TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T03500	Matrix metalloproteinase-12	D00HNB	Clodronate	Approved	25419	CH4Cl2O6P2	244.89	C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl	IC50 = 121000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B0V4OK	Naphthalen-1-yl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445229	C16H11NO3	265.26	C1=CC=C2C(=C1)C=CC=C2OC(=O)C3=CC=CC(=O)N3	IC50 = 111000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B1L8EV	4-(5-Bromo-4-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485513	C11H10BrN5	292.13	CC1=C(NC(=C1)C2=NC=CC3=C2N=C(N3)N)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B1OFL3	Hexyl 6-mercaptopicolinate	Investigative	44445270	C12H17NO2S	239.34	CCCCCCOC(=O)C1=CC=CC(=S)N1	IC50 = 105000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B2AR5L	2-Phenoxyethyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445211	C14H13NO4	259.26	C1=CC=C(C=C1)OCCOC(=O)C2=CC=CC(=O)N2	IC50 = 79000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B2EDN9	3-Methoxybenzyl 6-mercaptopicolinate	Investigative	44445251	C14H13NO3S	275.32	COC1=CC=CC(=C1)COC(=O)C2=CC=CC(=S)N2	IC50 = 78000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B2I7UA	1-Cinnamyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole	Investigative	44445277	C14H14N4O	254.29	C1COC(=N1)C2=CN(N=N2)C/C=C/C3=CC=CC=C3	IC50 = 61000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B2LIP5	3-Fluorobenzyl 6-mercaptopicolinate	Investigative	44445254	C13H10FNO2S	263.29	C1=CC(=CC(=C1)F)COC(=O)C2=CC=CC(=S)N2	IC50 = 151000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B2PDW6	3-Phenoxybenzyl 6-mercaptopicolinate	Investigative	44445267	C19H15NO3S	337.4	C1=CC=C(C=C1)OC2=CC=CC(=C2)COC(=O)C3=CC=CC(=S)N3	IC50 = 71000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B35NLF	2,6-Difluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445216	C13H9F2NO3	265.21	C1=CC(=C(C(=C1)F)COC(=O)C2=CC=CC(=O)N2)F	IC50 = 60000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B36ZMF	4-(4,5-Dibromo-1H-pyrrol-2-yl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	44426076	C12H11Br2N5	385.06	CNC1=NC2=C(N1C)C=CN=C2C3=CC(=C(N3)Br)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B3F2EQ	3-((2-Phenethyl-2H-tetrazol-5-yl)methyl)pyridine	Investigative	44445279	C15H15N5	265.31	C1=CC=C(C=C1)CCN2N=C(N=N2)CC3=CN=CC=C3	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B3M5RK	4-[3,5-Dibromo-4-[2-(trifluoromethyl)phenethyl]-1H-pyrrole-2-yl]-1H-imidazo[4,5-c]pyridine-2-amine	Investigative	45485558	C19H14Br2F3N5	529.2	C1=CC=C(C(=C1)CCC2=C(NC(=C2Br)C3=NC=CC4=C3N=C(N4)N)Br)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B3VCP2	5-Chloro-2-oxo-1,2,3,4-tetrahydroquinazoline-3-acetohydroxamic acid	Investigative	10467565	C10H10ClN3O3	255.66	C1C2=C(C=CC=C2Cl)NC(=O)N1CC(=O)NO	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B41BIN	2,6-Difluorobenzyl 6-mercaptopicolinate	Investigative	44445256	C13H9F2NO2S	281.28	C1=CC(=C(C(=C1)F)COC(=O)C2=CC=CC(=S)N2)F	IC50 = 127000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B49VDF	4-Methoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445210	C14H13NO4	259.26	COC1=CC=C(C=C1)COC(=O)C2=CC=CC(=O)N2	IC50 = 105000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B4KXM7	4-(5-Bromo-4-(3-phenylpropyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485463	C19H18BrN5	396.3	