TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T61400	Dihydroorotate dehydrogenase	B04DMR	N-(2,2-Diphenylethyl)-2-hydroxy-4-methoxybenzamide	Investigative	90665771	C22H21NO3	347.4	COC1=CC(=C(C=C1)C(=O)NCC(C2=CC=CC=C2)C3=CC=CC=C3)O	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B15PHK	Chembl4228730	Investigative	145969133	C23H23NO2	345.4	COC(=O)C1=CC(=NC2=CC=CC=C21)C3=CC=C(C=C3)C4CCCCC4	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B1DF9Z	2-Aminoethanol;5-[2-(5-carboxynaphthalen-2-yl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134155043	C22H28N4O8	476.5	C1=CC2=C(C=CC(=C2)CCC3=C(NC(=O)NC3=O)C(=O)O)C(=C1)C(=O)O.C(CO)N.C(CO)N	Ki > 2500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B23UYA	2-(4-Chlorophenyl)-3-hydroxy-6-phenylquinoline-4-carboxylic acid	Investigative	16099926	C22H14ClNO3	375.8	C1=CC=C(C=C1)C2=CC3=C(C=C2)N=C(C(=C3C(=O)O)O)C4=CC=C(C=C4)Cl	IC50 = 230000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B28PCH	N-(2,2-Diphenylethyl)-4-formyl-2-hydroxybenzamide	Investigative	90665777	C22H19NO3	345.4	C1=CC=C(C=C1)C(CNC(=O)C2=C(C=C(C=C2)C=O)O)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B2BOJ3	3-Carbamoyl-5-[4-[4-(trifluoromethyl)phenyl]phenyl]benzoic Acid	Investigative	10691466	C21H14F3NO3	385.3	C1=CC(=CC=C1C2=CC=C(C=C2)C(F)(F)F)C3=CC(=CC(=C3)C(=O)O)C(=O)N	Ki > 100000000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B2C0TQ	3-Carbamoyl-5-[4-(4-methylphenyl)phenyl]benzoic acid	Investigative	23647298	C21H17NO3	331.4	CC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC(=CC(=C3)C(=O)O)C(=O)N	Ki > 100000000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B2E4FT	2-Aminoethanol;5-[4-(6-carboxynaphthalen-2-yl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134157954	C24H32N4O8	504.5	C1=CC2=C(C=CC(=C2)C(=O)O)C=C1CCCCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N.C(CO)N	Ki = 986000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B2F6PH	Diethyl 2-[(3H-benzimidazol-5-ylamino)methylidene]propanedioate	Investigative	4605417	C15H17N3O4	303.31	CCOC(=O)C(=CNC1=CC2=C(C=C1)N=CN2)C(=O)OCC	IC50 > 500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B3EK4T	2-Aminoethanol;5-[2-[6-(2-hydroxyethylcarbamoyl)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134139862	C22H26N4O7	458.5	C1=CC2=C(C=CC(=C2)C(=O)NCCO)C=C1CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki > 500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B3QI6J	N-(2,2-Diphenylethyl)-2-hydroxy-5-methoxybenzamide	Investigative	90665772	C22H21NO3	347.4	COC1=CC(=C(C=C1)O)C(=O)NCC(C2=CC=CC=C2)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B3XTM6	2-Aminoethanol;2,4-dioxo-5-[2-[4-(trifluoromethyl)phenyl]ethyl]-1H-pyrimidine-6-carboxylic acid	Investigative	134134345	C16H18F3N3O5	389.33	C1=CC(=CC=C1CCC2=C(NC(=O)NC2=O)C(=O)O)C(F)(F)F.C(CO)N	Ki = 360000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B3YN4R	3-[4-(4-Tert-butylphenyl)phenyl]-5-carbamoylbenzoic acid	Investigative	10738106	C24H23NO3	373.4	CC(C)(C)C1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC(=CC(=C3)C(=O)O)C(=O)N	Ki > 100000000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B43OWH	Diethyl 2-[(4-phenylanilino)methylidene]propanedioate	Investigative	16102646	C20H21NO4	339.4	CCOC(=O)C(=CNC1=CC=C(C=C1)C2=CC=CC=C2)C(=O)OCC	IC50 > 500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B46KZL	2-Aminoethanol;5-[2-[6-(dimethylcarbamoyl)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134151915	C22H26N4O6	442.5	CN(C)C(=O)C1=CC2=C(C=C1)C=C(C=C2)CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki = 637000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B4B5MQ	N,5-Dimethyl-N-(2-naphthyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	