TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T07930 Histone deacetylase 5 D0M8FD SNDX-275 Phase 2 4261 C21H20N4O3 376.4 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 D0GE5B RG-2833 Phase 1 56654642 C20H25N3O2 339.4 CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N IC50 ~ 180000 nM Poor binder T07930 Histone deacetylase 5 B03PZD 2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(6-phenylhexyl)acetamide Investigative 136025984 C19H25N3O2S 359.5 CC1=CC(=O)NC(=N1)SCC(=O)NCCCCCCC2=CC=CC=C2 IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 B0GAH1 Pimelic Diphenylamide 106 Investigative 16070100 C20H25N3O2 339.4 CC1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 B0R4TM 2-{[2-(4-Tert-butylphenyl)-2-oxoethyl]sulfanyl}-6-methyl-3,4-dihydropyrimidin-4-one Investigative 135497781 C17H20N2O2S 316.4 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)C(C)(C)C IC50 = 94300 nM Poor binder T07930 Histone deacetylase 5 B13SGM (2E,4E)-5-[4-[3-(1-Adamantyl)-4-methoxyphenyl]phenyl]-N-hydroxypenta-2,4-dienamide Investigative 90654947 C28H31NO3 429.5 COC1=C(C=C(C=C1)C2=CC=C(C=C2)/C=C/C=C/C(=O)NO)C34CC5CC(C3)CC(C5)C4 IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 B1SXO5 N-[4-[2-(4-Methylpyrimidin-2-yl)sulfanylacetyl]phenyl]acetamide Investigative 56659403 C15H15N3O2S 301.4 CC1=NC(=NC=C1)SCC(=O)C2=CC=C(C=C2)NC(=O)C IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 B1TSK2 N-[(2S)-3-(1H-Indol-3-yl)-1-oxo-1-[4-(propylaminocarbamoyl)anilino]propan-2-yl]-4-methoxybenzamide Investigative 137635119 C29H31N5O4 513.6 CCCNNC(=O)C1=CC=C(C=C1)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)C4=CC=C(C=C4)OC IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 B2VLJ6 N-[4-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanylmethyl]phenyl]acetamide Investigative 136025842 C14H15N3O2S 289.35 CC1=CC(=O)NC(=N1)SCC2=CC=C(C=C2)NC(=O)C IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 B3MS6D 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide pyren-1-ylamide Investigative 57336564 C24H12F12N2O3 604.3 C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 B3UK0O Carbamic acid,N-[[4-[[(4-amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]-,methyl ester Investigative 25032862 C22H21N3O3 375.4 COC(=O)NCC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CC=C3)N IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 B40IVW 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid biphenyl-3-ylamide hydroxyamide Investigative 57336567 C20H12F12N2O3 556.3 C1=CC=C(C=C1)C2=CC(=CC=C2)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 B40XIT N-(2-Chlorophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide Investigative 137657892 C14H7ClF12N2O3 514.65 C1=CC=C(C(=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)Cl Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 B42YAZ CID 57336568 Investigative 57336568 C18H10F12N2O3 530.3 C1=CC=C2C=C(C=CC2=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 B5HIZ3 N-[4-[2-[(4-Methyl-6-oxo-1H-pyridin-2-yl)oxy]acetyl]phenyl]acetamide Investigative 56673261 C16H16N2O4 300.31 CC1=CC(=O)NC(=C1)OCC(=O)C2=CC=C(C=C2)NC(=O)C IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 B5R4IE 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide (4-iodo-phenyl)amide Investigative 57336559 C14H7F12IN2O3 606.1 C1=CC(=CC=C1NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)I Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 B5YA1D 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(2-methylphenyl)octanediamide Investigative 137647616 C15H10F12N2O3 494.23 CC1=CC=CC=C1NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 B67IZM 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic Acid(4-Chlorophenyl)Amide Hydroxyamide Investigative 57336555 C14H7ClF12N2O3 514.65 C1=CC(=CC=C1NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)Cl Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 B6K7LT Benzyl (2S)-4-[5-[(2-amino-5-phenylphenyl)carbamoyl]pyridin-2-yl]-2-methylpiperazine-1-carboxylate Investigative 16663079 C31H31N5O3 521.6 C[C@H]1CN(CCN1C(=O)OCC2=CC=CC=C2)C3=NC=C(C=C3)C(=O)NC4=C(C=CC(=C4)C5=CC=CC=C5)N IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 B76NHE 2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(4-phenylbutyl)acetamide Investigative 136086923 C17H21N3O2S 331.4 CC1=CC(=O)NC(=N1)SCC(=O)NCCCCC2=CC=CC=C2 IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 B7JEZ8 1-((4-Hydroxy-6-methylpyrimidin-2-yl)thio)propan-2-one Investigative 135462117 C8H10N2O2S 198.24 CC1=CC(=O)NC(=N1)SCC(=O)C IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 