C1=CC=C(C=C1)CCCC2=C(NC(=C2)C3=NC=CC4=C3N=C(N4)N)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B4NH7Q	4-(4-Methylphenoxy)-N-(4-pyridinylmethyl)benzenecarboxamide	Investigative	4358655	C20H18N2O2	318.4	CC1=CC=C(C=C1)OC2=CC=C(C=C2)C(=O)NCC3=CC=NC=C3	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B4O5BS	3-Methylbut-2-enyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445201	C11H13NO3	207.23	CC(=CCOC(=O)C1=CC=CC(=O)N1)C	IC50 = 67000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B4ZP8S	1-[[2-(4-Chlorophenoxy)acetyl]amino]-3-(4-cyclohexylbutyl)thiourea	Investigative	73349535	C19H28ClN3O2S	398	C1CCC(CC1)CCCCNC(=S)NNC(=O)COC2=CC=C(C=C2)Cl	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B52RVN	4-(4-Benzyl-5-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485520	C17H14BrN5	368.2	C1=CC=C(C=C1)CC2=C(NC(=C2)C3=NC=CC4=C3N=C(N4)N)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B5B8FZ	Naphthalen-1-yl 6-mercaptopicolinate	Investigative	44445263	C16H11NO2S	281.3	C1=CC=C2C(=C1)C=CC=C2OC(=O)C3=CC=CC(=S)N3	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B5ZP7Q	3-Acetoxy-5-(biphenyl-4-yl)pentanoic acid	Investigative	45482999	C19H20O4	312.4	CC(=O)OC(CCC1=CC=C(C=C1)C2=CC=CC=C2)CC(=O)O	IC50 = 54400 nM	Poor binder
T03500	Matrix metalloproteinase-12	B65WHM	4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-methylbenzamide	Investigative	57392969	C23H24N2O3	376.4	CNC(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)C#C[C@@]3(CN4CCC3CC4)O	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B6BTQ8	4-(4,5-Dihydrooxazol-2-yl)-1-phenethyl-1H-1,2,3-triazole	Investigative	44445275	C13H14N4O	242.28	C1COC(=N1)C2=CN(N=N2)CCC3=CC=CC=C3	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B6BZ7Q	Benzyl 6-mercaptopicolinate	Investigative	44445244	C13H11NO2S	245.3	C1=CC=C(C=C1)COC(=O)C2=CC=CC(=S)N2	IC50 = 82000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B6J1EV	6-Mercapto-pyridine-2-carboxylic acid 4-methyl-benzyl ester	Investigative	44445248	C14H13NO2S	259.329	CC1=CC=C(C=C1)COC(=O)C2=CC=CC(=S)N2	IC50 = 81000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B6O4DQ	(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide	Investigative	53374826	C10H8F3NO2	231.17	C1=CC(=CC=C1/C=C/C(=O)NO)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B7HAY0	Phenethyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445205	C14H13NO3	243.26	C1=CC=C(C=C1)CCOC(=O)C2=CC=CC(=O)N2	IC50 = 68000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B7L6VX	Chembl4160618	Investigative	145956426	C11H13N3O7S	331.3	C1=CC(=CC=C1[N+](=O)[O-])S(=O)(=O)N[C@@H](CCC(=O)N)C(=O)O	IC50 = 100100 nM	Poor binder
T03500	Matrix metalloproteinase-12	B7VS2E	3-Phenoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445234	C19H15NO4	321.3	C1=CC=C(C=C1)OC2=CC=CC(=C2)COC(=O)C3=CC=CC(=O)N3	IC50 = 118000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B7WNT8	4-Phenoxybutyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445212	C16H17NO4	287.31	C1=CC=C(C=C1)OCCCCOC(=O)C2=CC=CC(=O)N2	IC50 = 82000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B7Z6GY	1-Cyclohexenyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole	Investigative	44445271	C11H14N4O	218.26	C1CCC(=CC1)N2C=C(N=N2)C3=NCCO3	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B8DY7G	(R)-2-(4-Fluoro-3,5-dimethylphenylamino)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide	Investigative	24871537	