TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T10118	Chymotrypsin-C	D0J2VB	Iboctadekin + rituximab	Phase 1	5478883	C34H63N5O9	685.9	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)O)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C)O	IC50 ~ 100000 nM	Poor binder
T10118	Chymotrypsin-C	D0Y3DN	Flavonoid derivative 4	Patented	5280343	C15H10O7	302.23	C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O	IC50 = 100000 nM	Poor binder
T10118	Chymotrypsin-C	D0WY9H	ZD-0892	Discontinued in Phase 1	9892148	C24H32F3N3O5	499.5	CC(C)[C@@H](C(=O)C(F)(F)F)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)C2=CC=C(C=C2)OC	Ki = 200000 nM	Poor binder
T10118	Chymotrypsin-C	D0V5XL	KRI-1314	Terminated	6918046	C38H51N5O7	689.8	CC(C)OC(=O)[C@@H]([C@H](CC1CCCCC1)NC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC3=CC=CC4=CC=CC=C43)CC(=O)N5CCOCC5)O	IC50 ~ 100000 nM	Poor binder
T10118	Chymotrypsin-C	B02GEN	(4S)-4-[[(2S)-2-Amino-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[(2R)-2-[[(1R)-3-(4-tert-butylphenyl)-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]propyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid	Investigative	44338807	C47H73BN6O11	908.9	B1(O[C@@H]2C[C@@H]3C[C@H]([C@@]2(O1)C)C3(C)C)[C@H](CCC4=CC=C(C=C4)C(C)(C)C)NC(=O)[C@H]5CCCN5C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)N	IC50 ~ 60000 nM	Poor binder
T10118	Chymotrypsin-C	B0GZ1D	1-Naphthalenesulfonic acid, 3-hydroxy-4-[(1-hydroxy-2-naphthalenyl)azo]-	Investigative	19098	C20H14N2O5S	394.4	C1=CC=C2C(=C1)C=CC(=C2O)N=NC3=C(C=C(C4=CC=CC=C43)S(=O)(=O)O)O	IC50 = 90000 nM	Poor binder
T10118	Chymotrypsin-C	B13CZD	2H-Pyran-2-one, 5-phenyl-	Investigative	13615453	C11H8O2	172.18	C1=CC=C(C=C1)C2=COC(=O)C=C2	Ki = 75000 nM	Poor binder
T10118	Chymotrypsin-C	B2F5WP	[3,5-Dibutyl-2-oxo-6-(6-oxoundecan-5-yl)pyran-4-yl] acetate	Investigative	21603623	C26H42O5	434.6	CCCCCC(=O)C(CCCC)C1=C(C(=C(C(=O)O1)CCCC)OC(=O)C)CCCC	Ki = 190546.07 nM	Poor binder
T10118	Chymotrypsin-C	B5FHE8	2-Naphthalen-2-yl-6-p-tolyl-isonicotinic acid	Investigative	20443937	C23H17NO2	339.4	CC1=CC=C(C=C1)C2=NC(=CC(=C2)C(=O)O)C3=CC4=CC=CC=C4C=C3	IC50 = 50000 nM	Poor binder
T10118	Chymotrypsin-C	B6CMA3	2-Chloro-benzenesulfonic acid 3-(1-carbamimidoyl-piperidin-3-ylmethoxy)-5-methyl-phenyl ester	Investigative	44287798	C20H24ClN3O4S	437.9	CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCC3CCCN(C3)C(=N)N	Ki = 72000 nM	Poor binder
