TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T77548	Metabotropic glutamate receptor 8	B1U2ST	(2R,4R)-4-Amino-1-methylpyrrolidine-2,4-dicarboxylic acid	Investigative	44302818	C7H12N2O4	188.18	CN1C[C@](C[C@@H]1C(=O)O)(C(=O)O)N	IC50 > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	B1X8RG	(2R,4R)-4-Amino-1-biphenyl-2-ylmethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302608	C19H20N2O4	340.4	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC=C2C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	B3I0GF	(2S)-2-Amino-4-[[(3-cyanophenyl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid	Investigative	137643079	C12H15N2O5P	298.23	C1=CC(=CC(=C1)C(O)P(=O)(CC[C@@H](C(=O)O)N)O)C#N	EC50 = 219000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	B48TJE	(2R,4R)-4-Amino-1-(3-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302605	C13H15ClN2O4	298.72	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC(=CC=C2)Cl)C(=O)O	IC50 > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	B54BWE	(2R,4R)-4-Amino-1-naphthalen-2-ylmethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302609	C17H18N2O4	314.34	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC3=CC=CC=C3C=C2)C(=O)O	IC50 > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	B5T6CU	(2S,4S)-2-Amino-4-(2,2-diphenylethyl)pentanedioic Acid	Investigative	10359073	C19H21NO4	327.4	C1=CC=C(C=C1)C(C[C@@H](C[C@@H](C(=O)O)N)C(=O)O)C2=CC=CC=C2	Ki > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	B7O6AS	3-[[[(3S)-3-Amino-3-carboxypropyl]-hydroxyphosphoryl]methyl]benzoic acid	Investigative	24780089	C12H16NO6P	301.23	C1=CC(=CC(=C1)C(=O)O)CP(=O)(CC[C@@H](C(=O)O)N)O	EC50 = 511000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	BA89FL	(2R,4R)-4-Amino-1-(naphthalen-1-ylmethyl)pyrrolidine-2,4-dicarboxylic Acid	Investigative	10358265	C17H18N2O4	314.34	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC3=CC=CC=C32)C(=O)O	IC50 > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	BH3E4M	(S)-4-((1-Carboxyethyl)amino)benzoic acid	Investigative	22884216	C10H11NO4	209.2	C[C@@H](C(=O)O)NC1=CC=C(C=C1)C(=O)O	IC50 > 1000000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	BJ8Y6O	(S)-3,5-Dihydroxyphenylglycine	Investigative	443586	C8H9NO4	183.16	C1=C(C=C(C=C1O)O)[C@@H](C(=O)O)N	Ki > 1000000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	BNS67U	(2S)-2-Amino-4-[hydroxy-[(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	137646034	C11H15N2O7P	318.22	C1=CC(=C(C=C1CP(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-])O	EC50 = 277000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	BOCA73	(2R,4R)-4-Amino-1-ethylpyrrolidine-2,4-dicarboxylic acid	Investigative	44302837	C8H14N2O4	202.21	CCN1C[C@](C[C@@H]1C(=O)O)(C(=O)O)N	IC50 > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	BQIC40	2-Amino-2,3-methano-4-phosphonobutanoic acid	Investigative	125799	C5H10NO5P	195.11	C1[C@H]([C@]1(C(=O)O)N)CP(=O)(O)O	EC50 > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	BYK29C	(2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302856	C20H22N2O4	354.4	C1[C@@H](N(C[C@]1(C(=O)O)N)CC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	BYWE14	(2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302686	C13H14Cl2N2O4	333.16	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=C(C=CC=C2Cl)Cl)C(=O)O	IC50 > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	BZ5HB6	(2R,4R)-4-Amino-1-(2-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302819	C13H15ClN2O4	298.72	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC=C2Cl)C(=O)O	IC50 > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	D0N0NJ	1-benzyl-APDC	Investigative	15508178	C13H16N2O4	264.28	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC=C2)C(=O)O	IC50 > 300000 nM	Non binder
T77548	Metabotropic glutamate receptor 8	D0OV2V	LY307452	Investigative	6324634	C21H25NO4	355.4	C1=CC=C(C=C1)C(CCC[C@@H](C[C@@H](C(=O)O)N)C(=O)O)C2=CC=CC=C2	Ki > 300000 nM	Non binder