2-(3,3-dimethyl-butanoylamino)-3,3-dimethyl-butanoylamino]-N4,N4-dimethylsuccinamide	Investigative	9915812	C29H45N5O6	559.7	CC(C(=O)C(=O)NCC1=CC=CC=C1)NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 > 300000 nM	Non binder
T40332	Neutrophil elastase	BWP2T4	1-{[1-[2-(2-Acetylamino-2-cyclohexyl-acetylamino)-3-methyl-butyryl]-4-(naphthalen-1-ylmethoxy)-pyrrolidine-2-carbonyl]-amino}-cyclopropanecarboxylic acid	Investigative	481440	C35H46N4O7	634.8	CC(C)[C@@H](C(=O)N1C[C@@H](C[C@H]1C(=O)NC2(CC2)C(=O)O)OCC3=CC=CC4=CC=CC=C43)NC(=O)[C@H](C5CCCCC5)NC(=O)C	IC50 > 600000 nM	Non binder
T40332	Neutrophil elastase	BX2F3L	(2,4-Dioxo-9-propyl-1H-[1,3]oxazino[4,5-b]indol-6-yl) acetate	Investigative	44384638	C15H14N2O5	302.28	CCCN1C2=C(C=C(C=C2)OC(=O)C)C3=C1NC(=O)OC3=O	IC50 = 665000 nM	Non binder
T40332	Neutrophil elastase	BX2LW6	{(S)-2-Methyl-1-[(S)-2-(3,3,4,4,4-pentafluoro-1,1-dimethyl-2-oxo-butylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-carbamic acid tert-butyl ester	Investigative	10028968	C21H32F5N3O5	501.5	CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)NC(C)(C)C(=O)C(C(F)(F)F)(F)F)NC(=O)OC(C)(C)C	Ki > 500000 nM	Non binder
T40332	Neutrophil elastase	BX8ZH1	3-({1-[2-(2-Tert-Butoxycarbonylamino-propionylamino)-propionyl]-pyrrolidine-2-carbonyl}-amino)-2,2-difluoro-4-methyl-pentanoic acid ethyl ester	Investigative	44274239	C24H40F2N4O7	534.6	CCOC(=O)C(C(C(C)C)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(C)NC(=O)OC(C)(C)C)(F)F	Ki > 300000 nM	Non binder
T40332	Neutrophil elastase	BZB3C9	N-[3-[(3,4-Dimethoxyphenyl)methoxy]phenyl]-1-pyridin-4-ylpiperidine-4-carboxamide	Investigative	72712070	C26H29N3O4	447.5	COC1=C(C=C(C=C1)COC2=CC=CC(=C2)NC(=O)C3CCN(CC3)C4=CC=NC=C4)OC	Ki > 250000 nM	Non binder