C21H27F2N3O2	391.5	CC1=CC(=CC(=C1F)C)N[C@H](CCCCNCC2=CC=C(C=C2)F)C(=O)NO	Ki ~ 50000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B8H6ZF	6-Mercapto-pyridine-2-carboxylic acid biphenyl-4-ylmethyl ester	Investigative	44445265	C19H15NO2S	321.4	C1=CC=C(C=C1)C2=CC=C(C=C2)COC(=O)C3=CC=CC(=S)N3	IC50 = 135000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B8KJ7I	(S)-2-(4-Fluoro-3,5-dimethylbenzyl)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide	Investigative	24871655	C22H28F2N2O2	390.5	CC1=CC(=CC(=C1F)C)C[C@H](CCCCNCC2=CC=C(C=C2)F)C(=O)NO	Ki ~ 50000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B8U0SC	2-Chlorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445222	C13H10ClNO3	263.67	C1=CC=C(C(=C1)COC(=O)C2=CC=CC(=O)N2)Cl	IC50 = 68000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B8ZWO6	(2R,3R)-4-(2-(3-Chlorophenyl)pyrrolidin-1-yl)-2,3-dihydroxy-4-oxo-N-(2-(thiophen-2-yl)ethyl)butanamide	Investigative	11697504	C20H23ClN2O4S	422.9	C1CC(N(C1)C(=O)[C@@H]([C@H](C(=O)NCCC2=CC=CS2)O)O)C3=CC(=CC=C3)Cl	Ki ~ 50000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B95ZRL	4-Fluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445215	C13H10FNO3	247.22	C1=CC(=O)NC(=C1)C(=O)OCC2=CC=C(C=C2)F	IC50 = 65000 nM	Poor binder
T03500	Matrix metalloproteinase-12	B9DW4I	[(4S,5S)-2-(4-Nitro-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl]-methanol	Investigative	44394886	C12H12N2O4	248.23	C=C[C@H]1[C@@H](N=C(O1)C2=CC=C(C=C2)[N+](=O)[O-])CO	Ki ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BA39YM	Phenethyl 6-mercaptopicolinate	Investigative	44445245	C14H13NO2S	259.329	C1=CC=C(C=C1)CCOC(=O)C2=CC=CC(=S)N2	IC50 = 117000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BA8T1M	(2R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide	Investigative	70693710	C23H30F2N2O3	420.5	CCC(C1=CC=C(C=C1)F)NCCCC[C@H](C(=O)NO)OC2=CC(=C(C(=C2)C)F)C	Ki ~ 50000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BB5Y2L	4-(3,5-Dibromo-4-(3-phenylpropyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485476	C19H17Br2N5	475.2	C1=CC=C(C=C1)CCCC2=C(NC(=C2Br)C3=NC=CC4=C3N=C(N4)N)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BB9JA3	But-2-ynyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445202	C10H9NO3	191.18	CC#CCOC(=O)C1=CC=CC(=O)N1	IC50 = 71000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BB9P3G	4-(3,5-Dibromo-4-(3-(trifluoromethyl)phenethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485460	C19H14Br2F3N5	529.2	C1=CC(=CC(=C1)C(F)(F)F)CCC2=C(NC(=C2Br)C3=NC=CC4=C3N=C(N4)N)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BBC3H8	4-(4-Bromo-5-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485485	C11H10BrN5	292.13	CC1=C(C=C(N1)C2=NC=CC3=C2N=C(N3)N)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BC36TM	Cyclobutyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445200	C10H11NO3	193.2	C1CC(C1)OC(=O)C2=CC=CC(=O)N2	IC50 = 51000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BC6DG0	(2S)-2-[(4-Fluoro-3,5-dimethylphenyl)methyl]-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide	Investigative	57345501	C24H32F2N2O2	418.5	CCC(C1=CC=C(C=C1)F)NCCCC[C@@H](CC2=CC(=C(C(=C2)C)F)C)C(=O)NO	Ki ~ 50000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BDJ7N6	4-(4,5-Dihydrooxazol-2-yl)-1-(3-phenylpropyl)-1H-1,2,3-triazole	Investigative	44445276	C14H16N4O	256.3	C1COC(=N1)C2=CN(N=N2)CCCC3=CC=CC=C3	