TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T08123	Leucine-rich repeat kinase 2	B1U3DQ	Ethyl 2-[(3,7-diphenyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)sulfanyl]propanoate	Investigative	71579091	C22H20N4O2S	404.5	CCOC(=O)C(C)SC1=NN2C(=NN=C2C3=CC=CC=C3)C=C1C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T08123	Leucine-rich repeat kinase 2	B48HEJ	8-Methyl-3-thiophen-2-yl-6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazine	Investigative	71579090	C17H11F3N4S2	392.4	CC1=CC(=NN2C1=NN=C2C3=CC=CS3)SC4=CC=CC(=C4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T08123	Leucine-rich repeat kinase 2	B6ID2N	Ethyl 3-thiophen-2-yl-6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazine-8-carboxylate	Investigative	71579092	C19H13F3N4O2S2	450.5	CCOC(=O)C1=CC(=NN2C1=NN=C2C3=CC=CS3)SC4=CC=CC(=C4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T08123	Leucine-rich repeat kinase 2	B8KMY6	1H-Pyrrolo[2,3-B]pyridine-3-carbonitrile	Investigative	10313195	C8H5N3	143.15	C1=CC2=C(NC=C2C#N)N=C1	IC50 = 101080 nM	Poor binder
T08123	Leucine-rich repeat kinase 2	B9V0NX	3-(4,5-Dihydro-1H-imidazol-2-yl)-7-(4-methylsulfonylphenyl)-N-propan-2-ylquinolin-4-amine	Investigative	71718965	C22H24N4O2S	408.5	CC(C)NC1=C2C=CC(=CC2=NC=C1C3=NCCN3)C4=CC=C(C=C4)S(=O)(=O)C	IC50 = 88597 nM	Poor binder
T08123	Leucine-rich repeat kinase 2	B9XW1O	3-(1-Methylimidazol-4-yl)-5-(4-methylphenyl)pyridin-2-amine	Investigative	137637903	C16H16N4	264.32	CC1=CC=C(C=C1)C2=CC(=C(N=C2)N)C3=CN(C=N3)C	IC50 = 57000 nM	Poor binder
T08123	Leucine-rich repeat kinase 2	BEB0Y1	3-Phenyl-N-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-amine	Investigative	71579169	C18H12F3N5	355.3	C1=CC=C(C=C1)C2=NN=C3N2N=C(C=C3)NC4=CC=CC(=C4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder