TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T65019	Matrix metalloproteinase-14	B01CEJ	(1R,2S)-1-({3-Fluoro-4-[(2-phenylquinolin-4-yl)methoxy]phenyl}methyl)-2-N-hydroxycyclopropane-1,2-dicarboxamide	Investigative	25138228	C28H24FN3O4	485.5	C1[C@@H]([C@@]1(CC2=CC(=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5)F)C(=O)N)C(=O)NO	Ki = 4072000 nM	Non binder
T65019	Matrix metalloproteinase-14	B09XSF	Hydroxamate deriv., 78	Investigative	24799779	C23H23N3O4	405.4	CC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)C[C@@]4(C[C@@H]4C(=O)NO)C(=O)N	Ki = 2400000 nM	Non binder
T65019	Matrix metalloproteinase-14	B1W8UQ	(1R,2S)-Ethyl 2-(hydroxycarbamoyl)-1-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxylate	Investigative	44581111	C30H28N2O5	496.6	CCOC(=O)[C@]1(C[C@@H]1C(=O)NO)CC2=CC=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5	Ki > 10000000 nM	Non binder
T65019	Matrix metalloproteinase-14	B20AUN	Ethyl 5-{1-methyl-3-[(pyridin-4-ylmethyl)carbamoyl]-1H-pyrazol-5-yl}-1H-indole-2-carboxylate	Investigative	45377564	C22H21N5O3	403.4	CCOC(=O)C1=CC2=C(N1)C=CC(=C2)C3=CC(=NN3C)C(=O)NCC4=CC=NC=C4	IC50 > 500000 nM	Non binder
T65019	Matrix metalloproteinase-14	B2AW8L	(1R,2S)-Ethyl 2-(hydroxycarbamoyl)-1-(4-((2-methylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxylate	Investigative	44581071	C25H26N2O5	434.5	CCOC(=O)[C@]1(C[C@@H]1C(=O)NO)CC2=CC=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C	Ki > 10000000 nM	Non binder
T65019	Matrix metalloproteinase-14	B39ANH	Ethyl 5-(methanesulfonamido)-1H-indole-2-carboxylate	Investigative	53957122	C12H14N2O4S	282.32	CCOC(=O)C1=CC2=C(N1)C=CC(=C2)NS(=O)(=O)C	IC50 > 500000 nM	Non binder
T65019	Matrix metalloproteinase-14	B3JR8F	2-N-Ethyl-1H-indole-2,5-dicarboxamide	Investigative	56850270	C12H13N3O2	231.25	CCNC(=O)C1=CC2=C(N1)C=CC(=C2)C(=O)N	IC50 > 500000 nM	Non binder
T65019	Matrix metalloproteinase-14	B3K4BP	Chembl4171886	Investigative	145950074	C12H15N3O7S	345.33	CNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 > 500000 nM	Non binder
T65019	Matrix metalloproteinase-14	B62HUJ	(E)-2-(5-((5-(4-Methoxyphenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid	Investigative	2140735	C17H13NO5S2	375.4	COC1=CC=C(C=C1)C2=CC=C(O2)/C=C/3\\C(=O)N(C(=S)S3)CC(=O)O	IC50 = 310000 nM	Non binder
T65019	Matrix metalloproteinase-14	B68PDE	Ethyl 5-acetamido-1H-indole-2-carboxylate	Investigative	685005	C13H14N2O3	246.26	CCOC(=O)C1=CC2=C(N1)C=CC(=C2)NC(=O)C	IC50 > 500000 nM	Non binder
T65019	Matrix metalloproteinase-14	B8RO3G	(1S,2R)-2-Cyano-N-hydroxy-2-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxamide	Investigative	11575995	C28H23N3O3	449.5	C1[C@@H]([C@@]1(CC2=CC=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5)C#N)C(=O)NO	Ki > 10000000 nM	Non binder
T65019	Matrix metalloproteinase-14	BB98UI	3,2-Diguanidinoneamine	Investigative	23645953	C14H30N8O6	406.44	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N=C(N)N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N=C(N)N)O)O)N	Ki > 300000 nM	Non binder
T65019	Matrix metalloproteinase-14	BBKQ94	Ethyl 5-(3-methylpyridin-4-yl)-1H-indole-2-carboxylate	Investigative	56850407	C17H16N2O2	280.32	CCOC(=O)C1=CC2=C(N1)C=CC(=C2)C3=C(C=NC=C3)C	IC50 > 500000 nM	Non binder
T65019	Matrix metalloproteinase-14	BCQ82U	Ethyl 5-pyridin-2-yl-1H-indole-2-carboxylate	Investigative	14177156	C16H14N2O2	266.29	CCOC(=O)C1=CC2=C(N1)C=CC(=C2)C3=CC=CC=N3	IC50 > 500000 nM	Non binder
