TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T80975	Vascular endothelial growth factor receptor 2	D08CDI	Lapatinib	Approved	208908	C29H26ClFN4O4S	581.1	CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B0AU7G	Chembl4164979	Investigative	145959077	C23H21N3O4S	435.5	CCS(=O)(=O)C1=CC(=C(C=C1)OC)NC2=NC(=CO2)C3=CC=CC(=C3)C4=CC=CC=N4	IC50 = 564000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B0NJU8	2-(Diethylamino)ethyl 4-methoxy-3-[[5-pyrimidin-5-yl-2-(trifluoromethoxy)phenyl]carbamoylamino]benzoate	Investigative	122195148	C26H28F3N5O5	547.5	CCN(CC)CCOC(=O)C1=CC(=C(C=C1)OC)NC(=O)NC2=C(C=CC(=C2)C3=CN=CN=C3)OC(F)(F)F	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B18RDA	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[2-methylsulfonyl-1-(propan-2-ylamino)ethyl]furan-2-yl]quinazolin-4-amine	Investigative	118717615	C31H30ClFN4O4S	609.1	CC(C)NC(CS(=O)(=O)C)C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B1D2BK	2-Amino-4-(N-methyl-m-bromoanilino)-6-(2,5-dimethoxybenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine	Investigative	46912546	C23H24BrN5O2	482.4	CN1C(=CC2=C1N=C(N=C2N(C)C3=CC(=CC=C3)Br)N)CC4=C(C=CC(=C4)OC)OC	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B1LD6H	N-[3-[3-[[2-Methyl-6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide	Investigative	56676922	C26H30N8O3S	534.6	CC1=NC(=CC(=N1)NC2=NNC(=C2)C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CC=C4)NCCN5CCOCC5	IC50 > 1000000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B2CL6O	N-(3-Bromophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887111	C19H13BrCl2N4	448.1	C1=CC(=CC(=C1)Br)NC2=NC=NC3=C2C=C(N3)CC4=C(C=C(C=C4)Cl)Cl	IC50 > 300000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B2GI7T	[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] propanoate	Investigative	118717617	C31H28ClFN4O6S	639.1	CCC(=O)ON[C@H](CS(=O)(=O)C)C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B2HFN5	2-(Dimethylamino)ethyl 4-methoxy-3-[[3-pyrimidin-5-yl-5-(trifluoromethyl)phenyl]carbamoylamino]benzoate	Investigative	122195141	C24H24F3N5O4	503.5	CN(C)CCOC(=O)C1=CC(=C(C=C1)OC)NC(=O)NC2=CC(=CC(=C2)C(F)(F)F)C3=CN=CN=C3	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B2JB4R	2,4-Diaminofuro[2,3-d]pyrimidine, 8	Investigative	44246325	C18H22N4O2	326.4	CCCC(CC1=COC2=NC(=NC(=C12)N)N)C3=CC=CC=C3OC	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B30PYX	2-[Di(propan-2-yl)amino]ethyl 4-methoxy-3-[[5-(1H-pyrazol-4-yl)-2-(trifluoromethoxy)phenyl]carbamoylamino]benzoate	Investigative	122195153	C27H32F3N5O5	563.6	CC(C)N(CCOC(=O)C1=CC(=C(C=C1)OC)NC(=O)NC2=C(C=CC(=C2)C3=CNN=C3)OC(F)(F)F)C(C)C	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B35AQR	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(ethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine	Investigative	56640588	C30H28ClFN4O4S	595.1	CCNC(CS(=O)(=O)C)C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B3M4FG	1-[4-(3-Amino-1H-indazol-7-yl)phenyl]-3-(3-methylphenyl)urea	Investigative	70690323	C21H19N5O	357.4	CC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)C3=CC=CC4=C3NN=C4N	IC50 > 1000000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B4H7TR	[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] pentanoate	Investigative	118717618	C33H32ClFN4O6S	667.1	CCCCC(=O)ON[C@H](CS(=O)(=O)C)C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B4ND6W	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[2-methylsulfonyl-1-(2-methylsulfonylethylamino)ethyl]furan-2-yl]quinazolin-4-amine	Investigative	118717616	C31H30ClFN4O6S2	673.2	CS(=O)(=O)CCNC(CS(=O)(=O)C)C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B5IWZ8	N-(Pyridin-3-ylmethyl)benzofuro[2,3-b]pyridin-4-amine	Investigative	52942862	C17H13N3O	275.3	C1=CC=C2C(=C1)C3=C(C=CN=C3O2)NCC4=CN=CC=C4	Ki > 1000000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B5JP4Y	6-[5-(1-Amino-2-methylsulfonylethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine	Investigative	56640590	C28H24ClFN4O4S	567	CS(=O)(=O)CC(C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B5STJ4	N-[3-[3-[[6-(4-Hydroxypiperidin-1-yl)-2-methylpyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide	Investigative	56663233	C25H27N7O3S	505.6	CC1=NC(=CC(=N1)N2CCC(CC2)O)NC3=NNC(=C3)C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CC=C5	IC50 > 1000000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B6J2NI	6-(4-Methylpiperazin-1-yl)-3-(thiophen-2-yl)-1,4-dihydroindeno[1,2-c]pyrazole	Investigative	44415008	C19H20N4S	336.5	CN1CCN(CC1)C2=CC3=C(C=C2)C4=NNC(=C4C3)C5=CC=CS5	IC50 = 1005000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B6VQU9	2-Morpholin-4-ylethyl 3-[[3-(1H-indol-5-yl)-5-(trifluoromethyl)phenyl]carbamoylamino]-4-methoxybenzoate	Investigative	122195156	C30H29F3N4O5	582.6	COC1=C(C=C(C=C1)C(=O)OCCN2CCOCC2)NC(=O)NC3=CC(=CC(=C3)C(F)(F)F)C4=CC5=C(C=C4)NC=C5	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B82QDO	2-Amino-4-(N-methyl-m-bromoanilino)-6-(2-methylbenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine	Investigative	46912445	C22H22BrN5	436.3	CC1=CC=CC=C1CC2=CC3=C(N2C)N=C(N=C3N(C)C4=CC(=CC=C4)Br)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B8M6GE	2-Morpholin-4-ylethyl 4-methoxy-3-[[3-pyridin-3-yl-5-(trifluoromethyl)phenyl]carbamoylamino]benzoate	Investigative	122195155	C27H27F3N4O5	544.5	COC1=C(C=C(C=C1)C(=O)OCCN2CCOCC2)NC(=O)NC3=CC(=CC(=C3)C(F)(F)F)C4=CN=CC=C4	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B8NWY1	5-[2-Cyclopropyl-2-(2-methoxyphenyl)ethenyl]furo[2,3-d]pyrimidine-2,4-diamine	Investigative	52947802	C18H18N4O2	322.4	COC1=CC=CC=C1C(=CC2=COC3=NC(=NC(=C23)N)N)C4CC4	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B8V5AJ	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(cyclohexylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine	Investigative	118717614	C34H34ClFN4O4S	649.2	CS(=O)(=O)CC(C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl)NC6CCCCC6	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B8XE2A	2-[Di(propan-2-yl)amino]ethyl 4-methoxy-3-[[5-pyrimidin-5-yl-2-(trifluoromethoxy)phenyl]carbamoylamino]benzoate	Investigative	122195152	C28H32F3N5O5	575.6	CC(C)N(CCOC(=O)C1=CC(=C(C=C1)OC)NC(=O)NC2=C(C=CC(=C2)C3=CN=CN=C3)OC(F)(F)F)C(C)C	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	B8YC0L	CID 46866615	Investigative	46866615	C28H24ClFN4O4S	567	CS(=O)(=O)C[C@@H](C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BAW04S	4-N-(3-Bromophenyl)-7-[(2,4-dichlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	57394786	C19H14BrCl2N5	463.2	C1=CC(=CC(=C1)Br)NC2=C3C=CN(C3=NC(=N2)N)CC4=C(C=C(C=C4)Cl)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BB2S7Q	2-Amino-4-(N-methyl-m-bromoanilino)-6-benzyl-7-methyl-pyrrolo[2,3-d]pyrimidine	Investigative	