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BDX8N2	[4-(Trifluoromethyl)phenyl]methyl 6-oxo-1H-pyridine-2-carboxylate	Investigative	46905989	C14H10F3NO3	297.23	C1=CC(=O)NC(=C1)C(=O)OCC2=CC=C(C=C2)C(F)(F)F	IC50 = 64000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BE0ZB9	6-Mercapto-pyridine-2-carboxylic acid 3-methyl-benzyl ester	Investigative	44445247	C14H13NO2S	259.329	CC1=CC(=CC=C1)COC(=O)C2=CC=CC(=S)N2	IC50 = 70000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BE56OY	Furan-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445239	C10H7NO4	205.17	C1=CC(=O)NC(=C1)C(=O)OC2=CC=CO2	IC50 = 76000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BEW6D2	2,4,5-Trifluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445220	C13H8F3NO3	283.2	C1=CC(=O)NC(=C1)C(=O)OCC2=CC(=C(C=C2F)F)F	IC50 = 56000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BF0HQ4	Thiophen-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445235	C10H7NO3S	221.23	C1=CC(=O)NC(=C1)C(=O)OC2=CC=CS2	IC50 = 65000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BF12NZ	4-Phenoxybenzyl 6-mercaptopicolinate	Investigative	44445268	C19H15NO3S	337.4	C1=CC=C(C=C1)OC2=CC=C(C=C2)COC(=O)C3=CC=CC(=S)N3	IC50 = 109000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BFBK27	Naphthalen-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445230	C16H11NO3	265.26	C1=CC=C2C=C(C=CC2=C1)OC(=O)C3=CC=CC(=O)N3	IC50 = 97000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BFK93U	4-(5-(Biphenyl-4-yl)-4-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485508	C22H16BrN5	430.3	C1=CC=C(C=C1)C2=CC=C(C=C2)C3=C(C=C(N3)C4=NC=CC5=C4N=C(N5)N)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BG02JR	4-(3,4-Dibromo-5-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485486	C11H9Br2N5	371.03	CC1=C(C(=C(N1)C2=NC=CC3=C2N=C(N3)N)Br)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BG9U0C	Cyclohexyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445203	C12H15NO3	221.25	C1CCC(CC1)OC(=O)C2=CC=CC(=O)N2	IC50 = 71000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BGN3P0	2-(2-(4-Methoxyphenylsulfonyl)phenyl)acetic Acid	Investigative	44479700	C15H14O5S	306.3	COC1=CC=C(C=C1)S(=O)(=O)C2=CC=CC=C2CC(=O)O	IC50 = 89000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BGXT10	2-Bromobenzyl 6-mercaptopicolinate	Investigative	44445262	C13H10BrNO2S	324.19	C1=CC=C(C(=C1)COC(=O)C2=CC=CC(=S)N2)Br	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BH7FI5	Naphthalen-2-yl 6-mercaptopicolinate	Investigative	44445264	C16H11NO2S	281.3	C1=CC=C2C=C(C=CC2=C1)OC(=O)C3=CC=CC(=S)N3	IC50 = 101000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BH7L0B	4-(3,5-Dibromo-4-(4-(trifluoromethyl)phenethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485461	C19H14Br2F3N5	529.2	C1=CC(=CC=C1CCC2=C(NC(=C2Br)C3=NC=CC4=C3N=C(N4)N)Br)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BHK5T0	Thiophen-3-yl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445237	C10H7NO3S	221.23	C1=CC(=O)NC(=C1)C(=O)OC2=CSC=C2	IC50 = 62000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BI73TH	4-Fluorobenzyl 6-mercaptopicolinate	Investigative	44445255	C13H10FNO2S	263.29	C1=CC(=S)NC(=C1)C(=O)OCC2=CC=C(C=C2)F	IC50 = 112000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BIC4X9	6-Oxo-1,6-dihydro-pyridine-2-carboxylic acid biphenyl-3-ylmethyl ester	Investigative	44445233	C19H15NO3	305.3	C1=CC=C(C=C1)C2=CC=CC(=C2)COC(=O)C3=CC=CC(=O)N3	