TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T80276	PI3-kinase alpha	D0DF2M	PMID28870136-Compound-48	Patented	2153	C7H8N4O2	180.16	CN1C2=C(C(=O)N(C1=O)C)NC=N2	IC50 = 300000 nM	Non binder
T80276	PI3-kinase alpha	D0H9IX	PMID28870136-Compound-52	Patented	2519	C8H10N4O2	194.19	CN1C=NC2=C1C(=O)N(C(=O)N2C)C	IC50 = 400000 nM	Non binder
T80276	PI3-kinase alpha	B02JVW	Chembl4295167	Investigative	145993856	C17H16N2O5	328.32	COC1=C(C=C(C=C1)C2=C(NN=C2)C3=C(C(=C(C=C3)O)O)O)OC	EC50 = 242300 nM	Non binder
T80276	PI3-kinase alpha	B19RTQ	2-Oxo-1,2-diphenylethyl 3-fluorobenzoate	Investigative	16645457	C21H15FO3	334.3	C1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)OC(=O)C3=CC(=CC=C3)F	IC50 = 970000 nM	Non binder
T80276	PI3-kinase alpha	B2KQ0L	4-(Benzylamino)-2-morpholin-4-yl-1H-pyrimidin-6-one	Investigative	136227361	C15H18N4O2	286.33	C1COCCN1C2=NC(=CC(=O)N2)NCC3=CC=CC=C3	IC50 = 283000 nM	Non binder
T80276	PI3-kinase alpha	B3QVT7	6-[2-Hydroxyethyl(naphthalen-1-ylmethyl)amino]-4-[(2R)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one	Investigative	71458791	C22H26N4O3	394.5	C[C@@H]1CN(CCO1)C2=NC(=O)NC(=C2)N(CCO)CC3=CC=CC4=CC=CC=C43	IC50 = 349000 nM	Non binder
T80276	PI3-kinase alpha	B4E7QZ	7-[5-(2,2-Dimethylazetidin-1-yl)sulfonylpyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Investigative	71454160	C16H18N6O2S	358.4	CC1(CCN1S(=O)(=O)C2=CN=CC(=C2)C3=CC4=NC(=NN4C=C3)N)C	IC50 = 12589254.12 nM	Non binder
T80276	PI3-kinase alpha	B4VL3W	Chembl4228200	Investigative	145970017	C27H25N5O2	451.5	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=C(N=N4)C5=C(C=C(C=C5)OC)C	IC50 = 290000 nM	Non binder
T80276	PI3-kinase alpha	B5E4WO	(2-Oxo-1,2-diphenylethyl) 4-nitrobenzoate	Investigative	14320027	C21H15NO5	361.3	C1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]	IC50 = 880000 nM	Non binder
T80276	PI3-kinase alpha	B72XYZ	Chembl4279224	Investigative	145980061	C13H11NO4	245.23	C1=CC(=C(C(=C1C(=O)CC2=CC=NC=C2)O)O)O	EC50 > 500000 nM	Non binder
T80276	PI3-kinase alpha	B7UAE3	(2-Oxo-1,2-diphenylethyl) 4-chlorobenzoate	Investigative	3602063	C21H15ClO3	350.8	C1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)OC(=O)C3=CC=C(C=C3)Cl	IC50 = 730000 nM	Non binder
T80276	PI3-kinase alpha	B8B3QM	4-[2-[3-(Methoxymethyl)phenyl]-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine	Investigative	70692128	C18H23N3O4S	377.5	COCC1=CC(=CC=C1)C2=NC(=CC(=N2)N3CCOCC3)CS(=O)(=O)C	IC50 > 300000 nM	Non binder
T80276	PI3-kinase alpha	B8F2OT	5-(2-Amino-5-fluoro-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	Investigative	44621458	C15H17FN6O2S	364.4	CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C(=C2)F)N	IC50 = 3981071.71 nM	Non binder
T80276	PI3-kinase alpha	B9MXG8	Chembl4290972	Investigative	5350938	C15H9ClO4	288.68	C1=CC=C(C(=C1)C2=COC3=C(C2=O)C=CC(=C3O)O)Cl	EC50 > 500000 nM	Non binder
T80276	PI3-kinase alpha	B9VG4F	2-Oxo-1,2-diphenylethyl 4-fluorobenzoate	Investigative	2898075	C21H15FO3	334.3	C1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)OC(=O)C3=CC=C(C=C3)F	IC50 = 1290000 nM	Non binder
