TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T86702	Matrix metalloproteinase-3	D00HNB	Clodronate	Approved	25419	CH4Cl2O6P2	244.89	C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl	IC50 = 300000 nM	Non binder
T86702	Matrix metalloproteinase-3	D05EJG	L-Tryptophan	Approved	6305	C11H12N2O2	204.22	C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N	IC50 > 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	B0HYX7	N-Acetyl-L-tryptophan	Investigative	700653	C13H14N2O3	246.26	CC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O	IC50 = 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	B1FGY3	Fmoc-D-Trp-OH	Investigative	978344	C26H22N2O4	426.5	C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@H](CC4=CNC5=CC=CC=C54)C(=O)O	IC50 = 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	B1GTM5	5-(Ethylamino)-1,3,4-thiadiazole-2-thiol	Investigative	4907629	C4H7N3S2	161.3	CCNC1=NNC(=S)S1	IC50 > 2000000 nM	Non binder
T86702	Matrix metalloproteinase-3	B1W8UQ	(1R,2S)-Ethyl 2-(hydroxycarbamoyl)-1-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxylate	Investigative	44581111	C30H28N2O5	496.6	CCOC(=O)[C@]1(C[C@@H]1C(=O)NO)CC2=CC=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5	Ki > 10000000 nM	Non binder
T86702	Matrix metalloproteinase-3	B2AW8L	(1R,2S)-Ethyl 2-(hydroxycarbamoyl)-1-(4-((2-methylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxylate	Investigative	44581071	C25H26N2O5	434.5	CCOC(=O)[C@]1(C[C@@H]1C(=O)NO)CC2=CC=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C	Ki = 952000 nM	Non binder
T86702	Matrix metalloproteinase-3	B46STP	4-Phenoxy-N-[(1R,2S)-2-sulfanylcyclopentyl]benzenesulfonamide	Investigative	71682766	C17H19NO3S2	349.5	C1C[C@H]([C@H](C1)S)NS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki > 200000 nM	Non binder
T86702	Matrix metalloproteinase-3	B5J0UD	Boc-D-tyrosine	Investigative	1549481	C14H19NO5	281.3	CC(C)(C)OC(=O)N[C@H](CC1=CC=C(C=C1)O)C(=O)O	IC50 > 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	B5K0EX	5-(4-Phenyl-butylamino)-3H-[1,3,4]thiadiazole-2-thione	Investigative	10849322	C12H15N3S2	265.4	C1=CC=C(C=C1)CCCCNC2=NNC(=S)S2	IC50 = 318000 nM	Non binder
T86702	Matrix metalloproteinase-3	B5WC9O	1-(4-Phenoxyphenethyl)-3-hydroxy-1-methylurea	Investigative	44405998	C16H18N2O3	286.33	CN(CCC1=CC=C(C=C1)OC2=CC=CC=C2)C(=O)NO	IC50 = 380000 nM	Non binder
T86702	Matrix metalloproteinase-3	B62HUJ	(E)-2-(5-((5-(4-Methoxyphenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid	Investigative	2140735	C17H13NO5S2	375.4	COC1=CC=C(C=C1)C2=CC=C(O2)/C=C/3\\C(=O)N(C(=S)S3)CC(=O)O	IC50 = 850000 nM	Non binder
T86702	Matrix metalloproteinase-3	B6G7EI	N-Acetyl-D-tryptophan	Investigative	439917	C13H14N2O3	246.26	CC(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)O	IC50 = 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	B6U1WS	1-Benzyl-3-(1,3,4-thiadiazol-2-yl)urea	Investigative	10823585	C10H10N4OS	234.28	C1=CC=C(C=C1)CNC(=O)NC2=NN=CS2	IC50 > 2000000 nM	Non binder
T86702	Matrix metalloproteinase-3	B86BFX	N-[(Hydroxyamino)carbonyl]-D-leucyl-Lphenylalanine methylamide	Investigative	24881245	C17H26N4O4	350.4	CC(C)C[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC)NC(=O)NO	IC50 > 300000 nM	Non binder
T86702	Matrix metalloproteinase-3	B8R9AG	D-Leucyl-L-phenylalanine methylamide	Investigative	15296844	C16H25N3O2	291.39	CC(C)C[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC)N	IC50 > 300000 nM	Non binder
T86702	Matrix metalloproteinase-3	B8RO3G	(1S,2R)-2-Cyano-N-hydroxy-2-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxamide	Investigative	11575995	C28H23N3O3	449.5	C1[C@@H]([C@@]1(CC2=CC=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5)C#N)C(=O)NO	Ki > 10000000 nM	Non binder
T86702	Matrix metalloproteinase-3	B93MOD	1-(4-Phenoxyphenethyl)-3-hydroxyurea	Investigative	44405997	C15H16N2O3	272.3	C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC(=O)NO	IC50 > 380000 nM	Non binder