IC50 = 99000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BID20Z	Benzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445204	C13H11NO3	229.23	C1=CC=C(C=C1)COC(=O)C2=CC=CC(=O)N2	IC50 = 69000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BIDO53	Thiophen-3-yl 6-mercaptopicolinate	Investigative	44445269	C10H7NO2S2	237.3	C1=CC(=S)NC(=C1)C(=O)OC2=CSC=C2	IC50 = 93000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BJ27VX	Isopropyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445199	C9H11NO3	181.19	CC(C)OC(=O)C1=CC=CC(=O)N1	IC50 = 67000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BJW19F	3-((2-Benzyl-2H-tetrazol-5-yl)methyl)pyridine	Investigative	44445278	C14H13N5	251.29	C1=CC=C(C=C1)CN2N=C(N=N2)CC3=CN=CC=C3	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BK2NS9	Pentyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445240	C11H15NO3	209.24	CCCCCOC(=O)C1=CC=CC(=O)N1	IC50 = 68000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BKG9M5	4-(4,5-Dihydrooxazol-2-yl)-1-hexyl-1H-1,2,3-triazole	Investigative	44445272	C11H18N4O	222.29	CCCCCCN1C=C(N=N1)C2=NCCO2	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BKM83T	4-Chlorobenzyl 6-mercaptopicolinate	Investigative	44445261	C13H10ClNO2S	279.74	C1=CC(=S)NC(=C1)C(=O)OCC2=CC=C(C=C2)Cl	IC50 = 115000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BL2F0S	6-Oxo-1,6-dihydro-pyridine-2-carboxylic acid 4-methyl-benzyl ester	Investigative	44445206	C14H13NO3	243.26	CC1=CC=C(C=C1)COC(=O)C2=CC=CC(=O)N2	IC50 = 69000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BL58TM	Chembl4162521	Investigative	145957734	C15H21N3O7S	387.4	CCCCNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 = 198300 nM	Poor binder
T03500	Matrix metalloproteinase-12	BM0P4L	4-(4,5-Dibromo-1H-pyrrol-2-yl)-N,N-dimethyl-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	44426077	C12H11Br2N5	385.06	CN(C)C1=NC2=C(N1)C=CN=C2C3=CC(=C(N3)Br)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BMI8C2	Isopropyl 6-mercaptopicolinate	Investigative	44445241	C9H11NO2S	197.26	CC(C)OC(=O)C1=CC=CC(=S)N1	IC50 = 146000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BNEM74	2,5-Difluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445217	C13H9F2NO3	265.21	C1=CC(=O)NC(=C1)C(=O)OCC2=C(C=CC(=C2)F)F	IC50 = 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BNH40K	trans-2-Aminocyclohexylcarbamoylphosphonic acid	Investigative	24807817	C7H15N2O4P	222.18	C1CC[C@H]([C@@H](C1)N)NC(=O)P(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BNOK60	2-Fluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445213	C13H10FNO3	247.22	C1=CC=C(C(=C1)COC(=O)C2=CC=CC(=O)N2)F	IC50 = 68000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BNTY08	(E)-3-((2-Cinnamyl-2H-tetrazol-5-yl)methyl)pyridine	Investigative	44445281	C16H15N5	277.32	C1=CC=C(C=C1)/C=C/CN2N=C(N=N2)CC3=CN=CC=C3	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BNU1Q2	Cyclohexyl 6-mercaptopicolinate	Investigative	44445243	C12H15NO2S	237.32	C1CCC(CC1)OC(=O)C2=CC=CC(=S)N2	IC50 = 87000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BO9WE6	4-(4,5-Dihydrooxazol-2-yl)-1-heptyl-1H-1,2,3-triazole	Investigative	44445273	C12H20N4O	236.31	CCCCCCCN1C=C(N=N1)C2=NCCO2	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BOE7D4	4-(5-(Biphenyl-3-yl)-4-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485502	C22H16BrN5	430.3	