TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T67272	Aminopeptidase N	D0T2IQ	Actinonin	Terminated	443600	C19H35N3O5	385.5	CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO	Ki = 300000 nM	Non binder
T67272	Aminopeptidase N	B0HRW5	(2S)-2-[[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]methyl]-3-phenylpropanoic acid	Investigative	44450377	C41H56N8O8	788.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)NC[C@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)N	Ki = 407000000000000 nM	Non binder
T67272	Aminopeptidase N	B13JYG	(2S,4S)-Methyl 1-(3-(3,4-dimethoxyphenyl)propanoyl)-4-(cinnamamido)pyrrolidine-2-carboxylate	Investigative	25147060	C26H30N2O6	466.5	COC1=C(C=C(C=C1)CCC(=O)N2C[C@H](C[C@H]2C(=O)OC)NC(=O)/C=C/C3=CC=CC=C3)OC	IC50 = 232700 nM	Non binder
T67272	Aminopeptidase N	B24SQI	1-[(S)-2-((1S,2S)-2-Amino-1-carbamoyl-3-phenyl-propylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid methyl ester	Investigative	44284085	C22H34N4O4	418.5	CC(C)C[C@@H](C(=O)N1CCCC1C(=O)OC)N[C@H]([C@H](CC2=CC=CC=C2)N)C(=O)N	IC50 = 783000 nM	Non binder
T67272	Aminopeptidase N	B2SI6R	(6S,7S)-7-Amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-ol;hydrochloride	Investigative	53322290	C11H16ClNO	213.7	C1CC2=CC=CC=C2C[C@@H]([C@H]1N)O.Cl	IC50 = 300000 nM	Non binder
T67272	Aminopeptidase N	B2W4BU	(2-Amino-3-phenylpropyl)phosphonic acid	Investigative	12749378	C9H14NO3P	215.19	C1=CC=C(C=C1)CC(CP(=O)(O)O)N	IC50 = 500000 nM	Non binder
T67272	Aminopeptidase N	B32NIJ	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(3R)-3-[[(2S)-2-Amino-3-methylbutanoyl]amino]-4-(4-hydroxyphenyl)butanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Investigative	44450286	C41H56N8O8	788.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)C[C@@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)N	Ki = 219000000000000 nM	Non binder
T67272	Aminopeptidase N	B3RJH2	3-Amino-4-phenylbutanoic acid	Investigative	277936	C10H13NO2	179.22	C1=CC=C(C=C1)CC(CC(=O)O)N	IC50 = 800000 nM	Non binder
T67272	Aminopeptidase N	B49XJR	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[1-(Aminomethyl)cyclopentanecarbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Investigative	24828882	C42H56N8O8	800.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)C5(CCCC5)CN	Ki = 28800000000000 nM	Non binder
T67272	Aminopeptidase N	B5K9MD	(3S)-3-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2R)-2-(Aminomethyl)-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-4-phenylbutanoic acid	Investigative	24828881	C42H58N8O8	803	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)CC(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@@H](CN)C(C)C	Ki = 170000000000000 nM	Non binder
T67272	Aminopeptidase N	B5P9TH	Phenylalanylleucine	Investigative	76808	C15H22N2O3	278.35	CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)N	IC50 = 1000000 nM	Non binder
T67272	Aminopeptidase N	B5RLA8	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[[(2S)-2-[[(2S)-2-Amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]methyl]-4-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Investigative	44450222	C41H56N8O8	788.9	CC(C)C[C@@H](CNC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](C(C)C)N)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O	Ki = 91200000000000 nM	Non binder
T67272	Aminopeptidase N	B6MZL0	(2S)-2-[[(2S)-1-[(2S)-2-[[(3S,4S)-3-[[(2S)-2-[[(2S)-2-Amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylhexanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Investigative	24828324	C41H56N8O8	788.9	CC[C@H](C)[C@H](CC(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)N	Ki = 132000000000000 nM	Non binder
T67272	Aminopeptidase N	B6QYR2	2-(2,6-Dimethyl-phenyl)-4-hydroxy-isoindole-1,3-dione	Investigative	10492044	C16H13NO3	267.28	CC1=C(C(=CC=C1)C)N2C(=O)C3=C(C2=O)C(=CC=C3)O	IC50 = 264500 nM	Non binder
