TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T06046	Nitric-oxide synthase endothelial	D00STL	Nilotinib	Approved	11957582	C8H17N3O2	187.24	CC(=NCCCC[C@H](C(=O)O)N)N	IC50 = 78000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D0V0NL	Aminoguanidine	Phase 1	2146	CH6N4	74.09	C(=NN)(N)N	IC50 = 72000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B01SRT	N-(1,3-Benzodioxol-5-ylmethyl)-2-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrol-1-yl]-N-methylethanamine	Investigative	57394528	C23H24N6O2	416.5	CC1=CC(=NC(=N1)N2C=CN=C2)C3=CC=CN3CCN(C)CC4=CC5=C(C=C4)OCO5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B06JCU	Quinolinone, 11	Investigative	42618039	C21H15ClFN3O2S	427.9	CC1=C(SC=N1)C(=O)N(CC2=CC(=O)NC3=C2C=CC=C3F)C4=CC=CC=C4Cl	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B09ENW	4-Methyl-N-((2-oxo-1,2-dihydroquinolin-4-yl)methyl)-N-phenylthiazole-5-carboxamide	Investigative	42618037	C21H17N3O2S	375.4	CC1=C(SC=N1)C(=O)N(CC2=CC(=O)NC3=CC=CC=C32)C4=CC=CC=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B0C3GV	CID 11633531	Investigative	11633531	C21H22N6O3S	438.5	C1OC2=C(O1)C=C(C=C2)CNCCCN(CC3=CC=CO3)C4=NC(=NS4)N5C=CN=C5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B0CD8L	4-[[2-Cyclobutyl-7-(dimethylamino)imidazo[4,5-b]pyridin-3-yl]methyl]-7,8-difluoro-1H-quinolin-2-one	Investigative	25211494	C22H21F2N5O	409.4	CN(C)C1=C2C(=NC=C1)N(C(=N2)C3CCC3)CC4=CC(=O)NC5=C4C=CC(=C5F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B0R9SN	N'-[1-[2-(Diethylamino)ethyl]-2-oxo-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	90664839	C20H28Cl2N4OS	443.4	CCN(CC)CCN1C(=O)CCC2=C1C=CC(=C2)N=C(C3=CC=CS3)N.Cl.Cl	IC50 = 73600 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B0UZS4	2-[3-(1,3-Benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]-N,N-dimethylacetamide	Investigative	11532340	C20H25N7O3S	443.5	CN(C)C(=O)CN(CCCNCC1=CC2=C(C=C1)OCO2)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B0VQM5	N'-(3-Piperidin-4-yl-1H-indol-5-yl)thiophene-2-carboximidamide	Investigative	15951340	C18H20N4S	324.4	C1CNCCC1C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N	IC50 = 78100 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B0X5JW	N'-[3-(3-Fluoro-1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide	Investigative	15951407	C19H19FN4S	354.4	CN1CC=C(C(C1)F)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N	IC50 = 143000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B0YXI5	5-Methoxy-2-[2-(4-methoxypyridin-2-yl)ethyl]-1H-imidazo[4,5-b]pyridine	Investigative	10192988	C15H16N4O2	284.31	COC1=CC(=NC=C1)CCC2=NC3=C(N2)C=CC(=N3)OC	IC50 = 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B16DGW	2-[2-(4-Methoxypyridin-2-yl)ethyl]-7-(2-phenylethoxy)-1H-imidazo[4,5-b]pyridine	Investigative	10172593	C22H22N4O2	374.4	COC1=CC(=NC=C1)CCC2=NC3=NC=CC(=C3N2)OCCC4=CC=CC=C4	IC50 = 66069.34 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B19OFG	N-Benzyl-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine	Investigative	11695590	C16H20N6S	328.4	CN(CCCNCC1=CC=CC=C1)C2=NC(=NS2)N3C=CN=C3	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1AG2E	CID 11590027	Investigative	11590027	C19H23N7O3S	429.5	CNC(=O)CN(CCCNCC1=CC2=C(C=C1)OCO2)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1BRE7	n-Methyl-3,4,5,6-tetrahydropyridin-2-amine	Investigative	135458572	C6H12N2	112.17	CN=C1CCCCN1	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1F0QU	CID 11596934	Investigative	11596934	C22H24N6O3	420.5	CC1=CC(=NC(=N1)N2C=CN=C2)C3CCCN3C(=O)CNCC4=CC5=C(C=C4)OCO5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1HN8D	trans Rac-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)pyrrolidin-3-yl)-N2-phenethylethane-1,2-diamine	Investigative	49837388	C21H31N5	353.5	CC1=CC(=NC(=C1)N)C[C@H]2CNC[C@@H]2NCCNCCC3=CC=CC=C3	Ki = 123900 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1IKD6	4-Amino-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinoline-8-carbonitrile	Investigative	44320031	C13H13N3	211.26	C1C[C@H]2[C@@H](C1)C(=NC3=C2C=C(C=C3)C#N)N	IC50 = 54000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1IPL2	4-[(7-Chloro-2-cyclobutylimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one	Investigative	25211493	C20H15ClF2N4O	400.8	C1CC(C1)C2=NC3=C(C=CN=C3N2CC4=CC(=O)NC5=C4C=CC(=C5F)F)Cl	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1JUP2	N'-[1-[2-(Diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazol-5-yl]furan-3-carboximidamide;dihydrochloride	Investigative	62706765	C27H35Cl2N5O2	532.5	CCN(CC)CCN1C2=C(C=C(C=C2)N=C(C3=COC=C3)N)N=C1CC4=CC=C(C=C4)OCC.Cl.Cl	IC50 = 117000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1OZR4	4-(4-{6-[(Thiophene-2-carboximidoyl)-amino]-benzothiazol-2-ylamino}-piperidin-1-ylmethyl)-benzoic acid	Investigative	44430641	C25H25N5O2S2	491.6	C1CN(CCC1NC2=NC3=C(S2)C=C(C=C3)N=C(C4=CC=CS4)N)CC5=CC=C(C=C5)C(=O)O	IC50 = 59000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1PQH6	CID 57394615	Investigative	57394615	C25H24N6O3S	488.6	C1OC2=C(O1)C=C(C=C2)CNCCCN(CC3=CC4=C(C=C3)OC=C4)C5=NC(=NS5)N6C=CN=C6	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1R5NQ	(S)-3-(2-Acetimidoylamino-ethanesulfinyl)-2-amino-propionic acid	Investigative	44370736	C7H15N3O3S	221.28	CC(=NCCS(=O)C[C@H](C(=O)O)N)N	IC50 = 155000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1S8UO	7,8-Difluoro-4-((2-(thiazol-5-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one	Investigative	24782146	C20H12F2N4OS	394.4	C1=CC=C2C(=C1)N=C(N2CC3=CC(=O)NC4=C3C=CC(=C4F)F)C5=CN=CS5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1S9ZL	4-[(2-Cyclobutylimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one	Investigative	25211376	C20H16F2N4O	366.4	C1CC(C1)C2=NC3=C(N2CC4=CC(=O)NC5=C4C=CC(=C5F)F)N=CC=C3	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1SI2X	N'-(1-Piperidin-4-yl-2,3-dihydroindol-6-yl)thiophene-2-carboximidamide	Investigative	56950186	C18H22N4S	326.5	C1CNCCC1N2CCC3=C2C=C(C=C3)N=C(C4=CC=CS4)N	IC50 = 99000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1TJ0N	Quinolinone, 13	Investigative	42618041	C21H15ClFN3O2S	427.9	CC1=C(SC=N1)C(=O)N(CC2=CC(=O)NC3=C2C=CC=C3F)C4=CC=C(C=C4)Cl	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1VA0P	(2R)-2-Amino-2-[2-(diaminomethylideneamino)ethylsulfanylmethyl]butanoic acid;dihydrochloride	Investigative	134133362	C8H20Cl2N4O2S	307.24	CC[C@](CSCCN=C(N)N)(C(=O)O)N.Cl.Cl	IC50 = 78000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B1XZ9N	CID 11575808	Investigative	11575808	C18H20N10O2S	440.5	C1OC2=C(O1)C=C(C=C2)CNCCCN(CC3=NNN=N3)C4=NC(=NS4)N5C=CN=C5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B2CW5G	N'-[1-(1-Methylpyrrolidin-3-yl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	