52941368	C21H20BrN5	422.3	CN1C(=CC2=C1N=C(N=C2N(C)C3=CC(=CC=C3)Br)N)CC4=CC=CC=C4	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BBEH31	N4-(3-Ethynylphenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	44586526	C22H19N5	353.4	C#CC1=CC(=CC=C1)NC2=NC(=NC3=C2C=C(N3)CCC4=CC=CC=C4)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BCLV75	[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] heptanoate	Investigative	118717619	C35H36ClFN4O6S	695.2	CCCCCCC(=O)ON[C@H](CS(=O)(=O)C)C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BDQS26	4-N-(3-Bromophenyl)-7-[(2,5-dimethoxyphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	57398417	C21H20BrN5O2	454.3	COC1=CC(=C(C=C1)OC)CN2C=CC3=C(N=C(N=C32)N)NC4=CC(=CC=C4)Br	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BE2K7Z	5-[2-(2-Methoxyphenyl)-3-methylpent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine	Investigative	52945403	C19H22N4O2	338.4	CCC(C)C(=CC1=COC2=NC(=NC(=C12)N)N)C3=CC=CC=C3OC	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BE9C0U	N4-(2-Isopropylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	46887039	C22H21Cl2N5	426.3	CC(C)C1=CC=CC=C1NC2=NC(=NC3=C2C=C(N3)CC4=C(C=C(C=C4)Cl)Cl)N	IC50 > 300000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BEJ62B	4-Phenyl-[1]benzofuro[2,3-b]pyridine-3,6-diol	Investigative	51000510	C17H11NO3	277.27	C1=CC=C(C=C1)C2=C3C4=C(C=CC(=C4)O)OC3=NC=C2O	Ki > 1000000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BG19NC	2-[Di(propan-2-yl)amino]ethyl 3-[[3-(1H-indol-5-yl)-5-(trifluoromethyl)phenyl]carbamoylamino]-4-methoxybenzoate	Investigative	122195150	C32H35F3N4O4	596.6	CC(C)N(CCOC(=O)C1=CC(=C(C=C1)OC)NC(=O)NC2=CC(=CC(=C2)C(F)(F)F)C3=CC4=C(C=C3)NC=C4)C(C)C	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BGJH61	N-[4-(3-Bromo-4-fluoroanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide	Investigative	71525283	C24H24BrFN6O	511.4	CC(C)(C)C(=O)NC1=NC2=C(C=C(N2)CCC3=CC=CC=N3)C(=N1)NC4=CC(=C(C=C4)F)Br	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BGT5W3	6-(2,4-Dichlorobenzyl)-N-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887112	C20H13Cl2F3N4	437.2	C1=CC(=CC(=C1)NC2=NC=NC3=C2C=C(N3)CC4=C(C=C(C=C4)Cl)Cl)C(F)(F)F	IC50 > 300000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BGZ7Q5	CID 56659825	Investigative	56659825	C23H32N8O2S	484.6	CCCCS(=O)(=O)NC1=CC=CC(=C1)C2=CC(=NN2)NC3=CC(=NC(=N3)C)N4CCN(CC4)C	IC50 > 1000000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BHB93A	2,4-Diaminofuro[2,3-d]pyrimidine, 13	Investigative	44246330	C19H24N4O2	340.4	CCC(C)C(CC1=COC2=NC(=NC(=C12)N)N)C3=CC=CC=C3OC	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BI1B6L	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(1R)-1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine	Investigative	46865445	C30H28ClFN4O4S	595.1	CN(C)[C@@H](CS(=O)(=O)C)C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BI1HX2	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(1S)-1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine	Investigative	46865125	C30H28ClFN4O4S	595.1	CN(C)[C@H](CS(=O)(=O)C)C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BIA57B	6-(2,4-Dichlorobenzyl)-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887113	C21H14Cl2N4	393.3	C#CC1=CC(=CC=C1)NC2=NC=NC3=C2C=C(N3)CC4=C(C=C(C=C4)Cl)Cl	IC50 > 300000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BJ57YZ	