T80276	PI3-kinase alpha	BAC1R8	Chembl4287871	Investigative	145992071	C14H11ClO3	262.69	C1=CC(=C(C(=C1)O)O)C(=O)CC2=CC=C(C=C2)Cl	EC50 > 500000 nM	Non binder
T80276	PI3-kinase alpha	BC68EA	Methyl 2-(benzylamino)-6-morpholin-4-ylpyridine-4-carboxylate	Investigative	71453177	C18H21N3O3	327.4	COC(=O)C1=CC(=NC(=C1)N2CCOCC2)NCC3=CC=CC=C3	IC50 = 240000 nM	Non binder
T80276	PI3-kinase alpha	BCF8A3	Desyl benzoate	Investigative	246708	C21H16O3	316.3	C1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)OC(=O)C3=CC=CC=C3	IC50 = 2660000 nM	Non binder
T80276	PI3-kinase alpha	BCU70X	[1,2-Bis(4-methoxyphenyl)-2-oxoethyl] 4-fluorobenzoate	Investigative	122184765	C23H19FO5	394.4	COC1=CC=C(C=C1)C(C(=O)C2=CC=C(C=C2)OC)OC(=O)C3=CC=C(C=C3)F	IC50 = 2820000 nM	Non binder
T80276	PI3-kinase alpha	BD0CK7	2-Hydroxy-1,2-bis(4-methoxyphenyl)ethanone	Investigative	95415	C16H16O4	272.29	COC1=CC=C(C=C1)C(C(=O)C2=CC=C(C=C2)OC)O	IC50 = 1170000 nM	Non binder
T80276	PI3-kinase alpha	BEAP73	Ethanone, 2-(3,4-dimethoxyphenyl)-1-(2,3,4-trihydroxyphenyl)-	Investigative	13939416	C16H16O6	304.29	COC1=C(C=C(C=C1)CC(=O)C2=C(C(=C(C=C2)O)O)O)OC	EC50 = 242000 nM	Non binder
T80276	PI3-kinase alpha	BEI30J	2-Oxo-1,2-diphenylethyl 2-fluorobenzoate	Investigative	4160026	C21H15FO3	334.3	C1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)OC(=O)C3=CC=CC=C3F	IC50 = 910000 nM	Non binder
T80276	PI3-kinase alpha	BF70MB	CID 44621448	Investigative	44621448	C13H11F3N6O2S	372.33	C1=CN2C(=NC(=N2)N)C=C1C3=CC(=CN=C3)S(=O)(=O)NCC(F)(F)F	IC50 = 7943282.35 nM	Non binder
T80276	PI3-kinase alpha	BFB28C	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N,N-diethylpyridine-3-sulfonamide	Investigative	44621442	C15H18N6O2S	346.4	CCN(CC)S(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 7943282.35 nM	Non binder
T80276	PI3-kinase alpha	BG1L6I	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-3-sulfonamide	Investigative	44621456	C11H10N6O2S	290.3	C1=CN2C(=NC(=N2)N)C=C1C3=CC(=CN=C3)S(=O)(=O)N	IC50 = 15848931.92 nM	Non binder
T80276	PI3-kinase alpha	BG3HJ9	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-propylpyridine-3-sulfonamide	Investigative	44621440	C14H16N6O2S	332.38	CCCNS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 12589254.12 nM	Non binder
T80276	PI3-kinase alpha	BG5J6E	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	Investigative	44557921	C15H18N6O2S	346.4	CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 19952623.15 nM	Non binder
T80276	PI3-kinase alpha	BG5LM3	6-[Methyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71462308	C20H22N4O2	350.4	CN(CC1=CC=CC2=CC=CC=C21)C3=CC(=NC(=O)N3)N4CCOCC4	IC50 = 212000 nM	Non binder
T80276	PI3-kinase alpha	BGUY28	Chembl4294362	Investigative	145993646	C15H9FO4	272.23	C1=CC=C(C(=C1)C2=COC3=C(C2=O)C=CC(=C3O)O)F	EC50 > 500000 nM	Non binder
T80276	PI3-kinase alpha	BH0XL5	Chembl4229035	Investigative	145986347	C25H21N5O	407.5	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=C(N=N4)C5=CC=CC=C5	IC50 = 250000 nM	Non binder
