TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T02562	Prostaglandin E synthase	D0Z5IU	Sulindac	Approved	1548887	C20H17FO3S	356.4	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O	IC50 = 80000 nM	Poor binder
T02562	Prostaglandin E synthase	B0SO9X	(2E,5Z)-5-{3-Bromo-4-[(4-nitrobenzyl)oxy]benzylidene}-3-(4-methoxybenzyl)-2-(phenylimino)-1,3-thiazolidin-4-one	Investigative	9498257	C31H24BrN3O5S	630.5	COC1=CC=C(C=C1)CN2C(=O)/C(=C/C3=CC(=C(C=C3)OCC4=CC=C(C=C4)[N+](=O)[O-])Br)/SC2=NC5=CC=CC=C5	IC50 = 120000 nM	Poor binder
T02562	Prostaglandin E synthase	B16ZGO	N-(2-Methylphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide	Investigative	4690153	C14H11N3O4S	317.32	CC1=CC=CC=C1NC2=NS(=O)(=O)C3=C2C=CC(=C3)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	B2NH1C	N-(3-Tert-butylphenyl)-6-nitro-1,1-dioxo-1,2-benzothiazol-3-amine	Investigative	90643931	C17H17N3O4S	359.4	CC(C)(C)C1=CC(=CC=C1)NC2=NS(=O)(=O)C3=C2C=CC(=C3)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	B2U3QL	N-[(3-Bromophenyl)methyl]-6-nitro-1,1-dioxo-1,2-benzothiazol-3-imine	Investigative	136056624	C14H10BrN3O4S	396.22	C1=CC(=CC(=C1)Br)CN=C2C3=C(C=C(C=C3)[N+](=O)[O-])S(=O)(=O)N2	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	B3PB1L	5-(3-Hydroxypropyl)-2-(2-methoxy-4-hydroxyphenyl)benzofuran	Investigative	14213209	C18H18O4	298.3	COC1=C(C=CC(=C1)O)C2=CC3=C(O2)C=CC(=C3)CCCO	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	B4Z6RW	4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanyl]-1-phenylbutan-1-one	Investigative	6409184	C25H21N3OS	411.5	C1=CC=C(C=C1)C2=C(N=NC(=N2)SCCCC(=O)C3=CC=CC=C3)C4=CC=CC=C4	IC50 = 50800 nM	Poor binder
T02562	Prostaglandin E synthase	B56WUD	2-(2,4-Dichlorophenoxy)-N-[3-(N-{4-nitro-3-methylbenzoyl}ethanehydrazonoyl)phenyl]acetamide	Investigative	9654525	C24H20Cl2N4O5	515.299	CC1=C(C=CC(=C1)C(=O)N/N=C(\\C)/C2=CC(=CC=C2)NC(=O)COC3=C(C=C(C=C3)Cl)Cl)[N+](=O)[O-]	IC50 = 66000 nM	Poor binder
T02562	Prostaglandin E synthase	B64LSM	2-{[4-Methyl-5-(2-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-methyl-5-nitrophenyl)acetamide	Investigative	1129243	C19H19N5O3S	397.5	CC1=C(C=C(C=C1)[N+](=O)[O-])NC(=O)CSC2=NN=C(N2C)C3=CC=CC=C3C	IC50 = 54500 nM	Poor binder
T02562	Prostaglandin E synthase	B6JRQ3	N-[(E)-(4-Nitrophenyl)methylideneamino]-3,4,5-tris(phenylmethoxy)benzamide	Investigative	9662597	C35H29N3O6	587.6	C1=CC=C(C=C1)COC2=CC(=CC(=C2OCC3=CC=CC=C3)OCC4=CC=CC=C4)C(=O)N/N=C/C5=CC=C(C=C5)[N+](=O)[O-]	IC50 = 200000 nM	Poor binder
T02562	Prostaglandin E synthase	B73KGW	N-(3-((1-Benzyl-3-isopropylureido)methyl)phenyl)benzenesulfonamide	Investigative	53318885	C24H27N3O3S	437.6	CC(C)NC(=O)N(CC1=CC=CC=C1)CC2=CC(=CC=C2)NS(=O)(=O)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	B75YFS	1-(5-Ethylsulfonyl-1,3-benzoxazol-2-yl)-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]piperidine-4-carboxamide	Investigative	71553161	C22H31N3O5S	449.6	CCS(=O)(=O)C1=CC2=C(C=C1)OC(=N2)N3CCC(CC3)C(=O)N[C@H]4CCC[C@@H](C4)CO	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	B92BGM	Meso-3,3'-Didemethoxynectandrin B	Investigative	14213224	C18H20O3	284.3	C[C@@H]1[C@@H]([C@H](O[C@H]1C2=CC=C(C=C2)O)C3=CC=C(C=C3)O)C	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	B9BL1V	N-(1,3-Benzodioxol-4-yl)-6-nitro-1,1-dioxo-1,2-benzothiazol-3-amine	Investigative	90643935	C14H9N3O6S	347.3	C1OC2=CC=CC(=C2O1)NC3=NS(=O)(=O)C4=C3C=CC(=C4)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	B9TH1R	3-(5-{[3-(2-Anilino-2-oxoethyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}-2-furyl)-4-methylbenzoic acid	Investigative	1232170	C24H18N2O6S	462.5	CC1=C(C=C(C=C1)C(=O)O)C2=CC=C(O2)/C=C\\3/C(=O)N(C(=O)S3)CC(=O)NC4=CC=CC=C4	IC50 = 160000 nM	Poor binder
