TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T63966	Vascular endothelial growth factor receptor 1	B0SFH5	4-N-(4-Chlorophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	56951307	C20H18ClN5	363.8	CC1=CC=CC=C1CC2=CC3=C(N2)N=C(N=C3NC4=CC=C(C=C4)Cl)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	B14FAH	N-(3-Bromo-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887300	C20H16BrFN4	411.3	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=CN=C3NC4=CC(=C(C=C4)F)Br	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	B1LD6H	N-[3-[3-[[2-Methyl-6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide	Investigative	56676922	C26H30N8O3S	534.6	CC1=NC(=CC(=N1)NC2=NNC(=C2)C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CC=C4)NCCN5CCOCC5	IC50 > 1000000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	B21UJN	4-N-(3-Bromophenyl)-7-[(4-phenylphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	57391283	C25H20BrN5	470.4	C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C=CC4=C(N=C(N=C43)N)NC5=CC(=CC=C5)Br	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	B3M9AQ	N-(4-Chloro-2-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887349	C20H16ClFN4	366.8	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=CN=C3NC4=C(C=C(C=C4)Cl)F	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	B3Z1IA	N4-(3-Chloro-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	44586490	C20H17ClFN5	381.8	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=C(C=C4)F)Cl)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	B5STJ4	N-[3-[3-[[6-(4-Hydroxypiperidin-1-yl)-2-methylpyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide	Investigative	56663233	C25H27N7O3S	505.6	CC1=NC(=CC(=N1)N2CCC(CC2)O)NC3=NNC(=C3)C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CC=C5	IC50 > 1000000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	B5XSL9	N4-(3-Fluoro-4-trifluoromethylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	46886974	C20H13Cl2F4N5	470.2	C1=CC(=C(C=C1NC2=NC(=NC3=C2C=C(N3)CC4=C(C=C(C=C4)Cl)Cl)N)F)C(F)(F)F	IC50 > 300000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	B7WA1P	6-(2-Phenylethyl)-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887299	C21H17F3N4	382.4	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=CN=C3NC4=CC=CC(=C4)C(F)(F)F	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	B8X6SK	N-[3-[3-[[6-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide	Investigative	56666663	C26H30N8O3S	534.6	CC1=NC(=CC(=N1)N2CCN(CC2)CCO)NC3=NNC(=C3)C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CC=C5	IC50 > 1000000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BBEH31	N4-(3-Ethynylphenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	44586526	C22H19N5	353.4	C#CC1=CC(=CC=C1)NC2=NC(=NC3=C2C=C(N3)CCC4=CC=CC=C4)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BCS86E	4-N-(4-Chloro-2-fluorophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	56951305	C23H17ClFN5	417.9	C1=CC=C2C(=C1)C=CC=C2CC3=CC4=C(N3)N=C(N=C4NC5=C(C=C(C=C5)Cl)F)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BD1BX0	N-[4-(3-Chloro-4-fluoroanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide	Investigative	71525284	C24H24ClFN6O	466.9	CC(C)(C)C(=O)NC1=NC2=C(C=C(N2)CCC3=CC=CC=N3)C(=N1)NC4=CC(=C(C=C4)F)Cl	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BDQS26	4-N-(3-Bromophenyl)-7-[(2,5-dimethoxyphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	57398417	C21H20BrN5O2	454.3	COC1=CC(=C(C=C1)OC)CN2C=CC3=C(N=C(N=C32)N)NC4=CC(=CC=C4)Br	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BFQ9N7	6-(2-Pyridin-2-ylethyl)-4-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	71525248	C20H17F3N6	398.4	C1=CC=NC(=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC=CC(=C4)C(F)(F)F)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BGJH61	N-[4-(3-Bromo-4-fluoroanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide	Investigative	71525283	C24H24BrFN6O	511.4	CC(C)(C)C(=O)NC1=NC2=C(C=C(N2)CCC3=CC=CC=N3)C(=N1)NC4=CC(=C(C=C4)F)Br	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BGT5W3	6-(2,4-Dichlorobenzyl)-N-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887112	C20H13Cl2F3N4	437.2	C1=CC(=CC(=C1)NC2=NC=NC3=C2C=C(N3)CC4=C(C=C(C=C4)Cl)Cl)C(F)(F)F	IC50 > 300000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BGWS79	N-[3-[3-[[6-[2-(Dimethylamino)ethylamino]-2-methylpyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide	Investigative	