B81YTQ N-[4-[2-(3-Hydroxyphenyl)sulfanylacetyl]phenyl]acetamide Investigative 56666337 C16H15NO3S 301.4 CC(=O)NC1=CC=C(C=C1)C(=O)CSC2=CC=CC(=C2)O IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 B8YM4H N-[4-(Dimethylamino)phenyl]-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide Investigative 137631704 C16H13F12N3O3 523.27 CN(C)C1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 B93MKY N-[4-[1-Hydroxy-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]ethyl]phenyl]acetamide Investigative 136025843 C15H17N3O3S 319.4 CC1=CC(=O)NC(=N1)SCC(C2=CC=C(C=C2)NC(=O)C)O IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 B9OI5Q 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid biphenyl-2-ylamide hydroxyamide Investigative 57336569 C20H12F12N2O3 556.3 C1=CC=C(C=C1)C2=CC=CC=C2NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BA8BT9 (E)-3-[4-[3-(1-Adamantyl)-4-(cyanomethyl)phenyl]-3-chlorophenyl]-N-hydroxyprop-2-enamide Investigative 90654946 C27H27ClN2O2 447 C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=C(C=C(C=C5)/C=C/C(=O)NO)Cl)CC#N IC50 = 124000 nM Poor binder T07930 Histone deacetylase 5 BAD74G N-(3-Chlorophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide Investigative 137656303 C14H7ClF12N2O3 514.65 C1=CC(=CC(=C1)Cl)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BAL2D3 5-[[6-Oxo-4-(4-phenylphenyl)-1H-pyrimidin-2-yl]sulfanyl]pentanehydroxamic acid Investigative 136173089 C21H21N3O3S 395.5 C1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC(=O)NC(=N3)SCCCCC(=O)NO IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BC05YB E,E-5-(4''-Methoxybiphenyl-4-yl)-penta-2,4-dienoic acid Nhydroxyamide Investigative 42631047 C18H17NO3 295.3 COC1=CC=C(C=C1)C2=CC=C(C=C2)/C=C/C=C/C(=O)NO IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BC54SO 2-[2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]sulfanyl-4-methyl-1H-pyrimidin-6-one Investigative 136086920 C15H14N2O4S 318.3 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC3=C(C=C2)OCCO3 IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BCN8A1 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic Acid(4-Cyanophenyl)Amide Hydroxyamide Investigative 57336558 C15H7F12N3O3 505.21 C1=CC(=CC=C1C#N)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BD4E0N CID 57336565 Investigative 57336565 C22H13F12N5O3 623.4 C1=CC=C(C=C1)N2C(=CN=N2)C3=CC=C(C=C3)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BDCZ86 2-[(4-Methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(2-phenylethyl)acetamide Investigative 135441620 C15H17N3O2S 303.4 CC1=CC(=O)NC(=N1)SCC(=O)NCCC2=CC=CC=C2 IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BEP61I 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic Acid(3-Ethylphenyl)Amide Hydroxyamide Investigative 57336562 C16H12F12N2O3 508.26 CCC1=CC(=CC=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BFC08Z 2-[2-(4-Hydroxyphenyl)-2-oxoethyl]sulfanyl-4-methyl-1H-pyrimidin-6-one Investigative 135928628 C13H12N2O3S 276.31 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)O IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BG09QH N-{4-[2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetyl]-phenyl}-acetamide Investigative 1108280 C16H17N3O2S 315.4 CC1=CC(=NC(=N1)SCC(=O)C2=CC=C(C=C2)NC(=O)C)C IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BHB09K 2-(2,2-Dimethylpropanoyl)-N-hydroxy-1,3-dihydroisoindole-5-carboxamide Investigative 58147224 C14H18N2O3 262.3 CC(C)(C)C(=O)N1CC2=C(C1)C=C(C=C2)C(=O)NO IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BHGX52 6-Methyl-2-phenacylsulfanyl-1H-pyrimidin-4-one Investigative 135412194 C13H12N2O2S 260.31 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=CC=C2 IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BI5YC9 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-[3-(1-phenyltriazol-4-yl)phenyl]octanediamide Investigative 137632251 C22H13F12N5O3 623.4 C1=CC=C(C=C1)N2C=C(N=N2)C3=CC(=CC=C3)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BI6ZB1 N-Methyl-N-[4-[2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]acetamide Investigative 136025986 C16H17N3O3S 331.4 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)N(C)C(=O)C IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BI97WY N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-1,3,4,5-tetrahydro-2-benzazepine-7-carboxamide Investigative 58147302 C17H19N3O3 313.35 CN1C=CC=C1C(=O)N2CCCC3=C(C2)C=CC(=C3)C(=O)NO IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BIV94E 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid (4-acetylaminophenyl)-amide