TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T00933 Histone lysine demethylase PHF8 B0E2WV 3-(10-Methylundecanoylhydroxyamino)propionic acid methyl ester Investigative 73333510 C16H31NO4 301.42 CC(C)CCCCCCCCC(=O)N(CCC(=O)OC)O IC50 = 150000 nM Poor binder T00933 Histone lysine demethylase PHF8 B4G7CL 3-[Hydroxy-[5-[methyl(pentyl)amino]pentanoyl]amino]propanoic acid Investigative 122181583 C14H28N2O4 288.38 CCCCCN(C)CCCCC(=O)N(CCC(=O)O)O IC50 ~ 100000 nM Poor binder T00933 Histone lysine demethylase PHF8 B9PNO0 4-(Isopropylamino)-4-oxobutanoic acid Investigative 245007 C7H13NO3 159.18 CC(C)NC(=O)CCC(=O)O IC50 ~ 100000 nM Poor binder T00933 Histone lysine demethylase PHF8 BA28NV Chembl4130224 Investigative 145962269 C25H32INO3 521.4 CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC=C(C=C3)OCCC[N+](C)(C)C.[I-] IC50 = 120000 nM Poor binder T00933 Histone lysine demethylase PHF8 BD10SA 3-[5-[Butyl(methyl)amino]pentanoyl-hydroxyamino]propanoic acid Investigative 122181577 C13H26N2O4 274.36 CCCCN(C)CCCCC(=O)N(CCC(=O)O)O IC50 ~ 100000 nM Poor binder T00933 Histone lysine demethylase PHF8 BKY6V7 3-[6-[Butyl(methyl)amino]hexanoyl-hydroxyamino]propanoic acid Investigative 53380104 C14H28N2O4 288.38 CCCCN(C)CCCCCC(=O)N(CCC(=O)O)O IC50 = 58000 nM Poor binder T00933 Histone lysine demethylase PHF8 BN19FL Chembl4126406 Investigative 145961684 C22H26INO3 479.4 CC1=C(C2=CC=CC=C2O1)C(=O)C3=CC=C(C=C3)OCCC[N+](C)(C)C.[I-] IC50 = 126000 nM Poor binder T00933 Histone lysine demethylase PHF8 BN86AV N'1,N'1,N'4,N'4-Tetramethylsuccinohydrazide Investigative 2238068 C8H18N4O2 202.25 CN(C)NC(=O)CCC(=O)NN(C)C IC50 = 117000 nM Poor binder T00933 Histone lysine demethylase PHF8 BXM35A NCDM-82a Investigative 122181584 C15H30N2O4 302.41 CCCCCCN(C)CCCCC(=O)N(CCC(=O)O)O IC50 = 73000 nM Poor binder