90664855	C20H28Cl2N4S	427.4	CN1CCC(C1)N2CCCCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N.Cl.Cl	IC50 = 60500 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B2H1AZ	N-[(2-Oxo-1H-quinolin-4-yl)methyl]-N-phenylfuran-2-carboxamide	Investigative	1375038	C21H16N2O3	344.4	C1=CC=C(C=C1)N(CC2=CC(=O)NC3=CC=CC=C32)C(=O)C4=CC=CO4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B2H8YZ	CID 57401588	Investigative	57401588	C18H22N6O2S	386.5	CN(CCCNCCC1=CC2=C(C=C1)OCO2)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B2PM4U	1-[4-(Aminomethyl)benzoyl]-5'-fluoro-1'H-spiro[piperidine-4,2'-quinazolin]-4'-amine	Investigative	24894149	C20H22FN5O	367.4	C1CN(CCC12NC3=C(C(=CC=C3)F)C(=N2)N)C(=O)C4=CC=C(C=C4)CN	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B2X1TE	Ethyl N'-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]carbamimidothioate;dihydrochloride	Investigative	90664975	C17H24Cl2N4S	387.4	CCSC(=NC1=CC2=C(C=C1)NC=C2C3=CCN(CC3)C)N.Cl.Cl	IC50 = 105200 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B30TFI	7,8-Difluoro-4-((2-(4-methylpyridin-3-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one	Investigative	24782649	C23H16F2N4O	402.4	CC1=C(C=NC=C1)C2=NC3=CC=CC=C3N2CC4=CC(=O)NC5=C4C=CC(=C5F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B36FAQ	1-Methyl-2-piperidinimine	Investigative	12449028	C6H12N2	112.17	CN1CCCCC1=N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B3FXE9	4-[(2-Cyclobutyl-7-methylimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one	Investigative	25211378	C21H18F2N4O	380.4	CC1=C2C(=NC=C1)N(C(=N2)C3CCC3)CC4=CC(=O)NC5=C4C=CC(=C5F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B3H1UM	CID 57403339	Investigative	57403339	C25H29N7O2S	491.6	CN(C)C1=CC=C(C=C1)CN(CCCNCC2=CC3=C(C=C2)OCO3)C4=NC(=NS4)N5C=CN=C5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B3J2FU	7,8-Difluoro-4-((2-isobutyl-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one	Investigative	24782142	C21H19F2N3O	367.4	CC(C)CC1=NC2=CC=CC=C2N1CC3=CC(=O)NC4=C3C=CC(=C4F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B3WO6V	2-Methyl-octahydro-benzo[b][1,4]thiazepin-(4E)-ylideneamine	Investigative	44396192	C10H18N2S	198.33	CC1CC(=NC2CCCCC2S1)N	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B43BSD	[{3-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-propyl}-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-amino]-acetic acid	Investigative	11495366	C18H20N6O4S	416.5	C1OC2=C(O1)C=C(C=C2)CNCCCN(CC(=O)O)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B43FJQ	N'-[4-(Dimethylamino)phenyl]ethanimidamide;dihydrobromide	Investigative	45261151	C10H17Br2N3	339.07	CC(=NC1=CC=C(C=C1)N(C)C)N.Br.Br	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B47BWS	6-Methyl-[1,4]thiazepan-(5E)-ylideneamine	Investigative	18721729	C6H12N2S	144.24	CC1CSCCN=C1N	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B47GMO	4-(2-Acetimidoylamino-ethoxy)-2-amino-butyric acid	Investigative	44370705	C8H17N3O3	203.24	CC(=NCCOCCC(C(=O)O)N)N	IC50 = 72000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B48ZQV	Chembl1957350	Investigative	15951196	C19H20N4O	320.4	CN1CCC(=CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CO4)N	IC50 = 54000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B4FO3X	(3As,9bR)-3a-Fluoro-7-methylaminomethyl-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	Investigative	44377152	C14H18FN3	247.31	CNCC1=CC2=C(C=C1)[C@H]3CCC[C@]3(C(=N2)N)F	IC50 = 66000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B4K8BL	N'-[3-(1-Benzoylpiperidin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide	Investigative	15951269	C25H24N4OS	428.6	C1CN(CCC1C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N)C(=O)C5=CC=CC=C5	IC50 = 50900 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B4KQ3U	4-Propyl-pyrrolidin-(2Z)-ylideneamine	Investigative	18983434	C7H14N2	126.2	CCCC1CC(=NC1)N	IC50 = 53000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B4MQZ8	(2S)-2-Amino-6-(1-aminoethylideneamino)-5,5-difluorohexanoic acid;dihydrochloride	Investigative	45263011	C8H17Cl2F2N3O2	296.14	CC(=NCC(CC[C@@H](C(=O)O)N)(F)F)N.Cl.Cl	IC50 = 57500 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B4W6MG	N-(1,3-Benzodioxol-5-ylmethyl)-N'-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)propan-2-yl]ethane-1,2-diamine	Investigative	11524048	C21H26N6O2	394.5	CC1=CC(=NC(=N1)N2C=CN=C2)C(C)(C)NCCNCC3=CC4=C(C=C3)OCO4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B4ZLK3	Chembl2203711	Investigative	71486408	C18H24Cl2N4S	399.4	C1CC(CNC1)N2CCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N.Cl.Cl	IC50 = 52200 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B52WXY	8-Fluoro-4-[[2-(2-methylpropyl)imidazo[4,5-b]pyrazin-3-yl]methyl]-1H-quinolin-2-one	Investigative	25211804	C19H18FN5O	351.4	CC(C)CC1=NC2=NC=CN=C2N1CC3=CC(=O)NC4=C3C=CC=C4F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B57OZF	1400W Dihydrochloride	Investigative	2733515	C10H17Cl2N3	250.17	CC(=NCC1=CC=CC(=C1)CN)N.Cl.Cl	Ki = 75000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B58UDC	CID 11523510	Investigative	11523510	C18H21N7S	367.5	CN(CCCNCC1=CC2=C(C=C1)NC=C2)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B5WDR2	(S)-6-Acetimidoylamino-2-(S)-amino-5-fluoro-hexanoic acid	Investigative	9815642	C8H16FN3O2	205.23	CC(=NC[C@H](CC[C@@H](C(=O)O)N)F)N	IC50 = 81000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B64SJR	N'-[3-[4-(Dimethylamino)cyclohexen-1-yl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	Investigative	57384807	C21H25ClN4S	401	CN(C)C1CCC(=CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N.Cl	IC50 = 51400 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B65VDM	N'-[3-(1-Ethylpiperidin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide	Investigative	15951197	C20H24N4S	352.5	CCN1CCC(CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N	IC50 = 57300 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B69AMD	6,7-Dihydro-5H-cyclopenta[b]pyridin-2-amine	Investigative	10103217	C8H10N2	134.18	C1CC2=C(C1)N=C(C=C2)N	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B6GZ5C	N'-[3-(1-Azabicyclo[2.2.2]octan-3-yl)-1H-indol-5-yl]furan-2-carboximidamide	Investigative	15951405	C20H22N4O	334.4	C1CN2CCC1C(C2)C3=CNC4=C3C=C(C=C4)N=C(C5=CC=CO5)N	IC50 = 66000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B6JFO5	6-Butyl-2-[2-(4-methoxypyridin-2-yl)ethyl]-1H-imidazo[4,5-b]pyridine	Investigative	56669739	C18H22N4O	310.4	CCCCC1=CC2=C(N=C1)N=C(N2)CCC3=NC=CC(=C3)OC	IC50 = 87096.36 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B6KIG8	N'-[1-[2-(Dimethylamino)ethyl]-8-fluoro-2-oxo-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	90664970	