TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T96144	DNA topoisomerase II	D0S0XS	SR-271425	Discontinued in Phase 1	9909677	C22H27N3O3S	413.5	CCN(CC)CCNC1=C2C(=C(C=C1)CNC=O)SC3=C(C2=O)C=C(C=C3)OC	EC50 > 480000 nM	Non binder
T96144	DNA topoisomerase II	D03GQC	PD-117596	Terminated	122796	C17H17F2N3O3	349.33	C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)F)N4CCC(C4)N)F)C(=O)O	EC50 = 340000 nM	Non binder
T96144	DNA topoisomerase II	B10KJE	1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-2-phenylquinolin-4-one	Investigative	14969598	C25H20F2N2O	402.4	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=O)C=C(N(C3=C2F)C4CC4)C5=CC=CC=C5)F	EC50 > 240000 nM	Non binder
T96144	DNA topoisomerase II	B12UNF	N-[[14-[2-(Diethylamino)ethyl]-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]methanesulfonamide	Investigative	10049918	C22H28N4O3S2	460.6	CCN(CC)CCN1C2=C3C(=C(C=C2)CNS(=O)(=O)C)SC4=C(C3=N1)C=C(C=C4)OC	EC50 > 210000 nM	Non binder
T96144	DNA topoisomerase II	B1PC8O	[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-acetic acid	Investigative	10647065	C29H50O3	446.7	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@@H](C4)OCC(=O)O)C)C	IC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	B1Y0WZ	N-[[1-[2-(Diethylamino)ethylamino]-7-methoxy-9-oxothioxanthen-4-yl]methyl]methanesulfonamide	Investigative	10576072	C22H29N3O4S2	463.6	CCN(CC)CCNC1=C2C(=C(C=C1)CNS(=O)(=O)C)SC3=C(C2=O)C=C(C=C3)OC	EC50 > 210000 nM	Non binder
T96144	DNA topoisomerase II	B2E0KV	Dihydrocholesterol	Investigative	6665	C27H48O	388.7	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@@H](C4)O)C)C	IC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	B2FN4G	[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-acetic acid	Investigative	44396511	C29H48O3	444.7	C[C@H](CCCC(C)C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)OCC(=O)O)C)C	IC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	B2GAP0	1-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethane-1,2-diol	Investigative	76325888	C29H52O3	448.7	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@@H](C4)OC(CO)O)C)C	IC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	B2J4FD	1,4-Dihydro-4-oxo-6,8-difluoro-7-(2,6-dimethylpyridin-4-yl)quinoline-3-carboxylic acid	Investigative	14969593	C17H12F2N2O3	330.28	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)NC=C(C3=O)C(=O)O)F	EC50 > 300000 nM	Non binder
T96144	DNA topoisomerase II	B2PJC3	3-(Cyclohexylmethyl)-1-cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoroquinolin-4-one	Investigative	44264807	C26H28F2N2O	422.5	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C(C3=O)CC4CCCCC4)C5CC5)F	EC50 > 230000 nM	Non binder
T96144	DNA topoisomerase II	B2SWK1	6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-2,2-dimethyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid	Investigative	44292319	C21H19FN2O4	382.4	CC1=CC(=CC(=N1)C)C2=C(C=C3C4=C2OCC(N4C=C(C3=O)C(=O)O)(C)C)F	EC50 = 510000 nM	Non binder
T96144	DNA topoisomerase II	B4Q3AV	1-[2-(Diethylamino)ethylamino]-7-methoxy-4-(methylaminomethyl)thioxanthen-9-one	Investigative	10668643	C22H29N3O2S	399.6	CCN(CC)CCNC1=C2C(=C(C=C1)CNC)SC3=C(C2=O)C=C(C=C3)OC	EC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	B4Z6XY	(2S)-6-(2,6-Dimethylpyridin-4-yl)-2-ethyl-7-fluoro-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid	Investigative	14501400	C21H19FN2O4	382.4	CC[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2C4=CC(=NC(=C4)C)C)F)C(=O)O	EC50 = 420000 nM	Non binder
T96144	DNA topoisomerase II	B6ESN7	2-[10-(Aminomethyl)-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-14-yl]-N,N-diethylethanamine	Investigative	9886271	C21H26N4OS	382.5	CCN(CC)CCN1C2=C3C(=C(C=C2)CN)SC4=C(C3=N1)C=C(C=C4)OC	EC50 > 260000 nM	Non binder
T96144	DNA topoisomerase II	B6H7ZX	N,N-Diethyl-2-[10-(methylaminomethyl)-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-14-yl]ethanamine	Investigative	10618929	C21H26N4S	366.5	CCN(CC)CCN1C2=C3C(=C(C=C2)CNC)SC4=CC=CC=C4C3=N1	EC50 > 220000 nM	Non binder