C1=CC=C(C=C1)C2=CC(=CC=C2)C3=C(C=C(N3)C4=NC=CC5=C4N=C(N5)N)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BOLF53	4-(4,5-Dibromo-3-phenethyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485477	C18H15Br2N5	461.2	C1=CC=C(C=C1)CCC2=C(NC(=C2Br)Br)C3=NC=CC4=C3N=C(N4)N	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BORP07	5-(3-Pyridylmethyl)-1H-tetrazole	Investigative	28602444	C7H7N5	161.16	C1=CC(=CN=C1)CC2=NNN=N2	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BPM2J0	3-Methoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445209	C14H13NO4	259.26	COC1=CC=CC(=C1)COC(=O)C2=CC=CC(=O)N2	IC50 = 69000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BQK5W3	4-Methoxybenzyl 6-mercaptopicolinate	Investigative	44445252	C14H13NO3S	275.32	COC1=CC=C(C=C1)COC(=O)C2=CC=CC(=S)N2	IC50 = 96000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BQX1W6	Cinnamyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445228	C15H13NO3	255.27	C1=CC=C(C=C1)/C=C/COC(=O)C2=CC=CC(=O)N2	IC50 = 70000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BR28PO	Chembl4163839	Investigative	145959777	C18H19N3O7S	421.4	C1=CC=C(C=C1)CNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)[N+](=O)[O-]	IC50 = 95200 nM	Poor binder
T03500	Matrix metalloproteinase-12	BRCZ16	1-Benzyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole	Investigative	44445274	C12H12N4O	228.25	C1COC(=N1)C2=CN(N=N2)CC3=CC=CC=C3	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BRFY07	3-(Trifluoromethyl)benzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445207	C14H10F3NO3	297.23	C1=CC(=CC(=C1)C(F)(F)F)COC(=O)C2=CC=CC(=O)N2	IC50 = 82000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BRTE39	Benzo[d][1,3]dioxol-5-ylmethyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445231	C14H11NO5	273.24	C1OC2=C(O1)C=C(C=C2)COC(=O)C3=CC=CC(=O)N3	IC50 = 105000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BSD4C0	Cyclobutyl 6-mercaptopicolinate	Investigative	44445242	C10H11NO2S	209.27	C1CC(C1)OC(=O)C2=CC=CC(=S)N2	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BSD50Z	4-(Trifluoromethyl)benzyl 6-mercaptopicolinate	Investigative	44445250	C14H10F3NO2S	313.3	C1=CC(=S)NC(=C1)C(=O)OCC2=CC=C(C=C2)C(F)(F)F	IC50 = 94000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BSM73K	4-(4-Bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	44426071	C10H8BrN5	278.11	C1=CN=C(C2=C1NC(=N2)N)C3=CC(=CN3)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BT16SP	Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-Carboxylate	Investigative	9896504	C21H16N2O4S	392.4	C1=CC=C(C=C1)CN2C(=O)C=C3N(C2=O)C=C(S3)C(=O)OCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BT1Q5P	(5-Chloro-3,4-dihydro-1H-2,1,3-benzothiadiazine-3-acetohydroxamic acid)2,2-dioxide	Investigative	10732349	C9H10ClN3O4S	291.71	C1C2=C(C=CC=C2Cl)NS(=O)(=O)N1CC(=O)NO	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BT4QP5	4-(5-Bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	44426072	C10H8BrN5	278.11	C1=CN=C(C2=C1NC(=N2)N)C3=CC=C(N3)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BT61GW	4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic Acid	Investigative	10224181	C26H20N2O4	424.4	CN1C2=C(C=C(C=C2)C#CCC3=CC=CC=C3)C(=O)N(C1=O)CC4=CC=C(C=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BTE7I6	6-Mercapto-pyridine-2-carboxylic acid biphenyl-3-ylmethyl ester	Investigative	44445266	C19H15NO2S	321.4	