TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T77400	Phosphodiesterase 2A	D0E0SW	Enoximone	Approved	53708	C12H12N2O2S	248.3	CC1=C(NC(=O)N1)C(=O)C2=CC=C(C=C2)SC	IC50 = 520000 nM	Non binder
T77400	Phosphodiesterase 2A	D0R6TI	Inamrinone Lactate	Approved	3698	C10H9N3O	187.2	C1=CN=CC=C1C2=CNC(=O)C(=C2)N	IC50 = 580000 nM	Non binder
T77400	Phosphodiesterase 2A	D0DF2M	PMID28870136-Compound-48	Patented	2153	C7H8N4O2	180.16	CN1C2=C(C(=O)N(C1=O)C)NC=N2	IC50 = 210000 nM	Non binder
T77400	Phosphodiesterase 2A	D0BK6B	CI-930	Discontinued in Phase 2	3021729	C14H14N4O	254.29	CC1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	IC50 = 380000 nM	Non binder
T77400	Phosphodiesterase 2A	D07FHZ	Ro 20-1724	Terminated	5087	C15H22N2O3	278.35	CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC	IC50 = 390000 nM	Non binder
T77400	Phosphodiesterase 2A	B0GE4Y	4,5-Dihydro-6-[4-(4-hydroxymethyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone	Investigative	14099426	C14H14N4O2	270.29	C1CC(=O)NN=C1C2=CC=C(C=C2)N3C=C(N=C3)CO	IC50 = 350000 nM	Non binder
T77400	Phosphodiesterase 2A	B15ULR	6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one	Investigative	14099444	C13H12N4O	240.26	C1CC(=O)NN=C1C2=CC(=CC=C2)N3C=CN=C3	IC50 = 330000 nM	Non binder
T77400	Phosphodiesterase 2A	B5BC1H	Proxyphylline	Investigative	4977	C10H14N4O3	238.24	CC(CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O	Ki = 600000 nM	Non binder
T77400	Phosphodiesterase 2A	B7R6IP	8-Methoxymethyl-3-isobutyl-1-methylxanthine	Investigative	155806	C12H18N4O3	266.3	CC(C)CN1C2=C(C(=O)N(C1=O)C)NC(=N2)COC	IC50 = 212000 nM	Non binder
T77400	Phosphodiesterase 2A	B8F0HW	4,5-Dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone	Investigative	13233889	C14H14N4O	254.29	CC1=NC=CN1C2=CC=C(C=C2)C3=NNC(=O)CC3	IC50 = 380000 nM	Non binder
T77400	Phosphodiesterase 2A	BFAK10	6-(4-Imidazol-1-yl-phenyl)-2-methyl-4,5-dihydro-2H-pyridazin-3-one	Investigative	13233881	C14H14N4O	254.29	CN1C(=O)CCC(=N1)C2=CC=C(C=C2)N3C=CN=C3	IC50 = 280000 nM	Non binder
T77400	Phosphodiesterase 2A	BPH9A4	Imazodan	Investigative	55918	C13H12N4O	240.26	C1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	IC50 = 500000 nM	Non binder
T77400	Phosphodiesterase 2A	BT5F7W	Chembl4228423	Investigative	145967733	C23H20F4N2O2S	464.5	CS(=O)(=O)C1=CC(=CC2=C1N(C3=C2CCCC3CC#N)CC4=CC=C(C=C4)C(F)(F)F)F	IC50 > 278000 nM	Non binder
T77400	Phosphodiesterase 2A	BW9EM5	1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (R)-	Investigative	158962	C10H14N4O3	238.24	C[C@H](CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O	Ki = 600000 nM	Non binder
T77400	Phosphodiesterase 2A	BXD8Z7	1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (S)-	Investigative	158961	C10H14N4O3	238.24	C[C@@H](CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O	Ki = 700000 nM	Non binder
T77400	Phosphodiesterase 2A	BY74RZ	6-(4-Imidazol-1-yl-phenyl)-4-methyl-4,5-dihydro-2H-pyridazin-3-one	Investigative	13233882	C14H14N4O	254.29	CC1CC(=NNC1=O)C2=CC=C(C=C2)N3C=CN=C3	IC50 = 260000 nM	Non binder