T96144	DNA topoisomerase II	B6TE7R	(2-(Diethylamino)ethyl]-2H-[1]-benzothiopyrano[4,3,2-cd]indazole-5-methanamine	Investigative	10521963	C20H24N4S	352.5	CCN(CC)CCN1C2=C3C(=C(C=C2)CN)SC4=CC=CC=C4C3=N1	EC50 > 250000 nM	Non binder
T96144	DNA topoisomerase II	B7R9PV	1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-2-methyl-4-oxoquinoline-3-carboxylic acid	Investigative	14969595	C21H18F2N2O3	384.4	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C(=C(C3=O)C(=O)O)C)C4CC4)F	EC50 > 260000 nM	Non binder
T96144	DNA topoisomerase II	B8AH1K	Methyl N-[[1-[2-(diethylamino)ethylamino]-7-methoxy-9-oxothioxanthen-4-yl]methyl]carbamate	Investigative	9933099	C23H29N3O4S	443.6	CCN(CC)CCNC1=C2C(=C(C=C1)CNC(=O)OC)SC3=C(C2=O)C=C(C=C3)OC	EC50 > 220000 nM	Non binder
T96144	DNA topoisomerase II	B8F2EM	1-[[2-(Diethylamino)ethyl]amino]-4-[(methylamino)methyl]thioxanthen-9-one	Investigative	10785350	C21H27N3OS	369.5	CCN(CC)CCNC1=C2C(=C(C=C1)CNC)SC3=CC=CC=C3C2=O	EC50 > 270000 nM	Non binder
T96144	DNA topoisomerase II	B8VI6A	[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-acetic acid	Investigative	44396484	C31H50O3	470.7	CC[C@H](/C=C/[C@@H](C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)OCC(=O)O)C)C)C(C)C	IC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	B92OFY	1,4-Dihydro-1-(2-fluoroethyl)-4-oxo-6,8-difluoro-7-(2,6-dimethylpyridin-4-yl)quinoline-3-carboxylic acid	Investigative	14969592	C19H15F3N2O3	376.3	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F	EC50 > 530000 nM	Non binder
T96144	DNA topoisomerase II	B92UJG	N-[[14-[2-(Diethylamino)ethyl]-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-10-yl]methyl]methanesulfonamide	Investigative	10598750	C21H26N4O2S2	430.6	CCN(CC)CCN1C2=C3C(=C(C=C2)CNS(=O)(=O)C)SC4=CC=CC=C4C3=N1	EC50 > 230000 nM	Non binder
T96144	DNA topoisomerase II	B93CZG	1,4-Dihydro-1-(4-fluorophenyl)-4-oxo-6,8-difluoro-7-(2,6-dimethylpyridin-4-yl)quinoline-3-carboxylic acid	Investigative	14969588	C23H15F3N2O3	424.4	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F	EC50 > 430000 nM	Non binder
T96144	DNA topoisomerase II	B9FPT5	1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-5-phenylsulfanylquinoline-3-carboxylic acid	Investigative	14969600	C26H20F2N2O3S	478.5	CC1=CC(=CC(=N1)C)C2=C(C3=C(C(=C2F)SC4=CC=CC=C4)C(=O)C(=CN3C5CC5)C(=O)O)F	EC50 > 420000 nM	Non binder
T96144	DNA topoisomerase II	BAG2X5	2-[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethanol	Investigative	9802791	C29H50O2	430.7	C[C@H](CCCC(C)C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)OCCO)C)C	IC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	BF24GL	2-[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethanol	Investigative	44396529	C31H52O2	456.7	CC[C@H](/C=C/[C@@H](C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)OCCO)C)C)C(C)C	IC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	BGE53O	(2S)-6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-2-methyl-10-oxo-1,4-diazatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid	Investigative	44292374	C20H18FN3O3	367.4	C[C@H]1CNC2=C3N1C=C(C(=O)C3=CC(=C2C4=CC(=NC(=C4)C)C)F)C(=O)O	EC50 = 730000 nM	Non binder
T96144	DNA topoisomerase II	BI3A6N	(2R)-6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid	Investigative	14501369	C20H17FN2O4	368.4	C[C@@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2C4=CC(=NC(=C4)C)C)F)C(=O)O	EC50 > 540000 nM	Non binder
T96144	DNA topoisomerase II	BI6YR0	1-Ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid	Investigative	13958508	C19H17FN2O3	340.3	CCN1C=C(C(=O)C2=CC(=C(C=C21)C3=CC(=NC(=C3)C)C)F)C(=O)O	EC50 > 570000 nM	Non binder
