TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T76846	Melanocortin receptor 3	B0QHJ6	N-(2-Guanidino-ethyl)-4-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-butyramide	Investigative	44434797	C26H29N5O	427.5	C1=CC=C2C=C(C=CC2=C1)CN(CCN=C(N)N)C(=O)CCCC3=CNC4=CC=CC=C43	Ki = 204000 nM	Non binder
T76846	Melanocortin receptor 3	B13SDC	(R)-4-Amino-4-(naphthalen-2-ylmethyl-naphthalen-1-ylmethyl-carbamoyl)-butyric acid	Investigative	44265351	C27H26N2O3	426.5	C1=CC=C2C=C(C=CC2=C1)CN(CC3=CC=CC4=CC=CC=C43)C(=O)[C@@H](CCC(=O)O)N	Ki = 294000 nM	Non binder
T76846	Melanocortin receptor 3	B36BPE	4-(2-Naphthylmethyl)-1-piperazinecarboxamidine	Investigative	44265479	C16H20N4	268.36	C1CN(CCN1CC2=CC3=CC=CC=C3C=C2)C(=N)N	Ki > 1000000 nM	Non binder
T76846	Melanocortin receptor 3	B3GU7S	(R)-2-[(1H-Indol-3-ylmethyl)-amino]-3-naphthalen-2-yl-propionamide	Investigative	44265719	C22H21N3O	343.4	C1=CC=C2C=C(C=CC2=C1)C[C@H](C(=O)N)NCC3=CNC4=CC=CC=C43	Ki > 1000000 nM	Non binder
T76846	Melanocortin receptor 3	B42WUF	(1H-Indol-3-ylmethyl)-naphthalen-1-ylmethyl-amine	Investigative	44265312	C20H18N2	286.4	C1=CC=C2C(=C1)C=CC=C2CNCC3=CNC4=CC=CC=C43	Ki = 214000 nM	Non binder
T76846	Melanocortin receptor 3	B4GUO7	N-(4-(Diethylamino)benzyl)-4-(1H-indol-3-yl)-N-pentylbutanamide	Investigative	44434561	C28H39N3O	433.6	CCCCCN(CC1=CC=C(C=C1)N(CC)CC)C(=O)CCCC2=CNC3=CC=CC=C32	Ki = 289000 nM	Non binder
T76846	Melanocortin receptor 3	B58VZA	(S)-2-[(1H-Indol-3-ylmethyl)-amino]-3-naphthalen-2-yl-propionamide	Investigative	44265708	C22H21N3O	343.4	C1=CC=C2C=C(C=CC2=C1)C[C@@H](C(=O)N)NCC3=CNC4=CC=CC=C43	Ki > 1000000 nM	Non binder
T76846	Melanocortin receptor 3	B5UI2Z	(2R)-1-[2-(1H-Indol-3-yl)ethyl]-N-(naphthalen-2-ylmethyl)pyrrolidine-2-carboxamide	Investigative	71449140	C26H27N3O	397.5	C1C[C@@H](N(C1)CCC2=CNC3=CC=CC=C32)C(=O)NCC4=CC5=CC=CC=C5C=C4	Ki = 752000 nM	Non binder
T76846	Melanocortin receptor 3	B6UD5G	3-(Piperazin-1-ylmethyl)-1H-indole	Investigative	17880880	C13H17N3	215.29	C1CN(CCN1)CC2=CNC3=CC=CC=C32	Ki > 1000000 nM	Non binder
T76846	Melanocortin receptor 3	B9Q7KP	N-(3-Aminopropyl)-5-(benzyloxy)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide	Investigative	44434613	C29H31N3O2	453.6	C1CC2=CC=CC=C2CC1N(CCCN)C(=O)C3=CC4=C(N3)C=CC(=C4)OCC5=CC=CC=C5	Ki = 542000 nM	Non binder
T76846	Melanocortin receptor 3	BA9C5Y	(1R,4S,6R)-N-[(2R)-1-[4-(Tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-7-methyl-7-azabicyclo[2.2.2]octane-6-carboxamide	Investigative	6918851	C34H51FN4O3	582.8	CC(C)(C)NC(=O)C1(CCN(CC1)C(=O)[C@@H](CC2=CC=C(C=C2)F)NC(=O)[C@@H]3C[C@@H]4CC[C@H]3N(C4)C)C5CCCCC5	IC50 = 942000 nM	Non binder
T76846	Melanocortin receptor 3	BBX71R	N-(4-(Methylthio)benzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide	Investigative	44434700	C40H51N3O2S	637.9	CSC1=CC=C(C=C1)CN(C2CCC(CC2)CC3CCC(CC3)N)C(=O)CCCC4=C(NC5=CC=CC=C54)CC6=CC=C(C=C6)O	Ki = 201000 nM	Non binder
T76846	Melanocortin receptor 3	BCZG01	N-(4-(Methylthio)benzyl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamide	Investigative	44434699	C33H45N3OS	531.8	CSC1=CC=C(C=C1)CN(C2CCC(CC2)CC3CCC(CC3)N)C(=O)CCCC4=CNC5=CC=CC=C54	Ki = 249000 nM	Non binder
T76846	Melanocortin receptor 3	BKT82V	4-(1H-Indole-3-ylmethyl)-1-piperazinecarboxamidine	Investigative	44265225	C14H19N5	257.329	C1CN(CCN1CC2=CNC3=CC=CC=C32)C(=N)N	Ki > 1000000 nM	Non binder
T76846	Melanocortin receptor 3	BP4W2T	N-(4-((4-Aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)butanamide	Investigative	44434780	C35H47N3O	525.8	C1CC(CCC1CC2CCC(CC2)N(C3CCC4=CC=CC=C4C3)C(=O)CCCC5=CNC6=CC=CC=C65)N	Ki = 278000 nM	Non binder
T76846	Melanocortin receptor 3	BR2U7Q	N-{4-[(4-Aminocyclohexyl)methyl]cyclohexyl}-4-(1H-indol-3-yl)-N-[(4-methylphenyl)methyl]butanamide	Investigative	44434706	C33H45N3O	499.7	CC1=CC=C(C=C1)CN(C2CCC(CC2)CC3CCC(CC3)N)C(=O)CCCC4=CNC5=CC=CC=C54	Ki = 220000 nM	Non binder
T76846	Melanocortin receptor 3	BR42DX	(R)-5-Guanidino-2-[(naphthalen-2-ylmethyl)-amino]-pentanoic acid amide	Investigative	44265675	C17H23N5O	313.4	C1=CC=C2C=C(C=CC2=C1)CN[C@H](CCCN=C(N)N)C(=O)N	Ki > 1000000 nM	Non binder
T76846	Melanocortin receptor 3	BSU9D8	N-(1-Naphthylmethyl)-N-(2-naphthylmethyl)amine	Investigative	2817655	C22H19N	297.4	C1=CC=C2C=C(C=CC2=C1)CNCC3=CC=CC4=CC=CC=C43	Ki > 1000000 nM	Non binder
T76846	Melanocortin receptor 3	BSZO64	Nalpha-(1H-Indole-3-ylmethyl)-L-Arg-L-Trp-NH2	Investigative	44265656	C26H32N8O2	488.6	C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NCC3=CNC4=CC=CC=C43	Ki > 1000000 nM	Non binder
T76846	Melanocortin receptor 3	BT8M7U	N-{4-[(4-Aminocyclohexyl)methyl]cyclohexyl}-4-{2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl}-N-[(2-methylphenyl)methyl]butanamide	Investigative	44434704	C40H51N3O2	605.9	CC1=CC=CC=C1CN(C2CCC(CC2)CC3CCC(CC3)N)C(=O)CCCC4=C(NC5=CC=CC=C54)CC6=CC=C(C=C6)O	Ki = 349000 nM	Non binder
T76846	Melanocortin receptor 3	BZ3SP7	N-(3-Guanidino-propyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide	Investigative	44434799	C25H27N5O	413.5	C1=CC=C2C=C(C=CC2=C1)CN(CCCN=C(N)N)C(=O)CC3=CNC4=CC=CC=C43	Ki = 228000 nM	Non binder
T76846	Melanocortin receptor 3	BZYD45	1-(Naphthalen-2-ylmethyl)piperazine	Investigative	910537	C15H18N2	226.32	C1CN(CCN1)CC2=CC3=CC=CC=C3C=C2	Ki > 1000000 nM	Non binder