24882197	C17H15N5	289.33	CC1=NC2=NC=NN2C(=C1)N(C)C3=CC4=CC=CC=C4C=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B4KV2T	Chembl4227966	Investigative	145970932	C22H22N2O2	346.4	COC(=O)C1=CC(=NC2=CC=CC=C21)C3=CC=C(C=C3)N4CCCCC4	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B4S6OF	N-(2,2-Diphenylethyl)-2-hydroxy-5-(hydroxymethyl)benzamide	Investigative	90665776	C22H21NO3	347.4	C1=CC=C(C=C1)C(CNC(=O)C2=C(C=CC(=C2)CO)O)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B4SR8F	2-Aminoethanol;5-[3-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]propyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134132701	C22H29N5O7S	507.6	CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)NCCCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki > 313000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B57YXP	2-Aminoethanol;5-[1-(4-methoxycarbonylphenyl)triazol-4-yl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134141516	C17H18N6O7	418.4	COC(=O)C1=CC=C(C=C1)N2C=C(N=N2)C3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki = 420000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B58LZO	2-Aminoethanol;5-[3-(naphthalene-1-carbonylamino)propyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134133820	C21H24N4O6	428.4	C1=CC=C2C(=C1)C=CC=C2C(=O)NCCCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki > 625000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B58TUZ	Chembl4225152	Investigative	5184531	C23H17NO2	339.4	COC(=O)C1=CC(=NC2=CC=CC=C21)C3=CC=C(C=C3)C4=CC=CC=C4	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B5AKV8	2-Aminoethanol;5-[4-(2-carboxyphenyl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134132554	C20H30N4O8	454.5	C1=CC=C(C(=C1)CCCCC2=C(NC(=O)NC2=O)C(=O)O)C(=O)O.C(CO)N.C(CO)N	Ki = 319000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B5M2OK	Chembl4226739	Investigative	145967884	C20H13N3O2	327.3	C1=CC=C2C(=C1)C(=CC(=N2)C3=CC=C(C=C3)C4=CN=CN=C4)C(=O)O	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B64BRY	2-Aminoethanol;5-[2-(4-carbamoylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134150022	C16H20N4O6	364.35	C1=CC(=CC=C1CCC2=C(NC(=O)NC2=O)C(=O)O)C(=O)N.C(CO)N	Ki > 500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B6MYE2	2-Aminoethanol;5-[2-(4-methoxycarbonylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134148877	C17H21N3O7	379.4	COC(=O)C1=CC=C(C=C1)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki = 1395000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B6NO4K	2-{[(6-Bromonaphthalen-2-yl)carbonyl](methyl)amino}benzoic acid	Investigative	11703683	C19H14BrNO3	384.2	CN(C1=CC=CC=C1C(=O)O)C(=O)C2=CC3=C(C=C2)C=C(C=C3)Br	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B70UAZ	3-(Biphenyl-4-ylamino)-2-cyano-acrylic acid ethyl ester	Investigative	16102643	C18H16N2O2	292.3	CCOC(=O)/C(=C\\NC1=CC=C(C=C1)C2=CC=CC=C2)/C#N	IC50 > 500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B84DEX	2-Aminoethanol;2,4-dioxo-5-(2-quinolin-3-ylethyl)-1H-pyrimidine-6-carboxylic acid	Investigative	134132876	C18H20N4O5	372.4	C1=CC=C2C(=C1)C=C(C=N2)CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki = 1300000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B8ESA9	N-(2,2-Diphenylethyl)-2-hydroxybenzamide	Investigative	90665760	C21H19NO2	317.4	C1=CC=C(C=C1)C(CNC(=O)C2=CC=CC=C2O)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B8VAU0	Diethyl 2-(2-toluidinomethylene)malonate	Investigative	4221076	C15H19NO4	277.31	CCOC(=O)C(=CNC1=CC=CC=C1C)C(=O)OCC	IC50 = 292200 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B9S2AH	3-Carbamoyl-5-(3,5-diphenylphenyl)benzoic acid	Investigative	44409277	C26H19NO3	393.4	