T96144	DNA topoisomerase II	BM6W5Y	1-[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethane-1,2-diol	Investigative	44396581	C29H50O3	446.7	C[C@H](CCCC(C)C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)OC(CO)O)C)C	IC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	BMI4J5	1-[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethane-1,2-diol	Investigative	44396563	C31H52O3	472.7	CC[C@H](/C=C/[C@@H](C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)OC(CO)O)C)C)C(C)C	IC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	BOCD81	(2S)-6-(2,6-Dimethylpyridin-4-yl)-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxylic acid	Investigative	44292541	C20H18N2O4	350.4	C[C@H]1COC2=C(C=CC3=C2N1C=C(C3=O)C(=O)O)C4=CC(=NC(=C4)C)C	EC50 > 290000 nM	Non binder
T96144	DNA topoisomerase II	BOYI16	N-[[14-[2-(Diethylamino)ethyl]-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-10-yl]methyl]formamide	Investigative	10547820	C21H24N4OS	380.5	CCN(CC)CCN1C2=C3C(=C(C=C2)CNC=O)SC4=CC=CC=C4C3=N1	EC50 > 260000 nM	Non binder
T96144	DNA topoisomerase II	BP5FT6	(2R)-6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-2-methyl-10-oxo-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid	Investigative	10068583	C20H17FN2O3S	384.4	C[C@@H]1CSC2=C3N1C=C(C(=O)C3=CC(=C2C4=CC(=NC(=C4)C)C)F)C(=O)O	EC50 > 260000 nM	Non binder
T96144	DNA topoisomerase II	BQ2BL9	(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol	Investigative	44396595	C29H48O	412.7	CC[C@H](/C=C/[C@@H](C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(C)C	IC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	BQF07Z	1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-3-(naphthalen-1-ylmethyl)quinolin-4-one	Investigative	44264825	C30H24F2N2O	466.5	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C(C3=O)CC4=CC=CC5=CC=CC=C54)C6CC6)F	EC50 > 210000 nM	Non binder
T96144	DNA topoisomerase II	BQL45H	[[2-[2-(Diethylamino)ethyl]-2H-[1]benzothiopyrano[4,3,2-cd]indazole-5-yl]methyl]carbamic acid methyl ester	Investigative	10501735	C22H26N4O2S	410.5	CCN(CC)CCN1C2=C3C(=C(C=C2)CNC(=O)OC)SC4=CC=CC=C4C3=N1	EC50 > 240000 nM	Non binder
T96144	DNA topoisomerase II	BRB30X	Methyl N-[[14-[2-(diethylamino)ethyl]-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]carbamate	Investigative	10478426	C23H28N4O3S	440.6	CCN(CC)CCN1C2=C3C(=C(C=C2)CNC(=O)OC)SC4=C(C3=N1)C=C(C=C4)OC	EC50 > 220000 nM	Non binder
T96144	DNA topoisomerase II	BRD4U6	N-[[14-[2-(Diethylamino)ethyl]-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]formamide	Investigative	10341523	C22H26N4O2S	410.5	CCN(CC)CCN1C2=C3C(=C(C=C2)CNC=O)SC4=C(C3=N1)C=C(C=C4)OC	EC50 > 240000 nM	Non binder
T96144	DNA topoisomerase II	BRVY47	1-[[2-(Diethylamino)ethyl]amino]-4-(formylaminomethyl)-9H-thioxanthene-9-one	Investigative	10362559	C21H25N3O2S	383.5	CCN(CC)CCNC1=C2C(=C(C=C1)CNC=O)SC3=CC=CC=C3C2=O	EC50 = 510000 nM	Non binder
T96144	DNA topoisomerase II	BW35ZI	1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-2-phenylquinoline-3-carboxylic acid	Investigative	14969596	C26H20F2N2O3	446.4	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C(=C(C3=O)C(=O)O)C4=CC=CC=C4)C5CC5)F	EC50 > 220000 nM	Non binder
T96144	DNA topoisomerase II	BWMS06	6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;hydrochloride	Investigative	45260072	C19H16ClFN2O4	390.8	CC1=CC(=CC(=N1)C)C2=C(C=C3C4=C2OCCN4C=C(C3=O)C(=O)O)F.Cl	EC50 > 560000 nM	Non binder
T96144	DNA topoisomerase II	BWU3P8	1-Cyclopropyl-3-[[4-(dimethylamino)phenyl]methyl]-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoroquinolin-4-one	Investigative	44264866	C28H27F2N3O	459.5	CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2F)N(C=C(C3=O)CC4=CC=C(C=C4)N(C)C)C5CC5)F	EC50 > 210000 nM	Non binder
T96144	DNA topoisomerase II	BY82RV	2-[(3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethylhexyl)-10,13-dimethylhexadecahydrocyclopenta[a]phenanthren-3-yloxy]ethanol	Investigative	66825540	C29H52O2	432.7	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@@H](C4)OCCO)C)C	IC50 > 500000 nM	Non binder
T96144	DNA topoisomerase II	D02DLW	Cholesterol	Investigative	5997	C27H46O	386.7	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C	IC50 > 500000 nM	Non binder