56683569	C24H28N8O2S	492.6	CC1=NC(=CC(=N1)NC2=NNC(=C2)C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CC=C4)NCCN(C)C	IC50 > 1000000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BGZ7Q5	CID 56659825	Investigative	56659825	C23H32N8O2S	484.6	CCCCS(=O)(=O)NC1=CC=CC(=C1)C2=CC(=NN2)NC3=CC(=NC(=N3)C)N4CCN(CC4)C	IC50 > 1000000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BIA57B	6-(2,4-Dichlorobenzyl)-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887113	C21H14Cl2N4	393.3	C#CC1=CC(=CC=C1)NC2=NC=NC3=C2C=C(N3)CC4=C(C=C(C=C4)Cl)Cl	IC50 > 300000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BK1VI4	N4-1H-Indol-5-yl-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	44586577	C22H20N6	368.4	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC5=C(C=C4)NC=C5)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BKV54S	N-1H-Indol-5-yl-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887397	C22H19N5	353.4	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=CN=C3NC4=CC5=C(C=C4)NC=C5	IC50 = 223800 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BMEZ71	4-N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	71525249	C20H16F4N6	416.4	C1=CC=NC(=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=C(C=C4)F)C(F)(F)F)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BND9X0	6-Phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	25022736	C21H18F3N5	397.4	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC=CC(=C4)C(F)(F)F)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BP3VD9	N4-(4-Fluoro-3-(trifluoromethyl)phenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	25022735	C21H17F4N5	415.4	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=C(C=C4)F)C(F)(F)F)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BP6RW4	N-(3-Bromophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887074	C20H17BrN4	393.3	CC1=CC=CC=C1CC2=CC3=C(N2)N=CN=C3NC4=CC(=CC=C4)Br	IC50 > 300000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BQ16DR	N4-(4-Chloro-2-fluorophenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	44586527	C20H17ClFN5	381.8	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=C(C=C(C=C4)Cl)F)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BS0W1X	6-[(2,4-Dichlorophenyl)methyl]-4-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	46886973	C21H15Cl2N5	408.3	C#CC1=CC(=CC=C1)NC2=NC(=NC3=C2C=C(N3)CC4=C(C=C(C=C4)Cl)Cl)N	IC50 > 300000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BSC95P	CID 56676977	Investigative	56676977	C26H30N8O2S	518.6	CC1=CC(=CC=C1)S(=O)(=O)NC2=CC=CC(=C2)C3=CC(=NN3)NC4=CC(=NC(=N4)C)N5CCN(CC5)C	IC50 > 1000000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BTIG04	4-N-(3-Chloro-4-fluorophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	71525246	C19H16ClFN6	382.8	C1=CC=NC(=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=C(C=C4)F)Cl)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BU75KG	N-[3-[3-[[2-Methyl-6-(3-morpholin-4-ylpropylamino)pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide	Investigative	56659759	C27H32N8O3S	548.7	CC1=NC(=CC(=N1)NC2=NNC(=C2)C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CC=C4)NCCCN5CCOCC5	IC50 > 1000000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BW1NE7	N4-(4-Bromo-2-chlorophenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	46845026	C19H13BrCl3N5	497.6	C1=CC(=C(C=C1Cl)Cl)CC2=CC3=C(N2)N=C(N=C3NC4=C(C=C(C=C4)Br)Cl)N	IC50 > 300000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BWR5P7	(3S)-3-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylpentanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid	Investigative	137644697	C57H85N15O17	1252.4	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CO)NC(=O)C	IC50 = 271100 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BXY0S7	4-N-(4-Chlorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	44586528	C20H18ClN5	363.8	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC=C(C=C4)Cl)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BZ2AF9	N4-(3-Bromo-4-fluorophenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	10251852	C20H17BrFN5	426.3	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=C(C=C4)F)Br)N	IC50 > 200000 nM	Non binder
T63966	Vascular endothelial growth factor receptor 1	BZW8Q7	N-(3-Bromophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887110	C21H19BrN4O2	439.3	COC1=CC(=C(C=C1)OC)CC2=CC3=C(N2)N=CN=C3NC4=CC(=CC=C4)Br	IC50 > 300000 nM	Non binder