TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T05114	Chymase	B34DKG	[4-[3-(Aminomethyl)phenyl]piperidin-1-yl]-[5-(2-pyridin-2-ylethynyl)furan-2-yl]methanone;2,2,2-trifluoroacetic acid	Investigative	57396788	C26H24F3N3O4	499.5	C1CN(CCC1C2=CC=CC(=C2)CN)C(=O)C3=CC=C(O3)C#CC4=CC=CC=N4.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T05114	Chymase	B4YPJ2	N-{4-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-phenyl}-acetamide	Investigative	10811389	C17H14ClN3O5S	407.8	CC(=O)NC1=CC=C(C=C1)N2CC(=O)N(C2=O)S(=O)(=O)C3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T05114	Chymase	B8ZP6N	[4-(3-Aminomethylphenyl)-piperidin-1-yl]-[5-(2-fluorophenylethynyl)-furan-2-yl]-methanone trifluoroacetate	Investigative	57395169	C27H24F4N2O4	516.5	C1CN(CCC1C2=CC=CC(=C2)CN)C(=O)C3=CC=C(O3)C#CC4=CC=CC=C4F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T05114	Chymase	B9FUP5	1-Phenyl-3-phenylmethanesulfonyl-imidazolidine-2,4-dione	Investigative	10616405	C16H14N2O4S	330.4	C1C(=O)N(C(=O)N1C2=CC=CC=C2)S(=O)(=O)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T05114	Chymase	BAUK64	(S)-Ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazol-3-yl)-6-amino-1-oxohexan-2-ylcarbamate	Investigative	15984063	C26H32N4O5	480.6	CCOC(=O)N[C@@H](CCCCN)C(=O)C1=NOC(=N1)CC2=CC=C(C=C2)OCCC3=CC=CC=C3	Ki ~ 150000 nM	Poor binder
T05114	Chymase	BB8DR9	6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylbutyl)-1,4-diazepane-1-carboxamide	Investigative	44440022	C24H28ClN3O4	457.9	CCCC(C1=CC=CC=C1)NC(=O)N2CC(=O)NCC(C2=O)CC3=C(C=CC(=C3)Cl)OC	IC50 = 69300 nM	Poor binder
T05114	Chymase	BD37PS	6-(5-Chloro-2-methoxybenzyl)-N-benzhydryl-3,7-dioxo-1,4-diazepane-1-carboxamide	Investigative	44440023	C27H26ClN3O4	492	COC1=C(C=C(C=C1)Cl)CC2CNC(=O)CN(C2=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T05114	Chymase	BDK70S	4-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-benzoic acid	Investigative	10572734	C16H11ClN2O6S	394.8	C1C(=O)N(C(=O)N1C2=CC=C(C=C2)C(=O)O)S(=O)(=O)C3=CC=C(C=C3)Cl	IC50 = 100000 nM	Poor binder
T05114	Chymase	BI7MJ1	6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrile	Investigative	44143089	C14H8F4N6	336.25	C1=C(C=C(C=C1F)F)NC2=C3C(=NC(=N2)C#N)N(C=N3)CC(F)F	IC50 = 89125.09 nM	Poor binder
T05114	Chymase	BJ98LI	N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride	Investigative	45263389	C30H29Cl3F2N4O4	653.9	C1=CC(=CC=C1CC2=NC(=NO2)C(=O)[C@H](CCCCN)NC(=O)C3=CC(=C(C=C3)F)F)OCCC4=CC(=C(C=C4)Cl)Cl.Cl	Ki ~ 150000 nM	Poor binder
T05114	Chymase	BM65KC	Methyl 3-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-diazepane-4-carboxamido)propyl)benzoate	Investigative	44440032	C25H28ClN3O6	502	CCC(C1=CC(=CC=C1)C(=O)OC)NC(=O)N2CC(=O)NCC(C2=O)CC3=C(C=CC(=C3)Cl)OC	IC50 = 51400 nM	Poor binder
T05114	Chymase	BMJ1S0	5-Chloro-2-benzothiazolinone	Investigative	603829	C7H4ClNOS	185.63	C1=CC2=C(C=C1Cl)NC(=O)S2	IC50 = 90000 nM	Poor binder
T05114	Chymase	BP56FA	3-[1-(5-Phenylethynyl-furan-2-carbonyl)-piperidin-4-yl]-benzylamine trifluoroacetate	Investigative	10228659	C27H25F3N2O4	498.5	C1CN(CCC1C2=CC=CC(=C2)CN)C(=O)C3=CC=C(O3)C#CC4=CC=CC=C4.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T05114	Chymase	BV6W8D	(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-undecanoylamino]-3-phenyl-propionic acid ethyl ester	Investigative	10697572	C32H43N3O4	533.7	CCCCCCCCC(C(C)(C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC)NC(=O)C2=CC=C(C=C2)C#N	IC50 = 62000 nM	Poor binder
T05114	Chymase	BV85PQ	Brintonamide A	Investigative	145951877	C39H60N6O9	756.9	CC[C@H](C)[C@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)OC)O	IC50 = 101000 nM	Poor binder
T05114	Chymase	BVD2P6	3-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-benzoic acid	Investigative	10739429	C16H11ClN2O6S	394.8	C1C(=O)N(C(=O)N1C2=CC=CC(=C2)C(=O)O)S(=O)(=O)C3=CC=C(C=C3)Cl	IC50 = 65000 nM	Poor binder
T05114	Chymase	BY06LO	6-(5-Chloro-2-methoxybenzyl)-N-benzyl-N-methyl-3,7-dioxo-1,4-diazepane-1-carboxamide	Investigative	44440011	C22H24ClN3O4	429.9	CN(CC1=CC=CC=C1)C(=O)N2CC(=O)NCC(C2=O)CC3=C(C=CC(=C3)Cl)OC	IC50 ~ 100000 nM	Poor binder