C18H23Cl2FN4OS	433.4	CN(C)CCN1C(=O)CCC2=C1C(=CC(=C2)N=C(C3=CC=CS3)N)F.Cl.Cl	IC50 = 194000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B6L0NS	(2R)-2-Amino-3-[2-(diaminomethylideneamino)ethylsulfanyl]-2-methylpropanoic acid;dihydrochloride	Investigative	134150762	C7H18Cl2N4O2S	293.21	C[C@](CSCCN=C(N)N)(C(=O)O)N.Cl.Cl	IC50 = 77000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B6LK2G	2-[(4-Methoxypyridin-2-yl)methylsulfanyl]-1H-imidazo[4,5-b]pyridine	Investigative	13768254	C13H12N4OS	272.33	COC1=CC(=NC=C1)CSC2=NC3=C(N2)C=CC=N3	IC50 = 53703.18 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B6MBY1	N'-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]thiophene-2-carboximidamide	Investigative	15951195	C18H22N4S	326.5	CN(C)CCC1=CNC2=C1C=C(C=C2)CN=C(C3=CC=CS3)N	IC50 = 86200 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B6VC7Q	N',N'-Dibenzyl-6-(4-methoxyphenyl)pteridine-2,4-diamine	Investigative	10575453	C27H24N6O	448.5	COC1=CC=C(C=C1)C2=CN=C3C(=N2)C(=NC(=N3)N)N(CC4=CC=CC=C4)CC5=CC=CC=C5	IC50 = 160000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B6WQ5E	Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1-carboxylate	Investigative	11161781	C14H21N3O3	279.33	CCOC(=O)N1CCC(CC1)NC2=NC=CC(=C2)OC	IC50 = 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B79KRQ	(3Ar,9bS)-7-[2-(methylamino)ethoxy]-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-amine;dihydrochloride	Investigative	45264324	C15H23Cl2N3O	332.3	CNCCOC1=CC2=C(C=C1)[C@H]3CCC[C@H]3C(=N2)N.Cl.Cl	IC50 = 52000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B7FE2C	N'-[4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)phenyl]ethanimidamide;dihydrobromide	Investigative	45261194	C18H23Br2N3	441.2	CC(=NC1=CC=C(C=C1)CN2CCC3=CC=CC=C3C2)N.Br.Br	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B7FO1U	CID 57394614	Investigative	57394614	C23H24N6O3S	464.5	C1OC2=C(O1)C=C(C=C2)CNCCCN(CC3=CC=C(C=C3)O)C4=NC(=NS4)N5C=CN=C5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B7QL9T	N'-[1-[2-(1-Methylpyrrolidin-2-yl)ethyl]-2-oxo-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	76033629	C21H28Cl2N4OS	455.4	CN1CCCC1CCN2C(=O)CCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N.Cl.Cl	IC50 = 68900 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B7UBL9	N'-[1-[2-[2-Hydroxyethyl(methyl)amino]ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	57341143	C19H28Cl2N4OS	431.4	CN(CCN1CCCC2=C1C=CC(=C2)N=C(C3=CC=CS3)N)CCO.Cl.Cl	IC50 = 63900 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B7Z9RS	4-((2-Tert-Butyl-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one	Investigative	24785966	C21H19F2N3O	367.4	CC(C)(C)C1=NC2=CC=CC=C2N1CC3=CC(=O)NC4=C3C=CC(=C4F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B7ZQB3	6-(4-Methoxyphenyl)-4-N,4-N-dipropyl-5,6,7,8-tetrahydropteridine-2,4-diamine	Investigative	10948273	C19H28N6O	356.5	CCCN(CCC)C1=NC(=NC2=C1NC(CN2)C3=CC=C(C=C3)OC)N	IC50 = 54640 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B83QJS	Quinolinone, 8	Investigative	42618036	C21H15FN2O3	362.4	C1=CC=C(C=C1)N(CC2=CC(=O)NC3=C2C=CC=C3F)C(=O)C4=CC=CO4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B83WDF	1-Amino-3-phenyl-8-fluoro-3,4-dihydroisoquinoline	Investigative	9873870	C15H13FN2	240.27	C1C(N=C(C2=C1C=CC=C2F)N)C3=CC=CC=C3	IC50 = 80000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B8B3US	N-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methyl]-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine	Investigative	57396367	C17H18F2N6O2S	408.4	CN(CCCNCC1=CC2=C(C=C1)OC(O2)(F)F)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B8J6QA	4-(4-Ethoxy-pyridin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester	Investigative	11369870	C15H23N3O3	293.36	CCOC1=CC(=NC=C1)NC2CCN(CC2)C(=O)OCC	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B8POT1	N-[2-[1,3-Benzodioxol-5-ylmethyl(methyl)amino]ethyl]-2-imidazol-1-yl-6-methylpyrimidine-4-carboxamide	Investigative	57401590	C20H22N6O3	394.4	CC1=CC(=NC(=N1)N2C=CN=C2)C(=O)NCCN(C)CC3=CC4=C(C=C3)OCO4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B8Q5SL	N'-[4-[2-(1-Methylpyrrolidin-2-yl)ethyl]-3-oxo-1,4-benzoxazin-7-yl]thiophene-2-carboximidamide	Investigative	44599931	C20H24N4O2S	384.5	CN1CCCC1CCN2C(=O)COC3=C2C=CC(=C3)N=C(C4=CC=CS4)N	IC50 = 87200 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B8S0VO	N'-[1-(2-Piperidin-1-ylethyl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	90664849	C22H32Cl2N4S	455.5	C1CCN(CC1)CCN2CCCCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N.Cl.Cl	IC50 = 56300 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B8WYI7	CID 11496223	Investigative	11496223	C20H21N7O2S2	455.6	C1OC2=C(O1)C=C(C=C2)CNCCCN(CC3=NC=CS3)C4=NC(=NS4)N5C=CN=C5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B91YOS	4-(4'-Amino-1'-ethyl-5'-fluorospiro[piperidine-4,2'-quinazoline]-1-carbonyl)benzonitrile	Investigative	24894150	C22H22FN5O	391.4	CCN1C2=C(C(=CC=C2)F)C(=NC13CCN(CC3)C(=O)C4=CC=C(C=C4)C#N)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B9GHC5	N'-[3-[3-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	Investigative	70686000	C20H25ClN4S	389	CNC1CCCC(C1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N.Cl	IC50 = 75000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B9GKU3	3,4-Dimethoxy-2-(methylsulfanylmethyl)pyridine	Investigative	56679900	C9H13NO2S	199.27	COC1=C(C(=NC=C1)CSC)OC	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B9GRH5	Quinolinone, 35	Investigative	42618062	C21H16ClN3O2S	409.9	CC1=C(SC=N1)C(=O)N(CC2=CC(=O)NC3=CC=CC=C32)C4=CC(=CC=C4)Cl	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B9HMS4	4-[(2-Cyclopentylbenzimidazol-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one	Investigative	24785698	C22H19F2N3O	379.4	C1CCC(C1)C2=NC3=CC=CC=C3N2CC4=CC(=O)NC5=C4C=CC(=C5F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	B9X4IJ	N-(1,3-Benzodioxol-5-ylmethyl)-2-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrolidin-1-yl]acetamide	Investigative	11582528	C22H24N6O3	420.5	CC1=CC(=NC(=N1)N2C=CN=C2)C3CCCN3CC(=O)NCC4=CC5=C(C=C4)OCO5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BA02KT	6-(4-Chloro-phenyl)-N*4*,N*4*-diethyl-5,6,7,8-tetrahydro-pteridine-2,4-diamine	Investigative	9819003	C16H21ClN6	332.8	CCN(CC)C1=NC(=NC2=C1NC(CN2)C3=CC=C(C=C3)Cl)N	IC50 = 56660 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BA2N9I	7,8-Difluoro-4-((2-isopentyl-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one	Investigative	24785697	C22H21F2N3O	381.4	CC(C)CCC1=NC2=CC=CC=C2N1CC3=CC(=O)NC4=C3C=CC(=C4F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BA3Q5S	Chembl1957354	Investigative	15951198	C19H22N4O	322.4	CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CO4)N	