T86702	Matrix metalloproteinase-3	BA3M4C	N-[(Hydroxyamino)carbonyl]-L-leucyl-Lphenylalanine methylamide	Investigative	24881246	C17H26N4O4	350.4	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC)NC(=O)NO	IC50 > 300000 nM	Non binder
T86702	Matrix metalloproteinase-3	BAHV32	[(2S)-1-[[(2S)-1-(Benzylamino)-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]oxy-[4-(1,3-dioxoisoindol-2-yl)butyl]phosphinic acid	Investigative	44340175	C34H40N3O7P	633.7	CC(C)C[C@@H](C(=O)NCC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)OP(=O)(CCCCN3C(=O)C4=CC=CC=C4C3=O)O	IC50 > 200000 nM	Non binder
T86702	Matrix metalloproteinase-3	BB98UI	3,2-Diguanidinoneamine	Investigative	23645953	C14H30N8O6	406.44	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N=C(N)N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N=C(N)N)O)O)N	Ki > 300000 nM	Non binder
T86702	Matrix metalloproteinase-3	BCE62Z	(2Z,NE)-N-benzylidene-4-(3,4-dimethoxyphenyl)-2-(phenylimino)thiazol-3(2H)-amine	Investigative	6882342	C24H21N3O2S	415.5	COC1=C(C=C(C=C1)C2=CSC(=NC3=CC=CC=C3)N2/N=C/C4=CC=CC=C4)OC	IC50 = 230000 nM	Non binder
T86702	Matrix metalloproteinase-3	BCS8G3	Z-D-Phe-OH	Investigative	675678	C17H17NO4	299.32	C1=CC=C(C=C1)C[C@H](C(=O)O)NC(=O)OCC2=CC=CC=C2	IC50 > 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	BFDW36	N-Acetyl-D-tyrosine	Investigative	853750	C11H13NO4	223.22	CC(=O)N[C@H](CC1=CC=C(C=C1)O)C(=O)O	IC50 > 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	BGV24B	Neamine guanidinylated deriv. 29	Investigative	23645959	C20H42N12O6	546.6	CO[C@H]1[C@@H](C[C@@H]([C@H]([C@@H]1OC)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN=C(N)N)OC)OC)N=C(N)N)N=C(N)N)N=C(N)N	Ki > 300000 nM	Non binder
T86702	Matrix metalloproteinase-3	BH2JN4	Boc-L-tyrosine	Investigative	117439	C14H19NO5	281.3	CC(C)(C)OC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O	IC50 = 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	BIQ73G	N-Acetyl-L-tyrosine	Investigative	68310	C11H13NO4	223.22	CC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O	IC50 > 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	BK2ZL3	Neamine guanidinylated deriv. 4	Investigative	9957228	C16H34N12O6	490.5	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N=C(N)N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN=C(N)N)O)O)N=C(N)N)O)O)N=C(N)N	Ki > 300000 nM	Non binder
T86702	Matrix metalloproteinase-3	BM6FO1	1-Ethyl-3-phenethyl-1-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea	Investigative	10542854	C13H16N4OS2	308.4	CCN(C1=NNC(=S)S1)C(=O)NCCC2=CC=CC=C2	IC50 > 1000000 nM	Non binder
T86702	Matrix metalloproteinase-3	BMD31S	N-[2-[4-(4-Cyanophenyl)phenoxy]-1-(4-fluorophenyl)ethyl]-N-hydroxyformamide	Investigative	21700191	C22H17FN2O3	376.4	C1=CC(=CC=C1C#N)C2=CC=C(C=C2)OCC(C3=CC=C(C=C3)F)N(C=O)O	IC50 = 300000 nM	Non binder
T86702	Matrix metalloproteinase-3	BN0RW9	N-Benzoyl-L-Tryptophan	Investigative	706490	C18H16N2O3	308.3	C1=CC=C(C=C1)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)O	IC50 = 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	BN81RO	(S)-Benzyl (1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate	Investigative	7016043	C17H19N3O4	329.35	C1=CC=C(C=C1)COC(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)NN	IC50 > 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	BO6HQ2	(1R,2S)-1-(3-Fluoro-4-((2-phenylquinolin-4-yl)methoxy)benzyl)-N2-hydroxy-N1,N1-dimethylcyclopropane-1,2-dicarboxamide	Investigative	44580801	C30H28FN3O4	513.6	CN(C)C(=O)[C@]1(C[C@@H]1C(=O)NO)CC2=CC(=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5)F	Ki > 10000000 nM	Non binder
T86702	Matrix metalloproteinase-3	BQFR87	1-(4-Methyl-5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-3-phenethyl-urea	Investigative	10708950	C12H14N4OS2	294.4	CN1C(=S)SC(=N1)NC(=O)NCCC2=CC=CC=C2	IC50 = 694000 nM	Non binder