T10118	Chymotrypsin-C	B6RJN1	3-(4-{[(S)-1-(2-Tert-Butoxycarbonylamino-4-carboxy-butyryl)-pyrrolidine-2-carbonyl]-amino}-2,2-difluoro-3-oxo-5-phenyl-pentanoylamino)-naphthalene-1-carboxylic acid	Investigative	44382957	C37H40F2N4O10	738.7	CC(C)(C)OC(=O)NC(CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)NC(CC2=CC=CC=C2)C(=O)C(C(=O)NC3=CC4=CC=CC=C4C(=C3)C(=O)O)(F)F	Ki = 92900 nM	Poor binder
T10118	Chymotrypsin-C	B7NTI8	4-[2-(2,4-Difluoroanilino)-4-thiazolyl]pyrocatechol	Investigative	5190983	C15H10F2N2O2S	320.3	C1=CC(=C(C=C1C2=CSC(=N2)NC3=C(C=C(C=C3)F)F)O)O	IC50 = 100000 nM	Poor binder
T10118	Chymotrypsin-C	B98TPM	2H-Pyran-2-one, 6-chloro-5-(phenylmethyl)-	Investigative	44270803	C12H9ClO2	220.65	C1=CC=C(C=C1)CC2=C(OC(=O)C=C2)Cl	Ki = 50000 nM	Poor binder
T10118	Chymotrypsin-C	B9OXD2	6-Chloro-5-naphthalen-2-ylmethyl-pyran-2-one	Investigative	13615447	C16H11ClO2	270.71	C1=CC=C2C=C(C=CC2=C1)CC3=C(OC(=O)C=C3)Cl	Ki = 63000 nM	Poor binder
T10118	Chymotrypsin-C	BA23PG	2-(4-(6-Bromo-1-hydroxy-2-naphthylazo)phenoxy)acetic acid	Investigative	4422179	C18H13BrN2O4	401.2	C1=CC(=CC=C1N=NC2=C(C3=C(C=C2)C=C(C=C3)Br)O)OCC(=O)O	IC50 = 80000 nM	Poor binder
T10118	Chymotrypsin-C	BB4EU2	3-[[(3R,3Ar,6aS)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-3-yl]methyl]benzenecarboximidamide;acetic acid	Investigative	44331422	C17H22N2O4	318.4	CC(=O)O.C1C[C@H]2[C@H](C1)OC(=O)[C@@H]2CC3=CC(=CC=C3)C(=N)N	IC50 ~ 100000 nM	Poor binder
T10118	Chymotrypsin-C	BB67TI	(4S)-4-[[(2S)-2-Amino-3-carboxypropanoyl]amino]-5-[[(2S)-3-methyl-1-[[(2S)-3-methyl-1-oxo-1-[(2R)-2-[[(1R)-3-(4-phenoxyphenyl)-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]propyl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]amino]-1-oxobutan-2-yl]amino]-5-oxopentanoic acid	Investigative	44338659	C49H69BN6O12	944.9	B1(O[C@@H]2C[C@@H]3C[C@H]([C@@]2(O1)C)C3(C)C)[C@H](CCC4=CC=C(C=C4)OC5=CC=CC=C5)NC(=O)[C@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)N	IC50 ~ 60000 nM	Poor binder
T10118	Chymotrypsin-C	BB9RO4	Rose Bengal lactone	Investigative	69439	C20H4Cl4I4O5	973.7	C1=C2C(=C(C(=C1I)O)I)OC3=C(C(=C(C=C3C24C5=C(C(=C(C(=C5Cl)Cl)Cl)Cl)C(=O)O4)I)O)I	IC50 = 50000 nM	Poor binder
T10118	Chymotrypsin-C	BBN1E5	3-Benzyl-6-chloro-2-pyrone	Investigative	135053	C12H9ClO2	220.65	C1=CC=C(C=C1)CC2=CC=C(OC2=O)Cl	Ki = 76000 nM	Poor binder
T10118	Chymotrypsin-C	BC3TB2	2H-Pyran-2-one, 6-bromo-3-(phenylmethyl)-	Investigative	13615438	C12H9BrO2	265.1	C1=CC=C(C=C1)CC2=CC=C(OC2=O)Br	Ki = 112000 nM	Poor binder