T67272	Aminopeptidase N	B76DZP	(2S)-2-[[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-Carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]methyl]-4-methylpentanoic acid	Investigative	44450334	C42H57N7O9	803.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC[C@H](CC(C)C)C(=O)O	Ki = 7080000000000000 nM	Non binder
T67272	Aminopeptidase N	B7TC3X	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[[(2S)-2-Amino-3-methylbutanoyl]amino]methyl]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Investigative	44450246	C41H56N8O8	788.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@@H](CC4=CC=C(C=C4)O)CNC(=O)[C@H](C(C)C)N	Ki = 97700000000000 nM	Non binder
T67272	Aminopeptidase N	B80UXO	(S)-2-((1R,2S)-2-Tert-Butoxycarbonylamino-1-cyano-3-phenyl-propylamino)-3-phenyl-propionic acid methyl ester	Investigative	44283851	C25H31N3O4	437.5	CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)[C@@H](C#N)N[C@@H](CC2=CC=CC=C2)C(=O)OC	IC50 = 1000000 nM	Non binder
T67272	Aminopeptidase N	B8B2JR	(S)-2-((S)-2-Tert-Butoxycarbonylamino-1-cyano-3-phenyl-propylamino)-4-methyl-pentanoic acid methyl ester	Investigative	15342195	C22H33N3O4	403.5	CC(C)C[C@@H](C(=O)OC)NC(C#N)[C@H](CC1=CC=CC=C1)NC(=O)OC(C)(C)C	IC50 = 1000000 nM	Non binder
T67272	Aminopeptidase N	B8T0CY	(3S)-3-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-4-phenylbutanoic acid	Investigative	24828325	C41H56N8O8	788.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)CC(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)N	Ki = 407000000000000 nM	Non binder
T67272	Aminopeptidase N	B9WK4P	(2S)-2-[[2-[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]acetyl]amino]-3-phenylpropanoic acid	Investigative	24828600	C41H56N8O8	788.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2CC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)N	Ki = 186000000000000 nM	Non binder
T67272	Aminopeptidase N	B9Y6WZ	2-[2,6-Bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3-dihydro-1H-isoindol-1-one	Investigative	10064801	C20H21NOS	323.5	CC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=CC=CC=C3C2=S	IC50 = 309200 nM	Non binder
T67272	Aminopeptidase N	BA8K7G	1-[(S)-2-((1S,2S)-2-Tert-Butoxycarbonylamino-1-cyano-3-phenyl-propylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid methyl ester	Investigative	44283849	C27H40N4O5	500.6	CC(C)C[C@@H](C(=O)N1CCCC1C(=O)OC)N[C@@H](C#N)[C@H](CC2=CC=CC=C2)NC(=O)OC(C)(C)C	IC50 = 1000000 nM	Non binder
T67272	Aminopeptidase N	BAFK17	1-[(S)-2-((1R,2S)-2-Tert-Butoxycarbonylamino-1-cyano-3-phenyl-propylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid methyl ester	Investigative	44284086	C27H40N4O5	500.6	CC(C)C[C@@H](C(=O)N1CCCC1C(=O)OC)N[C@H](C#N)[C@H](CC2=CC=CC=C2)NC(=O)OC(C)(C)C	IC50 = 1000000 nM	Non binder
T67272	Aminopeptidase N	BC10VU	(2S)-2-Amino-N-[(2R)-1-[[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]amino]-1-oxo-3-phenylpropan-2-yl]-4-methylpentanamide	Investigative	56665195	C24H33N5O5	471.5	CC(C)C[C@@H](C(=O)N[C@H](CC1=CC=CC=C1)C(=O)NC[C@@H]([C@H](C2=CC=C(C=C2)[N+](=O)[O-])O)N)N	IC50 = 289950 nM	Non binder
T67272	Aminopeptidase N	BC9AB4	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2R)-2-(Aminomethyl)-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Investigative	24828743	C41H56N8O8	788.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@@H](CN)C(C)C	Ki = 224000000000000 nM	Non binder
T67272	Aminopeptidase N	BDMC54	(2S)-2-[[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-Carboxy-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]methyl]-4-methylpentanoic acid	Investigative	44450320	C43H59N7O9	818	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)CC(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC[C@H](CC(C)C)C(=O)O	Ki = 14500000000000 nM	Non binder