N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine	Investigative	50908681	C19H16N2O2	304.3	COC1=CC=C(C=C1)CNC2=C3C4=CC=CC=C4OC3=NC=C2	Ki > 1000000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BKFV04	4-N-(3-Bromophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-4-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	46912446	C22H22BrN5O2	468.3	CN(C1=CC(=CC=C1)Br)C2=NC(=NC3=C2C=C(N3)CC4=C(C=CC(=C4)OC)OC)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BKT0O2	(4-Methylpiperazin-1-yl)(3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazol-7-yl)methanone	Investigative	44414974	C20H20N4OS	364.5	CN1CCN(CC1)C(=O)C2=CC3=C(CC4=C3NN=C4C5=CSC=C5)C=C2	IC50 = 4081000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BL13KT	2-[Di(propan-2-yl)amino]ethyl 4-methoxy-3-[[5-(1-methylpyrazol-4-yl)-2-(trifluoromethoxy)phenyl]carbamoylamino]benzoate	Investigative	122195154	C28H34F3N5O5	577.6	CC(C)N(CCOC(=O)C1=CC(=C(C=C1)OC)NC(=O)NC2=C(C=CC(=C2)C3=CN(N=C3)C)OC(F)(F)F)C(C)C	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BLA57Y	N-(3-Chlorobenzyl)benzofuro[2,3-b]pyridin-4-amine	Investigative	52942446	C18H13ClN2O	308.8	C1=CC=C2C(=C1)C3=C(C=CN=C3O2)NCC4=CC(=CC=C4)Cl	Ki > 1000000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BLS9J5	2-[Di(propan-2-yl)amino]ethyl 3-[[5-(1H-indol-5-yl)-2-(trifluoromethoxy)phenyl]carbamoylamino]-4-methoxybenzoate	Investigative	122195151	C32H35F3N4O5	612.6	CC(C)N(CCOC(=O)C1=CC(=C(C=C1)OC)NC(=O)NC2=C(C=CC(=C2)C3=CC4=C(C=C3)NC=C4)OC(F)(F)F)C(C)C	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BND9X0	6-Phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	25022736	C21H18F3N5	397.4	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC=CC(=C4)C(F)(F)F)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BOD1W4	CID 46866616	Investigative	46866616	C28H24ClFN4O4S	567	CS(=O)(=O)C[C@H](C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BOMZ50	2,4-Diaminofuro[2,3-d]pyrimidine, 12	Investigative	44246329	C19H24N4O2	340.4	CC(C)CC(CC1=COC2=NC(=NC(=C12)N)N)C3=CC=CC=C3OC	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BP3VD9	N4-(4-Fluoro-3-(trifluoromethyl)phenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	25022735	C21H17F4N5	415.4	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=C(C=C4)F)C(F)(F)F)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BPL8M1	2-Amino-4-(m-bromoanilino)-6-(2,5-dimethoxybenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine	Investigative	52947574	C22H22BrN5O2	468.3	CN1C(=CC2=C(N=C(N=C21)N)NC3=CC(=CC=C3)Br)CC4=C(C=CC(=C4)OC)OC	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BPYK25	1-(3-Methylphenyl)-3-[4-(3-oxo-1,2-dihydroisoindol-4-yl)phenyl]urea	Investigative	70690322	C22H19N3O2	357.4	CC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)C3=CC=CC4=C3C(=O)NC4	IC50 > 1000000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BQ16DR	N4-(4-Chloro-2-fluorophenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	44586527	C20H17ClFN5	381.8	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=C(C=C(C=C4)Cl)F)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BQR5H8	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(methylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine	Investigative	56640518	C29H26ClFN4O4S	581.1	CNC(CS(=O)(=O)C)C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BSC95P	CID 56676977	Investigative	