TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T06773 Hypoxia-inducible factor 1 alpha B0KE7W 3-[[4-(3-Phenylureido)phenyl]aminomethyl]phenol Investigative 54580396 C20H19N3O2 333.4 C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)NCC3=CC(=CC=C3)O IC50 = 69900 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha B1Q7TN 3-(2-(4-Ethylphenoxy)acetamido)-4-hydroxyphenylboronic acid Investigative 46232965 C16H18BNO5 315.1 B(C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)CC)(O)O IC50 ~ 100000 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha B4GW3S 2-(4-Cyclohexylphenoxy)-N-(2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide Investigative 46232962 C26H34BNO5 451.4 B1(OC(C(O1)(C)C)(C)C)C2=CC(=C(C=C2)O)NC(=O)COC3=CC=C(C=C3)C4CCCCC4 IC50 = 70400 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha B5OHM8 N-(2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-(p-tolyloxy)acetamide Investigative 46232841 C21H26BNO5 383.2 B1(OC(C(O1)(C)C)(C)C)C2=CC(=C(C=C2)O)NC(=O)COC3=CC=C(C=C3)C IC50 = 90600 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha B7NI2B 1-[4-(3-Methoxy-benzylamino)phenyl]-3-phenylurea Investigative 54586265 C21H21N3O2 347.4 COC1=CC=CC(=C1)CNC2=CC=C(C=C2)NC(=O)NC3=CC=CC=C3 IC50 = 52100 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha B89VFB 3-(2-(Biphenyl-4-yloxy)acetamido)-4-hydroxyphenylboronic acid Investigative 46233004 C20H18BNO5 363.2 B(C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C3=CC=CC=C3)(O)O IC50 ~ 100000 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha B96DYE 2-(Biphenyl-4-yloxy)-N-(2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide Investigative 46232961 C26H28BNO5 445.3 B1(OC(C(O1)(C)C)(C)C)C2=CC(=C(C=C2)O)NC(=O)COC3=CC=C(C=C3)C4=CC=CC=C4 IC50 ~ 100000 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha BA3FX7 Ethyl 5-[(4-chlorophenyl)sulfonylamino]-3-methyl-1-benzofuran-2-carboxylate Investigative 127048857 C18H16ClNO5S 393.8 CCOC(=O)C1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)Cl)C IC50 = 50000 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha BB1JE0 2-{[4-(3-Phenylureido)phenylamino]methyl}-benzoic acid Investigative 54581400 C21H19N3O3 361.4 C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)NCC3=CC=CC=C3C(=O)O IC50 = 51700 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha BBJ75S 4-{[4-(3-Phenylureido)phenylamino]methyl}-benzoic acid Investigative 54587290 C21H19N3O3 361.4 C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)NCC3=CC=C(C=C3)C(=O)O IC50 ~ 100000 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha BG04YP 4-Hydroxy-3-(2-(p-tolyloxy)acetamido)phenylboronic acid Investigative 46232964 C15H16BNO5 301.1 B(C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C)(O)O IC50 ~ 100000 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha BO2Q7Y 3-(2-(4-Cyclohexylphenoxy)acetamido)-4-hydroxyphenylboronic acid Investigative 46233005 C20H24BNO5 369.2 B(C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C3CCCCC3)(O)O IC50 = 84800 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha BPV8G7 (3S)-2'-Bromo-5'-[[(3S)-4'-bromo-8-hydroxy-3'-oxospiro[6,10,15-triazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),2(7),8,10,12(16)-pentaene-3,6'-cyclohexa-1,4-diene]-1'-yl]disulfanyl]-8-hydroxyspiro[6,10,15-triazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),2(7),8,10,12(16)-pentaene-3,4'-cyclohexa-2,5-diene]-1'-one Investigative 136721264 C36H26Br2N6O4S2 830.6 C1CN=C2C3=C1C=NC3=C(C4=C2[C@]5(CCN4)C=C(C(=O)C=C5SSC6=CC(=O)C(=C[C@]67CCNC8=C7C9=NCCC1=C9C(=C8O)N=C1)Br)Br)O IC50 ~ 100000 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha BUF58E 2-(4-Ethylphenoxy)-N-(2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide Investigative 46232842 C22H28BNO5 397.3 B1(OC(C(O1)(C)C)(C)C)C2=CC(=C(C=C2)O)NC(=O)COC3=CC=C(C=C3)CC IC50 = 91800 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha BWDV57 Moracin M Investigative 185848 C14H10O4 242.23 C1=CC2=C(C=C1O)OC(=C2)C3=CC(=CC(=C3)O)O IC50 ~ 50000 nM Poor binder T06773 Hypoxia-inducible factor 1 alpha BYW03H 1-[4-[4-(Methoxycarbonyl)benzylamino]phenyl]-3-phenylurea Investigative 54580397 C22H21N3O3 375.4 COC(=O)C1=CC=C(C=C1)CNC2=CC=C(C=C2)NC(=O)NC3=CC=CC=C3 IC50 ~ 100000 nM Poor binder