C1=CC=C(C=C1)C2=CC(=CC(=C2)C3=CC(=CC(=C3)C(=O)O)C(=O)N)C4=CC=CC=C4	Ki > 100000000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B9Y1SJ	2-Aminoethanol;5-[2-(6-carbamoylnaphthalen-2-yl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134152327	C20H22N4O6	414.4	C1=CC2=C(C=CC(=C2)C(=O)N)C=C1CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki > 2500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	B9Y3OT	5-Ethyl-N-(2-naphthyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	24882196	C17H15N5	289.33	CCC1=NC2=NC=NN2C(=C1)NC3=CC4=CC=CC=C4C=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BAC08G	N-(2,2-Diphenylethyl)-2-hydroxy-3-methoxybenzamide	Investigative	90665770	C22H21NO3	347.4	COC1=CC=CC(=C1O)C(=O)NCC(C2=CC=CC=C2)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BAOP91	N-(2,2-Diphenylethyl)-2-hydroxy-3-(hydroxymethyl)benzamide	Investigative	90665774	C22H21NO3	347.4	C1=CC=C(C=C1)C(CNC(=O)C2=CC=CC(=C2O)CO)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BAT3N7	2-Aminoethanol;5-[2-(8-benzamidonaphthalen-2-yl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134146300	C26H26N4O6	490.5	C1=CC=C(C=C1)C(=O)NC2=CC=CC3=C2C=C(C=C3)CCC4=C(NC(=O)NC4=O)C(=O)O.C(CO)N	Ki = 262000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BAXV38	2-Aminoethanol;5-[2-(3-methoxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134151822	C16H21N3O6	351.35	COC1=CC=CC(=C1)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki = 484000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BC91GO	4-Chloro-N-(2,2-diphenylethyl)-2-hydroxybenzamide	Investigative	90665762	C21H18ClNO2	351.8	C1=CC=C(C=C1)C(CNC(=O)C2=C(C=C(C=C2)Cl)O)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BD7KZ3	2-Aminoethanol;5-[2-[6-(methylcarbamoyl)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134147611	C21H24N4O6	428.4	CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki = 1111000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BD9GB7	5-[2-(8-Acetamidonaphthalen-2-yl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid;2-aminoethanol	Investigative	134153435	C21H24N4O6	428.4	CC(=O)NC1=CC=CC2=C1C=C(C=C2)CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki = 1980000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BDA49E	2-[(Biphenyl-4-ylcarbonyl)(methyl)amino]benzoic acid	Investigative	11530041	C21H17NO3	331.4	CN(C1=CC=CC=C1C(=O)O)C(=O)C2=CC=C(C=C2)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BDC1Y8	5,6-Dimethyl-N-(2-naphthyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	24882112	C17H15N5	289.33	CC1=C(N2C(=NC=N2)N=C1C)NC3=CC4=CC=CC=C4C=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BE39NX	2-Aminoethanol;5-[2-(4-ethylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134139256	C17H23N3O5	349.4	CCC1=CC=C(C=C1)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki = 248000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BE4KS0	N-Anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	24882195	C20H15N5	325.4	CC1=NC2=NC=NN2C(=C1)NC3=CC4=CC5=CC=CC=C5C=C4C=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BEX18W	2-Aminoethanol;5-[4-(4-methoxycarbonylphenyl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134138544	C19H25N3O7	407.4	COC(=O)C1=CC=C(C=C1)CCCCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki = 217000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BFJ9M4	2-(4-Chlorophenyl)-3-hydroxy-8-isopropylquinoline-4-carboxylicacid	Investigative	16099919	C19H16ClNO3	341.8	CC(C)C1=CC=CC2=C(C(=C(N=C21)C3=CC=C(C=C3)Cl)O)C(=O)O	IC50 = 283000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BFQ6W9	N-(2-Naphthyl)-5-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	24882111	C16H10F3N5	329.28	C1=CC=C2C=C(C=CC2=C1)NC3=CC(=NC4=NC=NN34)C(F)(F)F	