56676977	C26H30N8O2S	518.6	CC1=CC(=CC=C1)S(=O)(=O)NC2=CC=CC(=C2)C3=CC(=NN3)NC4=CC(=NC(=N4)C)N5CCN(CC5)C	IC50 > 1000000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BSIO95	2,4-Diaminofuro[2,3-d]pyrimidine, 11	Investigative	44246328	C19H24N4O2	340.4	CCCCC(CC1=COC2=NC(=NC(=C12)N)N)C3=CC=CC=C3OC	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BTC42Q	N-Ethyl-N-((3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazol-7-yl)methyl)ethanamine	Investigative	44414965	C19H21N3S	323.5	CCN(CC)CC1=CC2=C(CC3=C2NN=C3C4=CSC=C4)C=C1	IC50 = 824000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BTIG04	4-N-(3-Chloro-4-fluorophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	71525246	C19H16ClFN6	382.8	C1=CC=NC(=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC(=C(C=C4)F)Cl)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BTQ70E	5-[2-(2-Methoxyphenyl)-4-methylpent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine	Investigative	52946619	C19H22N4O2	338.4	CC(C)CC(=CC1=COC2=NC(=NC(=C12)N)N)C3=CC=CC=C3OC	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BTU79P	2-Amino-4-(m-bromoanilino)-6-benzyl-7-methyl-pyrrolo-[2,3-d]pyrimidine	Investigative	46912443	C20H18BrN5	408.3	CN1C(=CC2=C(N=C(N=C21)N)NC3=CC(=CC=C3)Br)CC4=CC=CC=C4	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BU2D0R	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine	Investigative	56640520	C30H28ClFN4O4S	595.1	CN(C)C(CS(=O)(=O)C)C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BU71CV	5-(4-Chlorophenyl)sulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine	Investigative	137652218	C16H12ClN5S	341.8	C1=CC2=C(C(=C1)SC3=CC=C(C=C3)Cl)C4=C(N=C(N=C4N2)N)N	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BV5N2G	5-[2-(2-Methoxyphenyl)-3-methylbut-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine	Investigative	52942956	C18H20N4O2	324.4	CC(C)C(=CC1=COC2=NC(=NC(=C12)N)N)C3=CC=CC=C3OC	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BVG59H	5-[2-(2-Methoxyphenyl)hex-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine	Investigative	52947801	C19H22N4O2	338.4	CCCCC(=CC1=COC2=NC(=NC(=C12)N)N)C3=CC=CC=C3OC	IC50 > 500000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BVOW30	4-N-(3-Bromophenyl)-4-N-methyl-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	46912444	C21H20BrN5	422.3	CC1=CC=CC=C1CC2=CC3=C(N2)N=C(N=C3N(C)C4=CC(=CC=C4)Br)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BW3S6G	6-[(2,4-Dichlorophenyl)methyl]-4-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	46886972	C20H14Cl2F3N5	452.3	C1=CC(=CC(=C1)NC2=NC(=NC3=C2C=C(N3)CC4=C(C=C(C=C4)Cl)Cl)N)C(F)(F)F	IC50 > 300000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BW8X1V	4-((3-(Thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazol-7-yl)methyl)piperazine-1-carbaldehyde	Investigative	44414981	C20H20N4OS	364.5	C1CN(CCN1CC2=CC3=C(CC4=C3NN=C4C5=CSC=C5)C=C2)C=O	IC50 = 665000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BXY0S7	4-N-(4-Chlorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	44586528	C20H18ClN5	363.8	C1=CC=C(C=C1)CCC2=CC3=C(N2)N=C(N=C3NC4=CC=C(C=C4)Cl)N	IC50 > 200000 nM	Non binder
T80975	Vascular endothelial growth factor receptor 2	BZW8Q7	N-(3-Bromophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	46887110	C21H19BrN4O2	439.3	COC1=CC(=C(C=C1)OC)CC2=CC3=C(N2)N=CN=C3NC4=CC(=CC=C4)Br	IC50 > 300000 nM	Non binder