T86702	Matrix metalloproteinase-3	BQI6W0	N-[(Tert-Butoxy)carbonyl]-D-tryptophan	Investigative	111050	C16H20N2O4	304.34	CC(C)(C)OC(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)O	IC50 = 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	BQN7T5	N-[1-[4-(4-Cyanophenyl)phenoxy]propan-2-yl]-N-hydroxyformamide	Investigative	10402302	C17H16N2O3	296.32	CC(COC1=CC=C(C=C1)C2=CC=C(C=C2)C#N)N(C=O)O	IC50 = 620000 nM	Non binder
T86702	Matrix metalloproteinase-3	BR4K6G	Z-L-Tyrosine amide	Investigative	6992459	C17H18N2O4	314.34	C1=CC=C(C=C1)COC(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N	IC50 > 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	BRC53V	N-[(1S,2S)-2-Hydroxycyclopentyl]-4-phenoxybenzenesulfonamide	Investigative	71682917	C17H19NO4S	333.4	C1C[C@@H]([C@H](C1)O)NS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki > 200000 nM	Non binder
T86702	Matrix metalloproteinase-3	BRLX70	L-Tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-	Investigative	978343	C26H22N2O4	426.5	C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@@H](CC4=CNC5=CC=CC=C54)C(=O)O	IC50 = 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	BS1DV9	N-[(1S,2S)-2-Sulfanylcyclopentyl]benzenesulfonamide	Investigative	71682913	C11H15NO2S2	257.399	C1C[C@@H]([C@H](C1)S)NS(=O)(=O)C2=CC=CC=C2	Ki > 200000 nM	Non binder
T86702	Matrix metalloproteinase-3	BSC72X	(1S,2R)-N-Hydroxy-2-((S)-2-(hydroxymethyl)pyrrolidine-1-carbonyl)-2-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxamide	Investigative	44580802	C33H33N3O5	551.6	C1C[C@H](N(C1)C(=O)[C@]2(C[C@@H]2C(=O)NO)CC3=CC=C(C=C3)OCC4=CC(=NC5=CC=CC=C54)C6=CC=CC=C6)CO	Ki > 10000000 nM	Non binder
T86702	Matrix metalloproteinase-3	BSJB18	4-Phenoxy-N-[(1S,2S)-2-sulfanylcyclopentyl]benzamide	Investigative	71683062	C18H19NO2S	313.4	C1C[C@@H]([C@H](C1)S)NC(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki > 200000 nM	Non binder
T86702	Matrix metalloproteinase-3	BSK63Q	Z-L-Leu-L-Phe-OMe	Investigative	13968141	C24H30N2O5	426.5	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)OCC2=CC=CC=C2	IC50 > 300000 nM	Non binder
T86702	Matrix metalloproteinase-3	BSYC09	Benzyl N-[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate	Investigative	853880	C19H19N3O3	337.4	C1=CC=C(C=C1)COC(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N	IC50 = 500000 nM	Non binder
T86702	Matrix metalloproteinase-3	BU3R2X	(R)-2-(((Benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoic acid	Investigative	736160	C17H17NO5	315.32	C1=CC=C(C=C1)COC(=O)N[C@H](CC2=CC=C(C=C2)O)C(=O)O	Ki = 356000 nM	Non binder
T86702	Matrix metalloproteinase-3	BVET23	(R)-2-[(S)-3-(4-Cyclopentylmethyl-phenoxy)-1-((S)-6-methylcarbamoyl-tetrahydro-pyridazine-1-carbonyl)-propylamino]-propionic acid	Investigative	44294804	C25H38N4O5	474.6	C[C@H](C(=O)O)N[C@@H](CCOC1=CC=C(C=C1)CC2CCCC2)C(=O)N3[C@@H](CCCN3)C(=O)NC	IC50 > 200000 nM	Non binder
T86702	Matrix metalloproteinase-3	BVL83B	N-(2beta-Mercaptocyclopentane-1alpha-yl)-4-phenoxybenzenesulfonamide	Investigative	71682915	C17H19NO3S2	349.5	C1C[C@@H]([C@H](C1)S)NS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki > 200000 nM	Non binder
T86702	Matrix metalloproteinase-3	BW5FE4	1,3,2-Triguanidinoneamine	Investigative	11328354	C15H32N10O6	448.48	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N=C(N)N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N=C(N)N)O)O)N=C(N)N	Ki > 300000 nM	Non binder
T86702	Matrix metalloproteinase-3	BY2QI3	5-[(2-Furylmethyl)amino]-1,3,4-thiadiazole-2-thiol	Investigative	4962547	C7H7N3OS2	213.3	C1=COC(=C1)CNC2=NNC(=S)S2	IC50 = 289000 nM	Non binder
T86702	Matrix metalloproteinase-3	BZJ71N	(R)-2-[(S)-3-(4-Isopropyl-phenoxy)-1-((S)-6-methylcarbamoyl-tetrahydro-pyridazine-1-carbonyl)-propylamino]-propionic acid	Investigative	44294736	C22H34N4O5	434.5	C[C@H](C(=O)O)N[C@@H](CCOC1=CC=C(C=C1)C(C)C)C(=O)N2[C@@H](CCCN2)C(=O)NC	IC50 > 200000 nM	Non binder
T86702	Matrix metalloproteinase-3	D08CBB	D-tryptophan	Investigative	9060	C11H12N2O2	204.22	C1=CC=C2C(=C1)C(=CN2)C[C@H](C(=O)O)N	IC50 > 500000 nM	Non binder