C1=CC=C(C=C1)C2=CC=CC(=C2)COC(=O)C3=CC=CC(=S)N3	IC50 = 52000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BUK1T6	3-(Trifluoromethyl)benzyl 6-mercaptopicolinate	Investigative	44445249	C14H10F3NO2S	313.3	C1=CC(=CC(=C1)C(F)(F)F)COC(=O)C2=CC=CC(=S)N2	IC50 = 134000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BVN52W	4-(4-Bromo-5-phenyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485487	C16H12BrN5	354.2	C1=CC=C(C=C1)C2=C(C=C(N2)C3=NC=CC4=C3N=C(N4)N)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BW1KQ0	4-Phenoxybutyl 6-mercaptopicolinate	Investigative	44445253	C16H17NO3S	303.4	C1=CC=C(C=C1)OCCCCOC(=O)C2=CC=CC(=S)N2	IC50 = 78000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BW35RO	(2R)-2-(4-Fluoro-3,5-dimethylanilino)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide	Investigative	57345500	C23H31F2N3O2	419.5	CCC(C1=CC=C(C=C1)F)NCCCC[C@H](C(=O)NO)NC2=CC(=C(C(=C2)C)F)C	Ki ~ 50000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BW5QT9	4-(1H-Pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-ylamine	Investigative	44426073	C10H9N5	199.21	C1=CNC(=C1)C2=NC=CC3=C2N=C(N3)N	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BWR10G	Perfluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445221	C13H6F5NO3	319.18	C1=CC(=O)NC(=C1)C(=O)OCC2=C(C(=C(C(=C2F)F)F)F)F	IC50 = 63000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BX28NQ	Chembl4164016	Investigative	145960035	C13H17N3O7S	359.36	CCNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 = 109100 nM	Poor binder
T03500	Matrix metalloproteinase-12	BX46HB	4-(4-Benzyl-3,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	45485521	C17H13Br2N5	447.1	C1=CC=C(C=C1)CC2=C(NC(=C2Br)C3=NC=CC4=C3N=C(N4)N)Br	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BX78KQ	(R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide	Investigative	54580973	C21H26F2N2O3	392.4	CC1=CC(=CC(=C1F)C)O[C@H](CCCCNCC2=CC=C(C=C2)F)C(=O)NO	Ki ~ 50000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BX7B5M	4-(4,5-Dibromo-1H-pyrrol-2-yl)-1-methyl-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	44426075	C11H9Br2N5	371.03	CN1C2=C(C(=NC=C2)C3=CC(=C(N3)Br)Br)N=C1N	IC50 = 56900 nM	Poor binder
T03500	Matrix metalloproteinase-12	BX7RZ0	3-((2-(3-Phenylpropyl)-2H-tetrazol-5-yl)methyl)pyridine	Investigative	44445280	C16H17N5	279.34	C1=CC=C(C=C1)CCCN2N=C(N=N2)CC3=CN=CC=C3	IC50 ~ 150000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BX9QY5	4-(1-Methyl-4,5-dibromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine	Investigative	44426074	C11H9Br2N5	371.03	CN1C(=CC(=C1Br)Br)C2=NC=CC3=C2N=C(N3)N	IC50 ~ 100000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BXS9P4	4-Bromobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445226	C13H10BrNO3	308.13	C1=CC(=O)NC(=C1)C(=O)OCC2=CC=C(C=C2)Br	IC50 = 105000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BZ8IT5	2,4,5-Trifluorobenzyl 6-mercaptopicolinate	Investigative	44445258	C13H8F3NO2S	299.27	C1=CC(=S)NC(=C1)C(=O)OCC2=CC(=C(C=C2F)F)F	IC50 = 106000 nM	Poor binder
T03500	Matrix metalloproteinase-12	BZ97RT	3-Phenylpropyl 6-mercaptopicolinate	Investigative	44445246	C15H15NO2S	273.4	C1=CC=C(C=C1)CCCOC(=O)C2=CC=CC(=S)N2	IC50 = 85000 nM	Poor binder
T03500	Matrix metalloproteinase-12	D0T1FR	Cis-2-aminocyclohexylcarbamoylphosphonic acid	Investigative	44457233	C7H15N2O4P	222.18	C1CC[C@H]([C@H](C1)N)NC(=O)P(=O)(O)O	IC50 ~ 100000 nM	Poor binder