T65019	Matrix metalloproteinase-14	BEU14G	Chembl4175156	Investigative	145949783	C16H23N3O7S	401.4	CCCCCNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 = 435800 nM	Non binder
T65019	Matrix metalloproteinase-14	BF4D1H	N-[2-(4,5-Dihydro-1,3-oxazol-2-yl)-1H-indol-5-yl]acetamide	Investigative	57394678	C13H13N3O2	243.26	CC(=O)NC1=CC2=C(C=C1)NC(=C2)C3=NCCO3	IC50 > 500000 nM	Non binder
T65019	Matrix metalloproteinase-14	BFZ5I0	Chembl4167291	Investigative	145955226	C15H21N3O7S	387.4	CC(C)CNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 = 309300 nM	Non binder
T65019	Matrix metalloproteinase-14	BGV24B	Neamine guanidinylated deriv. 29	Investigative	23645959	C20H42N12O6	546.6	CO[C@H]1[C@@H](C[C@@H]([C@H]([C@@H]1OC)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN=C(N)N)OC)OC)N=C(N)N)N=C(N)N)N=C(N)N	Ki > 300000 nM	Non binder
T65019	Matrix metalloproteinase-14	BI7MJ1	6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrile	Investigative	44143089	C14H8F4N6	336.25	C1=C(C=C(C=C1F)F)NC2=C3C(=NC(=N2)C#N)N(C=N3)CC(F)F	IC50 = 426579.52 nM	Non binder
T65019	Matrix metalloproteinase-14	BJD2Z7	2-Butanoyl-1H-indole-5-carboxamide	Investigative	56850269	C13H14N2O2	230.26	CCCC(=O)C1=CC2=C(N1)C=CC(=C2)C(=O)N	IC50 > 500000 nM	Non binder
T65019	Matrix metalloproteinase-14	BK2ZL3	Neamine guanidinylated deriv. 4	Investigative	9957228	C16H34N12O6	490.5	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N=C(N)N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN=C(N)N)O)O)N=C(N)N)O)O)N=C(N)N	Ki > 300000 nM	Non binder
T65019	Matrix metalloproteinase-14	BO6HQ2	(1R,2S)-1-(3-Fluoro-4-((2-phenylquinolin-4-yl)methoxy)benzyl)-N2-hydroxy-N1,N1-dimethylcyclopropane-1,2-dicarboxamide	Investigative	44580801	C30H28FN3O4	513.6	CN(C)C(=O)[C@]1(C[C@@H]1C(=O)NO)CC2=CC(=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5)F	Ki > 10000000 nM	Non binder
T65019	Matrix metalloproteinase-14	BRC53V	N-[(1S,2S)-2-Hydroxycyclopentyl]-4-phenoxybenzenesulfonamide	Investigative	71682917	C17H19NO4S	333.4	C1C[C@@H]([C@H](C1)O)NS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki > 200000 nM	Non binder
T65019	Matrix metalloproteinase-14	BS45NE	Ethyl 5-phenyl-1H-indole-2-carboxylate	Investigative	12404978	C17H15NO2	265.31	CCOC(=O)C1=CC2=C(N1)C=CC(=C2)C3=CC=CC=C3	IC50 > 500000 nM	Non binder
T65019	Matrix metalloproteinase-14	BSC72X	(1S,2R)-N-Hydroxy-2-((S)-2-(hydroxymethyl)pyrrolidine-1-carbonyl)-2-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxamide	Investigative	44580802	C33H33N3O5	551.6	C1C[C@H](N(C1)C(=O)[C@]2(C[C@@H]2C(=O)NO)CC3=CC=C(C=C3)OCC4=CC(=NC5=CC=CC=C54)C6=CC=CC=C6)CO	Ki > 10000000 nM	Non binder
T65019	Matrix metalloproteinase-14	BW5FE4	1,3,2-Triguanidinoneamine	Investigative	11328354	C15H32N10O6	448.48	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N=C(N)N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N=C(N)N)O)O)N=C(N)N	Ki > 300000 nM	Non binder
T65019	Matrix metalloproteinase-14	BWUH98	5-Pyridin-4-yl-1H-indole-2-carboxylic acid ethyl ester	Investigative	56850272	C16H14N2O2	266.29	CCOC(=O)C1=CC2=C(N1)C=CC(=C2)C3=CC=NC=C3	IC50 = 225000 nM	Non binder
T65019	Matrix metalloproteinase-14	BXH05U	Chembl4170455	Investigative	145956298	C14H19N3O7S	373.38	CC(C)NC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 = 301100 nM	Non binder
T65019	Matrix metalloproteinase-14	BY97GQ	Ethyl 5-carbamoyl-1H-indole-2-carboxylate	Investigative	47162079	C12H12N2O3	232.23	CCOC(=O)C1=CC2=C(N1)C=CC(=C2)C(=O)N	IC50 > 500000 nM	Non binder