TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T58970	Extracellular signal-regulated kinase 2	B0VU9K	(4R)-5-(1H-Benzimidazol-2-ylmethyl)-4-(5-methyl-1H-imidazol-4-yl)-1,4,6,7-tetrahydroimidazo[4,5-c]pyridine	Investigative	76309526	C18H19N7	333.4	CC1=C(N=CN1)[C@@H]2C3=C(CCN2CC4=NC5=CC=CC=C5N4)NC=N3	Ki = 1000000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	B2LHQ0	(3R)-3-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol	Investigative	10339935	C20H29N7O	383.5	CC[C@H](C(C)(C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=N3	IC50 > 200000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	B2O0HE	2-Bromo-5H-pyrrolo[2,3-b]pyrazine	Investigative	25067308	C6H4BrN3	198.02	C1=CNC2=NC=C(N=C21)Br	IC50 > 200000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	B3Y6ZP	(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-ol	Investigative	10001666	C22H33N7O	411.5	CC[C@H](C(C(C)(C)C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=N3	IC50 > 200000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	B7FWP5	(3S)-2-Methyl-3-[[9-propan-2-yl-6-(pyridin-2-ylmethylamino)purin-2-yl]amino]pentan-2-ol	Investigative	10317812	C20H29N7O	383.5	CC[C@@H](C(C)(C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=N3	IC50 > 200000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	B8FR5X	2-[[(8-Methylimidazo[1,2-a]pyridin-2-yl)methyl-propan-2-ylamino]methyl]-3H-quinazolin-4-one	Investigative	136245248	C21H23N5O	361.4	CC1=CC=CN2C1=NC(=C2)CN(CC3=NC4=CC=CC=C4C(=O)N3)C(C)C	Ki = 1000000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	BEY4Q8	3-(5H-Pyrrolo[2,3-b]pyrazin-2-yl)benzamide	Investigative	122193281	C13H10N4O	238.24	C1=CC(=CC(=C1)C(=O)N)C2=CN=C3C(=N2)C=CN3	IC50 > 200000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	BH4J6R	(4S)-2-Methyl-4-[[9-propan-2-yl-6-(pyridin-2-ylmethylamino)purin-2-yl]amino]hexan-3-ol	Investigative	10475938	C21H31N7O	397.5	CC[C@@H](C(C(C)C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=N3	IC50 > 200000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	BHSV61	(4S)-5-(1H-Benzimidazol-2-ylmethyl)-4-(5-methyl-1H-imidazol-4-yl)-1,4,6,7-tetrahydroimidazo[4,5-c]pyridine	Investigative	76316736	C18H19N7	333.4	CC1=C(N=CN1)[C@H]2C3=C(CCN2CC4=NC5=CC=CC=C5N4)NC=N3	Ki = 1000000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	BI62QL	3-(5H-Pyrrolo[2,3-b]pyrazin-2-yl)phenol	Investigative	122193282	C12H9N3O	211.22	C1=CC(=CC(=C1)O)C2=CN=C3C(=N2)C=CN3	IC50 > 200000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	BJ59US	(3RS,4R)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2,2-dimethyl-hexan-3-ol	Investigative	10136280	C23H34N6O	410.6	CC[C@H](C(C(C)(C)C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	BODI17	(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-ol	Investigative	10000883	C21H31N7O	397.5	CC[C@H](C(C(C)C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=N3	IC50 > 200000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	BPBJ93	(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-ol	Investigative	10339936	C20H29N7O	383.5	CC[C@H](C(CC)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=N3	IC50 = 230000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	BQN2O3	(3RS,4S)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2,2-dimethyl-hexan-3-ol	Investigative	10273006	C23H34N6O	410.6	CC[C@@H](C(C(C)(C)C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T58970	Extracellular signal-regulated kinase 2	BY0V1T	(4R)-4-[[6-(Benzylamino)-9-propan-2-ylpurin-2-yl]amino]-2-methylhexan-3-ol	Investigative	10272087	C22H32N6O	396.5	CC[C@H](C(C(C)C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3	IC50 > 200000 nM	Non binder