hydroxyamide Investigative 57336556 C16H11F12N3O4 537.26 CC(=O)NC1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BJ1OD3 2-(Tert-butylcarbonylmethylthio)-4-hydroxy-6-methylpyrimidine Investigative 135473106 C11H16N2O2S 240.32 CC1=CC(=O)NC(=N1)SCC(=O)C(C)(C)C IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BJ2Y3N 2-(4-Chlorophenacylthio)-4-hydroxy-6-methylpyrimidine Investigative 135437514 C13H11ClN2O2S 294.76 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)Cl IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BL9F0X Hdac3-IN-T326 Investigative 71721558 C21H18N6O3S 434.5 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(S2)C3=CN(N=N3)CCC4=CC(=CC=C4)[N+](=O)[O-] IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BLBA30 2-[(4-Hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(4-methoxyphenyl)ethanone Investigative 135449197 C14H14N2O3S 290.34 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)OC IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BLTC81 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide phenan-thren-9-ylamide Investigative 57336571 C22H12F12N2O3 580.3 C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BM9I8K Chembl4165684 Investigative 145953085 C25H23N3O5 445.5 C1COCCN1C2=C3C=CC=C4C3=C(C=C2)C(=O)N(C4=O)CCC5=CC=C(C=C5)C(=O)NO IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BMC98T 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-(4-fluorophenyl)-N'-hydroxyoctanediamide Investigative 137649646 C14H7F13N2O3 498.2 C1=CC(=CC=C1NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BMH13O Ethyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate Investigative 25155956 C21H21N3O3S 395.5 CCOC(=O)NCC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BMN7R5 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide (4-phenylthiazol-2-yl)amide Investigative 56951446 C17H9F12N3O3S 563.3 C1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BMZ5H3 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(4-methoxyphenyl)octanediamide Investigative 137652670 C15H10F12N2O4 510.23 COC1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BNI3M0 CID 57336570 Investigative 57336570 C22H12F12N2O3 580.3 C1=CC=C2C=C3C=C(C=CC3=CC2=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BNJI96 (7R)-N-Hydroxy-7-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxamide Investigative 92045024 C20H19N5O2 361.4 C1CC2=C(C[C@@H]1NC3=NC=CC(=N3)C4=CN=CC=C4)C=C(C=C2)C(=O)NO IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BNP3Y7 N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide Investigative 71721946 C21H19N5OS 389.5 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)C3=CN(N=N3)CCC4=CSC=C4 IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BOF9Z6 [4-(4-Amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester Investigative 25155417 C27H24N4O3 452.5 C1=CC=C(C=C1)C2=CC(=C(C=C2)N)NC(=O)C3=CC=C(C=C3)CNC(=O)OCC4=CN=CC=C4 IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BP25QZ 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid biphenyl-4-ylamide hydroxyamide Investigative 57336561 C20H12F12N2O3 556.3 C1=CC=C(C=C1)C2=CC=C(C=C2)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BP9E6M N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carboxamide Investigative 49831258 C16H17N3O3 299.32 CN1C=CC=C1C(=O)N2CCC3=C(C2)C=CC(=C3)C(=O)NO IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BPRY15 Methyl 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)acetate Investigative 135412048 C8H10N2O3S 214.24 CC1=CC(=O)NC(=N1)SCC(=O)OC IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BQA14N N-(2-Amino-5-(thiophen-2-yl)phenyl)-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)nicotinamide Investigative 24744325 C23H23N5O3S 449.5 C1CN(CCC12CNC(=O)O2)C3=NC=C(C=C3)C(=O)NC4=C(C=CC(=C4)C5=CC=CS5)N IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BR52IK N1-(2-Aminophenyl)-N7-phenylheptanediamide Investigative 9543539 C19H23N3O2 325.4 C1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N IC50 ~ 180000 nM Poor binder T07930 Histone deacetylase 5 BR6BY4 N-Hydroxy-2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]isoindoline-5-carboxamide Investigative 58147189 C15H15N3O3 285.3 CN1C=CC=C1C(=O)N2CC3=C(C2)C=C(C=C3)C(=O)NO IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BR9PK4 Diethyl(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzylamino)methylphosphonate Investigative 42601485 C23H28N3O4PS 473.5 CCOP(=O)(CNCC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N)OCC IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BRGV98 