T10118	Chymotrypsin-C	BCG56V	[Tris-(2,2-dicarboxycyclopropyl)]-Buckmins model	Investigative	44293166	C69H6O12	1026.8	C12=C3C4=C5C6=C1C7=C8C6=C9C1=C6C%10=C%11C%12=C%13C(=C9%10)C8=C8C%139C%10(C9(C(=O)O)C(=O)O)C9=C%13C8=C7C7=C2C2=C3C3=C8C%14=C%15C%16=C%17C%18=C%14C3=C4C(=C51)C%18=C6C%171C%11(C1(C(=O)O)C(=O)O)C1=C%16C3=C(C9=C4C(=C7%13)C2=C8C42C%153C2(C(=O)O)C(=O)O)C%10=C%121	IC50 = 60000 nM	Poor binder
T10118	Chymotrypsin-C	BCP3L8	3-[((3E)-3-{[(E)-Amino(imino)methyl]hydrazono}propyl)oxy]-5-methylphenyl 2-(trifluoromethoxy)benzenesulfonate	Investigative	44352031	C18H19F3N4O5S	460.4	CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2OC(F)(F)F)OCC/C=N/N=C(N)N	Ki = 88000 nM	Poor binder
T10118	Chymotrypsin-C	BD3U9F	2H-Pyran-2-one, 3-(phenylmethyl)-	Investigative	13660351	C12H10O2	186.21	C1=CC=C(C=C1)CC2=CC=COC2=O	Ki = 160000 nM	Poor binder
T10118	Chymotrypsin-C	BER68J	6-Chloro-3-naphthalen-1-ylmethyl-pyran-2-one	Investigative	13615437	C16H11ClO2	270.71	C1=CC=C2C(=C1)C=CC=C2CC3=CC=C(OC3=O)Cl	Ki = 93000 nM	Poor binder
T10118	Chymotrypsin-C	BEW06C	(4S)-4-[[(2S)-2-Amino-3-carboxypropanoyl]amino]-5-[[(2S)-3-methyl-1-[[(2S)-3-methyl-1-oxo-1-[(2R)-2-[[(1R)-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]propyl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]amino]-1-oxobutan-2-yl]amino]-5-oxopentanoic acid	Investigative	44338821	C37H61BN6O11	776.7	B1(O[C@@H]2C[C@@H]3C[C@H]([C@@]2(O1)C)C3(C)C)[C@H](CC)NC(=O)[C@H]4CCCN4C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)N	IC50 ~ 60000 nM	Poor binder
T10118	Chymotrypsin-C	BF31GU	5-(4-{[(S)-1-(2-Tert-Butoxycarbonylamino-4-carboxy-butyryl)-pyrrolidine-2-carbonyl]-amino}-2,2-difluoro-3-oxo-5-phenyl-pentanoylamino)-thiophene-3-carboxylic acid	Investigative	44383483	C31H36F2N4O10S	694.7	CC(C)(C)OC(=O)NC(CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)NC(CC2=CC=CC=C2)C(=O)C(C(=O)NC3=CC(=CS3)C(=O)O)(F)F	Ki ~ 100000 nM	Poor binder
T10118	Chymotrypsin-C	BI4K5L	4-[[(3R,3Ar,6aS)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-3-yl]methyl]benzenecarboximidamide;acetic acid	Investigative	44331418	C17H22N2O4	318.4	CC(=O)O.C1C[C@H]2[C@H](C1)OC(=O)[C@@H]2CC3=CC=C(C=C3)C(=N)N	IC50 = 70300 nM	Poor binder
T10118	Chymotrypsin-C	BJNW78	(4S)-4-[[(2S)-2-Amino-3-carboxypropanoyl]amino]-5-[[(2S)-3-methyl-1-[[(2S)-3-methyl-1-oxo-1-[(2R)-2-[[(1R)-3-(4-propan-2-ylphenyl)-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]propyl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]amino]-1-oxobutan-2-yl]amino]-5-oxopentanoic acid	Investigative	44338660	C46H71BN6O11	894.9	B1(O[C@@H]2C[C@@H]3C[C@H]([C@@]2(O1)C)C3(C)C)[C@H](CCC4=CC=C(C=C4)C(C)C)NC(=O)[C@H]5CCCN5C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)N	IC50 ~ 60000 nM	Poor binder