T02562	Prostaglandin E synthase	BE5OS7	6-Nitro-1,1-dioxo-N-(3-phenylphenyl)-1,2-benzothiazol-3-amine	Investigative	90643932	C19H13N3O4S	379.4	C1=CC=C(C=C1)C2=CC(=CC=C2)NC3=NS(=O)(=O)C4=C3C=CC(=C4)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	BHL85T	4-Chlorobenzyl 5,6-diphenyl-1,2,4-triazin-3-yl sulfide	Investigative	3126444	C22H16ClN3S	389.9	C1=CC=C(C=C1)C2=C(N=NC(=N2)SCC3=CC=C(C=C3)Cl)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T02562	Prostaglandin E synthase	BHWP83	1-[6-Acetyl-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazol-9-yl]ethanone	Investigative	45487816	C25H16ClFN2O2	430.9	CC(=O)C1=CC2=C(C=C1)C3=C(C4=C2C=C(C=C4)C(=O)C)N=C(N3)C5=C(C=CC=C5Cl)F	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	BIC60G	1-[5-Chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-4-piperidinecarboxamide	Investigative	53252516	C26H29Cl2N3O3	502.4	C1C[C@@H](C[C@H](C1)NC(=O)C2CCN(CC2)C3=NC4=C(O3)C=C(C(=C4)Cl)C5=CC=C(C=C5)Cl)CO	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	BIF7O4	N-(2,5-Dimethylphenyl)-2-((7-(p-tolyl)-6,7-dihydro-5H-imidazo[2,1-c][1,2,4]triazol-3-yl)thio)acetamide	Investigative	41160317	C21H23N5OS	393.5	CC1=CC=C(C=C1)N2CCN3C2=NN=C3SCC(=O)NC4=C(C=CC(=C4)C)C	IC50 ~ 100000 nM	Poor binder
T02562	Prostaglandin E synthase	BIK10B	2-[4-[[(1S,3S)-3-(Hydroxymethyl)cyclohexyl]carbamoyl]piperidin-1-yl]-1,3-benzoxazole-5-carboxamide	Investigative	71553162	C21H28N4O4	400.5	C1C[C@@H](C[C@H](C1)NC(=O)C2CCN(CC2)C3=NC4=C(O3)C=CC(=C4)C(=O)N)CO	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	BRZD31	N-(3,4-Dimethoxyphenyl)-6-nitro-1,1-dioxo-1,2-benzothiazol-3-amine	Investigative	72548264	C15H13N3O6S	363.3	COC1=C(C=C(C=C1)NC2=NS(=O)(=O)C3=C2C=CC(=C3)[N+](=O)[O-])OC	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	BS0PZ2	Chembl4278385	Investigative	145980268	C25H25NO3	387.5	CCOC(=O)C1=C(NC2=C1C=C(C3=CC=CC=C32)O)CC4=C(C=C(C=C4C)C)C	IC50 = 58800 nM	Poor binder
T02562	Prostaglandin E synthase	BS48IY	(-)-Larreatricin	Investigative	26389403	C18H20O3	284.3	C[C@@H]1[C@@H]([C@H](O[C@@H]1C2=CC=C(C=C2)O)C3=CC=C(C=C3)O)C	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	BTD13S	2-(4-Bromophenyl)-2-oxoethyl 1,3-dioxo-2-(4-phenoxyphenyl)-5-isoindolinecarboxylate	Investigative	1719649	C29H18BrNO6	556.4	C1=CC=C(C=C1)OC2=CC=C(C=C2)N3C(=O)C4=C(C3=O)C=C(C=C4)C(=O)OCC(=O)C5=CC=C(C=C5)Br	IC50 = 200000 nM	Poor binder
T02562	Prostaglandin E synthase	BUT2R4	N-(5-Bromonaphthalen-1-yl)-6-nitro-1,1-dioxo-1,2-benzothiazol-3-amine	Investigative	90643934	C17H10BrN3O4S	432.2	C1=CC2=C(C=CC=C2Br)C(=C1)NC3=NS(=O)(=O)C4=C3C=CC(=C4)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T02562	Prostaglandin E synthase	BV45EZ	N-[5-(3,4-Dichlorophenyl)pyridin-2-yl]-4-hydroxy-1,1-dioxo-2H-1lambda6,2-benzothiazine-3-carboxamide	Investigative	54728421	C20H13Cl2N3O4S	462.3	C1=CC=C2C(=C1)C(=C(NS2(=O)=O)C(=O)NC3=NC=C(C=C3)C4=CC(=C(C=C4)Cl)Cl)O	IC50 = 65600 nM	Poor binder
T02562	Prostaglandin E synthase	BV69QB	3-({2-Hydroxy-3,5-bisnitrobenzylidene}amino)-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one	Investigative	135419964	C18H15N5O6S	429.4	CC1=NC2=C(C3=C(S2)CCCC3)C(=O)N1/N=C/C4=C(C(=CC(=C4)[N+](=O)[O-])[N+](=O)[O-])O	IC50 = 130000 nM	Poor binder
T02562	Prostaglandin E synthase	BYJ70T	6-Nitro-1,1-dioxo-N-(3-propan-2-ylphenyl)-1,2-benzothiazol-3-amine	Investigative	90643930	C16H15N3O4S	345.4	CC(C)C1=CC(=CC=C1)NC2=NS(=O)(=O)C3=C2C=CC(=C3)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder