TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T67162	Dopamine D2 receptor	D0OU7P	SKF 38393	Terminated	1242	C16H17NO2	255.31	C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3	Ki = 720000 nM	Non binder
T67162	Dopamine D2 receptor	B1TZ2X	2{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-4-(4''-fluorophenyl)piperazine	Investigative	25158436	C27H31FN2O2	434.5	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCN(CC3)C4=CC=C(C=C4)F	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	B28IUF	6,9-Dichloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol;hydrochloride	Investigative	45261596	C17H18Cl3NO2	374.7	CN1CCC2=C(C(C1)C3=CC=CC=C3)C(=C(C(=C2Cl)O)O)Cl.Cl	Ki = 810000 nM	Non binder
T67162	Dopamine D2 receptor	B3ZES5	2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-4-(3''-trifluoromethyl)piperazine	Investigative	25158434	C28H31F3N2O2	484.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	B5T8BE	2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-(3,4-dihydroisoquinoline)	Investigative	25157546	C26H29NO2	387.5	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCC4=CC=CC=C4C3	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	B68GSA	(E)-6-((6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyleneamino)-2,3-dihydro-1H-inden-1-ol	Investigative	9950396	C21H24N2O3	352.4	COC1=C(C=C2CN(CCC2=C1)C=NC3=CC4=C(CCC4O)C=C3)OC	Ki > 300000 nM	Non binder
T67162	Dopamine D2 receptor	B6KF2M	1-(1-Propylpiperidin-4-yl)benzimidazole	Investigative	71463195	C15H21N3	243.35	CCCN1CCC(CC1)N2C=NC3=CC=CC=C32	IC50 > 580000 nM	Non binder
T67162	Dopamine D2 receptor	B6NC4G	4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(3''-trifluoromethylphenyl)piperazine	Investigative	25156966	C30H35F3N2O2	512.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	B6RYK2	4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(2''-pyrimidyl)piperazine	Investigative	25156413	C27H34N4O2	446.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCN(CC3)C4=NC=CC=N4	Ki = 854000 nM	Non binder
T67162	Dopamine D2 receptor	B6UO4K	6,7-Dimethoxy-2-[2-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]ethyl]-3,4-dihydro-1H-isoquinoline	Investigative	25156685	C28H33NO4	447.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCC4=CC(=C(C=C4C3)OC)OC	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	B8CGQ2	trans-4-Tert-Butoxy-N-(4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexyl)-benzamide	Investigative	57386718	C32H44N2O3	504.7	CC(C)(C)OC1=CC=C(C=C1)C(=O)NC2CCC(CC2)CCN3CCC(CC3)C4=C5CCOC5=CC=C4	Ki > 10000000 nM	Non binder
T67162	Dopamine D2 receptor	B8IH3A	6,7-Dimethoxy-2-[4-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]butyl]-3,4-dihydro-1H-isoquinoline	Investigative	25156686	C30H37NO4	475.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCC4=CC(=C(C=C4C3)OC)OC	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	B8N5YX	4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(N-methyl)piperazine	Investigative	25157543	C24H34N2O2	382.5	CN1CCN(CC1)CCCCOC2=CC=CC=C2CCC3=CC(=CC=C3)OC	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	B98SDE	4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(3''-trifluoromethylphenyl)piperazine	Investigative	25158433	C29H35ClN2O2	479.1	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCN(CC3)C4=CC(=CC=C4)Cl	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	B9TLU8	6,7-Dimethoxy-2-[3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propyl]-3,4-dihydro-1H-isoquinoline	Investigative	25157845	C29H35NO4	461.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCN3CCC4=CC(=C(C=C4C3)OC)OC	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	B9XGS1	4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(4''-fluorophenyl)piperazine	Investigative	25157253	C29H35FN2O2	462.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCN(CC3)C4=CC=C(C=C4)F	Ki = 1324000 nM	Non binder
T67162	Dopamine D2 receptor	BAY41H	2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-4-(3''-chlorophenyl)piperazine	Investigative	25156688	C27H31ClN2O2	451	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCN(CC3)C4=CC(=CC=C4)Cl	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	BCD2S8	2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-4-(2''-pyrimidil)piperazine	Investigative	25156412	C25H30N4O2	418.5	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCN(CC3)C4=NC=CC=N4	Ki = 629000 nM	Non binder