T10118	Chymotrypsin-C	BJV9D5	(4S)-4-[[(2S)-2-Amino-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[(2R)-2-[[(1R)-3-(4-cyclohexylphenyl)-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]propyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid	Investigative	44338820	C49H75BN6O11	935	B1(O[C@@H]2C[C@@H]3C[C@H]([C@@]2(O1)C)C3(C)C)[C@H](CCC4=CC=C(C=C4)C5CCCCC5)NC(=O)[C@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)N	IC50 ~ 60000 nM	Poor binder
T10118	Chymotrypsin-C	BKAJ58	3,6-Bis((4-bromo-2-sulphophenyl)azo)-4,5-dihydroxynaphthalene-2,7-disulphonic acid	Investigative	135445689	C22H14Br2N4O14S4	846.4	C1=CC(=C(C=C1Br)S(=O)(=O)O)N=NC2=C(C3=C(C(=C(C=C3C=C2S(=O)(=O)O)S(=O)(=O)O)N=NC4=C(C=C(C=C4)Br)S(=O)(=O)O)O)O	IC50 = 110000 nM	Poor binder
T10118	Chymotrypsin-C	BOQ10E	3-(4-{[(S)-1-(2-Tert-Butoxycarbonylamino-3-carboxy-propionyl)-pyrrolidine-2-carbonyl]-amino}-2,2-difluoro-3-oxo-5-phenyl-pentanoylamino)-benzoic acid	Investigative	44384376	C32H36F2N4O10	674.6	CC(C)(C)OC(=O)NC(CC(=O)O)C(=O)N1CCC[C@H]1C(=O)NC(CC2=CC=CC=C2)C(=O)C(C(=O)NC3=CC=CC(=C3)C(=O)O)(F)F	Ki ~ 100000 nM	Poor binder
T10118	Chymotrypsin-C	BQFI94	CID 14799980	Investigative	14799980	C28H37NO	403.6	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCC4=CC=CC=C4)CCC5=C3C=CC(=C5)OC	IC50 = 200000 nM	Poor binder
T10118	Chymotrypsin-C	BQY91R	2-Butyl-2-(3,5-dibutyl-4-hydroxy-6-oxopyran-2-yl)octanal	Investigative	54732424	C25H42O4	406.6	CCCCCCC(CCCC)(C=O)C1=C(C(=C(C(=O)O1)CCCC)O)CCCC	Ki = 134896.29 nM	Poor binder
T10118	Chymotrypsin-C	BU2T4G	2-Chloro-benzenesulfonic acid 3-(5-guanidino-pentyloxy)-5-methyl-phenyl ester	Investigative	44287797	C19H24ClN3O4S	425.9	CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCCCCCN=C(N)N	Ki = 80000 nM	Poor binder
T10118	Chymotrypsin-C	BU9O7D	5-[(3R,3Ar,6aS)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-3-yl]pentanimidamide;acetic acid	Investigative	44331420	C14H24N2O4	284.35	CC(=O)O.C1C[C@H]2[C@H](C1)OC(=O)[C@@H]2CCCCC(=N)N	IC50 ~ 100000 nM	Poor binder
T10118	Chymotrypsin-C	BV6BW9	N'1,N'2-Bis(2-Hydroxybenzylidene)Oxalohydrazide	Investigative	135576411	C16H14N4O4	326.31	C1=CC=C(C(=C1)/C=N/NC(=O)C(=O)N/N=C/C2=CC=CC=C2O)O	IC50 = 55000 nM	Poor binder
T10118	Chymotrypsin-C	BZI1U2	3,5-Dibutyl-4-hydroxy-6-(1-oxo-1-phenylhexan-2-yl)pyran-2-one	Investigative	54707146	C25H34O4	398.5	CCCCC1=C(C(=C(OC1=O)C(CCCC)C(=O)C2=CC=CC=C2)CCCC)O	Ki = 79432.82 nM	Poor binder