TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T03691	Leukotriene A-4 hydrolase	D09JUG	Zileuton	Approved	60490	C11H12N2O2S	236.29	CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	D00QOF	ORG-13011	Phase 2	44473151	C38H43N3O4S	637.8	CCOC1=NC=C(C=C1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OCC5=NC=C(C=C5)C)C(=C3CC(C)(C)C(=O)O)SC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	D0C0JT	Nimesulide	Withdrawn from market	4495	C13H12N2O5S	308.31	CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B0TJ4F	N-(Methylsulfonyl)-N-(3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)-phenyl)methanesulfonamide	Investigative	49805305	C20H26N2O6S2	454.6	CS(=O)(=O)N(C1=CC(=CC=C1)OC2=CC=C(C=C2)OCCN3CCCC3)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B1UJS2	2-[5-[2-(4-Phenoxyphenoxy)ethoxy]-1H-indol-3-yl]ethylcarbamic acid	Investigative	71716159	C25H24N2O5	432.5	C1=CC=C(C=C1)OC2=CC=C(C=C2)OCCOC3=CC4=C(C=C3)NC=C4CCNC(=O)O	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B28DPV	(1S,6R)-3-Methyl-6-(6-methylhept-5-en-2-yl)cyclohex-3-ene-1,2-diol	Investigative	134131352	C15H26O2	238.37	CC1=CC[C@@H]([C@@H](C1O)O)C(C)CCC=C(C)C	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B2WG3A	2-[5-[2-[4-(4-Nitrophenoxy)phenoxy]ethoxy]-1H-indol-3-yl]ethanamine;hydrochloride	Investigative	71568934	C24H24ClN3O5	469.9	C1=CC(=CC=C1[N+](=O)[O-])OC2=CC=C(C=C2)OCCOC3=CC4=C(C=C3)NC=C4CCN.Cl	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B3MEY9	2-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)pyrazine	Investigative	49805055	C16H19N3O2	285.34	C1CCN(C1)CCOC2=CC=C(C=C2)OC3=NC=CN=C3	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B3Z2VD	2-[5-(Naphthalen-1-ylmethoxy)-1H-indol-3-yl]ethanamine;hydrochloride	Investigative	71568930	C21H21ClN2O	352.9	C1=CC=C2C(=C1)C=CC=C2COC3=CC4=C(C=C3)NC=C4CCN.Cl	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B47MDV	3-[[(2S,3S)-2-Hydroxy-3-amino-4-phenylbutanoyl]amino]propanoic acid	Investigative	10264885	C13H18N2O4	266.29	C1=CC=C(C=C1)C[C@@H]([C@@H](C(=O)NCCC(=O)O)O)N	IC50 ~ 80000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B48VCJ	(5S,7S)-7-Amino-5-benzylsulfanyl-5,7,8,9-tetrahydrobenzo[7]annulen-6-one;hydrochloride	Investigative	66560596	C18H20ClNOS	333.9	C1CC2=CC=CC=C2[C@@H](C(=O)[C@H]1N)SCC3=CC=CC=C3.Cl	Ki ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B4EW3S	N-Methyl-N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)phenyl)methanesulfonamide	Investigative	49805307	C20H26N2O4S	390.5	CN(C1=CC=CC=C1OC2=CC=C(C=C2)OCCN3CCCC3)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B4S0GK	Pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone	Investigative	44221318	C18H20N2O2	296.4	C1CCN(C1)CCOC2=CC=C(C=C2)C(=O)C3=CC=NC=C3	IC50 = 199000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B5FLI3	4-(3,4-Dimethoxyphenyl)butan-2-one	Investigative	237561	C12H16O3	208.25	CC(=O)CCC1=CC(=C(C=C1)OC)OC	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B5L0IR	(5R,7S)-7-Amino-5-(2-phenylethyl)-5,7,8,9-tetrahydrobenzo[7]annulen-6-one;hydrochloride	Investigative	66560604	C19H22ClNO	315.8	C1CC2=CC=CC=C2[C@H](C(=O)[C@H]1N)CCC3=CC=CC=C3.Cl	Ki ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B6Q7LU	5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)dodecan-3-one	Investigative	5275725	C19H30O4	322.4	CCCCCCCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)O	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B6S0TN	(S)-2-[[(2R,3S)-2-Hydroxy-3-amino-4-phenyl-1-thioxobutyl]amino]-4-methylpentanoic acid	Investigative	44310089	C16H24N2O3S	324.4	CC(C)C[C@@H](C(=O)O)NC(=S)[C@@H]([C@H](CC1=CC=CC=C1)N)O	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B6ZS8U	5-Hydroxy-1-[4-hydroxy-3-[2-hydroxy-5-(5-hydroxy-3-oxodecyl)-3-methoxyphenyl]-5-methoxyphenyl]decan-3-one	Investigative	