IC50 = 97400 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BA9S2V	Ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate	Investigative	11357119	C13H19N3O2	249.31	CCOC(=O)N1CCC(CC1)NC2=CC=CC=N2	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BAI10C	N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-2-methylnicotinamide	Investigative	42618047	C23H17ClFN3O2	421.8	CC1=C(C=CC=N1)C(=O)N(CC2=CC(=O)NC3=C2C=CC=C3F)C4=CC(=CC=C4)Cl	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BAU68G	Hexahydro-indolizin-(3E)-ylideneamine	Investigative	44393481	C8H14N2	138.21	C1CCN2C(C1)CCC2=N	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BAW8C9	4-[[2-(3,3-Difluorocyclobutyl)imidazo[4,5-b]pyrazin-3-yl]methyl]-8-fluoro-1H-quinolin-2-one	Investigative	49837170	C19H14F3N5O	385.3	C1C(CC1(F)F)C2=NC3=NC=CN=C3N2CC4=CC(=O)NC5=C4C=CC=C5F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BAX57C	Quinolinone, 16	Investigative	42618044	C22H18FN3O2S	407.5	CC1=CC(=CC=C1)N(CC2=CC(=O)NC3=C2C=CC=C3F)C(=O)C4=C(N=CS4)C	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BB09ES	N'-(1-Piperidin-4-yl-3,4-dihydro-2H-quinolin-6-yl)thiophene-2-carboximidamide;dihydrochloride	Investigative	90665208	C19H26Cl2N4S	413.4	C1CC2=C(C=CC(=C2)N=C(C3=CC=CS3)N)N(C1)C4CCNCC4.Cl.Cl	IC50 = 119000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BB3EH2	5-[4-[(4-Methoxypyridin-2-yl)amino]piperidine-1-carbonyl]pyridine-2-carbonitrile	Investigative	56659435	C18H19N5O2	337.4	COC1=CC(=NC=C1)NC2CCN(CC2)C(=O)C3=CN=C(C=C3)C#N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BBJ16P	2-[4-(1-Aminoethylideneamino)phenyl]acetic acid;hydrobromide	Investigative	45261155	C10H13BrN2O2	273.13	CC(=NC1=CC=C(C=C1)CC(=O)O)N.Br	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BBL13V	(2S)-2-Amino-6-(1-aminoethylideneamino)-N-(2H-tetrazol-5-yl)hexanamide	Investigative	9881505	C9H18N8O	254.29	CC(=NCCCC[C@@H](C(=O)NC1=NNN=N1)N)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BBUN85	N'-[1-[3-(Dimethylamino)propyl]-2-oxo-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	90664841	C19H26Cl2N4OS	429.4	CN(C)CCCN1C(=O)CCC2=C1C=CC(=C2)N=C(C3=CC=CS3)N.Cl.Cl	IC50 = 154000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BBY90N	4-[(2-Cyclobutylimidazo[4,5-c]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one	Investigative	49837063	C20H16F2N4O	366.4	C1CC(C1)C2=NC3=C(N2CC4=CC(=O)NC5=C4C=CC(=C5F)F)C=NC=C3	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BC0GV2	CID 11631971	Investigative	11631971	C16H18F2N6S	364.4	CN(CCCNCC1=CC(=C(C=C1)F)F)C2=NC(=NS2)N3C=CN=C3	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BC10FV	4-Methyl-6-[2-[3-[3-(methylamino)propyl]-5-(trifluoromethyl)phenyl]ethyl]pyridin-2-amine	Investigative	137633546	C19H24F3N3	351.4	CC1=CC(=NC(=C1)N)CCC2=CC(=CC(=C2)CCCNC)C(F)(F)F	Ki = 51542 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BC3F2L	2-(1,3-Benzodioxol-5-ylmethylamino)-N-[(2-imidazol-1-yl-6-methylpyrimidin-4-yl)methyl]acetamide	Investigative	11596038	C19H20N6O3	380.4	CC1=CC(=NC(=N1)N2C=CN=C2)CNC(=O)CNCC3=CC4=C(C=C3)OCO4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BC49FZ	4-((2-(Cyclopentylmethyl)-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one	Investigative	24785426	C23H21F2N3O	393.4	C1CCC(C1)CC2=NC3=CC=CC=C3N2CC4=CC(=O)NC5=C4C=CC(=C5F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BC7Y5U	Tetrahydro-pyrrolo[1,2-c]thiazol-(3Z)-ylideneamine	Investigative	44393485	C6H10N2S	142.22	C1CC2CSC(=N)N2C1	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BCDT71	N-[2-(1,3-Benzodioxol-5-ylmethoxy)ethyl]-1-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)ethanamine	Investigative	11589024	C20H23N5O3	381.4	CC1=CC(=NC(=N1)N2C=CN=C2)C(C)NCCOCC3=CC4=C(C=C3)OCO4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BCIE90	N'-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]ethanimidamide;dihydrobromide	Investigative	45261197	C11H14Br2N4S	394.13	CC(=NC1=CC=C(C=C1)C2=CSC(=N2)N)N.Br.Br	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BCS5M1	5-Methyloxazolo[5,4-b]pyridin-2-ol	Investigative	44329820	C7H6N2O2	150.13	CC1=NC2=C(C=C1)NC(=O)O2	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BCUA54	5-Fluorobenzo[d]oxazol-2(3H)-one	Investigative	287208	C7H4FNO2	153.11	C1=CC2=C(C=C1F)NC(=O)O2	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BD0BZ7	N-(1,3-Benzodioxol-5-ylmethyl)-4-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)butan-1-amine	Investigative	57392807	C20H23N5O2	365.4	CC1=CC(=NC(=N1)N2C=CN=C2)CCCCNCC3=CC4=C(C=C3)OCO4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BD18UV	N-(3-Chlorophenyl)-N-((5-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylthiazole-5-carboxamide	Investigative	42618065	C21H15ClFN3O2S	427.9	CC1=C(SC=N1)C(=O)N(CC2=CC(=O)NC3=C2C(=CC=C3)F)C4=CC(=CC=C4)Cl	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BD63ZE	Ethyl 4-[(4-chloropyridin-2-yl)amino]piperidine-1-carboxylate	Investigative	24894151	C13H18ClN3O2	283.75	CCOC(=O)N1CCC(CC1)NC2=NC=CC(=C2)Cl	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BD80ET	(3R)-3-(1,2,3,4-Tetrahydroisoquinolin-6-yloxymethyl)-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine	Investigative	49864405	C17H19N3O2S	329.4	C1CNCC2=C1C=C(C=C2)OC[C@@H]3COC4=C(C(=N3)N)SC=C4	IC50 = 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BDG64R	4-Acetimidoylamino-Benzoic Acid HCl	Investigative	45264759	C9H11ClN2O2	214.65	CC(=NC1=CC=C(C=C1)C(=O)O)N.Cl	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BDIE60	N-[2-(1,3-Benzodioxol-5-yl)ethyl]-2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrolidine-1-carboxamide	Investigative	11531856	C22H24N6O3	420.5	CC1=CC(=NC(=N1)N2C=CN=C2)C3CCCN3C(=O)NCCC4=CC5=C(C=C4)OCO5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BDQY75	5-Methyl-4,5-dihydro-1,3-thiazol-2-amine	Investigative	544920	C4H8N2S	116.19	CC1CN=C(S1)N	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BE72MO	N'-[1-[2-(Dimethylamino)ethyl]-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	67493358	C19H28Cl2N4S	415.4	CN(C)CCN1CCCCC2=C1C=CC(=C2)N=C(C3=CC=CS3)N.Cl.Cl	IC50 = 99100 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BE7J9W	N'-(1-Piperidin-4-yl-2,3,4,5-tetrahydro-1-benzazepin-7-yl)thiophene-2-carboximidamide;dihydrochloride	Investigative	90664346	C20H28Cl2N4S	427.4	C1CCN(C2=C(C1)C=C(C=C2)N=C(C3=CC=CS3)N)C4CCNCC4.Cl.Cl	IC50 = 66200 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BE84VZ	N'-[1-(Oxan-4-yl)-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide	Investigative	56949934	C18H21N3OS	327.4	C1COCCC1N2CCC3=C2C=C(C=C3)N=C(C4=CC=CS4)N	IC50 = 84800 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BEDR71	CID 57396371	Investigative	57396371	