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BGHD05	2-Aminoethanol;5-(3-aminopropyl)-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134136454	C10H18N4O5	274.27	C(CC1=C(NC(=O)NC1=O)C(=O)O)CN.C(CO)N	Ki > 313000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BGN01E	2-Aminoethanol;5-[2-(3-chlorophenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134132798	C15H18ClN3O5	355.77	C1=CC(=CC(=C1)Cl)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki = 1285000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BGR78F	5-Bromo-N-(2,2-diphenylethyl)-2-hydroxybenzamide	Investigative	90665765	C21H18BrNO2	396.3	C1=CC=C(C=C1)C(CNC(=O)C2=C(C=CC(=C2)Br)O)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BGUV63	2-Aminoethanol;5-[2-(3-carboxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134132509	C18H26N4O8	426.4	C1=CC(=CC(=C1)C(=O)O)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N.C(CO)N	Ki = 1200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BH09MY	2-Aminoethanol;5-[2-[4-(methylcarbamoyl)phenyl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134146866	C17H22N4O6	378.4	CNC(=O)C1=CC=C(C=C1)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki > 500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BH29MW	2-Aminoethanol;5-[2-(6-carboxynaphthalen-2-yl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134137084	C22H28N4O8	476.5	C1=CC2=C(C=CC(=C2)C(=O)O)C=C1CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N.C(CO)N	Ki = 893000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BH7G4O	2-Methyl-7-[(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amino]chromen-4-one	Investigative	24882194	C16H13N5O2	307.31	CC1=CC(=O)C2=C(O1)C=C(C=C2)NC3=CC(=NC4=NC=NN34)C	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BI1F5Q	2-Aminoethanol;5-[2-(2-methoxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134132231	C16H21N3O6	351.35	COC1=CC=CC=C1CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki > 2500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BI82UT	N-(2,2-Diphenylethyl)-3-fluoro-2-hydroxybenzamide	Investigative	90665766	C21H18FNO2	335.4	C1=CC=C(C=C1)C(CNC(=O)C2=C(C(=CC=C2)F)O)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BI9ON2	8-Sec-butyl-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylicacid	Investigative	16099968	C20H18ClNO3	355.8	CCC(C)C1=CC=CC2=C(C(=C(N=C21)C3=CC=C(C=C3)Cl)O)C(=O)O	IC50 = 301000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BIX1K5	2-(4-Chlorophenyl)-3-hydroxy-8-methoxyquinoline-4-carboxylicacid	Investigative	16099894	C17H12ClNO4	329.7	COC1=CC=CC2=C(C(=C(N=C21)C3=CC=C(C=C3)Cl)O)C(=O)O	IC50 = 306000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BIY71Q	5-Methyl-N-naphthalen-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	660996	C16H13N5	275.31	CC1=NC2=NC=NN2C(=C1)NC3=CC4=CC=CC=C4C=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BJ1A6S	2-[Methyl(naphthalen-2-ylcarbonyl)amino]benzoic acid	Investigative	16777509	C19H15NO3	305.3	CN(C1=CC=CC=C1C(=O)O)C(=O)C2=CC3=CC=CC=C3C=C2	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BJ9MU3	Chembl4226410	Investigative	145969257	C20H18N2O3	334.4	C1COCCN1C2=CC=C(C=C2)C3=NC4=CC=CC=C4C(=C3)C(=O)O	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BJH72V	2-Aminoethanol;5-[2-[4-(cyanomethyl)phenyl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134142784	C17H20N4O5	360.4	C1=CC(=CC=C1CCC2=C(NC(=O)NC2=O)C(=O)O)CC#N.C(CO)N	Ki > 2500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BJY57T	2-Aminoethanol;5-(2-naphthalen-1-ylethyl)-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134143855	C19H21N3O5	371.4	C1=CC=C2C(=C1)C=CC=C2CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki = 217000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BKLP78	2-Aminoethanol;5-[2-(3-methoxycarbonylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134133701	C17H21N3O7	379.4	COC(=O)C1=CC=CC(=C1)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki = 382000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BL4K5G	N-Benzyl-5-methyl-N-(2-naphthyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	24882113	C23H19N5	365.4	CC1=NC2=NC=NN2C(=C1)N(CC3=CC=CC=C3)C4=CC5=CC=CC=C5C=C4	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BL87WN	5-Methyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	523003	C12H11N5	225.25	CC1=NC2=NC=NN2C(=C1)NC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BLB01R	2-Aminoethanol;5-[2-(2-methoxycarbonylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134141210	C17H21N3O7	379.4	COC(=O)C1=CC=CC=C1CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki > 500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BM0SB3	2-Aminoethanol;5-[3-(naphthalene-2-carbonylamino)propyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134154001	C21H24N4O6	428.4	C1=CC=C2C=C(C=CC2=C1)C(=O)NCCCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki > 625000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BM6S2G	5-Chloro-N-(2,2-diphenylethyl)-2-hydroxybenzamide	Investigative	90665763	C21H18ClNO2	351.8	C1=CC=C(C=C1)C(CNC(=O)C2=C(C=CC(=C2)Cl)O)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BM8BW1	2-Aminoethanol;5-(3-benzamidopropyl)-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134155982	C17H22N4O6	378.4	C1=CC=C(C=C1)C(=O)NCCCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki > 313000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BMV0U3	2-Aminoethanol;5-[1-(2-methoxycarbonylphenyl)triazol-4-yl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134152933	C17H18N6O7	418.4	COC(=O)C1=CC=CC=C1N2C=C(N=N2)C3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki > 250000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BN1MD8	2-Aminoethanol;5-[2-[6-(ethylcarbamoyl)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134132121	C22H26N4O6	442.5	CCNC(=O)C1=CC2=C(C=C1)C=C(C=C2)CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki = 236000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BN5HT1	N-(2,2-Diphenylethyl)-2-hydroxy-4-(hydroxymethyl)benzamide	Investigative	90665775	C22H21NO3	347.4	C1=CC=C(C=C1)C(CNC(=O)C2=C(C=C(C=C2)CO)O)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BNA2C1	2-Aminoethanol;2,4-dioxo-5-[2-[2-(trifluoromethyl)phenyl]ethyl]-1H-pyrimidine-6-carboxylic acid	Investigative	134141087	C16H18F3N3O5	389.33	C1=CC=C(C(=C1)CCC2=C(NC(=O)NC2=O)C(=O)O)C(F)(F)F.C(CO)N	Ki > 2500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BQ9T5P	2-Aminoethanol;5-[2-(3,5-dimethoxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134131421	C17H23N3O7	381.4	COC1=CC(=CC(=C1)CCC2=C(NC(=O)NC2=O)C(=O)O)OC.C(CO)N	Ki = 530000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BR7U8M	2-Aminoethanol;5-[2-[3-(methylcarbamoyl)phenyl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134149497	C17H22N4O6	378.4	CNC(=O)C1=CC=CC(=C1)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki = 1035000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BSK6G7	2-Aminoethanol;5-[2-(3-carbamoylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134142176	C16H20N4O6	364.35	C1=CC(=CC(=C1)C(=O)N)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki > 500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BT1YE0	2-Aminoethanol;5-[2-[2-(hydroxymethyl)phenyl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134141914	C16H21N3O6	351.35	C1=CC=C(C(=C1)CCC2=C(NC(=O)NC2=O)C(=O)O)CO.C(CO)N	