134130915	C34H50O8	586.8	CCCCCC(CC(=O)CCC1=CC(=C(C(=C1)OC)O)C2=C(C(=CC(=C2)CCC(=O)CC(CCCCC)O)OC)O)O	IC50 = 77820 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B7ML3F	N-(Methylsulfonyl)-N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)phenyl)methanesulfonamide	Investigative	49805304	C20H26N2O6S2	454.6	CS(=O)(=O)N(C1=CC=CC=C1OC2=CC=C(C=C2)OCCN3CCCC3)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B7WBE6	Methyl (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoate	Investigative	11128579	C11H15NO3	209.24	COC(=O)[C@H]([C@H](CC1=CC=CC=C1)N)O	Ki = 50000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B82YXZ	3-(3-Amino-2-hydroxy-4-phenyl-butyrylamino)-propionic acid	Investigative	15011209	C13H18N2O4	266.29	C1=CC=C(C=C1)C[C@H]([C@@H](C(=O)NCCC(=O)O)O)N	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B90AZM	1-(2-(4-(2-(Methylsulfonyl)phenoxy)phenoxy)ethyl)pyrrolidine	Investigative	49805051	C19H23NO4S	361.5	CS(=O)(=O)C1=CC=CC=C1OC2=CC=C(C=C2)OCCN3CCCC3	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	B9AW4O	1-(3,4-Dimethoxyphenyl)-5-methoxydecan-3-one	Investigative	91721119	C19H30O4	322.4	CCCCCC(CC(=O)CCC1=CC(=C(C=C1)OC)OC)OC	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BB42OT	Glycine, N-[(1-amino-2-phenylethyl)hydroxyphosphinyl]-	Investigative	11777264	C10H15N2O4P	258.209	C1=CC=C(C=C1)CC(N)P(=O)(NCC(=O)O)O	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BC6L0T	3-Amino-2-oxo-4-phenyl-butyric acid methyl ester	Investigative	10104462	C11H13NO3	207.23	COC(=O)C(=O)[C@H](CC1=CC=CC=C1)N	IC50 = 80000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BD27MZ	1-(2-(4-(4-(Methylsulfonyl)-2-nitrophenoxy)phenoxy)ethyl)pyrrolidine	Investigative	49805054	C19H22N2O6S	406.5	CS(=O)(=O)C1=CC(=C(C=C1)OC2=CC=C(C=C2)OCCN3CCCC3)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BE7PD5	1-(2-(4-(2,4-Dinitrophenoxy)phenoxy)ethyl)pyrrolidine	Investigative	49804920	C18H19N3O6	373.4	C1CCN(C1)CCOC2=CC=C(C=C2)OC3=C(C=C(C=C3)[N+](=O)[O-])[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BEA75L	(5R,7S)-7-Amino-5-benzyl-5,7,8,9-tetrahydrobenzo[7]annulen-6-one;hydrochloride	Investigative	66560606	C18H20ClNO	301.8	C1CC2=CC=CC=C2[C@H](C(=O)[C@H]1N)CC3=CC=CC=C3.Cl	Ki ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BENO90	(S)-2-[[(2S,3R)-2-Hydroxy-3-amino-4-phenyl-1-thioxobutyl]amino]-4-methylpentanoic acid	Investigative	14186556	C16H24N2O3S	324.4	CC(C)C[C@@H](C(=O)O)NC(=S)[C@H]([C@@H](CC1=CC=CC=C1)N)O	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BEO4L6	Pyridin-4-yl(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)methanol	Investigative	10732834	C18H22N2O2	298.4	C1CCN(C1)CCOC2=CC=C(C=C2)C(C3=CC=NC=C3)O	IC50 = 170000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BFBX82	(5S,7S)-7-Amino-5-phenylsulfanyl-5,7,8,9-tetrahydrobenzo[7]annulen-6-one;hydrochloride	Investigative	71459163	C17H18ClNOS	319.8	C1CC2=CC=CC=C2[C@@H](C(=O)[C@H]1N)SC3=CC=CC=C3.Cl	Ki ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BI1KF9	2-[5-(Naphthalen-2-ylmethoxy)-1H-indol-3-yl]ethanamine;hydrochloride	Investigative	70051222	C21H21ClN2O	352.9	C1=CC=C2C=C(C=CC2=C1)COC3=CC4=C(C=C3)NC=C4CCN.Cl	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BJX20B	5-Benzyloxytryptamine hydrochloride	Investigative	2828785	C17H19ClN2O	302.8	C1=CC=C(C=C1)COC2=CC3=C(C=C2)NC=C3CCN.Cl	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BJZ2G3	2-[5-[(3-Phenoxyphenyl)methoxy]-1H-indol-3-yl]ethanamine;hydrochloride	Investigative	70052430	C23H23ClN2O2	394.9	C1=CC=C(C=C1)OC2=CC=CC(=C2)COC3=CC4=C(C=C3)NC=C4CCN.Cl	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BLPA50	3-Decanone, 1-(4-hydroxy-3-methoxyphenyl)-5-methoxy-	Investigative	11771257	C18H28O4	308.4	CCCCCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)OC	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BM90LQ	