T67272	Aminopeptidase N	BE9UO2	(2S)-2-[[(2R)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]piperidine-2-carbonyl]amino]-3-phenylpropanoic acid	Investigative	44450376	C41H56N8O8	788.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCCC[C@@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)N	Ki = 339000000000000 nM	Non binder
T67272	Aminopeptidase N	BG8Y6D	6-Amino-5,6,8,9-tetrahydrobenzo[7]annulen-7-one;hydrochloride	Investigative	53320959	C11H14ClNO	211.69	C1CC(=O)C(CC2=CC=CC=C21)N.Cl	IC50 > 1000000 nM	Non binder
T67272	Aminopeptidase N	BGU78X	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-(Aminomethyl)-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Investigative	24828326	C41H56N8O8	788.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CN)C(C)C	Ki = 1150000000000 nM	Non binder
T67272	Aminopeptidase N	BHJ9V3	Pro-boroPro (PBP)	Investigative	44368735	C10H18BNO3	211.07	B([C@@H]1CCCC1C(=O)[C@@H]2CCCN2)(O)O	IC50 > 471600 nM	Non binder
T67272	Aminopeptidase N	BI7OA2	(S)-2-((S)-2-Tert-Butoxycarbonylamino-1-cyano-3-phenyl-propylamino)-3-methyl-butyric acid methyl ester	Investigative	44283812	C21H31N3O4	389.5	CC(C)[C@@H](C(=O)OC)NC(C#N)[C@H](CC1=CC=CC=C1)NC(=O)OC(C)(C)C	IC50 = 1000000 nM	Non binder
T67272	Aminopeptidase N	BI7OA4	1-[(S)-2-((1R,2S)-2-Amino-1-carbamoyl-3-phenyl-propylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid methyl ester	Investigative	44283814	C22H34N4O4	418.5	CC(C)C[C@@H](C(=O)N1CCCC1C(=O)OC)N[C@@H]([C@H](CC2=CC=CC=C2)N)C(=O)N	IC50 = 1000000 nM	Non binder
T67272	Aminopeptidase N	BJOL30	(S)-2-((1R,2S)-2-Amino-1-carbamoyl-3-phenyl-propylamino)-4-methyl-pentanoic acid methyl ester	Investigative	10245523	C17H27N3O3	321.4	CC(C)C[C@@H](C(=O)OC)N[C@@H]([C@H](CC1=CC=CC=C1)N)C(=O)N	IC50 = 1000000 nM	Non binder
T67272	Aminopeptidase N	BM3O5C	(2R)-2-Amino-N-[(2S)-3-[[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]amino]-2-hydroxy-3-oxopropyl]-3-phenylpropanamide	Investigative	56665196	C21H27N5O6	445.5	C1=CC=C(C=C1)C[C@H](C(=O)NC[C@@H](C(=O)NC[C@@H]([C@H](C2=CC=C(C=C2)[N+](=O)[O-])O)N)O)N	IC50 = 615560 nM	Non binder
T67272	Aminopeptidase N	BN6S5Z	(2S)-2-[[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-Carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]methyl]pentanoic acid	Investigative	44450345	C41H55N7O9	789.9	CCC[C@@H](CN[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)C(=O)O	Ki = 107000000000000 nM	Non binder
T67272	Aminopeptidase N	BO5UI8	(S)-6-Amino-2-((S)-2-tert-butoxycarbonylamino-1-cyano-3-phenyl-propylamino)-hexanoic acid methyl ester	Investigative	44283886	C22H34N4O4	418.5	CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)C(C#N)N[C@@H](CCCCN)C(=O)OC	IC50 = 1000000 nM	Non binder
T67272	Aminopeptidase N	BOKL91	(5S)-5-Amino-2,7-dimethyl-4-oxooctanoic acid	Investigative	14542146	C10H19NO3	201.26	CC(C)C[C@@H](C(=O)CC(C)C(=O)O)N	Ki = 660000 nM	Non binder
T67272	Aminopeptidase N	BQ68ZV	2-Aminocycloheptan-1-one hydrochloride	Investigative	13226136	C7H14ClNO	163.64	C1CCC(C(=O)CC1)N.Cl	IC50 = 310000 nM	Non binder
T67272	Aminopeptidase N	BV5TU4	1-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid methyl ester	Investigative	73356287	C21H31N3O4	389.5	CC(C)C[C@@H](C(=O)N1CCC[C@H]1C(=O)OC)NC(=O)[C@H](CC2=CC=CC=C2)N	IC50 = 793000 nM	Non binder
T67272	Aminopeptidase N	BX3UT1	(S)-2-((1S,2S)-2-Tert-Butoxycarbonylamino-1-cyano-3-phenyl-propylamino)-3-phenyl-propionic acid methyl ester	Investigative	44283863	C25H31N3O4	437.5	CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)[C@H](C#N)N[C@@H](CC2=CC=CC=C2)C(=O)OC	IC50 = 1000000 nM	Non binder
T67272	Aminopeptidase N	BXZD08	(3S)-3-Amino-5-methylhexan-2-one	Investigative	5311145	C7H15NO	129.199	CC(C)C[C@@H](C(=O)C)N	Ki = 430000 nM	Non binder
T67272	Aminopeptidase N	BZF41K	(2R)-2-Amino-N-[(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl]-3-sulfanylpropanamide	Investigative	56658262	C12H18N4O4S	314.36	C1=CC(=CC=C1[C@@H]([C@H](CNC(=O)[C@H](CS)N)N)O)[N+](=O)[O-]	IC50 = 248350 nM	Non binder