C22H23N7O2S	449.5	C1OC2=C(O1)C=C(C=C2)CNCCCN(CC3=CN=CC=C3)C4=NC(=NS4)N5C=CN=C5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BF4Q8Z	Quinolinone, 38	Investigative	42618064	C21H15ClFN3O2S	427.9	CC1=C(SC=N1)C(=O)N(CC2=CC(=O)NC3=C2C=C(C=C3)F)C4=CC(=CC=C4)Cl	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BF6TQ4	1-Amino-3-(4-fluorophenyl)-7-fluoro-3,4-dihydroisoquinoline	Investigative	18785796	C15H12F2N2	258.269	C1C(N=C(C2=C1C=CC(=C2)F)N)C3=CC=C(C=C3)F	IC50 = 55000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BFHT29	CID 11654166	Investigative	11654166	C19H22N6O2S	398.5	C1CC1N(CCCNCC2=CC3=C(C=C2)OCO3)C4=NC(=NS4)N5C=CN=C5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BFM6C1	(S)-3-(3-Acetimidoylamino-propoxy)-2-amino-propionic acid	Investigative	44370662	C8H17N3O3	203.24	CC(=NCCCOC[C@@H](C(=O)O)N)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BG7ZH0	N'-[(3S,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[[3-(trifluoromethyl)phenyl]methyl]ethane-1,2-diamine	Investigative	25209995	C21H28F3N5	407.5	CC1=CC(=NC(=C1)N)C[C@H]2CNC[C@H]2NCCNCC3=CC(=CC=C3)C(F)(F)F	Ki = 116000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BGLE51	(R)-3-(3-Acetimidoylamino-propylsulfanyl)-2-amino-propionic acid	Investigative	44370689	C8H17N3O2S	219.31	CC(=NCCCSC[C@@H](C(=O)O)N)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BGO6Z9	N'-[1-[2-(Diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazol-5-yl]ethanimidamide;dihydrochloride	Investigative	62706766	C24H35Cl2N5O	480.5	CCN(CC)CCN1C2=C(C=C(C=C2)N=C(C)N)N=C1CC3=CC=C(C=C3)OCC.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BH0TY9	N'-(1-Cyclohexyl-2,3-dihydroindol-6-yl)thiophene-2-carboximidamide	Investigative	56949933	C19H23N3S	325.5	C1CCC(CC1)N2CCC3=C2C=C(C=C3)N=C(C4=CC=CS4)N	IC50 = 109000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BH35YB	4-Methyl-6-(2-(5-(4-Methylpiperazin-1-Yl)pyridin-3-Yl)ethyl)pyridin-2-Amine	Investigative	119057273	C18H25N5	311.4	CC1=CC(=NC(=C1)N)CCC2=CC(=CN=C2)N3CCN(CC3)C	Ki = 73006 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BH4QW3	[{3-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-propyl}-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-amino]-acetonitrile	Investigative	11625423	C18H19N7O2S	397.5	C1OC2=C(O1)C=C(C=C2)CNCCCN(CC#N)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BH5DV3	6-(2-{3-[3-(Dimethylamino)propyl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-amine	Investigative	130449158	C19H26FN3	315.4	CC1=CC(=NC(=C1)N)CCC2=CC(=CC(=C2)CCCN(C)C)F	Ki = 83976 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BH7B8T	7,8-Difluoro-4-((2-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one	Investigative	49836941	C22H14F2N4O	388.4	C1=CC=C2C(=C1)N=C(N2CC3=CC(=O)NC4=C3C=CC(=C4F)F)C5=CC=CC=N5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BH9B5V	N-Iminoethyl-L-lysine dihydrochloride	Investigative	2733505	C8H19Cl2N3O2	260.16	CC(=NCCCC[C@@H](C(=O)O)N)N.Cl.Cl	IC50 = 138000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BHEK71	CID 11703771	Investigative	11703771	C18H24N6O2S	388.5	CN(CCCNCC1=CC(=C(C=C1)OC)OC)C2=NC(=NS2)N3C=CN=C3	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BHMF80	(2R)-2-Amino-3-[2-(diaminomethylideneamino)ethylsulfinyl]-2-methylpropanoic acid;dihydrochloride	Investigative	134154591	C7H18Cl2N4O3S	309.21	C[C@](CS(=O)CCN=C(N)N)(C(=O)O)N.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BI04BN	[4-(4-Methoxy-pyridin-2-ylamino)-piperidin-1-yl]-phenyl-methanone	Investigative	11426929	C18H21N3O2	311.4	COC1=CC(=NC=C1)NC2CCN(CC2)C(=O)C3=CC=CC=C3	IC50 = 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BI0SB9	CID 11639946	Investigative	11639946	C19H24N6O2S	400.5	CCCN(CCCNCC1=CC2=C(C=C1)OCO2)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BI18KW	N'-[3-(8-Methyl-8-azabicyclo[3.2.1]oct-3-en-3-yl)-1H-indol-5-yl]thiophene-2-carboximidamide	Investigative	15951270	C21H22N4S	362.5	CN1C2CCC1C=C(C2)C3=CNC4=C3C=C(C=C4)N=C(C5=CC=CS5)N	IC50 = 67900 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BI1XR9	4-Propyl-2-piperidinimine	Investigative	10655660	C8H16N2	140.23	CCCC1CCN=C(C1)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BI46CF	2-[2-(4-Methoxypyridin-2-yl)ethyl]-6-bromo-3H-imidazo[4,5-b]pyridine	Investigative	10308710	C14H13BrN4O	333.18	COC1=CC(=NC=C1)CCC2=NC3=C(N2)C=C(C=N3)Br	IC50 = 87096.36 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BIK96Z	4-(2-Acetimidoylamino-ethanesulfonyl)-2-amino-butyric acid	Investigative	44370690	C8H17N3O4S	251.31	CC(=NCCS(=O)(=O)CCC(C(=O)O)N)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BIS90H	2-Amino-3-[2-(diaminomethylideneamino)ethylsulfanyl]-2-methylpropanoic acid;2,2,2-trifluoroacetic acid	Investigative	134150121	C11H18F6N4O6S	448.34	CC(CSCCN=C(N)N)(C(=O)O)N.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BIU63T	Hexahydro-thiazolo[3,4-a]pyridin-(3Z)-ylideneamine	Investigative	44393495	C7H12N2S	156.25	C1CCN2C(C1)CSC2=N	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BJ6R2U	8-Trifluoromethyl-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	Investigative	44320084	C13H13F3N2	254.25	C1C[C@H]2[C@@H](C1)C(=NC3=C2C=C(C=C3)C(F)(F)F)N	IC50 = 57000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BJ70PT	7-Acetimidoylamino-2-amino-heptanoic acid	Investigative	22133392	C9H19N3O2	201.27	CC(=NCCCCCC(C(=O)O)N)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BK1WB9	6-Cyclohexyl-2-piperidinimine	Investigative	10822632	C11H20N2	180.29	C1CCC(CC1)C2CCCC(=N2)N	IC50 = 142000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BK30PR	N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)thiazole-5-carboxamide	Investigative	42618046	C20H13ClFN3O2S	413.9	C1=CC(=CC(=C1)Cl)N(CC2=CC(=O)NC3=C2C=CC=C3F)C(=O)C4=CN=CS4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BK5NQ0	N'-[3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl]furan-2-carboximidamide;dihydrochloride	Investigative	90664727	C19H24Cl2N4O	395.3	CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CO4)N.Cl.Cl	IC50 = 97400 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BK9X1B	N'-(1-Pyrrolidin-3-yl-2,3,4,5-tetrahydro-1-benzazepin-7-yl)thiophene-2-carboximidamide;dihydrochloride	Investigative	90664347	C19H26Cl2N4S	413.4	C1CCN(C2=C(C1)C=C(C=C2)N=C(C3=CC=CS3)N)C4CCNC4.Cl.Cl	IC50 = 75000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BL05JC	N'-(4-Nitrophenyl)ethanimidamide;hydrochloride	Investigative	45264695	C8H10ClN3O2	215.64	CC(=NC1=CC=C(C=C1)[N+](=O)[O-])N.Cl	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BL59PB	(3As,9bR)-3a-Fluoro-7-(2-methylamino-ethyl)-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	Investigative	10220855	C15H20FN3	261.339	CNCCC1=CC2=C(C=C1)[C@H]3CCC[C@]3(C(=N2)N)F	