2-(1-Benzyl-5-methoxy-2-methylindol-3-yl)acetamide	Investigative	244154	C19H20N2O2	308.4	CC1=C(C2=C(N1CC3=CC=CC=C3)C=CC(=C2)OC)CC(=O)N	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BM9FT5	2-(3-Amino-2-hydroxy-4-phenyl-thiobutyrylamino)-4-methyl-pentanoic acid	Investigative	10403990	C16H24N2O3S	324.4	CC(C)C[C@@H](C(=O)O)NC(=S)[C@@H]([C@@H](CC1=CC=CC=C1)N)O	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BMA8Z3	(5R,7S)-7-Amino-5-phenylsulfanyl-5,7,8,9-tetrahydrobenzo[7]annulen-6-one;hydrochloride	Investigative	66560602	C17H18ClNOS	319.8	C1CC2=CC=CC=C2[C@H](C(=O)[C@H]1N)SC3=CC=CC=C3.Cl	Ki ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BN1J4F	1-[2-(4-Benzyl-3-methoxy-phenoxy)-ethyl]-pyrrolidine	Investigative	10543074	C20H25NO2	311.4	COC1=C(C=CC(=C1)OCCN2CCCC2)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BOM7V6	(5R,7S)-7-Amino-5-(3-phenylpropyl)-5,7,8,9-tetrahydrobenzo[7]annulen-6-one;hydrochloride	Investigative	66559287	C20H24ClNO	329.9	C1CC2=CC=CC=C2[C@H](C(=O)[C@H]1N)CCCC3=CC=CC=C3.Cl	Ki ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BP7AW9	1-(3,4-Dimethoxyphenyl)-5-hydroxydecan-3-one	Investigative	71391212	C18H28O4	308.4	CCCCCC(CC(=O)CCC1=CC(=C(C=C1)OC)OC)O	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BPO7C9	1-(2-(4-(4-(Methylsulfonyl)phenoxy)phenoxy)ethyl)pyrrolidine	Investigative	49805053	C19H23NO4S	361.5	CS(=O)(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)OCCN3CCCC3	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BPZD51	5-Hydroxy-1-(3-methoxy-4-prop-2-enoxyphenyl)decan-3-one	Investigative	134129959	C20H30O4	334.4	CCCCCC(CC(=O)CCC1=CC(=C(C=C1)OCC=C)OC)O	IC50 = 56270 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BS5D3M	2-[5-[(3-Phenoxyphenyl)methoxy]-1H-indol-3-yl]ethylcarbamic acid	Investigative	71720417	C24H22N2O4	402.4	C1=CC=C(C=C1)OC2=CC=CC(=C2)COC3=CC4=C(C=C3)NC=C4CCNC(=O)O	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BSBJ08	3-Amino-N-benzyl-2-hydroxy-4-phenyl-butyramide	Investigative	44309819	C17H20N2O2	284.35	C1=CC=C(C=C1)C[C@@H]([C@@H](C(=O)NCC2=CC=CC=C2)O)N	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BSG98J	1-(2-(4-(3-(Methylsulfonyl)phenoxy)phenoxy)ethyl)pyrrolidine	Investigative	49805052	C19H23NO4S	361.5	CS(=O)(=O)C1=CC=CC(=C1)OC2=CC=C(C=C2)OCCN3CCCC3	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BTG31D	2-[5-[2-[4-(2-Nitrophenoxy)phenoxy]ethoxy]-1H-indol-3-yl]ethanamine;hydrochloride	Investigative	71569090	C24H24ClN3O5	469.9	C1=CC=C(C(=C1)[N+](=O)[O-])OC2=CC=C(C=C2)OCCOC3=CC4=C(C=C3)NC=C4CCN.Cl	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BUPE05	5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)octan-3-one	Investigative	5317596	C15H22O4	266.33	CCCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)O	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BV3H1X	1-(2-(4-(3-(Trifluoromethyl)phenoxy)phenoxy)ethyl)pyrrolidine	Investigative	49805176	C19H20F3NO2	351.4	C1CCN(C1)CCOC2=CC=C(C=C2)OC3=CC=CC(=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BW02NL	[6]-Gingerol	Investigative	3473	C17H26O4	294.4	CCCCCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)O	IC50 = 56120 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BXG0Y9	3-Amino-1,4-diphenyl-butan-2-ol	Investigative	10331928	C16H19NO	241.33	C1=CC=C(C=C1)C[C@@H]([C@@H](CC2=CC=CC=C2)O)N	IC50 = 140000 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	BZX9D2	(E)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradec-8-en-3-one	Investigative	134130173	C21H32O4	348.5	CCCCC/C=C/CCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)O	IC50 = 67120 nM	Poor binder
T03691	Leukotriene A-4 hydrolase	D04QJY	KELATORPHAN	Investigative	123982	C14H18N2O5	294.3	C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)CC(=O)NO	IC50 ~ 50000 nM	Poor binder