T80276	PI3-kinase alpha	BH2TX4	2-(2-Chlorophenyl)-1-(2,3,4-trihydroxyphenyl)ethanone	Investigative	2906609	C14H11ClO4	278.69	C1=CC=C(C(=C1)CC(=O)C2=C(C(=C(C=C2)O)O)O)Cl	EC50 > 500000 nM	Non binder
T80276	PI3-kinase alpha	BJ9T6X	2-((9H-Purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3H)-one	Investigative	6852165	C21H15ClN6O2S	450.9	COC1=CC=CC=C1N2C(=NC3=C(C2=O)C(=CC=C3)Cl)CSC4=NC=NC5=C4NC=N5	IC50 > 200000 nM	Non binder
T80276	PI3-kinase alpha	BJTZ07	6-[(3-Hydroxy-2,2-dimethylpropyl)-(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71453425	C24H30N4O3	422.5	CC(C)(CN(CC1=CC=CC2=CC=CC=C21)C3=CC(=NC(=O)N3)N4CCOCC4)CO	IC50 = 205000 nM	Non binder
T80276	PI3-kinase alpha	BK4BY1	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-methylpyridine-3-sulfonamide	Investigative	44621447	C12H12N6O2S	304.33	CNS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 12589254.12 nM	Non binder
T80276	PI3-kinase alpha	BK6Y9P	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-propan-2-ylpyridine-3-sulfonamide	Investigative	44621441	C14H16N6O2S	332.38	CC(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 12589254.12 nM	Non binder
T80276	PI3-kinase alpha	BKNH58	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-benzylpyridine-3-sulfonamide	Investigative	44621452	C18H16N6O2S	380.4	C1=CC=C(C=C1)CNS(=O)(=O)C2=CN=CC(=C2)C3=CC4=NC(=NN4C=C3)N	IC50 = 10000000 nM	Non binder
T80276	PI3-kinase alpha	BKW5D3	7-(5-Methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Investigative	44621454	C12H11N5O2S	289.32	CS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 19952623.15 nM	Non binder
T80276	PI3-kinase alpha	BO74VR	Chembl4293291	Investigative	145989663	C13H11NO4	245.23	C1=CC(=CN=C1)CC(=O)C2=C(C(=C(C=C2)O)O)O	EC50 > 500000 nM	Non binder
T80276	PI3-kinase alpha	BPQ89H	4H-1-Benzopyran-4-one, 3-(3,4-dimethoxyphenyl)-7,8-dihydroxy-	Investigative	13939417	C17H14O6	314.29	COC1=C(C=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3O)O)OC	EC50 = 335500 nM	Non binder
T80276	PI3-kinase alpha	BS7R6T	Chembl4291276	Investigative	23797298	C14H11FO4	262.23	C1=CC=C(C(=C1)CC(=O)C2=C(C(=C(C=C2)O)O)O)F	EC50 > 500000 nM	Non binder
T80276	PI3-kinase alpha	BTE37L	Methyl (6-morpholino-2-phenyl-4-pyrimidinyl)methyl sulfone	Investigative	1476679	C16H19N3O3S	333.4	CS(=O)(=O)CC1=CC(=NC(=N1)C2=CC=CC=C2)N3CCOCC3	IC50 > 1000000 nM	Non binder
T80276	PI3-kinase alpha	BURI07	CID 44621449	Investigative	44621449	C15H15F3N6O2S	400.4	CC(C)(C(F)(F)F)NS(=O)(=O)C1=CN=CC(=C1)C2=CC3=NC(=NN3C=C2)N	IC50 = 10000000 nM	Non binder
T80276	PI3-kinase alpha	BX5E8Y	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-phenylpyridine-3-sulfonamide	Investigative	44621451	C17H14N6O2S	366.4	C1=CC=C(C=C1)NS(=O)(=O)C2=CN=CC(=C2)C3=CC4=NC(=NN4C=C3)N	IC50 = 39810717.06 nM	Non binder
T80276	PI3-kinase alpha	D0Z5KQ	BENZOIN	Investigative	8400	C14H12O2	212.24	C1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)O	IC50 = 2120000 nM	Non binder