IC50 = 79000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BL96IZ	Methyl 2-[4-(1-aminoethylideneamino)phenyl]acetate;hydrochloride	Investigative	45261160	C11H15ClN2O2	242.7	CC(=NC1=CC=C(C=C1)CC(=O)OC)N.Cl	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BL9XD8	CID 11561546	Investigative	11561546	C21H22N6O2S2	454.6	C1OC2=C(O1)C=C(C=C2)CNCCCN(CC3=CC=CS3)C4=NC(=NS4)N5C=CN=C5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BLQ51X	Chembl1957358	Investigative	15951268	C17H22N4S	314.5	CCSC(=NC1=CC2=C(C=C1)NC=C2C3=CCN(CC3)C)N	IC50 = 105000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BLQ75H	N'-[1-[2-(Diethylamino)ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	90664722	C20H30Cl2N4S	429.4	CCN(CC)CCN1CCCC2=C1C=CC(=C2)N=C(C3=CC=CS3)N.Cl.Cl	IC50 = 64400 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BLT46D	3-[3-(1-Iminoethylamino)propylsulfonyl]-L-alanine	Investigative	44370661	C8H17N3O4S	251.31	CC(=NCCCS(=O)(=O)C[C@@H](C(=O)O)N)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BM30LP	5-Methyl-3,4,5,6-tetrahydropyridin-2-amine	Investigative	15453846	C6H12N2	112.17	CC1CCC(=NC1)N	IC50 = 58000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BM97KS	4-[[2-Cyclobutyl-7-(trifluoromethyl)imidazo[4,5-b]pyridin-3-yl]methyl]-7,8-difluoro-1H-quinolin-2-one	Investigative	25211597	C21H15F5N4O	434.4	C1CC(C1)C2=NC3=C(C=CN=C3N2CC4=CC(=O)NC5=C4C=CC(=C5F)F)C(F)(F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BMW32Y	7,8-Difluoro-4-((2-(pyridin-3-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one	Investigative	24782902	C22H14F2N4O	388.4	C1=CC=C2C(=C1)N=C(N2CC3=CC(=O)NC4=C3C=CC(=C4F)F)C5=CN=CC=C5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BN84KM	Quinolinone, 36	Investigative	42618060	C21H15Cl2N3O2S	444.3	CC1=C(SC=N1)C(=O)N(CC2=CC(=O)NC3=C2C=CC=C3Cl)C4=CC(=CC=C4)Cl	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BN9HA4	Quinolinone, 25	Investigative	42618053	C22H20ClFN2O2	398.9	C1CCC(C1)C(=O)N(CC2=CC(=O)NC3=C2C=CC=C3F)C4=CC(=CC=C4)Cl	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BNA50Q	N'-[4-[2-(Dimethylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-7-yl]furan-2-carboximidamide	Investigative	44600247	C17H22N4OS	330.4	CN(C)CCN1CCSC2=C1C=CC(=C2)N=C(C3=CC=CO3)N	IC50 = 94700 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BNYU36	Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-carboxylate	Investigative	11149707	C14H21N3O2	263.34	CCOC(=O)N1CCC(CC1)NC2=NC=CC(=C2)C	IC50 = 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BO8JT0	N'-Benzo[1,3]dioxol-5-ylmethyl-N-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-N-methyl-propane-1,3-diamine	Investigative	11646432	C17H20N6O2S	372.4	CN(CCCNCC1=CC2=C(C=C1)OCO2)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BO9G5M	4,5-Dimethoxy-2-(methylsulfanylmethyl)pyridine	Investigative	56666339	C9H13NO2S	199.27	COC1=C(C=NC(=C1)CSC)OC	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BOF0B8	N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)isobutyramide	Investigative	42618054	C20H18ClFN2O2	372.8	CC(C)C(=O)N(CC1=CC(=O)NC2=C1C=CC=C2F)C3=CC(=CC=C3)Cl	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BP1H5M	CID 57391112	Investigative	57391112	C21H24N8O2S	452.5	CN1C=C(N=C1)CN(CCCNCC2=CC3=C(C=C2)OCO3)C4=NC(=NS4)N5C=CN=C5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BP7BO1	Ethyl 4''-amino-1H,1''H-spiro[piperidine-4,2''-thieno[3,2-d]pyrimidine]-1-carboxylate	Investigative	11098403	C13H18N4O2S	294.38	CCOC(=O)N1CCC2(CC1)NC3=C(C(=N2)N)SC=C3	IC50 = 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BP89EX	N'-[1-[4-(Methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide	Investigative	56924689	C20H26N4S	354.5	CNC1CCC(CC1)N2CCC3=C2C=C(C=C3)N=C(C4=CC=CS4)N	IC50 = 195000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BPJ7O2	1-Amino-3-(4-chlorophenyl)-3,4-dihydroisoquinoline	Investigative	18785914	C15H13ClN2	256.73	C1C(N=C(C2=CC=CC=C21)N)C3=CC=C(C=C3)Cl	IC50 = 86000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BPQ6E0	4-Methyl-1,3-benzoxazol-2(3H)-one	Investigative	12709336	C8H7NO2	149.15	CC1=C2C(=CC=C1)OC(=O)N2	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BPS90G	6-Methyl-1,3-benzoxazol-2(3H)-one	Investigative	322634	C8H7NO2	149.15	CC1=CC2=C(C=C1)NC(=O)O2	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BPUT52	4-Phenyl-4,5-dihydro-1,3-thiazol-2-amine	Investigative	13196077	C9H10N2S	178.26	C1C(N=C(S1)N)C2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BQ19JL	N'-[1-(2-Pyrrolidin-1-ylethyl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	90664608	C21H30Cl2N4S	441.5	C1CCN(C2=C(C1)C=C(C=C2)N=C(C3=CC=CS3)N)CCN4CCCC4.Cl.Cl	IC50 = 82200 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BQ5KE7	N'-[3-(Aminomethyl)phenyl]ethanimidamide;dihydrobromide	Investigative	45261191	C9H15Br2N3	325.04	CC(=NC1=CC=CC(=C1)CN)N.Br.Br	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BQ78UK	2-[2-(4-Methoxypyridin-2-yl)ethyl]-5,7-dimethyl-1H-imidazo[4,5-b]pyridine	Investigative	10286162	C16H18N4O	282.34	CC1=CC(=NC2=C1NC(=N2)CCC3=NC=CC(=C3)OC)C	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BQ91CX	N-[3-[(3-Imidazol-1-yl-1,2,4-thiadiazol-5-yl)-methylamino]propyl]-1,3-benzodioxole-5-carboxamide	Investigative	11610728	C17H18N6O3S	386.4	CN(CCCNC(=O)C1=CC2=C(C=C1)OCO2)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BQY8P2	N-{(3R,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine	Investigative	45259040	C21H30FN5	371.5	CC1=CC(=NC(=C1)N)C[C@H]2CNC[C@@H]2NCCNCCC3=CC(=CC=C3)F	Ki = 53400 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BR40HJ	4-Methyl-6-[2-(5-{4-[(methylamino)methyl]phenyl}pyridin-3-yl)ethyl]pyridin-2-amine	Investigative	134686797	C21H24N4	332.4	CC1=CC(=NC(=C1)N)CCC2=CC(=CN=C2)C3=CC=C(C=C3)CNC	Ki = 68539 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BR4YC1	N'-[(3S,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-(2-phenylethyl)ethane-1,2-diamine	Investigative	24759763	C21H31N5	353.5	CC1=CC(=NC(=C1)N)C[C@H]2CNC[C@H]2NCCNCCC3=CC=CC=C3	Ki = 78450 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BR5FW9	2-({1H-Imidazo[4,5-c]pyridin-2-ylsulfanyl}methyl)-4-methoxypyridine	Investigative	13768262	C13H12N4OS	272.33	COC1=CC(=NC=C1)CSC2=NC3=C(N2)C=NC=C3	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BRL20A	Ethyl 4-(1-aminoethylideneamino)piperidine-1-carboxylate;hydrobromide	Investigative	25231666	C10H20BrN3O2	294.19	CCOC(=O)N1CCC(CC1)N=C(C)N.Br	IC50 = 90000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BS3U2I	N'-[3-[4-(Dimethylamino)cyclohexen-1-yl]-1H-indol-5-yl]thiophene-2-carboximidamide	Investigative	15951406	C21H24N4S	364.5	CN(C)C1CCC(=CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N	