1-(3,4-Dihydroxyphenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-YL)thio]ethanone Investigative 135444536 C13H12N2O4S 292.31 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC(=C(C=C2)O)O IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BRH7M9 N-(2-Aminophenyl)-4-[[[(4R,5S)-4,5-diphenyl-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide Investigative 136110961 C29H26N4O2 462.5 C1=CC=C(C=C1)[C@@H]2[C@@H](OC(=NCC3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N)N2)C5=CC=CC=C5 IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BS8PG9 2-(2,2-Dimethylpropanoyl)-N-hydroxy-3,4-dihydro-1H-isoquinoline-6-carboxamide Investigative 49855444 C15H20N2O3 276.33 CC(C)(C)C(=O)N1CCC2=C(C1)C=CC(=C2)C(=O)NO IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BTA14N (E)-3-[4-[3-(1-Adamantyl)-4-hydroxyphenyl]phenyl]-N-hydroxyprop-2-enamide Investigative 15986417 C25H27NO3 389.5 C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC=C(C=C5)/C=C/C(=O)NO)O IC50 = 78400 nM Poor binder T07930 Histone deacetylase 5 BU4XY9 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid (3,4-dimethylphenyl)-amide hydroxyamide Investigative 57336560 C16H12F12N2O3 508.26 CC1=C(C=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)C Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BULF09 N-(2-Amino-5-thiophen-2-ylphenyl)benzamide Investigative 44454144 C17H14N2OS 294.4 C1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BV9UD6 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide naph-thalen-1-ylamide Investigative 57336566 C18H10F12N2O3 530.3 C1=CC=C2C(=C1)C=CC=C2NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BVA69W 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N,N'-diphenyloctanediamide Investigative 57401090 C20H12F12N2O2 540.3 C1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NC2=CC=CC=C2)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BVSP75 6-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]-1,3-dihydroindol-2-one Investigative 136086921 C15H13N3O3S 315.3 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC3=C(CC(=O)N3)C=C2 IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BW53QM N-[4-[2-(4-Methoxy-6-methylpyrimidin-2-yl)sulfanylacetyl]phenyl]acetamide Investigative 56673234 C16H17N3O3S 331.4 CC1=CC(=NC(=N1)SCC(=O)C2=CC=C(C=C2)NC(=O)C)OC IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BW7C9A 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(3-methylphenyl)octanediamide Investigative 137658785 C15H10F12N2O3 494.23 CC1=CC(=CC=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BX62ZD 6-Methyl-2-{[2-oxo-2-(thiophen-2-yl)ethyl]sulfanyl}-3,4-dihydropyrimidin-4-one Investigative 135407493 C11H10N2O2S2 266.3 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=CS2 IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BX8AF0 N-[4-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]benzamide Investigative 136025837 C20H17N3O3S 379.4 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)NC(=O)C3=CC=CC=C3 IC50 ~ 100000 nM Poor binder T07930 Histone deacetylase 5 BYW6V2 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide 4-methyl-phenylamide Investigative 57336554 C15H10F12N2O3 494.23 CC1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 BZ0O7G 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid anthracen-1-ylamide hydroxyamide Investigative 57336572 C22H12F12N2O3 580.3 C1=CC=C2C=C3C(=CC2=C1)C=CC=C3NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T07930 Histone deacetylase 5 D04UVL N-(2-aminophenyl)nicotinamide Investigative 1133083 C12H11N3O 213.23 C1=CC=C(C(=C1)N)NC(=O)C2=CN=CC=C2 IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 D0E0TA N-(4-hydroxybiphenyl-3-yl)benzamide Investigative 44454650 C19H15NO2 289.3 C1=CC=C(C=C1)C2=CC(=C(C=C2)O)NC(=O)C3=CC=CC=C3 IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 D0M9LJ N-(4-aminobiphenyl-3-yl)nicotinamide Investigative 44454415 C18H15N3O 289.3 C1=CC=C(C=C1)C2=CC(=C(C=C2)N)NC(=O)C3=CN=CC=C3 IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 D0MD7H N-(4-aminobiphenyl-3-yl)benzamide Investigative 44454143 C19H16N2O 288.3 C1=CC=C(C=C1)C2=CC(=C(C=C2)N)NC(=O)C3=CC=CC=C3 IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 D0Q2GM N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide Investigative 44454416 C16H13N3OS 295.4 C1=CC(=CN=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N IC50 ~ 50000 nM Poor binder T07930 Histone deacetylase 5 D0U8FC N-(2-aminophenyl)benzamide Investigative 759408 C13H12N2O 212.25 C1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N IC50 ~ 50000 nM Poor binder