T67162	Dopamine D2 receptor	BF3QK7	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-4-(3''-chlorophenyl)piperazine	Investigative	25155851	C30H37ClN2O2	493.1	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCN(CC3)C4=CC(=CC=C4)Cl	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	BG1D6T	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-4-(2''-pyrimidyl)piperazine	Investigative	25157850	C28H36N4O2	460.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCN(CC3)C4=NC=CC=N4	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	BI0CM9	4-Tert-butyl-N-[4-[2-[4-(2,3-dihydro-1-benzofuran-4-yl)piperidin-1-yl]ethyl]cyclohexyl]benzamide	Investigative	57385936	C32H44N2O2	488.7	CC(C)(C)C1=CC=C(C=C1)C(=O)NC2CCC(CC2)CCN3CCC(CC3)C4=C5CCOC5=CC=C4	Ki > 10000000 nM	Non binder
T67162	Dopamine D2 receptor	BISD74	1-[3-[2-[2-(3-Methoxyphenyl)ethyl]phenoxy]propyl]-4-methylpiperazine	Investigative	25156414	C23H32N2O2	368.5	CN1CCN(CC1)CCCOC2=CC=CC=C2CCC3=CC(=CC=C3)OC	Ki = 565000 nM	Non binder
T67162	Dopamine D2 receptor	BJ0YT5	3-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-4-(3''-trifluoromethylphenyl)piperazine	Investigative	25156129	C29H33F3N2O2	498.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F	Ki = 1412000 nM	Non binder
T67162	Dopamine D2 receptor	BJ1O0D	6,7-Dimethoxy-2-[5-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]pentyl]-3,4-dihydro-1H-isoquinoline	Investigative	25157848	C31H39NO4	489.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCC4=CC(=C(C=C4C3)OC)OC	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	BLD94F	(E)-6-((3,4-Dihydroisoquinolin-2(1H)-yl)methyleneamino)-2,3-dihydro-1H-inden-1-ol	Investigative	44439402	C19H20N2O	292.4	C1CC2=C(C1O)C=C(C=C2)N=CN3CCC4=CC=CC=C4C3	Ki > 300000 nM	Non binder
T67162	Dopamine D2 receptor	BMS76X	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-4-(N-methyl)piperazine	Investigative	25156415	C25H36N2O2	396.6	CN1CCN(CC1)CCCCCOC2=CC=CC=C2CCC3=CC(=CC=C3)OC	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	BP69UG	(4As,5R,10bR)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diol	Investigative	46869265	C19H21NO2	295.4	C1CNC[C@@H]2[C@@H]1[C@@H](CC3=C2C=CC(=C3O)O)C4=CC=CC=C4	Ki = 750000 nM	Non binder
T67162	Dopamine D2 receptor	BPUG28	3-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-4-(4''-fluorophenyl)piperazine	Investigative	25156133	C28H33FN2O2	448.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCN3CCN(CC3)C4=CC=C(C=C4)F	Ki = 655000 nM	Non binder
T67162	Dopamine D2 receptor	BQFS49	2{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl-4-(2''-methoxyphenyl)piperazine	Investigative	25156130	C28H34N2O3	446.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCN3CCN(CC3)C4=CC=CC=C4OC	Ki = 427000 nM	Non binder
T67162	Dopamine D2 receptor	BSI5O1	3-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-4-(3''-chlorophenyl)piperazine	Investigative	25155850	C28H33ClN2O2	465	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCN3CCN(CC3)C4=CC(=CC=C4)Cl	Ki = 298000 nM	Non binder
T67162	Dopamine D2 receptor	BT3GN6	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-4-(2''-methoxyphenyl)piperazine	Investigative	25156132	C31H40N2O3	488.7	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCN(CC3)C4=CC=CC=C4OC	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	BU38KS	4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-(3,4-dihydroisoquinoline)	Investigative	25156684	C28H33NO2	415.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCN3CCC4=CC=CC=C4C3	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	BUIE98	1-Phenyl-2,3,4,9-tetrahydro-1H-beta-carboline	Investigative	198967	C17H16N2	248.32	C1CNC(C2=C1C3=CC=CC=C3N2)C4=CC=CC=C4	Ki > 300000 nM	Non binder
T67162	Dopamine D2 receptor	BV2B4A	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-(3,4-dihydroisoquinoline)	Investigative	25157549	C29H35NO2	429.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCC4=CC=CC=C4C3	Ki > 1000000 nM	Non binder
T67162	Dopamine D2 receptor	BZV25H	5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}pentyl-4-(4''-fluorophenyl)piperazine	Investigative	25156411	C30H37FN2O2	476.6	COC1=CC=CC(=C1)CCC2=CC=CC=C2OCCCCCN3CCN(CC3)C4=CC=C(C=C4)F	Ki = 847000 nM	Non binder