IC50 = 51400 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BS8GE2	2-Amino-4-(trifluoromethyl)pyridine	Investigative	2778315	C6H5F3N2	162.11	C1=CN=C(C=C1C(F)(F)F)N	IC50 = 72400 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BSA71R	4-[(2-Cyclopentylimidazo[4,5-b]pyrazin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one	Investigative	25211599	C20H17F2N5O	381.4	C1CCC(C1)C2=NC3=NC=CN=C3N2CC4=CC(=O)NC5=C4C=CC(=C5F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BSCO43	4-[(3-Chloro-N-pyrimidin-5-ylanilino)methyl]-7,8-difluoro-1H-quinolin-2-one	Investigative	57393439	C20H13ClF2N4O	398.8	C1=CC(=CC(=C1)Cl)N(CC2=CC(=O)NC3=C2C=CC(=C3F)F)C4=CN=CN=C4	IC50 = 79000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BSK43O	N-{(3s,4s)-4-[(6-Amino-4-Methylpyridin-2-Yl)methyl]pyrrolidin-3-Yl}-N'-(4-Chlorobenzyl)ethane-1,2-Diamine	Investigative	24798097	C20H28ClN5	373.9	CC1=CC(=NC(=C1)N)C[C@H]2CNC[C@H]2NCCNCC3=CC=C(C=C3)Cl	Ki = 85160 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BSU3L8	8-Chloro-6-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	Investigative	44319709	C12H12ClFN2	238.69	C1C[C@H]2[C@@H](C1)C(=NC3=C2C=C(C=C3F)Cl)N	IC50 = 72000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BT13QP	4-(2-Acetimidoylamino-ethanesulfinyl)-2-amino-butyric acid	Investigative	44370704	C8H17N3O3S	235.31	CC(=NCCS(=O)CCC(C(=O)O)N)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BT26KA	(S)-Pyrrolidine-2-carboximidamide	Investigative	54583301	C5H11N3	113.16	C1C[C@H](NC1)C(=N)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BT71WY	N'-[3-[(1R,3S)-3-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	Investigative	57386322	C20H25ClN4S	389	CN[C@H]1CCC[C@H](C1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N.Cl	IC50 = 77600 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BT7G2I	Ethyl 4-amino-5-fluorospiro[1H-quinazoline-2,4'-piperidine]-1'-carboxylate	Investigative	11034111	C15H19FN4O2	306.34	CCOC(=O)N1CCC2(CC1)NC3=C(C(=CC=C3)F)C(=N2)N	IC50 = 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BT95JE	N-[3-(Aminomethyl)phenyl]-N'-methylethanimidamide;dihydrobromide	Investigative	45261222	C10H17Br2N3	339.07	CC(=NC)NC1=CC=CC(=C1)CN.Br.Br	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BTE80V	Chembl1957349	Investigative	15951194	C19H20N4S	336.5	CN1CCC(=CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N	IC50 = 51100 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BTH89F	5-Chloro-2-mercaptobenzoxazole	Investigative	708870	C7H4ClNOS	185.63	C1=CC2=C(C=C1Cl)NC(=S)O2	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BU39CV	N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-3-methylpicolinamide	Investigative	42618050	C23H17ClFN3O2	421.8	CC1=C(N=CC=C1)C(=O)N(CC2=CC(=O)NC3=C2C=CC=C3F)C4=CC(=CC=C4)Cl	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BUBF89	CID 11538267	Investigative	11538267	C18H22N6O2S	386.5	CN(CCCNCC1=CC2=C(C=C1)OCCO2)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BUNA84	(R)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-butyric acid	Investigative	12109769	C8H17N3O2S	219.31	CC(=NCCSCC[C@H](C(=O)O)N)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BUPC07	Quinolinone, 15	Investigative	42618043	C22H15FN4O2S	418.4	CC1=C(SC=N1)C(=O)N(CC2=CC(=O)NC3=C2C=CC=C3F)C4=CC=CC(=C4)C#N	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BV3U7X	2-Amino-6-(1-aminoethylideneamino)-5,5-difluorohexanoic acid;dihydrochloride	Investigative	45263031	C8H17Cl2F2N3O2	296.14	CC(=NCC(CCC(C(=O)O)N)(F)F)N.Cl.Cl	IC50 = 139000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BV50BQ	5-Methyl-N'-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	90664607	C20H24Cl2N4S	423.4	CC1=CC=C(S1)C(=NC2=CC3=C(C=C2)NC=C3C4=CCN(CC4)C)N.Cl.Cl	IC50 = 65300 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BVDH76	1-[2-(1,3-Benzodioxol-5-yl)ethyl]-3-[(2-imidazol-1-yl-6-methylpyrimidin-4-yl)methyl]urea	Investigative	11646596	C19H20N6O3	380.4	CC1=CC(=NC(=N1)N2C=CN=C2)CNC(=O)NCCC3=CC4=C(C=C3)OCO4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BVJT92	3-Phenyl-3,4-dihydro-2h-pyrrol-5-amine	Investigative	211124	C10H12N2	160.22	C1C(CN=C1N)C2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BVL94T	Ethyl 2-[3-(1,3-benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]acetate	Investigative	11532357	C20H24N6O4S	444.5	CCOC(=O)CN(CCCNCC1=CC2=C(C=C1)OCO2)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BVS78X	N'-[4-[(Hydroxyamino)methyl]phenyl]ethanimidamide;dihydrobromide	Investigative	45264790	C9H15Br2N3O	341.04	CC(=NC1=CC=C(C=C1)CNO)N.Br.Br	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BW13XJ	Quinolinone, 17	Investigative	42618045	C22H18FN3O3S	423.5	CC1=C(SC=N1)C(=O)N(CC2=CC(=O)NC3=C2C=CC=C3F)C4=CC(=CC=C4)OC	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BW1X2M	N-(3-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-1H-indol-5-yl)thiophene-2-carboximidamide	Investigative	15951476	C20H20N4S	348.5	C1CN2CCC1C(=C2)C3=CNC4=C3C=C(C=C4)N=C(C5=CC=CS5)N	IC50 = 105000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BW42NF	6-Acetimidoylamino-2-amino-5-fluoro-hexanoic acid	Investigative	10219896	C8H16FN3O2	205.23	CC(=NCC(CCC(C(=O)O)N)F)N	IC50 = 182000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BW4O5E	CID 11624646	Investigative	11624646	C17H22N6OS	358.5	CN(CCCNCC1=CC=C(C=C1)OC)C2=NC(=NS2)N3C=CN=C3	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BW57QS	N'-[1-(2-Phenylethyl)indol-6-yl]thiophene-2-carboximidamide	Investigative	15951126	C21H19N3S	345.5	C1=CC=C(C=C1)CCN2C=CC3=C2C=C(C=C3)N=C(C4=CC=CS4)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BWN50K	N'-(4-Bromophenyl)ethanimidamide;hydrochloride	Investigative	45261153	C8H10BrClN2	249.53	CC(=NC1=CC=C(C=C1)Br)N.Cl	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BWX05V	Tert-butyl 4-(1-aminoethylideneamino)benzoate;hydrochloride	Investigative	45261193	C13H19ClN2O2	270.75	CC(=NC1=CC=C(C=C1)C(=O)OC(C)(C)C)N.Cl	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BX21GP	2,3,6,7-Tetrahydro-1H-1,4-diazepin-5-amine	Investigative	18721714	C5H11N3	113.16	C1CNCCN=C1N	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BXCK12	N'-[[3-(1-Methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]methyl]thiophene-2-carboximidamide;dihydrochloride	Investigative	57474449	C20H24Cl2N4S	423.4	CN1CCC(=CC1)C2=CNC3=C2C=C(C=C3)CN=C(C4=CC=CS4)N.Cl.Cl	IC50 = 64700 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BXD70V	6-[[(3S,4S)-1-Benzyl-4-(3-phenylpropylamino)pyrrolidin-3-yl]methyl]pyridin-2-amine	Investigative	24850852	C26H32N4	400.6	C1[C@@H]([C@@H](CN1CC2=CC=CC=C2)NCCCC3=CC=CC=C3)CC4=NC(=CC=C4)N	Ki = 122000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BXG92L	