Ki > 2500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BU5W8L	2-(4-Chlorophenyl)-3-hydroxy-8-methylquinoline-4-carboxylicacid	Investigative	16099916	C17H12ClNO3	313.7	CC1=C2C(=CC=C1)C(=C(C(=N2)C3=CC=C(C=C3)Cl)O)C(=O)O	IC50 = 212000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BUW90L	N-(2,2-Diphenylethyl)-2-hydroxy-5-methylbenzamide	Investigative	90665769	C22H21NO2	331.4	CC1=CC(=C(C=C1)O)C(=O)NCC(C2=CC=CC=C2)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BV08ZK	3,5-Dichloro-N-(2,2-diphenylethyl)-2-hydroxybenzamide	Investigative	90665764	C21H17Cl2NO2	386.3	C1=CC=C(C=C1)C(CNC(=O)C2=C(C(=CC(=C2)Cl)Cl)O)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BV1SG5	N-(5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)quinolin-6-amine	Investigative	24882115	C15H12N6	276.3	CC1=NC2=NC=NN2C(=C1)NC3=CC4=C(C=C3)N=CC=C4	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BV8FM0	4-({5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}amino)benzamide	Investigative	24882114	C13H12N6O	268.27	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)C(=O)N	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BVM47W	3-Chloro-N-(2,2-diphenylethyl)-2-hydroxybenzamide	Investigative	90665761	C21H18ClNO2	351.8	C1=CC=C(C=C1)C(CNC(=O)C2=C(C(=CC=C2)Cl)O)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BW51CO	N-(5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)quinolin-3-amine	Investigative	24882198	C15H12N6	276.3	CC1=NC2=NC=NN2C(=C1)NC3=CC4=CC=CC=C4N=C3	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BWX3V0	Chembl4228737	Investigative	145969586	C22H16N2O2	340.4	COC(=O)C1=CC(=NC2=CC=CC=C21)C3=CC=C(C=C3)C4=CN=CC=C4	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BX3UR6	2-Aminoethanol;5-(2-isoquinolin-1-ylethyl)-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134137428	C18H20N4O5	372.4	C1=CC=C2C(=C1)C=CN=C2CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki > 625000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BXW7N9	2-Aminoethanol;5-[2-(4-methoxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134143381	C16H21N3O6	351.35	COC1=CC=C(C=C1)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki = 1255000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BYS07T	N-[(7E)-5-Methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-ylidene]naphthalen-1-amine	Investigative	743061	C16H13N5	275.31	CC1=NC2=NC=NN2C(=C1)NC3=CC=CC4=CC=CC=C43	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BZ6L7Y	Chembl4227860	Investigative	145970439	C20H13N3O2	327.3	C1=CC=C2C(=C1)C(=CC(=N2)C3=CC=C(C=C3)C4=NC=CC=N4)C(=O)O	IC50 > 200000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BZ7B6D	2-Aminoethanol;2,4-dioxo-5-(2-phenylethyl)-1H-pyrimidine-6-carboxylic acid	Investigative	134148955	C15H19N3O5	321.33	C1=CC=C(C=C1)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki > 2500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BZE3S1	2-Aminoethanol;5-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134144586	C15H26N4O7	374.39	CC(C)(C)OC(=O)NCCCC1=C(NC(=O)NC1=O)C(=O)O.C(CO)N	Ki > 313000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	BZWX03	2-Aminoethanol;5-[2-(3,4-difluorophenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134156999	C15H17F2N3O5	357.31	C1=CC(=C(C=C1CCC2=C(NC(=O)NC2=O)C(=O)O)F)F.C(CO)N	Ki > 2500000 nM	Non binder
T61400	Dihydroorotate dehydrogenase	D05YJP	Ethyl 3-(biphenyl-3-ylamino)-2-cyanoacrylate	Investigative	16102644	C18H16N2O2	292.3	CCOC(=O)/C(=C\\NC1=CC=CC(=C1)C2=CC=CC=C2)/C#N	IC50 = 219800 nM	Non binder
T61400	Dihydroorotate dehydrogenase	D0HQ1I	GNF-PF-85	Investigative	777193	C16H13N5O	291.31	CC1=NC2=NC=NN2C(=C1)NC3=CC4=CC=CC=C4C=C3O	IC50 > 200000 nM	Non binder