6-[2-[3-Fluoro-5-[4-(methylaminomethyl)phenyl]phenyl]ethyl]-4-methylpyridin-2-amine	Investigative	137637529	C22H24FN3	349.4	CC1=CC(=NC(=C1)N)CCC2=CC(=CC(=C2)F)C3=CC=C(C=C3)CNC	Ki = 69888 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BXHA23	1-Amino-3-(4-fluorophenyl)-6-fluoro-3,4-dihydroisoquinoline	Investigative	18785788	C15H12F2N2	258.269	C1C(N=C(C2=C1C=C(C=C2)F)N)C3=CC=C(C=C3)F	IC50 = 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BXHI36	CID 11502103	Investigative	11502103	C21H26N6O2	394.5	CC1=CC(=NC(=N1)N2C=CN=C2)C(C)NCCN(C)CC3=CC4=C(C=C3)OCO4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BY0FE2	2-[{3-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-propyl}-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-amino]-acetamide	Investigative	11546144	C18H21N7O3S	415.5	C1OC2=C(O1)C=C(C=C2)CNCCCN(CC(=O)N)C3=NC(=NS3)N4C=CN=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BY39VW	2-(2-(2-(1H-Imidazol-1-yl)-6-methylpyrimidin-4-yl)pyrrolidin-1-yl)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methylethanamine	Investigative	11539024	C23H28N6O2	420.5	CC1=CC(=NC(=N1)N2C=CN=C2)C3CCCN3CCN(C)CC4=CC5=C(C=C4)OCO5	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BY3RI9	2-Oxo-2,3-dihydrobenzo[d]oxazole-5-carbonitrile	Investigative	12969094	C8H4N2O2	160.13	C1=CC2=C(C=C1C#N)NC(=O)O2	IC50 = 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BY4Q9R	N'-[1-[2-(Dimethylamino)ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	90664721	C18H26Cl2N4S	401.4	CN(C)CCN1CCCC2=C1C=CC(=C2)N=C(C3=CC=CS3)N.Cl.Cl	IC50 = 58700 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BYC8R0	CID 11609610	Investigative	11609610	C15H19N7S	329.4	CN(CCCNCC1=CC=NC=C1)C2=NC(=NS2)N3C=CN=C3	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BYZ39B	N'-[4-(2-Morpholin-4-yl-2-oxoethyl)phenyl]ethanimidamide;hydrobromide	Investigative	45264962	C14H20BrN3O2	342.23	CC(=NC1=CC=C(C=C1)CC(=O)N2CCOCC2)N.Br	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BZ8YN3	3,4-Dihydro-2H-pyrrol-5-amine hydrochloride	Investigative	12778905	C4H9ClN2	120.58	C1CC(=NC1)N.Cl	IC50 = 93000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BZ9J4C	Quinolinone, 10	Investigative	42618038	C21H16FN3O2S	393.4	CC1=C(SC=N1)C(=O)N(CC2=CC(=O)NC3=C2C=CC=C3F)C4=CC=CC=C4	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BZB7D4	S-{2-[(E)-(1-Aminoethylidene)amino]ethyl}-L-cysteine	Investigative	44370730	C7H15N3O2S	205.28	CC(=NCCSC[C@@H](C(=O)O)N)N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BZG93P	4-Acetimidoylamino-Benzamide HCl	Investigative	45264763	C9H12ClN3O	213.66	CC(=NC1=CC=C(C=C1)C(=O)N)N.Cl	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BZIC14	N'-[4-[(Pyridin-2-ylamino)methyl]phenyl]ethanimidamide;dihydrobromide	Investigative	45261152	C14H18Br2N4	402.13	CC(=NC1=CC=C(C=C1)CNC2=CC=CC=N2)N.Br.Br	Ki ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BZOS17	4-((2-Cyclohexyl-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one	Investigative	24785702	C23H21F2N3O	393.4	C1CCC(CC1)C2=NC3=CC=CC=C3N2CC4=CC(=O)NC5=C4C=CC(=C5F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BZS6A1	4-[(2-Cyclobutyl-7-methoxyimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one	Investigative	25211596	C21H18F2N4O2	396.4	COC1=C2C(=NC=C1)N(C(=N2)C3CCC3)CC4=CC(=O)NC5=C4C=CC(=C5F)F	EC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	BZV8Y7	N'-(1-Phenylpropyl)ethanimidamide;hydrobromide	Investigative	25231660	C11H17BrN2	257.17	CCC(C1=CC=CC=C1)N=C(C)N.Br	IC50 = 80000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D00KOE	4-Isopropyl-pyrrolidin-(2Z)-ylideneamine	Investigative	18983431	C7H14N2	126.2	CC(C)C1CC(=NC1)N	IC50 = 87800 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D01MEA	3-Butyl-[1,4]thiazepan-(5E)-ylideneamine	Investigative	22617750	C9H18N2S	186.32	CCCCC1CSCCC(=N1)N	IC50 = 77000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D02MFQ	Azonan-(2Z)-ylideneamine	Investigative	10606829	C8H16N2	140.23	C1CCCC(=NCCC1)N	IC50 = 90000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D03ODQ	[1,4]Oxazepan-(5E)-ylideneamine	Investigative	15463448	C5H10N2O	114.15	C1COCCN=C1N	IC50 = 72680 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D03QMU	7-Butyl-azepan-(2Z)-ylideneamine	Investigative	10104379	C10H20N2	168.28	CCCCC1CCCCC(=N1)N	IC50 = 102500 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D04QFO	Hexahydro-cyclopenta[b]pyrrol-(2Z)-ylideneamine	Investigative	44393534	C7H12N2	124.18	C1CC2CC(=NC2C1)N	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D05VAB	AR-C102222	Investigative	9886249	C19H16F2N6O	382.4	C1CN(CCC12NC3=C(C=CC(=C3C(=N2)N)F)F)C(=O)C4=CN=C(C=C4)C#N	IC50 ~ 100000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D07BLJ	[1,5]Thiazocan-(4E)-ylideneamine	Investigative	44322961	C6H12N2S	144.24	C1CN=C(CCSC1)N	IC50 = 186300 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D07OQX	4-Butyl-thiazolidin-(2E)-ylideneamine	Investigative	9812839	C7H14N2S	158.27	CCCCC1CSC(=N1)N	IC50 ~ 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D08CMQ	3-Isobutyl-[1,4]thiazepan-(5E)-ylideneamine	Investigative	18721725	C9H18N2S	186.32	CC(C)CC1CSCCC(=N1)N	IC50 = 60000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D08ISP	5-Methyl-4-propyl-pyrrolidin-(2Z)-ylideneamine	Investigative	19049152	C8H16N2	140.23	CCCC1CC(=NC1C)N	IC50 = 104000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D08JSR	Tetrahydro-pyrimidin-2-ylideneamine	Investigative	3287412	C4H9N3	99.13	C1CNC(=NC1)N	IC50 = 87000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D08PZX	(R)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine	Investigative	15463450	C8H16N2S	172.29	CCC[C@@H]1CSCCC(=N1)N	IC50 = 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D09BKV	3-Propyl-[1,4]thiazepan-(5E)-ylideneamine	Investigative	15463449	C8H16N2S	172.29	CCCC1CSCCC(=N1)N	IC50 = 50000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D0D3CJ	BYK-191023	Investigative	10308091	C14H14N4O	254.29	COC1=CC(=NC=C1)CCC2=NC3=C(N2)C=CC=N3	IC50 = 112201.85 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D0J2RI	4-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine	Investigative	19049061	C7H14N2	126.2	CCC1CN=C(C1C)N	IC50 = 60600 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D0K1CM	Azocan-(2Z)-ylideneamine	Investigative	10749191	C7H14N2	126.2	C1CCCN=C(CC1)N	IC50 = 58900 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D0K4SV	3,4-Dihydro-1H-quinolin-(2E)-ylideneamine	Investigative	4102304	C9H10N2	146.19	C1CC(=NC2=CC=CC=C21)N	IC50 = 85000 nM	Poor binder
T06046	Nitric-oxide synthase endothelial	D0OW8M	AR-C133057XX	Investigative	9797857	C19H20N4O2	336.4	COC1=CC(=NC=C1)NC2CCN(CC2)C(=O)C3=CC=C(C=C3)C#N	IC50 ~ 100000 nM	Poor binder